id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262795-u56u9mjz	Wang, Jiwei	Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions	2019-07-12		.txt	text/plain	7996	348	34	title: Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions Furthermore, our data implies that thermal effects and osmotic shear stress (OSS) associated with LIUS may potentially play a role in inducing the differential gene expression patterns of the cell death regulatome that we observed. Our report allows us to propose a new molecular working model for LIUS therapies for the treatment of cancers and inflammation: First, LIUS differentially upregulates cell death regulators in cancer cells, and downregulates inflammatory pathways in noncancer cells potentially via transcription factors TP53-, and SRF-, mediated pathways; Second, the therapeutic applications of LIUS may depend on the propagation of ultrasound waves through tissues to produce thermal and non-thermal mechanic effects; Third, LIUS may modulate chromatin long-range interactions to differentially regulate cell death gene expressions in cancer cells and non-cancer cells.	./cache/cord-262795-u56u9mjz.txt	./txt/cord-262795-u56u9mjz.txt