id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017841-57rm046y	Flower, Darren R.	Immunomic Discovery of Adjuvants, Delivery Systems, and Candidate Subunit Vaccines: A Brief Introduction	2012-09-28		.txt	text/plain	4995	230	43	What the pharmaceutical industry needs is the capacity to apply the same systematic, automated, high-technology approaches used to identify new small-molecule drugs to the discovery and development of vaccines. Just over a decade ago, Rino Rappuoli used the expression "reverse vaccinology" to describe development of vaccines using a genomic-based approach, rather than the ponderous empirical methods favoured then, and still in use today. This book looks in turn at reverse vaccinology and the identification of putative candidate antigens, at the discovery of a wide range of different types of adjuvants, and finally at the development of sophisticated new delivery mechanisms, such as liposomes and other applications of nanotechnology. They also highlight how advances in genome-based techniques and in so-called next-generation sequencing approaches and technologies will help to enhance reverse vaccinology, enabling timely identification of novel candidate antigens for new, emerging, or recrudescent infectious diseases.	./cache/cord-017841-57rm046y.txt	./txt/cord-017841-57rm046y.txt