id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-278136-ol2buwld	Gonzales, Natalia M.	29th International Mammalian Genome Conference meeting report	2016-05-02		.txt	text/plain	4685	180	34	The session showcased tools such as recombinant inbred lines (RILs), outbred populations, classic crosses, and ENU mutagenesis to yield new understanding and identify candidate genes for disease susceptibility, while knockout and patient-derived xenograft mice enabled further mechanistic insight. Other features of this session included a GWAS of aerobic capacity in rats segregated on running ability by Yu Wang German Center for Neurodegenerative Diseases Tuebingen) conducted a massive forward genetic screen using human exome data, followed by systematic RNAi screens in worms, flies, and human cell lines to identify genes and pathways involved in Parkinson's disease. This plenary session encompassed the use of mouse embryonic stem cells (mESCs), gene expression analysis, and recent advances in genome engineering to address fundamental questions about development and degenerative disease. A common approach featured at the IMGC each year is the use of the mouse as a model for understanding how biological processes influence and respond to changes in the mammalian genomic landscape.	./cache/cord-278136-ol2buwld.txt	./txt/cord-278136-ol2buwld.txt