id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-028275-szb45jm2	Reza Khorramizadeh, M.	Animal models for human disease	2020-06-26		.txt	text/plain	11604	616	45	To study the pathogenesis of RA, we explained collagen-induced arthritis as an animal model that reflects a characteristic feature of RA patients. For example, experimental animal models for diseases like rheumatoid arthritis or multiple sclerosis have been successfully employed to screen new bioengineered, chemical, or herbal therapeutics that might have the potential for the treatment of human patients. Furthermore, the biopsy analysis of clinically symptomless knee joints in patients with early rheumatoid arthritis shows active synovitis, highlighting the poor correlation between clinical assessment and disease progression, and the rapid development of polyarticular synovitis. The findings illustrate the consequences of progressive disease and have shown the need for the development of new and more effective therapies based on the therapeutic principles used for oncology; it means that treatment protocols for RA patients require the use of several therapeutic agents from different classes to be used in combination.	./cache/cord-028275-szb45jm2.txt	./txt/cord-028275-szb45jm2.txt