id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337487-1lbopaso	Hansildaar, Romy	Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout	2020-09-01		.txt	text/plain	9481	480	34	The underlying pathophysiology of increased cardiovascular risk relevant to inflammatory arthritis, as well as the observed effect of antiinflammatory and disease modifying treatments such as uratelowering therapies in gout, will be reviewed and discussed. Postulated shared mechanisms of rheumatoid arthritis and gout are systemic inflammation, reactive oxygen species (ROS)induced oxidative stress, and endothelial dysfunction, all of which lead to atherosclerosis (figure 2). 59 Another study found an increased prevalence of heart failure with preserved ejection fraction in patients with rheumatoid arthritis, which correlated primarily with disease activity and with antiinflammatory treat ments (ie, conventional synthetic DMARDs and biological DMARDs). Rheumatoid arthritis and gout-two inflammatory joint diseases with different underlying causes-are associated with about a 50-70% increased risk of cardiovascular disease compared with the general population. Diseasemodifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study	./cache/cord-337487-1lbopaso.txt	./txt/cord-337487-1lbopaso.txt