id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293714-s6ezxi5r	Principi, Nicola	The role of infection in Kawasaki syndrome	2013-04-18		.txt	text/plain	6229	323	44	Further findings that strongly support an infectious origin of KS are those of Orenstein et al., who used light microscopy and TEM to study tissue specimens from 32 autopsies, eight heart transplants and an excised coronary aneurysm of patients with KS and identified three different vasculopathic processes: acute self-limited necrotising arteritis (NA), subacute/chronic vasculitis, and luminal myofibroplastic proliferation. More recently, Japanese and Taiwanese groups independently reported a significant association between KS and polymorphisms in the intergenic region on chromosome 8p23-p22 between B lymphoid kinase (BLK ), a tyrosine kinase involved in B-cell receptor signal transduction and FAM167A, a functionally uncharacterized gene. 117 They found that polymorphisms at BLK gene together with genetic abnormalities at CD40, were associated with KS at genomewide significance (p < 5.5 Â 10 À8 ) confirming the role of immune activation and inflammation in the pathogenesis of the syndrome. Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease	./cache/cord-293714-s6ezxi5r.txt	./txt/cord-293714-s6ezxi5r.txt