id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-315462-u2dj79yw	Hewitt, Judith A.	ACTIVating Resources for the COVID-19 Pandemic: In vivo Models for Vaccines and Therapeutics	2020-10-01		.txt	text/plain	8953	469	44	The selection of appropriate animal models of infection, disease manifestation, and efficacy measurements is important for vaccines and therapeutics to be compared under ACTIV's umbrella using Master Protocols with standardized endpoints and assay readouts. Models of SARS-CoV-2 infection include mice (ACE2 transgenic strains, mouse adapted virus, and AAV transduced ACE2 mice), hamsters, rats, ferrets and non-human primates (NHPs). Following infection by the intranasal route, golden Syrian Hamsters demonstrate clinical features, viral kinetics, histopathological changes, and immune responses that closely mimic the mild to moderate disease described in human COVID-19 patients (Chan et al., 2020b; Imai et al., 2020; Sia et al., 2020) . In an initial study of SARS-CoV-2 infection of hACE2-hamsters, clinical signs were observed including elevated body temperatures, slow or reduced mobility, weight loss and mortality (1 out of 4 animals). Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease.	./cache/cord-315462-u2dj79yw.txt	./txt/cord-315462-u2dj79yw.txt