id author title date pages extension mime words sentences flesch summary cache txt cord-276616-odmnvv7m Darcel, C. Reflections on scrapie and related disorders, with consideration of the possibility of a viral aetiology 1995 .txt text/plain 10478 494 48 Conclusions drawn from the vaccination trials and transmission experiments were that ~crapie, given by subcutaneous inoculation, had a latent period of 2 years and longer; that the infective agent was resistant to 0.35% formalin; that the disease appeared more quickly and in a higher percentage of recipients following intracerebral than following~subcutaneous injection; and that the causative agent was probably a filtrable virus. There are many difficulties in studying either the natural or experimentally induced diseases: the animals involved, the incubation period required for the emergence of the disease, the innate resistance of a proportion of the population seen as an expression of genetic influences, the differing behaviour of strains of agents isolated from a given species, the symptomatology, the pathology, the uncertain nature of the agent and its means of transmission, the perceived 'lack' of an immunological response or changes in the immune system, and the biological hazards involved in conducting experiments. ./cache/cord-276616-odmnvv7m.txt ./txt/cord-276616-odmnvv7m.txt