id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011053-gza05hsv	Tiew, Pei Yee	The Mycobiome in Health and Disease: Emerging Concepts, Methodologies and Challenges	2020-01-01		.txt	text/plain	10936	561	30	In this state-of-the-art review, we discuss current diagnostic and therapeutic challenges associated with fungal disease and provide key examples where the application of sequencing technologies has potential diagnostic application in assessing the human 'mycobiome'. Despite their natural environmental abundance, few fungi are human pathogens, and while fulminant fungal infection is uncommon in the healthy individuals, invasive fungal disease is a concern in the immuno-compromised host with significant associated morbidity and mortality [2] . Increasing numbers of patients are at risk of invasive fungal disease including those with human immunodeficiency virus (HIV), malignancy and transplant recipients on immunosuppressive or immunomodulatory therapies, each contributing to the rising global trend of fungal infections among susceptible populations. Despite treatment, mortality rates for invasive fungal disease remain high with factors contributing to poor prognosis including delayed diagnosis and initiation of antifungal treatment, host factors, site of infection, emerging antifungal resistance and drug toxicity.	./cache/cord-011053-gza05hsv.txt	./txt/cord-011053-gza05hsv.txt