id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302277-c66xm2n4	Bakaletz, Lauren O.	Developing animal models for polymicrobial diseases	2004		.txt	text/plain	10910	537	33	Briefly, viral infection compromises the protective functions of the Eustachian tube, alters respiratory-tract secretions, damages the mucosal epithelial lining, interferes with antibiotic efficacy, modulates the immune response and enhances bacterial adherence 77 and colonization 78 to predispose the host to bacterial OM. In otitis media, which is a middle ear infection, a synergistic interaction that results in disease owing to co-infection with an upper respiratory tract virus and three bacterial species -Streptococcus pneumoniae, nontypeable Haemophilus influenzae (NTHI) and Moraxella catarrhalis -is well documented. It seems likely that the transient suppression of RDC migration and the delayed development of an effective adaptive immune response to a second infection might be another mechanism by which influenza virus predisposes the host to bacterial co-infection. Using this criterion, a mouse model of polymicrobial-induced osteoclastogenesis, bacterial penetration, leukocyte recruitment and softtissue necrosis has been developed to clarify the role of cytokines in periodontal disease.	./cache/cord-302277-c66xm2n4.txt	./txt/cord-302277-c66xm2n4.txt