id author title date pages extension mime words sentences flesch summary cache txt cord-018493-q24f86e9 Ranjan, Prabhat Importance of Natural Proteins in Infectious Diseases 2015-08-08 .txt text/plain 3930 209 39 Other extracellular proteins like invasive enzymes, e.g., coagulase, contributes to the formation of fibrin walls around staphylococcal lesions [10] ; exotoxins (proteins released extracellularly), like neurotoxin (Tetanus toxin, by Clostridium tetani, Botulinum toxin by Clostridium botulinum) [11] and cytotoxins (Diphtheria toxin produced by Corynebacterium dipthereae) [12, 13] , also known as A-B toxins (consisting of 2 subunits: one binds to cell surface receptor and the other is transferred into the cell to damage the cell) [14] , cytolytic toxins (attacking cell constituents causing lysis) like hemolysins produced by Bordetella pertussis, inducing apoptosis of host cells, super antigen toxins (e.g., superantigen, sized 22KDa produced by 5-25 % of Staphylococcus aureus isolates, causing toxic shock syndrome (TSS) by stimulating the release of large amounts of interleukin-1, interleukin-2 and tumor necrosis factor, etc.) [15] . Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are a group of evolutionarily conserved intracellular proteinaceous PRRs that play a vital role in innate immunity and host physiology, in both plants and animals [30, 31] . Heat shock proteins can be expressed on the surface of infected cells, and this is likely to provide a target for the innate immune response. ./cache/cord-018493-q24f86e9.txt ./txt/cord-018493-q24f86e9.txt