id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-290472-w77cmljm	Sharon, Donald	Systems Biology Approaches to Disease Marker Discovery	2010-06-09		.txt	text/plain	8665	393	39	These markers, such as protein (including autoantibodies, which are antibodies specific to self-antigens [43] ), hormonal markers (such as lack of insulin in Type I diabetic patients [89] ), and genetic/genomic markers (such as BRCA1 mutation in breast cancer patients [52] ), enable clinicians to diagnose the disease while it is still at early stages, to ensure appropriate surgical intervention, efficient drug treat-ment and monitoring, and to predict an individual's risk of developing specific diseases before they experience symptoms. Scientists, such as the group led by Gil Mor at Yale University, recruited proteomics-based approaches using antibody-based protein microarrays to identify new serum biomarkers, which, in combination with CA-125, may enhance the early detection of ovarian cancer [48, 66, 110] . To date, no studies that attempt to identify novel breast cancer markers have been performed using high-density protein microarrays.	./cache/cord-290472-w77cmljm.txt	./txt/cord-290472-w77cmljm.txt