id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006780-l503f86l	Leitch, A E	Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa	2008-07-02		.txt	text/plain	9371	471	32	It is evident that granulocytes play an important role in the pathogenesis of pulmonary inflammation but other cell types such as macrophages, dendritic cells, mast cells, and lymphocytes are equally and potentially more influential in subsets of inflammatory respiratory disease. It is not surprising, given the constant exposure of the vast respiratory mucosa to threat, the fine balance of the immune response and the pivotal inflammatory role played by neutrophils, that neutrophil-dominant inflammation has been implicated in the pathophysiology of numerous inflammatory respiratory diseases including pneumonia, COPD, IPF, CF, and ARDS. Elastase, reactive oxygen species, and myeloperoxidase cause further lung damage, and the clearance of inflammatory cells is so poor that Abbreviations: ARDS/ALI, adult respiratory distress syndrome/acute lung injury; CF, cystic fi brosis; COPD, chronic obstructive pulmonary disease; IPF, idiopathic pulmonary fi brosis.	./cache/cord-006780-l503f86l.txt	./txt/cord-006780-l503f86l.txt