id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267182-ctvnmjsl	Mboowa, Gerald	Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies	2018-03-20		.txt	text/plain	4737	226	29	High-throughput sequencing (HTS) has transformed both the management of infectious diseases and continues to enable large-scale functional characterization of host resistance/susceptibility alleles and loci; a paradigm shift from single candidate gene studies. Human populations are constantly locked in evolutionary arms races with pathogens; therefore, identification of common infectious disease-associated genomic variants/markers is important in therapeutic, vaccine development, and screening susceptible individuals in a population. Malaria, HIV/AIDS, and tuberculosis are some of the common infectious diseases in which a range of genetic susceptibilities and resistant conferring loci have been identified using both traditional molecular-based approaches and HTS technologies. HTS applied to screening populations of host immune-specific cells and their respective pathogens can highlight the host-pathogen unique genetic signatures important in host-pathogen coevolution, profiling immunological history, pathogen-induced immunodominance genetic patterns, predicting clinical outcomes of common infections (such as HIV/AIDS disease progression phenotypes like long-term nonprogressors and rapid progressors, as well as highly exposed persistently seronegative group), rapid diagnosis plus screening outbreaks involving Risk Group 4 highly infectious pathogens, and genetic characterization of live-attenuated vaccine vectors (Figures 1(a) and 1(b)).	./cache/cord-267182-ctvnmjsl.txt	./txt/cord-267182-ctvnmjsl.txt