id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302435-6nrfipz8	Jay, Taylor R.	TREM2 in Neurodegenerative Diseases	2017-08-02		.txt	text/plain	21740	1041	45	Because TREM2 encodes a receptor exclusively expressed on immune cells, identification of these variants conclusively demonstrates that the immune response can play an active role in the pathogenesis of NDDs. These TREM2 variants also confer the highest risk for developing Alzheimer's disease of any risk factor identified in nearly two decades, suggesting that understanding more about TREM2 function could provide key insights into NDD pathology and provide avenues for novel immune-related NDD biomarkers and therapeutics. The application of whole exome sequencing [5] and GWAS with imputation based on predicted genetic associations [6] to AD led to the identification of relatively rare variants in the gene triggering receptor expressed on myeloid cells 2 (TREM2) that are associated with a high risk for developing AD. The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia	./cache/cord-302435-6nrfipz8.txt	./txt/cord-302435-6nrfipz8.txt