id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-301856-71syce4n	Domínguez-Andrés, Jorge	Impact of Historic Migrations and Evolutionary Processes on Human Immunity	2019-11-27		.txt	text/plain	8191	335	33	With the burst of next-generation sequencing and the development of cutting-edge technologies such as transcriptomics, proteomics, and systems biology, we are starting to witness the great impact of evolutionary processes on human immunity and how the interactions between microorganisms and humans that took place millennia ago might play a fundamental role not only in the response against modern pathogenic threats, but also in the emergence of autoimmune and inflammatory diseases observed in modern populations worldwide. Specific genetic variants selected throughout different periods of human history may have influenced immune responses of present-day populations against pathogenic microorganisms and may have played a role in the development of certain inflammatory and autoimmune diseases. Patients with African ancestry present a higher frequency of MTB-related genetic variants than individuals from other populations, including variants in the gene encoding for Toll-like receptor 6 (TLR6), mediating cellular responses to bacterial Malaria is one of the greatest causes of morbidity and mortality in the history of humanity.	./cache/cord-301856-71syce4n.txt	./txt/cord-301856-71syce4n.txt