id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002441-w731ehtz	Jeon, Young Joo	Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress	2017-02-28		.txt	text/plain	4141	227	44	The expression of interferon-stimulated gene 15 (ISG15), the first identified ubiquitin-like protein, has recently been shown to be induced under various DNA damage conditions, such as exposure to UV, camptothecin, and doxorubicin. Here we overview the recent findings on the role of ISG15 and its conjugation to target proteins (e.g., p53, ΔNp63α, and PCNA) in the control of cellular responses to genotoxic stress, such as the inhibition of cell growth and tumorigenesis. Accordingly, treatment with DNA-damaging agents, such as UV, camptothecin, and doxorubicin, markedly induces both the mRNA and protein further accelerates p53 ISGylation and subsequent processes for suppression of cell growth and tumor development by forming a positive feedback loop. Thus, it appears clear that ISG15 and its conjugation to target proteins play a crucial function in the control of cellular responses to genotoxic stresses and in turn in suppression of DNA damage-mediated tumorigenesis.	./cache/cord-002441-w731ehtz.txt	./txt/cord-002441-w731ehtz.txt