id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269170-9f460xbq	Kaneko, Kazunari	Our Evolving Understanding of Kawasaki Disease Pathogenesis: Role of the Gut Microbiota	2020-07-24		.txt	text/plain	4597	248	35	The disease seems to result from the interplay of genetic and environmental susceptibility factors with infectious triggers, followed by a subsequent abnormal immune response characterized by increased levels of inflammatory cytokines and chemokines during the acute phase. Recent advances in culture-independent techniques for detection and identification of intestinal commensal bacteria enabled the discovery that Th17 and Treg differentiation are regulated by short chain fatty acids (SCFAs), in particular butyrate, produced by the gut microbiota. This perspective is illustrated in Figure 1 and can be explained as follows: [1] various factors during the in utero and postnatal period drive dysbiosis in young children; [2] dysbiosis results in reduced intestinal production of SCFAs including butyrate; [3] reduced levels of SCFAs in the gut cause an imbalance of Th17s/Tregs; and [4] individuals with Th17/Treg imbalances develop hypercytokinemia triggered by ubiquitous infectious agents(s), followed by KD (Figure 1) .	./cache/cord-269170-9f460xbq.txt	./txt/cord-269170-9f460xbq.txt