id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268326-sbz3uk5h	Bonam, Srinivasa Reddy	Lysosomes as a therapeutic target	2019-09-02		.txt	text/plain	17899	839	37	With a focus on lysosomal dysfunction in autoimmune disorders and neurodegenerative diseases — including lupus, rheumatoid arthritis, multiple sclerosis, Alzheimer disease and Parkinson disease — this Review critically analyses progress and opportunities for therapeutically targeting lysosomal proteins and processes, particularly with small molecules and peptide drugs. Alterations in lysosomal functions, either in the fusion processes involved in the general pathways mentioned above or related to the function of lyso somal enzymes and non enzymatic proteins, can result in broad detrimental effects, including failure to clear potentially toxic cellular waste, inflammation, apopto sis and dysregulation of cellular signalling 8 .	./cache/cord-268326-sbz3uk5h.txt	./txt/cord-268326-sbz3uk5h.txt