id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018452-qyf2vymf	Sica, Valentina	Pathophysiologic Role of Autophagy in Human Airways	2016-03-07		.txt	text/plain	6989	324	35	Increasing evidences have highlighted the implication of the autophagic pathways in the pathogenesis of lung diseases and, in some cases, the deregulated molecular mechanisms underlying autophagy may be considered as potential new therapeutic targets. The inhibition of mTOR is linked to autophagy induction, but Rtp801 expression enhances oxidative stress-dependent cell death, amplifying the development of CS-induced lung injury [ 105 ] . Furthermore, the higher expression of autophagy proteins has been linked to lung epithelial cell death, airway dysfunction and emphysema in response to CS. Restoration of Beclin 1 activity, depletion of p62 by genetic manipulation or treatment with autophagy-stimulatory proteostasis regulators, such as cystamine, functionally rescue the CFTR mutated protein at the apical surface of epithelial cells both in vitro and in vivo [ 54 ] . Defective CFTR induces aggresome formation and lung infl ammation in cystic fi brosis through ROS-mediated autophagy inhibition	./cache/cord-018452-qyf2vymf.txt	./txt/cord-018452-qyf2vymf.txt