id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007726-bqlf72fe	Rydell-Törmänen, Kristina	The Applicability of Mouse Models to the Study of Human Disease	2018-11-09		.txt	text/plain	7985	308	35	The laboratory mouse Mus musculus has long been used as a model organism to test hypotheses and treatments related to understanding the mechanisms of disease in humans; however, for these experiments to be relevant, it is important to know the complex ways in which mice are similar to humans and, crucially, the ways in which they differ. This chapter will provide an overview of the important similarities and differences between Mus musculus and Homo sapiens and their relevance to the use of the mouse as a model organism and provide specific examples of the quality of mouse models used to investigate the mechanisms, pathology, and treatment of human lung diseases. Overall, these studies showed that although gene expression is fairly similar between mice and humans, considerable differences were observed in the regulatory networks controlling the activity of the immune system, metabolic functions, and responses to stress, all of which have important implications when using mice to model human disease.	./cache/cord-007726-bqlf72fe.txt	./txt/cord-007726-bqlf72fe.txt