id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-324667-wmhdw1qs	Nishtala, Krishnatej	Tear biomarkers for keratoconus	2016-08-04		.txt	text/plain	4082	226	36	Advances in technologies such as mass spectrometry and NMR have helped in studying and understanding molecular changes in the tear proteome, lipidome and metabolome relating to an ocular disease condition. Enzyme linked immunosorbent assay (ELISA) analysis of capillary collected tears in 28 [61] , 30 [62] and 94 [63] patients with keratoconus in three different studies showed elevated levels of inflammatory markers IL-6, TNFα and MMP9. Protein levels of gross cystic disease fluid protein-15/ prolactin-inducible protein (PIP) and zinc-alpha-2glycoprotein have been found to be elevated in tears of 36 patients by proteomic analysis, suggesting their application as prognostic markers for keratoconus [72] ( Table 2 ). A multi-omics approach integrating data from proteomics, lipidomics and metabolomics is the need of the hour for studying tear fluid as an important source of biomarkers in keratoconus to lead to effective prognosis and treatment of the disease.	./cache/cord-324667-wmhdw1qs.txt	./txt/cord-324667-wmhdw1qs.txt