id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346389-gbmnoo84	Callender, Lauren A.	The Impact of Pre-existing Comorbidities and Therapeutic Interventions on COVID-19	2020-08-11		.txt	text/plain	10042	514	40	Here, we review immune dysfunction in response to SARS-CoV-2 infection and the impact of pre-existing comorbidities on the development of COVID-19. Furthermore, cardiovascular complications such as thromboembolic events, myocarditis, acute coronary syndrome, arrythmia, cardiogenic shock and heat failure, have been documented in COVID-19 patients without prior cardiovascular disease (71), demonstrating a significant impact of SARS-CoV-2 infection on the heart. As infection with SARS-CoV-2 results in an acute respiratory disease that can progress to ARDS, respiratory failure and potentially even death, it is reasonable to speculate that patients with pre-existing respiratory disease would be at increased risk of severe COVID-19. Consequently, it has been proposed that liver damage associated with severe COVID-19 patients is due to dysregulated innate immunity against SARS-CoV-2, or hepatoxicity in response to treatments, rather than pre-existing liver disease. Therefore, the underlying pathogenesis of chronic kidney disease may increase vulnerability to hyperinflammation and cytokine storm upon SARS-CoV-2 infection, resulting in severe COVID-19.	./cache/cord-346389-gbmnoo84.txt	./txt/cord-346389-gbmnoo84.txt