id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006664-ykfvbypo	McLaughlin, R.	The role of apoptotic cell death in cardiovascular disease	2001		.txt	text/plain	7439	499	35	RESULTS AND CONCLUSIONS: Apoptotic cell death is a key element in the pathogenesis and progression of ischaemia-reperfusion (IR) injury, cardiac failure, myocardial infarction, atherosclerosis, endothelial dysfunction and the clinical syndromes which these situations produce. Experimental and autopsy studies have confirmed that cardiomyocytes undergo cell death by apoptosis as a component of hypoxia,43 IR,14 heart failure 15, 16, 44, 117, 119 and myocardial infarction.l$ Following on from this work, the traditional viewpoint of heart failure as a purely haemodynamic continuum has been modified by an increasing awareness of the fact that the interaction of cytokines, neurohormones and apoptotic mediators play a significant role in the evolution and progression of this disease process."° As the myocardium has no regenerative capacity, prevention of apoptosis-induced cardiomyocyte loss has potentially significant clinical implications.	./cache/cord-006664-ykfvbypo.txt	./txt/cord-006664-ykfvbypo.txt