id author title date pages extension mime words sentences flesch summary cache txt cord-320463-4nchg95h Rampling, Tommy International Biological Reference Preparations for Epidemic Infectious Diseases 2019-02-17 .txt text/plain 3946 176 29 In 2015, WHO launched the Research and Development Blueprint for Action to Prevent Epidemics, a global strategy and preparedness plan that seeks to build upon the successes and address the gaps identified during the 2014 EVD outbreak by focusing on severe, emerging diseases with the potential to create a public health emergency and for which inadequate treatment and preventive options are currently available (8, 9) . Although this accelerated production represents an impressive collaborative feat, the lack of availability of PCR, antigen, and antibody IRPs at the start of this EVD outbreak, and for subsequent outbreaks of infection with MERS-CoV and Zika virus, likely hampered development of accurate diagnostics and vaccines (16) . Although many previous clinical studies of the research and development blueprint priority diseases have resulted in collection and storage of plasma from convalescent patients, several obstacles would largely preclude these samples being repurposed to generate reference materials. ./cache/cord-320463-4nchg95h.txt ./txt/cord-320463-4nchg95h.txt