id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003063-mowj6wyl	Zhou, Xuezhong	A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks	2018-04-06		.txt	text/plain	9360	432	45	After that, we clustered the 223 disease sub-categories additionally by a widely used non-overlapping community detection algorithm (considering the link weight and setting the resolution parameter as 0.5) into 17 top-level categories (which corresponds to the number of original chapter-level categories in ICD, which we named as New Chapters, NCs) using the shared ICD codes (Fig. S11c & Data S10). To extend and redefine disease concepts by discovering additional categories of a disease, we generated a novel disease taxonomy by constructing an integrated disease network (IDN) with: (a) Shared clinical phenotypes including shared symptoms; (b) Shared molecular profiles including (i) shared genes and molecular module similarity and (ii) shortest path lengths in the PPI network, based on a systematic integration process to filter out possible false positive associations (see Methods, SM Section 6, Fig. S9 and Fig. S11a) , which includes 1857 diseases and 35,114 links (Data S9).	./cache/cord-003063-mowj6wyl.txt	./txt/cord-003063-mowj6wyl.txt