id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340285-mq9x12nw	Blagosklonny, Mikhail V.	From causes of aging to death from COVID-19	2020-06-12		.txt	text/plain	5963	391	43	In contrast, as we will discuss in the next section, it is hyper-functional immune response that leads to death from COVID-19 in the elderly by causing cytokine storm. It is driven by nutrient/hormone/cytokinesensing and growth-promoting signaling pathways such as Target of Rapamycin (TOR; mTOR), which are involved in developmental growth and later cause hyperfunctional aging and its diseases [24, 26] . Nutrients and obesity activate growth-promoting pathways (e.g., mTOR), thus accelerating development of quasi-programmed (age-related) diseases. Continuous use of rapamycin is expected to improve health, decrease age-related diseases and extend healthy lifespan, rendering individuals less vulnerable, when infected with the virus. As we discussed in the section "Cytokine storm is a hyperfunction", cytokine storm and hyper-inflammation is a main cause of death in COVID-19 pneumonia [36-40, 42, 45, 135, 141-143] Rapamycin, an antiinflammatory agent, inhibits hyper-functions, cellular senescence and decrease secretion of cytokines ( [74, 81, 144] .	./cache/cord-340285-mq9x12nw.txt	./txt/cord-340285-mq9x12nw.txt