id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293622-gdplbrsf	Arget, Michael	Successful Treatment of Legionnaires’ Disease with Tigecycline in an Immunocompromised Man with a Legion of Antibiotic Allergies	2019-04-30		.txt	text/plain	1944	99	35	We describe an immunocompromised and severely ill patient with Legionnaires' disease and who also has allergies to both fluoroquinolones and macrolides; he was successfully treated using tigecycline, a third generation glycylcycline, indicating that tigecycline may serve as a safe and effective alternative therapeutic option for treatment of Legionnaires' disease in select cases. A recently published case series describes eight patients with Legionnaires' disease who were switched to tigecycline, often due to worsening sepsis and/or respiratory status, following initial exposure to macrolide and/or fluoroquinolone therapy (median of three days) [8] . While the integrated results of these two randomized controlled trials support the early use of tigecycline as empiric treatment of community-acquired pneumonia, one of these trials permitted switching to oral levofloxacin following at least three days of intravenous therapy if evidence of clinical improvement.	./cache/cord-293622-gdplbrsf.txt	./txt/cord-293622-gdplbrsf.txt