id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332093-iluqwwxs	Lessler, Justin	Mechanistic Models of Infectious Disease and Their Impact on Public Health	2016-02-17		.txt	text/plain	5501	231	38	Though never published by Reed and Frost (versions of the model were eventually published by their students (3, 4) ), their model was one of the first mechanistic models of infectious disease transmission, and at a time long before digital computing, they may have been the first to use simulation methods to understand the epidemic process. Perhaps the first mechanistic model of infectious disease transmission used in assessing intervention strategies was a mathematical model of malaria transmission developed and refined by Ronald Ross in a series of papers published between 1908 and 1921 (9) (10) (11) , pre-dating the work of Reed and Frost by decades. The aforementioned work, particularly that of the World Health Organization Ebola Response Team, also characterized important aspects of Ebola's natural history and epidemiology, including its basic reproductive number (R 0 ), the decline in R over the course of the epidemic, the incubation period, and the serial interval, properties of the disease that will be important to understand should it re-emerge.	./cache/cord-332093-iluqwwxs.txt	./txt/cord-332093-iluqwwxs.txt