id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007170-svsfu7fj	Richt, J. A.	Infection with Borna Disease Virus: Molecular and Immunobiological Characterization of the Agent	1992-06-17		.txt	text/plain	6125	325	42	Studies on BDV may help to illuminate several important areas of neurobiology, including the mechanisms regulating the replication of a new type of RNA virus in the nuclei of neural cells, the neuroinvasiveness and neurotropism of such viruses, their T cell-mediated immunopathology, tolerance in newborn animals to persistent viral infection of the central nervous system, and behavioral diseases and eating disorders induced by such agents. Persistently infected MDCK (Madin-Darby canine kidney) cells are widely used in indirect immunofluorescence assays for the detection of BDV-specific antibodies in serum and CSF of affected animals and humans [18, 20] . The pathological changes in the brain and retina of BDVinfected animals resemble certain types of encephalitis and Most studies on the pathogenesis of BDV infection have involved experimentally inoculated Lewis rats. Although infection of newborn rats resulted in persistent viral replication in the CNS as well as in visceral organs, these animals developed no inflammatory response or signs of Borna disease.	./cache/cord-007170-svsfu7fj.txt	./txt/cord-007170-svsfu7fj.txt