key: cord-352532-xqphom6x authors: Papanikolaou, Ilias C; Sharma, Om P title: 1 Tropical Lung Diseases date: 2013-12-31 journal: Hunter's Tropical Medicine and Emerging Infectious Disease DOI: 10.1016/b978-1-4160-4390-4.00001-1 sha: doc_id: 352532 cord_uid: xqphom6x nan The term "tropics" refers to the region of the earth lying between the Tropic of Cancer and the Tropic of Capricorn. In the tropics, warm climate, poverty, lack of education, and poor sanitation provide an ideal environment for pathogens, vectors and intermediate hosts to flourish [1] . In this vast landmass, respiratory infections are a major cause of morbidity and mortality in children and adults [2] . In a typical tropical clinic, 20-40% of outpatients have respiratory complaints, and 20-30% of inpatients have lung disease (Table 1-1) [2] . Many tropical patients suffer from lung diseases that are found worldwide, e.g. asthma, bronchiectasis, chronic obstructive lung disease, HIV infection-related lung disease, and lung cancer. Numerous dust diseases, e.g. silicosis, asbestosis, byssinosis, hypersensitivity pneumonitis, and diseases due to microbial contamination of agricultural products, remain under-recognized. Diseases associated with pulmonary symptoms and infection that are concentrated in the tropics include malaria, pulmonary schistosomiasis, melioidosis, paragonimiasis, echinococcal cysts, tropical eosinophilia, and diseases related to nutritional deficiencies [3] . In addition, individuals who come in contact with birds or animals may develop zoonoses such as tularemia, psittacosis, Q fever and leptospirosis [4] . In the tropics, indoor air pollution caused by biomass fuels used for cooking and heating of the homes and huts is an important cause of obstructive lung disease and chronic lung infections [5] . The following are the common tropical pulmonary conditions: l pneumonia: typical and atypical l eosinophilic pneumonias and tropical pulmonary eosinophilia l bronchiectasis, asthma and chronic obstructive pulmonary disease (COPD) l pleural effusion l nontuberculous granulomatous lung disease l occupational lung diseases. A reasonable approach to the patient with lung disease in the tropic starts with age, occupational exposure, physical examination, HIV status, chest x-ray and blood tests. In children, bacterial pneumonia is the most common and life-threatening disorder. Known immunodeficiency suggests tuberculosis, fungi and opportunistic pathogens. Peripheral blood eosinophilia with either a pleural effusion or diffuse parenchymal consolidation may suggest a parasitic infection, or, when combined with wheezing, tropical pulmonary eosinophilia. Worldwide diseases like COPD may affect nonsmoking individuals due to indoor pollutants. Streptococcus pneumoniae is the most common bacterial cause of pneumonia. Upper respiratory involvement often precedes the onset of pneumococcal pneumonia, which is characterized by fever, chills, malaise and sweating. The patient is flushed and febrile with a rapid pulse and respiratory rate. Dyspnea is associated with a nonproductive cough, and sputum, if present, may be thick, tenacious or "rusty". Severe pleuritic chest pain causing tachypnea and grunting respiration is often present. Such symptoms are abrupt in young, immunocompetent patients ( Fig.1.1 ) [6] . In elderly patients, symptoms may be few and can be dominated by confusion, delirium and prostration [7] . Physical examination of the affected lung, usually the lower lobe, reveals diminished lung expansion, impaired percussion note, decreased breath sounds, crepitations (crackles/rales) and bronchial breath sounds. Cyanosis is common and a herpes simplex eruption may be seen on the lips. With proper treatment, most patients with pneumococcal pneumonia improve clinically and radiographically within 1-2 weeks. When resolution occurs, fever subsides within a week as the temperature decreases following a crisis pattern ( Fig. 1.2A) . Delayed resolution is seen in smokers, the elderly, and in those with poor nutrition, diabetes or other comorbid illnesses. Staphylococcal pneumonia (Staphylococcus aureus), accounts for 2-10% of acute community-acquired pneumonias. It is an important cause of pneumonia in children, the elderly, patients recovering from influenza, people with diabetes mellitus, and those who are immunocompromised. Methicillin-resistant Staphylococcus aureus (MRSA) causes illness in 1% of cases of upper or lower respiratory tract infection in the community and in 10% of patients who are hospitalized. Patients with staphylococcal pneumonia are usually ill with high fever, shaking chills, chest pain, cough and purulent sputum. Chest x-ray films show patchy consolidation and cavities. Sputum examination is an important aid in the diagnosis of pneumonia. Color, amount, consistency and odor are helpful: mucopurulent sputum is commonly found in bacterial pneumonia or bronchitis; scanty watery sputum is often noted in atypical pneumonia; "rusty" sputum is seen in pneumococcal pneumonia; and currant-jelly or dark-red sputum suggests Klebsiella pneumoniae. Foul-smelling expectoration is associated with anaerobic infections due to aspiration, Ilias C Papanikolaou, Om P Sharma give an inhaled bronchodilator for 5 days* • Soothe the throat and relieve the cough with a safe remedy • If coughing for more than 3 weeks or if having recurrent wheezing, refer for assessment for TB or asthma • Advise the mother when to return immediately • Follow-up in 2 days • If wheezing (even if it disappeared after rapidly acting bronchodilator) give an inhaled bronchodilator for 5 days* • Soothe the throat and relieve the cough with a safe remedy • If coughing for more than 3 weeks or if having recurrent wheezing, refer for assessment for TB or asthma • Advise the mother when to return immediately • Follow-up in 5 days if not improving A blood count usually reveals leukocytosis in bacterial pneumonia, leukopenia in viral infection, and eosinophilia in parasitic infestation. When available, chest x-ray is extremely helpful ( Table 1 -2). Tuberculosis is omnipresent in the tropics; upper lobe lesions with or without cavities strongly suggest tuberculosis. In children, the Integrated Management of Childhood Illness (IMCI) guidelines for treating pneumonia are recommended (see Fig. 1 .1) [8] . Nevertheless, a patient's illness has to be assessed based on geography, prevalence of potential etiologies, virulence of the organism, and the drug sensitivity pattern (Box 1.1). In some areas, particularly Papua New Guinea, South Africa and Spain, resistance of the pneumococcus to penicillin is common. For children with non-severe pneumonia, the World Health Organization (WHO) recommends oral trimethoprim-sulfamethoxazole (TMP-SMX) or oral amoxicillin for 5 days [9] . In severe pneumonia in hospitalized children, the policy in low-income countries is to first give benzylpenicillin injections, changing the therapy to oral amoxicillin when the child responds. In very severe pneumonia, in children in low-income settings, chloramphenicol may be given first with benzylpenicillin and gentamicin in combination as an alternative [10, 11] . Atypical pneumonia is caused by Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella spp., viruses, tuberculosis, fungi and parasites. This syndrome is not extensively studied in the tropics because of the expense involved in culturing and isolating various organisms and obtaining serologic and immunologic tests. Mycoplasma pneumoniae infections occur worldwide, affecting mostly school-aged children and young adults. A typical patient with mycoplasma pneumonia is an older child or young adult with an insidious onset of fever, malaise, tightness of the chest, and dry brassy cough. Constitutional symptoms are out of proportion to the respiratory symptoms. Hemoptysis, pleural pain and gastrointestinal symptoms are uncommon. The tropical physician should be aware of the non-respiratory manifestations of mycoplasma infection, including anemia, myringitis, Stevens-Johnson syndrome, hepatitis and neuritis [12] (see Table 1 -2). Leptospirosis is common in tropical areas where sanitation is poor and water supply primitive. Epidemics of leptospirosis occur after high rainfall in monsoon seasons when the water supply is contaminated by sewage or animal urine. About half of the patients with leptospirosis have fever, cough, hemoptysis and pneumonitis [13] . Other features are jaundice, conjunctivitis and impaired renal function. Melioidosis, caused by Burkholderia pseudomallei, is endemic in Southeast Asia (Vietnam, Cambodia, Myanmar), northern Australia and West Africa. Melioidosis is hyperendemic in northern Australia, and in parts of northeastern Thailand it is an important cause of fatal community-acquired pneumonia [14] . Patients become infected while wading through fields, paddies, and flooded roads. Clinical presentation is protean and nonspecific. The radiologic picture of upper lobe infiltration and cavity formation can be indistinguishable from tuberculosis [15] . Diagnosis requires isolation of the organism. The mortality rate ranges from 20% to 50% but is higher in HIVinfected and immunocompromised hosts. Respiratory symptoms of cough and chest pain in typhoid are present in up to 50% of cases at the onset of the disease. Pulmonary infiltrates may be associated with positive sputum cultures for Salmonella typhi. A fever chart showing continuous fever is highly suggestive of enteric fever. Diagnosis may be difficult without blood and stool culture facilities. In brucellosis, the lungs are involved in about 5% to 10% of cases, usually following inhalation of organisms. Abnormalities include bronchopneumonia, solitary or multiple lung nodes, miliary interstitial lung disease, lung abscess and pleural effusion. Organisms can be identified on stains or sputum cultures. Tularemia is a generalized infection caused by Francisella tularensis and occurs after skin or mucous membrane contact with infected mammals or through the bite of an arthropod, usually a tick or biting fly. Diagnosis should be considered in the presence of a skin ulcer associated with fever, generalized lymphadenopathy, cough and signs of pneumonia. Pneumonia, either primary from inhalation of an infected aerosol or secondary to systemic infection, occurs in about 20% of cases. Children with malnutrition and edema should be admitted to hospital Pneumonic plague is less common than either bubonic or septicemic disease. Nevertheless, fatal bronchopneumonia can occur without lymphadenopathy and is characterized by watery, bloody sputum. A sputum Gram stain can show bipolar stunted rods. Pneumonic plague and tularemic pneumonia should be considered when a severe, rapidly progressive bronchopneumonia is reported in an endemic area, and "typical" bacterial pneumonias have been ruled out. In slaughterhouses, meat-processing plants, and areas with sheep and goat husbandry, Q fever (Coxiella burnetii) can cause epidemics of atypical pneumonia. Inhalation of dried infected material is the chief source, and fever, headache and dry cough are the main symptoms. Occasionally, the sputum is blood-streaked. Bornholm disease (caused by coxsackieviruses and occasionally other enteroviruses), also known as epidemic pleurodynia or Devil's grip, causes chest discomfort and cough. Widespread epidemics of Bornholm disease occur in the Pacific islands and South Africa. In 2002-2003, an unusual coronavirus was responsible for more than 8000 cases of a severe acute respiratory syndrome (SARS) that spread via international travel across continents from its origin in Guandong Province, China. The SARS coronavirus was previously unknown in humans; a possible reservoir was identified in civet cats and raccoons. After droplet inhalation of the virus, there was an incubation period of 2-7 days, then fever, cough, malaise and headache occurred. Pulmonary inflammation was characterized by desquamation of pneumocytes, hyaline membrane formation and acute respiratory distress syndrome (ARDS). The chest x-ray showed diffuse opacities or consolidation, especially in the lower lung fields. Recovery could be slow and some patients developed fibrosis. Mortality was 10-20%, with the elderly and those with cardiovascular problems being especially at risk. Kawasaki disease occurs in children under 5 years of age. This acute multisystem disease of unknown cause is characterized by fever of 5 days duration and four of five clinical features: non-purulent conjunctivitis; injected (or fissured) lips or pharynx or strawberry tongue; cervical adenopathy; a maculopapular rash; and changes in the extremities (erythema and edema of the palms and soles, associated with desquamation). Pneumonitis occurs in 10% of the children and coronary artery dilatation and aneurysms in 20-25% of untreated cases. In Brazil there has been a seasonal rise of the condition at the beginning and end of the monsoon season [16] . Cryptococcus neoformans and C. gatti are saprophytic fungi distributed worldwide and are particularly abundant in soil contaminated by pigeon droppings in the tropics as well as in temperate countries. Pulmonary infection results from inhalation of the organisms from environmental sources [17] . Systemic helminth infection usually elicits eosinophilia and increased IgE. Although eosinophilia can be a clue to a pulmonary helminth infestation, the definitive diagnosis requires demonstration of ova or larvae in sputum, bronchial alveolar lavage fluid, pleural fluid or lung biopsy [18] . Loeffler's syndrome refers to "simple" pulmonary eosinophilia with no or minimal systemic and pulmonary symptoms. In many helminth infestations (ascaris, strongyloidiasis, hookworm), the larvae migrate through the lung and can cause fever, cough, dyspnea, wheezing, hemoptysis and lung infiltrate. Schistosomes cause two clinical syndromes. In acute disease, immature schistosomula pass through the lung, and can lead to fever, eosinophilia and pulmonary infiltrate. In chronic schistosomiasis, especially when portal hypertension has led to venous shunts, eggs can bypass the liver and plug pulmonary capillaries and arterioles, producing granuloma and pulmonary hypertension. Radiographs may show dilated pulmonary arteries ( Fig. 1.3 ). In paragonimiasis, the lung is the predominantly involved organ. The diagnosis must be considered in a patient from Southeast Asia with cough, hemoptysis (which is recurrent in >80% of cases), a pulmonary cavity and pleural effusion. Tropical pulmonary eosinophilia, typically in India and other South Asian countries, causes immunologic hyperresponsiveness to Wuchereria bancrofti, Brugia malayi or other microfilariae. Clinical presentation consists of nocturnal cough, wheezing, fever and weight loss. Chest radiographs show diffuse interstitial miliary infiltrates ( Fig. 1.4) ; there is a high eosinophil count. In developed countries, serum IgE and antifilarial antibodies can be used to confirm the diagnosis (Table 1-3) . Bronchiectasis is a chronic, debilitating condition. Dilatation and distortion of the airways leads to impaired mucociliary clearance, which encourages bacterial colonization and bronchial inflammation. Patients have fever, chronic cough, mucopurulent sputum, hemoptysis (Table 1- 4) , wheezing, dyspnea and malaise (Box 1.2) . The primary cause of COPD is smoking l COPD affects men and women equally l COPD is not curable but can be prevented The diagnosis of bronchiectasis in developed countries is confirmed by computed tomography of the chest (Fig. 1.5) ; whereas, in the tropics, the diagnosis is mainly clinical and depends upon a compatible history, presence of finger clubbing, sputum that settles into three layers (mucoid or frothy, mucopurulent, and purulent) and a chest x-ray, if available. Treatment includes regular chest percussion, broadspectrum antibiotics for exacerbations, and influenza and pneumococcal vaccinations. The incidence of asthma in the tropics is low for unclear reasons; however, the disease remains underdiagnosed and untreated. "All that wheezes is not asthma" is a dictum that is true in the tropics, as there are many entities that cause wheezing and difficulty in breathing, including tropical eosinophilia and mitral stenosis. Asthma monitoring in the tropics can be achieved by using an inexpensive peak flow meter. Treatment should fit the frequency and severity of attacks. Betaagonists and cromolyn sodium (sodium cromoglycate) are usually available. Oral corticosteroids in short courses can be used to control severe episodes; however, long-term use of systemic corticosteroids, without adequate monitoring, is not safe. Aerosol inhalers are of great value but they are expensive, difficult to use, and require painstaking teaching. Chronic obstructive lung disease is a progressive disease which is characterized by airway obstruction that is only partially reversible by bronchodilator therapy. The term COPD encompasses chronic bronchitis and emphysema. Once a common disease of men, COPD is now as frequent in women because of increased tobacco use and the widespread use of dung and biomass for indoor cooking and heating in low-income countries (Box 1.3) . The most common symptoms are dyspnea and chronic cough. it is mild and occurs only on heavy exertion. With progression of airway obstruction, patients become more short of breath and eventually cannot breathe at rest. Physical examination in the early stage is normal, but in advanced disease, prolonged expiration and expiratory wheezes are audible. In severe cases, the thoracic cage becomes barrelshaped with increased anterior-posterior diameter; percussion note is hyperresonant. When chest x-ray and pulmonary function testing are not available, a peak-flow meter is an inexpensive device to assess severity of airway obstruction and monitor the response to treatment. Cessation of smoking is essential. Oral theophylline and beta-agonist drugs control symptoms. Antibiotics (ampicillin, tetracycline and sulfa drugs) are available to treat COPD exacerbations in the tropics. Pleural effusion is a frequent condition with variable clinical signs and symptoms. Small effusions can remain silent and are often detected only on chest radiography. Large effusions are associated with dyspnea and diminished chest movements on the affected side. Vocal fremitus is reduced; percussion note is stony dull; and auscultation reveals diminished breath sounds and decreased vocal resonance. Sometimes, bronchial breathing is heard at the upper level of dullness. In addition there may be a pleural friction sound. Exudative effusions typically have cell counts, protein and biochemical markers opposite to those of transudates. Exudates can be further classified into neutrophilic, lymphocytic and eosinophilic. Neutrophilic exudates may be due to bacterial infection, gastrointestinal diseases, pulmonary embolism, collagen-vascular diseases (CVD) and asbestos-related benign effusion. Pleural effusion occurs in about 50% cases of pneumonia, and can progress to a complicated effusion (pleural fluid pH<7.2, positive Gram stain) or to an empyema, both necessitating pleural fluid drainage with a chest tube thoracostomy in addition to antibiotic treatment. Empyema can occur in pneumococcal, staphylococcal (most often) and Klebsiella infections. A right-sided pleural effusion may be associated with amebic liver abscess. The disease presenting with the highest pleural fluid lymphocytosis is tuberculous pleuritis; however, early in the course, there can be a neutrophilic exudate. A large volume of pleural fluid should be obtained for examination for acid-fast bacilli. In about one-third of cases, the tuberculin skin test is negative initially and converts to positive after 2-4 weeks. Knowledge of the HIV status of a patient with pleural effusion, if positive, significantly inclines to a tuberculosis. An eosinophilic exudate is more common in the tropics. Endemic parasitic and fungal infections are major causes of such an effusion. Ascariasis, echinococcosis and paragonimiasis are some of the causative parasitic infections. Paragonimiasis is associated with low pleural fluid glucose and low pH. Fungal diseases responsible for such an effusion are histoplasmosis, cryptococcosis and coccidioidomycosis. In the absence of chest x-ray or biopsy evidence, it is not possible to diagnose pulmonary involvement due to sarcoidosis and other granulomatous diseases. Consequently, in the tropics, these disorders remain undiagnosed. The possibility of sarcoidosis should be considered in a patient with dyspnea, uveitis, hepatosplenomegaly, peripheral lymphadenopathy, chronic skin lesions, and a chest x-ray film showing bilateral hilar adenopathy [18] . The occupational disorders result from human social activity, and as such are preventable. The dusts that provoke occupational disorders can be classified into: those that induce granulomatous reaction (e.g. beryllium, talc and organic antigens); those that cause fibrosis (e.g. silica, asbestos and coal); and those that cause neither inflammation nor fibrosis, thus remaining inert (e.g. iron, barium and tin) ( Podoconiosis is an endemic nonfilarial elephantiasis occurring in individuals exposed to red clay soil derived from alkaline rock. A chronic and debilitating disease, it exerts a large economic burden. The silica particles are found in the skin, lymph nodes and lymphatics of affected and unaffected individuals. These individuals have reduced lung function as compared with adults living in areas of low silica concentration [19] . Immunological aspects of tropical lung disease Pneumonia: the forgotten killer of children. 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