id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010977-fwz7chzf	Myserlis, Pavlos	Translational Genomics in Neurocritical Care: a Review	2020-02-20		.txt	text/plain	11990	519	31	In this review, we describe some of the approaches being taken to apply translational genomics to the study of diseases commonly encountered in the neurocritical care setting, including hemorrhagic and ischemic stroke, traumatic brain injury, subarachnoid hemorrhage, and status epilepticus, utilizing both forward and reverse genomic translational techniques. Termed "reverse translation," this approach starts with humans as the model system, utilizing genomic associations to derive new information about biological mechanisms that can be in turn studied further in vitro and in animal models for target refinement (Fig. 1) . These results highlight the value of reverse genomic translation in first identifying human-relevant genetic risk factors for disease, and using model systems to understand the pathways impacted by their introduction to select rationally-informed modalities for potential treatment. These observations provide vital information about cellular mechanisms impacted by human disease-associated genetic risk factors without requiring the expense and time investment of creating, validating, and studying animal models.	./cache/cord-010977-fwz7chzf.txt	./txt/cord-010977-fwz7chzf.txt