id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353633-a4pu6rlu	Perakakis, Nikolaos	The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease	2020-07-23		.txt	text/plain	14722	701	32	Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose spectrum covers clinical, histological and pathophysiological developments ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) and liver fibrosis, potentially evolving into cirrhosis, hepatocellular carcinoma and liver failure. The disease is characterized initially by hepatic lipid accumulation (nonalcoholic fatty liver; NAFL), that can often progress to non-alcoholic steatohepatitis (NASH), liver fibrosis or cirrhosis, as outlined in detail elsewhere in this special issue [1] . Several studies have assessed the impact of epigenetic modifications in the development and progress of NAFLD ( Figure 2 ) as well as in the association of NAFLD with other metabolic diseases by focusing on DNA methylation, histone modifications and miRNA expression profiles that can significantly affect transcriptional activity. Proteomic analysis to identify differentially expressed proteins between subjects with metabolic healthy obesity and non-alcoholic fatty liver disease	./cache/cord-353633-a4pu6rlu.txt	./txt/cord-353633-a4pu6rlu.txt