id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262253-3ovqhypt	Iqbal, Umar H.	The Use of Antimicrobial and Antiviral Drugs in Alzheimer’s Disease	2020-07-12		.txt	text/plain	8832	461	45	The aggregation and accumulation of amyloid-β plaques and tau proteins in the brain have been central characteristics in the pathophysiology of Alzheimer's disease (AD), making them the focus of most of the research exploring potential therapeutics for this neurodegenerative disease. The present review will highlight the current understanding of amyloid-β, and the role of bacteria and viruses in AD, and will also explore the therapeutic potential of antimicrobial and antiviral drugs in Alzheimer's disease. Alzheimer's Disease Aβ amyloid-β AMP antimicrobial peptide APP amyloid precursor proteins BACE1 B-site ABPP cleaving enzyme BBB blood brain barrier CNS central nervous system HSV-1 herpes simplex virus-1 MBP-1 major basic protein-1 NFTS neurofibrillary tangles Protective Effect of Amyloid-beta Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1	./cache/cord-262253-3ovqhypt.txt	./txt/cord-262253-3ovqhypt.txt