id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334446-yf8vynqe	Agrawal, Gaurav	Putting Crohn’s on the MAP: Five Common Questions on the Contribution of Mycobacterium avium subspecies paratuberculosis to the Pathophysiology of Crohn’s Disease	2020-10-22		.txt	text/plain	6541	310	38	Further factors include the pathogenicity of the bacteria and strain varieties, host immune-microbe interaction, macrophage functioning, the influence of the gut microbiome, optimal testing and protocols, treatment trials, and appropriate antibiotic combination chemotherapy. Low cure rates MAP has been cultured and grown in human blood but took 18 months to do so Can create dysbiosis of the local (gut) microbiome leading to inflammatory cascades Disease is a result of host-microbe interaction and immune susceptibility of the host Infection does not mean disease is expressed but may result in colonization/persistence/latency Table 2 Koch's Postulates Hence, if Crohn's disease is similarly the result of a mycobacterial infection, such as MAP, then there should be similar clinical deterioration instead of a positive response in a cohort of patients to anti-TNF therapy. Involvement of Mycobacterium avium subspecies paratuberculosis in TNF-α production from macrophage: possible link between MAP and immune response in Crohn's disease	./cache/cord-334446-yf8vynqe.txt	./txt/cord-334446-yf8vynqe.txt