id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006653-fy0yg0xh	Popper, Helmut H.	Interstitial lung diseases—can pathologists arrive at an etiology-based diagnosis? A critical update	2012-12-07		.txt	text/plain	13637	807	40	Usual interstitial pneumonia/idiopathic pulmonary fibrosis UIP/IPF is a chronic progressive fibrosing disease of the lung, which leads to death of the patient usually within 5-10 years after the diagnosis is made. It affects predominantly patients in their fourth to fifth decade of life; however, lesions may occur much earlier and remain undetected until Acute interstitial pneumonia (AIP) Diffuse alveolar damage (DAD) they will cause impaired lung function by their increasing number-UIP/IPF is seen more often in younger-aged patients, probably due to increased awareness. This is meant by the term "timely heterogeneity." In the author's experience, a diagnosis of UIP/IPF can be established in some cases even without clinical information when the following features are given: fibroblastic foci, timely heterogeneity (involved and uninvolved peripheral lobules), cystic and fibrotic destruction resulting in honeycombing, and most importantly, the absence of inflammatory infiltrates in areas of fibroblastic foci, absence of granulomas, or features of other interstitial inflammation.	./cache/cord-006653-fy0yg0xh.txt	./txt/cord-006653-fy0yg0xh.txt