id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010056-zfin4bko	Mejia, Rojelio	Impact of intestinal parasites on microbiota and cobalamin gene sequences: a pilot study	2020-04-19		.txt	text/plain	4092	260	41	RESULTS: For Giardia-only infected children compared to uninfected children, DNA sequencing data showed a decrease in microbiota biodiversity that correlated with increasing Giardia burden and was statistically significant using Shannon's alpha diversity (Giardia-only > 1 fg/µl 2.346; non-infected group 3.253, P = 0.0317). CONCLUSION: The study results may provide evidence for an effect of parasitic infections enabling the permissive growth of anaerobic bacteria such as Prevotella, suggesting an altered capacity of vitamin B12 (cobalamin) biosynthesis and potential impact on growth and development in children [Image: see text]. There are few studies attributing gut microbiome changes to giardiasis [17] [18] [19] and no published studies showing the impact on the human intestinal microbiome using multi-parallel real-time quantitative (qPCR) to detect the presence of Giardia and quantitating the burden of infection [20] . In this pilot study, parasite qPCR and next-generation DNA sequencing was used to explore whether quantitative burden of specific parasites (Giardia duodenalis and soil-transmitted helminths) influence the composition of intestinal microbial communities.	./cache/cord-010056-zfin4bko.txt	./txt/cord-010056-zfin4bko.txt