id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346496-crhv0gnt	Sun, Ying	Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience	2020-04-24		.txt	text/plain	3402	178	51	Peripheral CD4(+), CD8(+) T lymphocytes, and B lymphocytes were significantly decreased in severe and critically ill patients, but there was only a non-statistically significant downward trend in NK cell numbers with severity. Natural killer (NK) cells, a key component of innate immunity against infection [7] , trended lower with increasing severity, but there was no statistically significant difference among the four groups. Though there was no statistically significant difference in these four different clinical classifications, the levels of creatine phosphokinase in the severe and critically ill groups were much higher than in the mild and moderate patients. The following variables showed significant positive correlation to the disease severity (p<0.01): advanced age, sputum production, shortness of breath, and higher neutrophil count, AST level (p<0.05), LDH level, GGT level, CRP level, ESR level, serum ferritin level, interleukin-6. Our findings indicated that C-reactive protein level, CD8 T lymphocyte count, and D-dimer were independent predictors of disease severity in Beijing COVID-19 patients.	./cache/cord-346496-crhv0gnt.txt	./txt/cord-346496-crhv0gnt.txt