id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326908-l9wrrapv	Duchêne, David A.	Evaluating the Adequacy of Molecular Clock Models Using Posterior Predictive Simulations	2015-07-10		.txt	text/plain	7596	370	47	We test the power of this approach using simulated data and find that the method is sensitive to bias in the estimates of branch lengths, which tends to occur when using underparameterized clock models. 2001) ; uncorrelated beta-distributed rate variation among lineages; misleading node-age priors (i.e., node calibrations that differ considerably from the true node ages); and when data were generated under a strict clock but analyzed with an underparameterized substitution model ( fig. The substitution model was identified as inadequate for the coronavirus data set by the multinomial test statistic estimated using posterior predictive data sets from a clock analysis (P < 0.05); however, it was identified as adequate when using a clock-free method (P = 0.20). In addition, our metric of uncertainty in posterior predictive branch lengths is sensitive to some cases of misspecification of clock models and node-age priors, but not to substitution model misspecification, as shown for our analyses of the coronavirus data set.	./cache/cord-326908-l9wrrapv.txt	./txt/cord-326908-l9wrrapv.txt