id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332038-icyut3xa	Pillaiyar, Thanigaimalai	A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery	2020-04-02		.txt	text/plain	11250	560	40	Recently, it emerges as an alternative approach for the rapid identification and development of new pharmaceuticals for various rare and complex diseases for which lack the effective drug treatments. While numerous studies suggest the potent anticancer activities of drug 20, the overall benefit is limited as it is associated with serious side effects including the gastrointestinal and renal toxicities. The recent phase 3 clinical trial studies using the occurrence of colorectal adenomas as a biomarker for cancer as a primary endpoint at 1 year after intervention revealed that metformin reduced both occurrence and number of adenomas/polyps in the patients at low dosage level. Out of the approved drugs, data for bexarotene have provided proof of concept as potential candidate for the treatment of Alzheimer's disease as noted above, whereas acitretin (93, Figure 7) , which is known to penetrate tissues including brain may also be a promising candidate for AD [177] .	./cache/cord-332038-icyut3xa.txt	./txt/cord-332038-icyut3xa.txt