id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343421-k1dqe4lk	Hoelzer, Karin	Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions	2018-07-31		.txt	text/plain	9639	428	34	Promising breakthroughs to overcome these limitations include new biotechnology techniques, new oral vaccine approaches, novel adjuvants, new delivery strategies based on bacterial spores, and live recombinant vectors; they also include new vaccination strategies in-ovo, and strategies that simultaneously protect against multiple pathogens. Oral vectored vaccines have also been developed for several other veterinary applications, including some economically important diseases of food-producing animals that are associated with considerable antibiotic use such as porcine circovirus type-2 (PCV-2); in some cases, the vaccine vector is a chimera containing parts of multiple microorganisms-for instance, an attenuated live vaccine may be used as the vector-and the resulting vaccine simultaneously confers protection against multiple diseases, for instance Marek's disease and infectious bursal disease or Newcastle disease and avian influenza [63, 64] . perfringens strains in the gut of broilers is a promising approach, but the vaccine delivery strategy still needs to be optimized to achieve optimal antigen presentation to the mucosal immune system and provide improved protection.	./cache/cord-343421-k1dqe4lk.txt	./txt/cord-343421-k1dqe4lk.txt