id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-023355-yi2bh0js	O'Brien, Mauria A.	Apoptosis: A review of pro‐apoptotic and anti‐apoptotic pathways and dysregulation in disease	2008-12-18		.txt	text/plain	8277	535	39	30 Initiation of this pathway eventually results in the release of pro-apoptotic proteins from the mitochondria that will activate caspase enzymes and trigger apoptosis. [49] [50] [51] [52] The success of the pathway in inducing apoptosis depends on the balance of activity between pro-apoptotic and anti-apoptotic members of the B-cell lymphoma-2 (Bcl-2) superfamily of proteins (Table 1) . 25, 69 In addition, the mitochondrial pathway pro-apoptotic Bcl-2 family protein, Bak, has been implicated in causing ER depletion of calcium, which can induce caspase-12 activation 70 (Table 1) . Mitochondrial factors: Increased mitochondrial outer membrane permeability can result in the release of mitochondrial pro-death substances in addition to cytochrome c, such as apoptosis inducing factor, 67 Smac/ DIABLO 80-82 (Second Mitochondrial-derived Activator of Caspases/Direct Inhibitor of Apoptosis-Binding protein with LOw pI), endonuclease G, HtrA2/Omi, and several procaspases 83 (eg, procaspase-2, -3, and -9).	./cache/cord-023355-yi2bh0js.txt	./txt/cord-023355-yi2bh0js.txt