id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272459-w14finxf	Heaton, Nicholas S.	Dengue Virus and Autophagy	2011-08-04		.txt	text/plain	3107	182	40	Recently, it was reported that autophagy plays an indirect role in DENV replication by modulating cellular lipid metabolism. Relevant to DENV infection, a type of selective autophagy termed lipophagy was described, wherein autophagosomes can target cellular stores of lipids known as lipid droplets (LDs) to generate energy for the cell [38] . In subsequent work, the authors reproduced the published results that DENV induces and requires autophagy for robust viral replication [39] . These autophagosomes did not co-localize with markers of the viral replication complex, suggesting that they may play an indirect, non-structural role in DENV replication. Alternatively, DENV infection induces a selective autophagy that is preferentially targeted to lipid droplets, which leads to changes in cellular metabolism. More work, however, is required to show whether the proposed viral triggers of autophagy reproduce all cellular signals and phenotypes that accompany autophagy induction in DENV-infected cells.	./cache/cord-272459-w14finxf.txt	./txt/cord-272459-w14finxf.txt