id sid tid token lemma pos cord-285833-7exenodj 1 1 key key JJ cord-285833-7exenodj 1 2 : : : cord-285833-7exenodj 1 3 cord-285833 cord-285833 NNP cord-285833-7exenodj 1 4 - - HYPH cord-285833-7exenodj 1 5 7exenodj 7exenodj CD cord-285833-7exenodj 1 6 authors author NNS cord-285833-7exenodj 1 7 : : : cord-285833-7exenodj 1 8 Alkan Alkan NNP cord-285833-7exenodj 1 9 , , , cord-285833-7exenodj 1 10 Ali Ali NNP cord-285833-7exenodj 1 11 ; ; : cord-285833-7exenodj 1 12 Uncu Uncu NNP cord-285833-7exenodj 1 13 , , , cord-285833-7exenodj 1 14 Asaf Asaf NNP cord-285833-7exenodj 1 15 ; ; : cord-285833-7exenodj 1 16 Taşkıran Taşkıran NNP cord-285833-7exenodj 1 17 , , , cord-285833-7exenodj 1 18 Irmak Irmak NNP cord-285833-7exenodj 1 19 ; ; : cord-285833-7exenodj 1 20 Tanrıverdi Tanrıverdi NNP cord-285833-7exenodj 1 21 , , , cord-285833-7exenodj 1 22 Özgür Özgür NNP cord-285833-7exenodj 2 1 title title NN cord-285833-7exenodj 2 2 : : : cord-285833-7exenodj 2 3 Double double RB cord-285833-7exenodj 2 4 - - HYPH cord-285833-7exenodj 2 5 edged edged JJ cord-285833-7exenodj 2 6 sword sword NN cord-285833-7exenodj 2 7 : : : cord-285833-7exenodj 3 1 Granulocyte Granulocyte NNP cord-285833-7exenodj 3 2 colony colony NN cord-285833-7exenodj 3 3 stimulating stimulate VBG cord-285833-7exenodj 3 4 factors factor NNS cord-285833-7exenodj 3 5 in in IN cord-285833-7exenodj 3 6 cancer cancer NN cord-285833-7exenodj 3 7 patients patient NNS cord-285833-7exenodj 3 8 during during IN cord-285833-7exenodj 3 9 the the DT cord-285833-7exenodj 3 10 COVID-19 covid-19 JJ cord-285833-7exenodj 3 11 era era NN cord-285833-7exenodj 3 12 date date NN cord-285833-7exenodj 3 13 : : : cord-285833-7exenodj 3 14 2020 2020 CD cord-285833-7exenodj 3 15 - - HYPH cord-285833-7exenodj 3 16 07 07 CD cord-285833-7exenodj 3 17 - - HYPH cord-285833-7exenodj 3 18 02 02 CD cord-285833-7exenodj 3 19 journal journal NN cord-285833-7exenodj 3 20 : : : cord-285833-7exenodj 4 1 Clinics clinic NNS cord-285833-7exenodj 4 2 ( ( -LRB- cord-285833-7exenodj 4 3 Sao Sao NNP cord-285833-7exenodj 4 4 Paulo Paulo NNP cord-285833-7exenodj 4 5 ) ) -RRB- cord-285833-7exenodj 5 1 DOI DOI NNP cord-285833-7exenodj 5 2 : : : cord-285833-7exenodj 6 1 10.6061 10.6061 CD cord-285833-7exenodj 6 2 / / SYM cord-285833-7exenodj 6 3 clinics/2020 clinics/2020 NNS cord-285833-7exenodj 6 4 / / SYM cord-285833-7exenodj 6 5 e2033 e2033 NNP cord-285833-7exenodj 6 6 sha sha NNP cord-285833-7exenodj 6 7 : : : cord-285833-7exenodj 7 1 91f52736e05e1685a5065d5a12d7338829dcbcfa 91f52736e05e1685a5065d5a12d7338829dcbcfa LS cord-285833-7exenodj 7 2 doc_id doc_id CD cord-285833-7exenodj 7 3 : : : cord-285833-7exenodj 7 4 285833 285833 CD cord-285833-7exenodj 7 5 cord_uid cord_uid NNS cord-285833-7exenodj 7 6 : : : cord-285833-7exenodj 8 1 7exenodj 7exenodj DT cord-285833-7exenodj 8 2 nan nan NNP cord-285833-7exenodj 9 1 To to IN cord-285833-7exenodj 9 2 the the DT cord-285833-7exenodj 9 3 Editor Editor NNP cord-285833-7exenodj 9 4 , , , cord-285833-7exenodj 9 5 The the DT cord-285833-7exenodj 9 6 whole whole JJ cord-285833-7exenodj 9 7 world world NN cord-285833-7exenodj 9 8 is be VBZ cord-285833-7exenodj 9 9 struggling struggle VBG cord-285833-7exenodj 9 10 because because IN cord-285833-7exenodj 9 11 of of IN cord-285833-7exenodj 9 12 coronavirus coronavirus NN cord-285833-7exenodj 9 13 disease disease NN cord-285833-7exenodj 9 14 , , , cord-285833-7exenodj 9 15 and and CC cord-285833-7exenodj 9 16 it -PRON- PRP cord-285833-7exenodj 9 17 has have VBZ cord-285833-7exenodj 9 18 already already RB cord-285833-7exenodj 9 19 triggered trigger VBN cord-285833-7exenodj 9 20 a a DT cord-285833-7exenodj 9 21 series series NN cord-285833-7exenodj 9 22 of of IN cord-285833-7exenodj 9 23 crises crisis NNS cord-285833-7exenodj 9 24 . . . cord-285833-7exenodj 10 1 Patients patient NNS cord-285833-7exenodj 10 2 with with IN cord-285833-7exenodj 10 3 comorbidities comorbiditie NNS cord-285833-7exenodj 10 4 are be VBP cord-285833-7exenodj 10 5 highly highly RB cord-285833-7exenodj 10 6 susceptible susceptible JJ cord-285833-7exenodj 10 7 to to IN cord-285833-7exenodj 10 8 infection infection NN cord-285833-7exenodj 10 9 and and CC cord-285833-7exenodj 10 10 thus thus RB cord-285833-7exenodj 10 11 have have VB cord-285833-7exenodj 10 12 a a DT cord-285833-7exenodj 10 13 poor poor JJ cord-285833-7exenodj 10 14 prognosis prognosis NN cord-285833-7exenodj 10 15 . . . cord-285833-7exenodj 11 1 Cancer cancer NN cord-285833-7exenodj 11 2 patients patient NNS cord-285833-7exenodj 11 3 have have VBP cord-285833-7exenodj 11 4 been be VBN cord-285833-7exenodj 11 5 heavily heavily RB cord-285833-7exenodj 11 6 impacted impact VBN cord-285833-7exenodj 11 7 by by IN cord-285833-7exenodj 11 8 the the DT cord-285833-7exenodj 11 9 onset onset NN cord-285833-7exenodj 11 10 of of IN cord-285833-7exenodj 11 11 this this DT cord-285833-7exenodj 11 12 pandemic pandemic NN cord-285833-7exenodj 11 13 . . . cord-285833-7exenodj 12 1 A a DT cord-285833-7exenodj 12 2 few few JJ cord-285833-7exenodj 12 3 recent recent JJ cord-285833-7exenodj 12 4 studies study NNS cord-285833-7exenodj 12 5 on on IN cord-285833-7exenodj 12 6 cancer cancer NN cord-285833-7exenodj 12 7 patients patient NNS cord-285833-7exenodj 12 8 have have VBP cord-285833-7exenodj 12 9 shown show VBN cord-285833-7exenodj 12 10 that that IN cord-285833-7exenodj 12 11 they -PRON- PRP cord-285833-7exenodj 12 12 are be VBP cord-285833-7exenodj 12 13 at at IN cord-285833-7exenodj 12 14 an an DT cord-285833-7exenodj 12 15 increased increase VBN cord-285833-7exenodj 12 16 risk risk NN cord-285833-7exenodj 12 17 for for IN cord-285833-7exenodj 12 18 severe severe JJ cord-285833-7exenodj 12 19 acute acute JJ cord-285833-7exenodj 12 20 respiratory respiratory JJ cord-285833-7exenodj 12 21 syndrome syndrome NN cord-285833-7exenodj 12 22 - - HYPH cord-285833-7exenodj 12 23 coronavirus-2 coronavirus-2 NNP cord-285833-7exenodj 13 1 ( ( -LRB- cord-285833-7exenodj 13 2 SARS SARS NNP cord-285833-7exenodj 13 3 - - HYPH cord-285833-7exenodj 13 4 CoV-2 CoV-2 NNP cord-285833-7exenodj 13 5 ) ) -RRB- cord-285833-7exenodj 13 6 infection infection NN cord-285833-7exenodj 13 7 . . . cord-285833-7exenodj 14 1 Furthermore furthermore RB cord-285833-7exenodj 14 2 , , , cord-285833-7exenodj 14 3 infected infected JJ cord-285833-7exenodj 14 4 patients patient NNS cord-285833-7exenodj 14 5 were be VBD cord-285833-7exenodj 14 6 found find VBN cord-285833-7exenodj 14 7 to to TO cord-285833-7exenodj 14 8 have have VB cord-285833-7exenodj 14 9 an an DT cord-285833-7exenodj 14 10 increased increase VBN cord-285833-7exenodj 14 11 risk risk NN cord-285833-7exenodj 14 12 of of IN cord-285833-7exenodj 14 13 admission admission NN cord-285833-7exenodj 14 14 to to IN cord-285833-7exenodj 14 15 the the DT cord-285833-7exenodj 14 16 intensive intensive JJ cord-285833-7exenodj 14 17 care care NN cord-285833-7exenodj 14 18 unit unit NN cord-285833-7exenodj 14 19 , , , cord-285833-7exenodj 14 20 requiring require VBG cord-285833-7exenodj 14 21 invasive invasive JJ cord-285833-7exenodj 14 22 ventilation ventilation NN cord-285833-7exenodj 14 23 , , , cord-285833-7exenodj 14 24 or or CC cord-285833-7exenodj 14 25 death death NN cord-285833-7exenodj 14 26 ( ( -LRB- cord-285833-7exenodj 14 27 1 1 CD cord-285833-7exenodj 14 28 ) ) -RRB- cord-285833-7exenodj 14 29 . . . cord-285833-7exenodj 15 1 Oncologists oncologist NNS cord-285833-7exenodj 15 2 are be VBP cord-285833-7exenodj 15 3 providing provide VBG cord-285833-7exenodj 15 4 optimal optimal JJ cord-285833-7exenodj 15 5 cancer cancer NN cord-285833-7exenodj 15 6 care care NN cord-285833-7exenodj 15 7 and and CC cord-285833-7exenodj 15 8 , , , cord-285833-7exenodj 15 9 simultaneously simultaneously RB cord-285833-7exenodj 15 10 , , , cord-285833-7exenodj 15 11 are be VBP cord-285833-7exenodj 15 12 trying try VBG cord-285833-7exenodj 15 13 to to TO cord-285833-7exenodj 15 14 protect protect VB cord-285833-7exenodj 15 15 these these DT cord-285833-7exenodj 15 16 fragile fragile JJ cord-285833-7exenodj 15 17 patients patient NNS cord-285833-7exenodj 15 18 from from IN cord-285833-7exenodj 15 19 SARS SARS NNP cord-285833-7exenodj 15 20 - - HYPH cord-285833-7exenodj 15 21 CoV-2 CoV-2 NNP cord-285833-7exenodj 15 22 infection infection NN cord-285833-7exenodj 15 23 and and CC cord-285833-7exenodj 15 24 its -PRON- PRP$ cord-285833-7exenodj 15 25 consequences consequence NNS cord-285833-7exenodj 15 26 . . . cord-285833-7exenodj 16 1 Cytopenia Cytopenia NNP cord-285833-7exenodj 16 2 , , , cord-285833-7exenodj 16 3 especially especially RB cord-285833-7exenodj 16 4 neutropenia neutropenia NN cord-285833-7exenodj 16 5 and and CC cord-285833-7exenodj 16 6 lymphopenia lymphopenia NNP cord-285833-7exenodj 16 7 , , , cord-285833-7exenodj 16 8 is be VBZ cord-285833-7exenodj 16 9 the the DT cord-285833-7exenodj 16 10 most most RBS cord-285833-7exenodj 16 11 frustrating frustrating JJ cord-285833-7exenodj 16 12 complication complication NN cord-285833-7exenodj 16 13 of of IN cord-285833-7exenodj 16 14 cancer cancer NN cord-285833-7exenodj 16 15 treatment treatment NN cord-285833-7exenodj 16 16 and and CC cord-285833-7exenodj 16 17 can can MD cord-285833-7exenodj 16 18 increase increase VB cord-285833-7exenodj 16 19 the the DT cord-285833-7exenodj 16 20 susceptibility susceptibility NN cord-285833-7exenodj 16 21 to to IN cord-285833-7exenodj 16 22 infection infection NN cord-285833-7exenodj 16 23 . . . cord-285833-7exenodj 17 1 Both both DT cord-285833-7exenodj 17 2 the the DT cord-285833-7exenodj 17 3 European European NNP cord-285833-7exenodj 17 4 Society Society NNP cord-285833-7exenodj 17 5 for for IN cord-285833-7exenodj 17 6 Medical Medical NNP cord-285833-7exenodj 17 7 Oncology Oncology NNP cord-285833-7exenodj 17 8 ( ( -LRB- cord-285833-7exenodj 17 9 ESMO ESMO NNP cord-285833-7exenodj 17 10 ) ) -RRB- cord-285833-7exenodj 17 11 and and CC cord-285833-7exenodj 17 12 the the DT cord-285833-7exenodj 17 13 National National NNP cord-285833-7exenodj 17 14 Comprehensive Comprehensive NNP cord-285833-7exenodj 17 15 Cancer Cancer NNP cord-285833-7exenodj 17 16 Network Network NNP cord-285833-7exenodj 17 17 ( ( -LRB- cord-285833-7exenodj 17 18 NCCN NCCN NNP cord-285833-7exenodj 17 19 ) ) -RRB- cord-285833-7exenodj 17 20 have have VBP cord-285833-7exenodj 17 21 recommended recommend VBN cord-285833-7exenodj 17 22 expanding expand VBG cord-285833-7exenodj 17 23 the the DT cord-285833-7exenodj 17 24 indications indication NNS cord-285833-7exenodj 17 25 for for IN cord-285833-7exenodj 17 26 use use NN cord-285833-7exenodj 17 27 of of IN cord-285833-7exenodj 17 28 granulocyte granulocyte NN cord-285833-7exenodj 17 29 colonystimulating colonystimulating NN cord-285833-7exenodj 17 30 factors factor NNS cord-285833-7exenodj 17 31 ( ( -LRB- cord-285833-7exenodj 17 32 G g NN cord-285833-7exenodj 17 33 - - HYPH cord-285833-7exenodj 17 34 CSFs csf NNS cord-285833-7exenodj 17 35 ) ) -RRB- cord-285833-7exenodj 17 36 in in IN cord-285833-7exenodj 17 37 cancer cancer NN cord-285833-7exenodj 17 38 patients patient NNS cord-285833-7exenodj 17 39 to to TO cord-285833-7exenodj 17 40 decrease decrease VB cord-285833-7exenodj 17 41 the the DT cord-285833-7exenodj 17 42 risk risk NN cord-285833-7exenodj 17 43 of of IN cord-285833-7exenodj 17 44 neutropenic neutropenic JJ cord-285833-7exenodj 17 45 fever fever NN cord-285833-7exenodj 17 46 and and CC cord-285833-7exenodj 17 47 prevent prevent VB cord-285833-7exenodj 17 48 them -PRON- PRP cord-285833-7exenodj 17 49 from from IN cord-285833-7exenodj 17 50 having have VBG cord-285833-7exenodj 17 51 to to TO cord-285833-7exenodj 17 52 visit visit VB cord-285833-7exenodj 17 53 a a DT cord-285833-7exenodj 17 54 hospital hospital NN cord-285833-7exenodj 17 55 ( ( -LRB- cord-285833-7exenodj 17 56 2 2 CD cord-285833-7exenodj 17 57 , , , cord-285833-7exenodj 17 58 3 3 CD cord-285833-7exenodj 17 59 ) ) -RRB- cord-285833-7exenodj 17 60 . . . cord-285833-7exenodj 18 1 The the DT cord-285833-7exenodj 18 2 efficacy efficacy NN cord-285833-7exenodj 18 3 of of IN cord-285833-7exenodj 18 4 G g NN cord-285833-7exenodj 18 5 - - HYPH cord-285833-7exenodj 18 6 CSFs csf NNS cord-285833-7exenodj 18 7 in in IN cord-285833-7exenodj 18 8 preventing prevent VBG cord-285833-7exenodj 18 9 febrile febrile JJ cord-285833-7exenodj 18 10 neutropenia neutropenia NN cord-285833-7exenodj 18 11 and and CC cord-285833-7exenodj 18 12 treatment treatment NN cord-285833-7exenodj 18 13 - - HYPH cord-285833-7exenodj 18 14 related relate VBN cord-285833-7exenodj 18 15 hospitalizations hospitalization NNS cord-285833-7exenodj 18 16 has have VBZ cord-285833-7exenodj 18 17 been be VBN cord-285833-7exenodj 18 18 well well RB cord-285833-7exenodj 18 19 documented document VBN cord-285833-7exenodj 18 20 in in IN cord-285833-7exenodj 18 21 earlier early JJR cord-285833-7exenodj 18 22 studies study NNS cord-285833-7exenodj 18 23 . . . cord-285833-7exenodj 19 1 Moreover moreover RB cord-285833-7exenodj 19 2 , , , cord-285833-7exenodj 19 3 a a DT cord-285833-7exenodj 19 4 5-day 5-day JJ cord-285833-7exenodj 19 5 course course NN cord-285833-7exenodj 19 6 of of IN cord-285833-7exenodj 19 7 G G NNP cord-285833-7exenodj 19 8 - - HYPH cord-285833-7exenodj 19 9 CSF csf NN cord-285833-7exenodj 19 10 prophylaxis prophylaxis NN cord-285833-7exenodj 19 11 in in IN cord-285833-7exenodj 19 12 most most JJS cord-285833-7exenodj 19 13 chemotherapy chemotherapy NN cord-285833-7exenodj 19 14 regimens regimen NNS cord-285833-7exenodj 19 15 has have VBZ cord-285833-7exenodj 19 16 been be VBN cord-285833-7exenodj 19 17 reported report VBN cord-285833-7exenodj 19 18 to to TO cord-285833-7exenodj 19 19 be be VB cord-285833-7exenodj 19 20 effective effective JJ cord-285833-7exenodj 19 21 ( ( -LRB- cord-285833-7exenodj 19 22 4 4 CD cord-285833-7exenodj 19 23 ) ) -RRB- cord-285833-7exenodj 19 24 ; ; : cord-285833-7exenodj 19 25 however however RB cord-285833-7exenodj 19 26 , , , cord-285833-7exenodj 19 27 limited limited JJ cord-285833-7exenodj 19 28 data datum NNS cord-285833-7exenodj 19 29 are be VBP cord-285833-7exenodj 19 30 available available JJ cord-285833-7exenodj 19 31 on on IN cord-285833-7exenodj 19 32 its -PRON- PRP$ cord-285833-7exenodj 19 33 efficacy efficacy NN cord-285833-7exenodj 19 34 in in IN cord-285833-7exenodj 19 35 COVID-19 COVID-19 NNP cord-285833-7exenodj 19 36 patients patient NNS cord-285833-7exenodj 19 37 . . . cord-285833-7exenodj 20 1 G g NN cord-285833-7exenodj 20 2 - - HYPH cord-285833-7exenodj 20 3 CSFs csf NNS cord-285833-7exenodj 20 4 are be VBP cord-285833-7exenodj 20 5 growth growth NN cord-285833-7exenodj 20 6 factors factor NNS cord-285833-7exenodj 20 7 that that WDT cord-285833-7exenodj 20 8 stimulate stimulate VBP cord-285833-7exenodj 20 9 the the DT cord-285833-7exenodj 20 10 survival survival NN cord-285833-7exenodj 20 11 , , , cord-285833-7exenodj 20 12 proliferation proliferation NN cord-285833-7exenodj 20 13 , , , cord-285833-7exenodj 20 14 differentiation differentiation NN cord-285833-7exenodj 20 15 , , , cord-285833-7exenodj 20 16 and and CC cord-285833-7exenodj 20 17 function function NN cord-285833-7exenodj 20 18 of of IN cord-285833-7exenodj 20 19 neutrophil neutrophil NN cord-285833-7exenodj 20 20 precursors precursor NNS cord-285833-7exenodj 20 21 and and CC cord-285833-7exenodj 20 22 mature mature VB cord-285833-7exenodj 20 23 neutrophils neutrophil NNS cord-285833-7exenodj 20 24 via via IN cord-285833-7exenodj 20 25 signal signal NN cord-285833-7exenodj 20 26 transduction transduction NN cord-285833-7exenodj 20 27 pathways pathway NNS cord-285833-7exenodj 20 28 . . . cord-285833-7exenodj 21 1 Studies study NNS cord-285833-7exenodj 21 2 on on IN cord-285833-7exenodj 21 3 healthy healthy JJ cord-285833-7exenodj 21 4 volunteers volunteer NNS cord-285833-7exenodj 21 5 revealed reveal VBD cord-285833-7exenodj 21 6 that that IN cord-285833-7exenodj 21 7 the the DT cord-285833-7exenodj 21 8 administration administration NN cord-285833-7exenodj 21 9 of of IN cord-285833-7exenodj 21 10 G G NNP cord-285833-7exenodj 21 11 - - HYPH cord-285833-7exenodj 21 12 CSFs CSFs NNP cord-285833-7exenodj 21 13 resulted result VBD cord-285833-7exenodj 21 14 in in IN cord-285833-7exenodj 21 15 increased increase VBD cord-285833-7exenodj 21 16 the the DT cord-285833-7exenodj 21 17 levels level NNS cord-285833-7exenodj 21 18 of of IN cord-285833-7exenodj 21 19 interleukin interleukin NN cord-285833-7exenodj 21 20 ( ( -LRB- cord-285833-7exenodj 21 21 IL)-1 IL)-1 '' cord-285833-7exenodj 21 22 , , , cord-285833-7exenodj 21 23 soluble soluble JJ cord-285833-7exenodj 21 24 tumor tumor NN cord-285833-7exenodj 21 25 necrosis necrosis NN cord-285833-7exenodj 21 26 factor factor NN cord-285833-7exenodj 21 27 ( ( -LRB- cord-285833-7exenodj 21 28 TNF TNF NNP cord-285833-7exenodj 21 29 ) ) -RRB- cord-285833-7exenodj 21 30 receptors receptor NNS cord-285833-7exenodj 21 31 ( ( -LRB- cord-285833-7exenodj 21 32 sTNF stnf NN cord-285833-7exenodj 21 33 - - HYPH cord-285833-7exenodj 21 34 Rs r NNS cord-285833-7exenodj 21 35 ) ) -RRB- cord-285833-7exenodj 21 36 , , , cord-285833-7exenodj 21 37 IL-6 IL-6 NNP cord-285833-7exenodj 21 38 , , , cord-285833-7exenodj 21 39 IL-8 IL-8 NNP cord-285833-7exenodj 21 40 , , , cord-285833-7exenodj 21 41 and and CC cord-285833-7exenodj 21 42 IL-10 IL-10 NNP cord-285833-7exenodj 21 43 and and CC cord-285833-7exenodj 21 44 reduced reduce VBD cord-285833-7exenodj 21 45 the the DT cord-285833-7exenodj 21 46 levels level NNS cord-285833-7exenodj 21 47 of of IN cord-285833-7exenodj 21 48 TNF TNF NNP cord-285833-7exenodj 21 49 - - HYPH cord-285833-7exenodj 21 50 a a NNP cord-285833-7exenodj 21 51 , , , cord-285833-7exenodj 21 52 interferon interferon NN cord-285833-7exenodj 21 53 ( ( -LRB- cord-285833-7exenodj 21 54 IFN)-g IFN)-g NNP cord-285833-7exenodj 21 55 , , , cord-285833-7exenodj 21 56 and and CC cord-285833-7exenodj 21 57 granulocyte granulocyte NN cord-285833-7exenodj 21 58 - - HYPH cord-285833-7exenodj 21 59 macrophage macrophage NN cord-285833-7exenodj 21 60 colony colony NN cord-285833-7exenodj 21 61 - - HYPH cord-285833-7exenodj 21 62 stimulating stimulate VBG cord-285833-7exenodj 21 63 factor factor NN cord-285833-7exenodj 21 64 ( ( -LRB- cord-285833-7exenodj 21 65 GM GM NNP cord-285833-7exenodj 21 66 - - HYPH cord-285833-7exenodj 21 67 CSF CSF NNP cord-285833-7exenodj 21 68 ) ) -RRB- cord-285833-7exenodj 21 69 ( ( -LRB- cord-285833-7exenodj 21 70 5 5 CD cord-285833-7exenodj 21 71 ) ) -RRB- cord-285833-7exenodj 21 72 . . . cord-285833-7exenodj 22 1 Data datum NNS cord-285833-7exenodj 22 2 from from IN cord-285833-7exenodj 22 3 a a DT cord-285833-7exenodj 22 4 limited limited JJ cord-285833-7exenodj 22 5 number number NN cord-285833-7exenodj 22 6 of of IN cord-285833-7exenodj 22 7 COVID-19 covid-19 JJ cord-285833-7exenodj 22 8 patients patient NNS cord-285833-7exenodj 22 9 have have VBP cord-285833-7exenodj 22 10 shown show VBN cord-285833-7exenodj 22 11 a a DT cord-285833-7exenodj 22 12 cytokine cytokine NN cord-285833-7exenodj 22 13 storm storm NN cord-285833-7exenodj 22 14 in in IN cord-285833-7exenodj 22 15 critically critically RB cord-285833-7exenodj 22 16 ill ill JJ cord-285833-7exenodj 22 17 patients patient NNS cord-285833-7exenodj 22 18 . . . cord-285833-7exenodj 23 1 Besides besides RB cord-285833-7exenodj 23 2 , , , cord-285833-7exenodj 23 3 the the DT cord-285833-7exenodj 23 4 levels level NNS cord-285833-7exenodj 23 5 of of IN cord-285833-7exenodj 23 6 IL-2 IL-2 NNP cord-285833-7exenodj 23 7 , , , cord-285833-7exenodj 23 8 IL-6 IL-6 NNP cord-285833-7exenodj 23 9 , , , cord-285833-7exenodj 23 10 IL-10 IL-10 NNP cord-285833-7exenodj 23 11 , , , cord-285833-7exenodj 23 12 and and CC cord-285833-7exenodj 23 13 IFN IFN NNP cord-285833-7exenodj 23 14 - - HYPH cord-285833-7exenodj 23 15 g g NNP cord-285833-7exenodj 23 16 were be VBD cord-285833-7exenodj 23 17 found find VBN cord-285833-7exenodj 23 18 to to TO cord-285833-7exenodj 23 19 be be VB cord-285833-7exenodj 23 20 higher high JJR cord-285833-7exenodj 23 21 in in IN cord-285833-7exenodj 23 22 severe severe JJ cord-285833-7exenodj 23 23 cases case NNS cord-285833-7exenodj 23 24 of of IN cord-285833-7exenodj 23 25 COVID-19 covid-19 CD cord-285833-7exenodj 23 26 than than IN cord-285833-7exenodj 23 27 in in IN cord-285833-7exenodj 23 28 mild mild JJ cord-285833-7exenodj 23 29 cases case NNS cord-285833-7exenodj 23 30 , , , cord-285833-7exenodj 23 31 and and CC cord-285833-7exenodj 23 32 a a DT cord-285833-7exenodj 23 33 strong strong JJ cord-285833-7exenodj 23 34 inflammatory inflammatory JJ cord-285833-7exenodj 23 35 response response NN cord-285833-7exenodj 23 36 during during IN cord-285833-7exenodj 23 37 its -PRON- PRP$ cord-285833-7exenodj 23 38 clinical clinical JJ cord-285833-7exenodj 23 39 course course NN cord-285833-7exenodj 23 40 was be VBD cord-285833-7exenodj 23 41 reported report VBN cord-285833-7exenodj 23 42 to to TO cord-285833-7exenodj 23 43 be be VB cord-285833-7exenodj 23 44 associated associate VBN cord-285833-7exenodj 23 45 with with IN cord-285833-7exenodj 23 46 high high JJ cord-285833-7exenodj 23 47 morbidity morbidity NN cord-285833-7exenodj 23 48 and and CC cord-285833-7exenodj 23 49 mortality mortality NN cord-285833-7exenodj 23 50 ( ( -LRB- cord-285833-7exenodj 23 51 6 6 CD cord-285833-7exenodj 23 52 ) ) -RRB- cord-285833-7exenodj 23 53 . . . cord-285833-7exenodj 24 1 Clinical clinical JJ cord-285833-7exenodj 24 2 outcomes outcome NNS cord-285833-7exenodj 24 3 are be VBP cord-285833-7exenodj 24 4 also also RB cord-285833-7exenodj 24 5 unpredictable unpredictable JJ cord-285833-7exenodj 24 6 in in IN cord-285833-7exenodj 24 7 COVID-19 covid-19 JJ cord-285833-7exenodj 24 8 patients patient NNS cord-285833-7exenodj 24 9 with with IN cord-285833-7exenodj 24 10 high high JJ cord-285833-7exenodj 24 11 levels level NNS cord-285833-7exenodj 24 12 of of IN cord-285833-7exenodj 24 13 inflammatory inflammatory JJ cord-285833-7exenodj 24 14 cytokines cytokine NNS cord-285833-7exenodj 24 15 undergoing undergo VBG cord-285833-7exenodj 24 16 G G NNP cord-285833-7exenodj 24 17 - - HYPH cord-285833-7exenodj 24 18 CSF csf NN cord-285833-7exenodj 24 19 prophylaxis prophylaxis NN cord-285833-7exenodj 24 20 . . . cord-285833-7exenodj 25 1 Furthermore furthermore RB cord-285833-7exenodj 25 2 , , , cord-285833-7exenodj 25 3 there there EX cord-285833-7exenodj 25 4 are be VBP cord-285833-7exenodj 25 5 chances chance NNS cord-285833-7exenodj 25 6 of of IN cord-285833-7exenodj 25 7 acute acute JJ cord-285833-7exenodj 25 8 respiratory respiratory JJ cord-285833-7exenodj 25 9 failure failure NN cord-285833-7exenodj 25 10 during during IN cord-285833-7exenodj 25 11 G G NNP cord-285833-7exenodj 25 12 - - HYPH cord-285833-7exenodj 25 13 CSF csf NN cord-285833-7exenodj 25 14 - - HYPH cord-285833-7exenodj 25 15 induced induce VBN cord-285833-7exenodj 25 16 neutropenia neutropenia NN cord-285833-7exenodj 25 17 recovery recovery NN cord-285833-7exenodj 25 18 . . . cord-285833-7exenodj 26 1 G g NN cord-285833-7exenodj 26 2 - - HYPH cord-285833-7exenodj 26 3 CSFs csf NNS cord-285833-7exenodj 26 4 have have VBP cord-285833-7exenodj 26 5 been be VBN cord-285833-7exenodj 26 6 reported report VBN cord-285833-7exenodj 26 7 to to TO cord-285833-7exenodj 26 8 be be VB cord-285833-7exenodj 26 9 associated associate VBN cord-285833-7exenodj 26 10 with with IN cord-285833-7exenodj 26 11 activation activation NN cord-285833-7exenodj 26 12 of of IN cord-285833-7exenodj 26 13 the the DT cord-285833-7exenodj 26 14 oxidative oxidative JJ cord-285833-7exenodj 26 15 burst burst NN cord-285833-7exenodj 26 16 mechanism mechanism NN cord-285833-7exenodj 26 17 within within IN cord-285833-7exenodj 26 18 circulating circulate VBG cord-285833-7exenodj 26 19 or or CC cord-285833-7exenodj 26 20 resident resident JJ cord-285833-7exenodj 26 21 alveolar alveolar JJ cord-285833-7exenodj 26 22 neutrophils neutrophil NNS cord-285833-7exenodj 26 23 and and CC cord-285833-7exenodj 26 24 macrophages macrophage NNS cord-285833-7exenodj 26 25 , , , cord-285833-7exenodj 26 26 further further RB cord-285833-7exenodj 26 27 complicating complicate VBG cord-285833-7exenodj 26 28 the the DT cord-285833-7exenodj 26 29 situation situation NN cord-285833-7exenodj 26 30 ( ( -LRB- cord-285833-7exenodj 26 31 7 7 CD cord-285833-7exenodj 26 32 , , , cord-285833-7exenodj 26 33 8) 8) NN cord-285833-7exenodj 26 34 . . . cord-285833-7exenodj 27 1 Therefore therefore RB cord-285833-7exenodj 27 2 , , , cord-285833-7exenodj 27 3 devastating devastating JJ cord-285833-7exenodj 27 4 results result NNS cord-285833-7exenodj 27 5 can can MD cord-285833-7exenodj 27 6 potentially potentially RB cord-285833-7exenodj 27 7 be be VB cord-285833-7exenodj 27 8 seen see VBN cord-285833-7exenodj 27 9 in in IN cord-285833-7exenodj 28 1 COVID-19-positive covid-19-positive JJ cord-285833-7exenodj 28 2 patients patient NNS cord-285833-7exenodj 28 3 administered administer VBD cord-285833-7exenodj 28 4 G G NNP cord-285833-7exenodj 28 5 - - HYPH cord-285833-7exenodj 28 6 CFSs cfs NNS cord-285833-7exenodj 28 7 or or CC cord-285833-7exenodj 28 8 in in IN cord-285833-7exenodj 28 9 those those DT cord-285833-7exenodj 28 10 exposed expose VBN cord-285833-7exenodj 28 11 to to IN cord-285833-7exenodj 28 12 infection infection NN cord-285833-7exenodj 28 13 while while IN cord-285833-7exenodj 28 14 undergoing undergo VBG cord-285833-7exenodj 28 15 G G NNP cord-285833-7exenodj 28 16 - - HYPH cord-285833-7exenodj 28 17 CSF csf NN cord-285833-7exenodj 28 18 therapy therapy NN cord-285833-7exenodj 28 19 . . . cord-285833-7exenodj 29 1 However however RB cord-285833-7exenodj 29 2 , , , cord-285833-7exenodj 29 3 very very RB cord-285833-7exenodj 29 4 limited limited JJ cord-285833-7exenodj 29 5 data datum NNS cord-285833-7exenodj 29 6 on on IN cord-285833-7exenodj 29 7 the the DT cord-285833-7exenodj 29 8 outcomes outcome NNS cord-285833-7exenodj 29 9 of of IN cord-285833-7exenodj 29 10 chemotherapy chemotherapy NN cord-285833-7exenodj 29 11 in in IN cord-285833-7exenodj 29 12 cancer cancer NN cord-285833-7exenodj 29 13 patients patient NNS cord-285833-7exenodj 29 14 in in IN cord-285833-7exenodj 29 15 the the DT cord-285833-7exenodj 29 16 COVID-19 COVID-19 NNP cord-285833-7exenodj 29 17 era era NN cord-285833-7exenodj 29 18 are be VBP cord-285833-7exenodj 29 19 currently currently RB cord-285833-7exenodj 29 20 available available JJ cord-285833-7exenodj 29 21 , , , cord-285833-7exenodj 29 22 with with IN cord-285833-7exenodj 29 23 no no DT cord-285833-7exenodj 29 24 specific specific JJ cord-285833-7exenodj 29 25 subgroup subgroup NN cord-285833-7exenodj 29 26 analysis analysis NN cord-285833-7exenodj 29 27 in in IN cord-285833-7exenodj 29 28 patients patient NNS cord-285833-7exenodj 29 29 treated treat VBN cord-285833-7exenodj 29 30 with with IN cord-285833-7exenodj 29 31 G g NN cord-285833-7exenodj 29 32 - - HYPH cord-285833-7exenodj 29 33 CSFs csf NNS cord-285833-7exenodj 29 34 . . . cord-285833-7exenodj 30 1 Although although IN cord-285833-7exenodj 30 2 the the DT cord-285833-7exenodj 30 3 described describe VBN cord-285833-7exenodj 30 4 scenarios scenario NNS cord-285833-7exenodj 30 5 are be VBP cord-285833-7exenodj 30 6 theoretical theoretical JJ cord-285833-7exenodj 30 7 and and CC cord-285833-7exenodj 30 8 speculative speculative JJ cord-285833-7exenodj 30 9 , , , cord-285833-7exenodj 30 10 both both CC cord-285833-7exenodj 30 11 NCCN NCCN NNP cord-285833-7exenodj 30 12 and and CC cord-285833-7exenodj 30 13 ESMO ESMO NNP cord-285833-7exenodj 30 14 have have VBP cord-285833-7exenodj 30 15 concluded conclude VBN cord-285833-7exenodj 30 16 that that IN cord-285833-7exenodj 30 17 the the DT cord-285833-7exenodj 30 18 benefits benefit NNS cord-285833-7exenodj 30 19 of of IN cord-285833-7exenodj 30 20 G G NNP cord-285833-7exenodj 30 21 - - HYPH cord-285833-7exenodj 30 22 CSF CSF NNP cord-285833-7exenodj 30 23 administration administration NN cord-285833-7exenodj 30 24 outweigh outweigh VBP cord-285833-7exenodj 30 25 its -PRON- PRP$ cord-285833-7exenodj 30 26 risks risk NNS cord-285833-7exenodj 30 27 and and CC cord-285833-7exenodj 30 28 have have VBP cord-285833-7exenodj 30 29 , , , cord-285833-7exenodj 30 30 therefore therefore RB cord-285833-7exenodj 30 31 , , , cord-285833-7exenodj 30 32 recommended recommend VBD cord-285833-7exenodj 30 33 its -PRON- PRP$ cord-285833-7exenodj 30 34 use use NN cord-285833-7exenodj 30 35 with with IN cord-285833-7exenodj 30 36 caution caution NN cord-285833-7exenodj 30 37 . . . cord-285833-7exenodj 31 1 Until until IN cord-285833-7exenodj 31 2 more more JJR cord-285833-7exenodj 31 3 data datum NNS cord-285833-7exenodj 31 4 are be VBP cord-285833-7exenodj 31 5 available available JJ cord-285833-7exenodj 31 6 , , , cord-285833-7exenodj 31 7 clinicians clinician NNS cord-285833-7exenodj 31 8 should should MD cord-285833-7exenodj 31 9 be be VB cord-285833-7exenodj 31 10 more more RBR cord-285833-7exenodj 31 11 cautious cautious JJ cord-285833-7exenodj 31 12 with with IN cord-285833-7exenodj 31 13 the the DT cord-285833-7exenodj 31 14 use use NN cord-285833-7exenodj 31 15 of of IN cord-285833-7exenodj 31 16 G g NN cord-285833-7exenodj 31 17 - - HYPH cord-285833-7exenodj 31 18 CSFs csf NNS cord-285833-7exenodj 31 19 in in IN cord-285833-7exenodj 31 20 cancer cancer NN cord-285833-7exenodj 31 21 patients patient NNS cord-285833-7exenodj 31 22 in in IN cord-285833-7exenodj 31 23 the the DT cord-285833-7exenodj 31 24 COVID-19 COVID-19 NNP cord-285833-7exenodj 31 25 era era NN cord-285833-7exenodj 31 26 . . . cord-285833-7exenodj 31 27 ' ' '' cord-285833-7exenodj 32 1 REFERENCES reference VBG cord-285833-7exenodj 32 2 Cancer cancer NN cord-285833-7exenodj 32 3 patients patient NNS cord-285833-7exenodj 32 4 in in IN cord-285833-7exenodj 32 5 SARS SARS NNP cord-285833-7exenodj 32 6 - - HYPH cord-285833-7exenodj 32 7 CoV-2 CoV-2 NNP cord-285833-7exenodj 32 8 infection infection NN cord-285833-7exenodj 32 9 : : : cord-285833-7exenodj 32 10 a a DT cord-285833-7exenodj 32 11 nationwide nationwide JJ cord-285833-7exenodj 32 12 analysis analysis NN cord-285833-7exenodj 32 13 in in IN cord-285833-7exenodj 32 14 China China NNP cord-285833-7exenodj 32 15 SUPPORTIVE supportive JJ cord-285833-7exenodj 32 16 CARE care NN cord-285833-7exenodj 32 17 STRATEGIES strategy NNS cord-285833-7exenodj 32 18 DURING during IN cord-285833-7exenodj 32 19 THE the DT cord-285833-7exenodj 32 20 COVID-19 COVID-19 NNP cord-285833-7exenodj 32 21 PANDEMIC PANDEMIC NNP cord-285833-7exenodj 32 22 Hematopoietic Hematopoietic NNP cord-285833-7exenodj 32 23 Growth Growth NNP cord-285833-7exenodj 32 24 Factors Factors NNPS cord-285833-7exenodj 32 25 . . . cord-285833-7exenodj 33 1 Short Short NNP cord-285833-7exenodj 33 2 - - HYPH cord-285833-7exenodj 33 3 Term Term NNP cord-285833-7exenodj 33 4 Recommendations Recommendations NNPS cord-285833-7exenodj 34 1 Specific specific JJ cord-285833-7exenodj 34 2 to to IN cord-285833-7exenodj 34 3 Issues issue NNS cord-285833-7exenodj 34 4 with with IN cord-285833-7exenodj 34 5 COVID-19 COVID-19 NNP cord-285833-7exenodj 35 1 ( ( -LRB- cord-285833-7exenodj 35 2 SARS SARS NNP cord-285833-7exenodj 35 3 - - HYPH cord-285833-7exenodj 35 4 CoV-2 CoV-2 NNP cord-285833-7exenodj 35 5 ) ) -RRB- cord-285833-7exenodj 36 1 A a DT cord-285833-7exenodj 36 2 multicentre multicentre NNP cord-285833-7exenodj 36 3 , , , cord-285833-7exenodj 36 4 randomised randomised JJ cord-285833-7exenodj 36 5 trial trial NN cord-285833-7exenodj 36 6 comparing compare VBG cord-285833-7exenodj 36 7 schedules schedule NNS cord-285833-7exenodj 36 8 of of IN cord-285833-7exenodj 36 9 G G NNP cord-285833-7exenodj 36 10 - - HYPH cord-285833-7exenodj 36 11 CSF CSF NNP cord-285833-7exenodj 36 12 ( ( -LRB- cord-285833-7exenodj 36 13 filgrastim filgrastim NNP cord-285833-7exenodj 36 14 ) ) -RRB- cord-285833-7exenodj 36 15 administration administration NN cord-285833-7exenodj 36 16 for for IN cord-285833-7exenodj 36 17 primary primary JJ cord-285833-7exenodj 36 18 prophylaxis prophylaxis NN cord-285833-7exenodj 36 19 of of IN cord-285833-7exenodj 36 20 chemotherapy chemotherapy NN cord-285833-7exenodj 36 21 - - HYPH cord-285833-7exenodj 36 22 induced induce VBN cord-285833-7exenodj 36 23 febrile febrile JJ cord-285833-7exenodj 36 24 neutropenia neutropenia NN cord-285833-7exenodj 36 25 in in IN cord-285833-7exenodj 36 26 early early JJ cord-285833-7exenodj 36 27 stage stage NN cord-285833-7exenodj 36 28 breast breast NN cord-285833-7exenodj 36 29 cancer cancer NN cord-285833-7exenodj 36 30 Effect effect NN cord-285833-7exenodj 36 31 of of IN cord-285833-7exenodj 36 32 granulocyte granulocyte NN cord-285833-7exenodj 36 33 colony colony NN cord-285833-7exenodj 36 34 - - HYPH cord-285833-7exenodj 36 35 stimulating stimulate VBG cord-285833-7exenodj 36 36 factor factor NN cord-285833-7exenodj 36 37 treatment treatment NN cord-285833-7exenodj 36 38 on on IN cord-285833-7exenodj 36 39 ex ex FW cord-285833-7exenodj 36 40 vivo vivo NN cord-285833-7exenodj 36 41 blood blood NN cord-285833-7exenodj 36 42 cytokine cytokine NN cord-285833-7exenodj 36 43 response response NN cord-285833-7exenodj 36 44 in in IN cord-285833-7exenodj 36 45 human human JJ cord-285833-7exenodj 36 46 volunteers volunteer NNS cord-285833-7exenodj 36 47 Longitudinal longitudinal JJ cord-285833-7exenodj 36 48 characteristics characteristic NNS cord-285833-7exenodj 36 49 of of IN cord-285833-7exenodj 36 50 lymphocyte lymphocyte NN cord-285833-7exenodj 36 51 responses response NNS cord-285833-7exenodj 36 52 and and CC cord-285833-7exenodj 36 53 cytokine cytokine NN cord-285833-7exenodj 36 54 profiles profile NNS cord-285833-7exenodj 36 55 in in IN cord-285833-7exenodj 36 56 the the DT cord-285833-7exenodj 36 57 peripheral peripheral JJ cord-285833-7exenodj 36 58 blood blood NN cord-285833-7exenodj 36 59 of of IN cord-285833-7exenodj 36 60 SARS SARS NNP cord-285833-7exenodj 36 61 - - HYPH cord-285833-7exenodj 36 62 CoV-2 CoV-2 NNP cord-285833-7exenodj 36 63 infected infect VBN cord-285833-7exenodj 36 64 patients patient NNS cord-285833-7exenodj 36 65 . . . cord-285833-7exenodj 37 1 Version version NN cord-285833-7exenodj 37 2 2 2 CD cord-285833-7exenodj 37 3 Deterioration deterioration NN cord-285833-7exenodj 37 4 of of IN cord-285833-7exenodj 37 5 previous previous JJ cord-285833-7exenodj 37 6 acute acute JJ cord-285833-7exenodj 37 7 lung lung NN cord-285833-7exenodj 37 8 injury injury NN cord-285833-7exenodj 37 9 during during IN cord-285833-7exenodj 37 10 neutropenia neutropenia NN cord-285833-7exenodj 37 11 recovery recovery NN cord-285833-7exenodj 37 12 Respiratory respiratory JJ cord-285833-7exenodj 37 13 status status NN cord-285833-7exenodj 37 14 deterioration deterioration NN cord-285833-7exenodj 37 15 during during IN cord-285833-7exenodj 37 16 G G NNP cord-285833-7exenodj 37 17 - - HYPH cord-285833-7exenodj 37 18 CSF csf NN cord-285833-7exenodj 37 19 - - HYPH cord-285833-7exenodj 37 20 induced induce VBN cord-285833-7exenodj 37 21 neutropenia neutropenia NN cord-285833-7exenodj 37 22 recovery recovery NN