id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256686-fwh926g4	Leggio, Loredana	Extracellular Vesicles as Nanotherapeutics for Parkinson’s Disease	2020-09-16		.txt	text/plain	14302	742	40	Notably, emerging studies on aging mouse models of PD, based on the exposure to the environmental neurotoxins 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine (6-OHDA), clearly indicate that aged glial cells lose their neuroprotective, pro-neurogenic, and regenerative functions, thereby contributing to the inflammatory and degenerative processes during PD onset and progression [21, 23, [55] [56] [57] [58] [59] [60] . The ReNCell VM immortalized human neural progenitor cell line-opportunely differentiated to assume a DAergic neuronal phenotype-was chosen as model of target cell, for evaluating the potential neuroprotective effects of SHED-derived EVs. To reproduce the parkinsonian/oxidative environment, the neurons were treated with the neurotoxin 6-OHDA [234] . The deriving M2 GDNF-producing macrophages were intravenously injected in the 6-OHDA PD mouse model, where they were able to cross exclusively the BBB of inflamed brains, inducing both neuroprotective and anti-inflammatory effects with consequent motor function improvements.	./cache/cord-256686-fwh926g4.txt	./txt/cord-256686-fwh926g4.txt