id	sid	tid	token	lemma	pos
cord-258787-n49zrfsp	1	1	key	key	NN
cord-258787-n49zrfsp	1	2	:	:	:
cord-258787-n49zrfsp	2	1	cord-258787-n49zrfsp	cord-258787-n49zrfsp	JJ
cord-258787-n49zrfsp	2	2	authors	author	NNS
cord-258787-n49zrfsp	2	3	:	:	:
cord-258787-n49zrfsp	2	4	Carnevale	Carnevale	NNP
cord-258787-n49zrfsp	2	5	,	,	,
cord-258787-n49zrfsp	2	6	Silvia	Silvia	NNP
cord-258787-n49zrfsp	2	7	;	;	:
cord-258787-n49zrfsp	2	8	Ghasemi	Ghasemi	NNP
cord-258787-n49zrfsp	2	9	,	,	,
cord-258787-n49zrfsp	2	10	Somayehsadat	Somayehsadat	NNP
cord-258787-n49zrfsp	2	11	;	;	:
cord-258787-n49zrfsp	2	12	Rigatelli	Rigatelli	NNP
cord-258787-n49zrfsp	2	13	,	,	,
cord-258787-n49zrfsp	2	14	Anna	Anna	NNP
cord-258787-n49zrfsp	2	15	;	;	:
cord-258787-n49zrfsp	2	16	Jaillon	Jaillon	NNP
cord-258787-n49zrfsp	2	17	,	,	,
cord-258787-n49zrfsp	2	18	Sebastien	Sebastien	NNP
cord-258787-n49zrfsp	2	19	title	title	NN
cord-258787-n49zrfsp	2	20	:	:	:
cord-258787-n49zrfsp	2	21	The	the	DT
cord-258787-n49zrfsp	2	22	complexity	complexity	NN
cord-258787-n49zrfsp	2	23	of	of	IN
cord-258787-n49zrfsp	2	24	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	2	25	in	in	IN
cord-258787-n49zrfsp	2	26	health	health	NN
cord-258787-n49zrfsp	2	27	and	and	CC
cord-258787-n49zrfsp	2	28	disease	disease	NN
cord-258787-n49zrfsp	2	29	:	:	:
cord-258787-n49zrfsp	3	1	Focus	focus	VB
cord-258787-n49zrfsp	3	2	on	on	IN
cord-258787-n49zrfsp	3	3	cancer	cancer	NN
cord-258787-n49zrfsp	3	4	date	date	NN
cord-258787-n49zrfsp	3	5	:	:	:
cord-258787-n49zrfsp	3	6	2020	2020	CD
cord-258787-n49zrfsp	3	7	-	-	HYPH
cord-258787-n49zrfsp	3	8	09	09	CD
cord-258787-n49zrfsp	3	9	-	-	SYM
cord-258787-n49zrfsp	3	10	18	18	CD
cord-258787-n49zrfsp	3	11	journal	journal	NN
cord-258787-n49zrfsp	3	12	:	:	:
cord-258787-n49zrfsp	4	1	Semin	Semin	NNP
cord-258787-n49zrfsp	4	2	Immunol	Immunol	NNP
cord-258787-n49zrfsp	4	3	DOI	DOI	NNP
cord-258787-n49zrfsp	4	4	:	:	:
cord-258787-n49zrfsp	4	5	10.1016	10.1016	CD
cord-258787-n49zrfsp	4	6	/	/	SYM
cord-258787-n49zrfsp	4	7	j.smim.2020.101409	j.smim.2020.101409	CD
cord-258787-n49zrfsp	4	8	sha	sha	NNP
cord-258787-n49zrfsp	4	9	:	:	:
cord-258787-n49zrfsp	4	10	381c3cb760b29f75db5b2b017be4d77174b9d4c8	381c3cb760b29f75db5b2b017be4d77174b9d4c8	NNP
cord-258787-n49zrfsp	4	11	doc_id	doc_id	CD
cord-258787-n49zrfsp	4	12	:	:	:
cord-258787-n49zrfsp	4	13	258787	258787	CD
cord-258787-n49zrfsp	4	14	cord_uid	cord_uid	NNS
cord-258787-n49zrfsp	4	15	:	:	:
cord-258787-n49zrfsp	4	16	n49zrfsp	n49zrfsp	JJ
cord-258787-n49zrfsp	4	17	Neutrophils	Neutrophils	NNP
cord-258787-n49zrfsp	4	18	are	be	VBP
cord-258787-n49zrfsp	4	19	essential	essential	JJ
cord-258787-n49zrfsp	4	20	soldiers	soldier	NNS
cord-258787-n49zrfsp	4	21	of	of	IN
cord-258787-n49zrfsp	4	22	the	the	DT
cord-258787-n49zrfsp	4	23	immune	immune	JJ
cord-258787-n49zrfsp	4	24	response	response	NN
cord-258787-n49zrfsp	4	25	and	and	CC
cord-258787-n49zrfsp	4	26	their	-PRON-	PRP$
cord-258787-n49zrfsp	4	27	role	role	NN
cord-258787-n49zrfsp	4	28	have	have	VBP
cord-258787-n49zrfsp	4	29	long	long	RB
cord-258787-n49zrfsp	4	30	been	be	VBN
cord-258787-n49zrfsp	4	31	restricted	restrict	VBN
cord-258787-n49zrfsp	4	32	to	to	IN
cord-258787-n49zrfsp	4	33	their	-PRON-	PRP$
cord-258787-n49zrfsp	4	34	activities	activity	NNS
cord-258787-n49zrfsp	4	35	in	in	IN
cord-258787-n49zrfsp	4	36	defence	defence	NN
cord-258787-n49zrfsp	4	37	against	against	IN
cord-258787-n49zrfsp	4	38	microbial	microbial	JJ
cord-258787-n49zrfsp	4	39	infections	infection	NNS
cord-258787-n49zrfsp	4	40	and	and	CC
cord-258787-n49zrfsp	4	41	during	during	IN
cord-258787-n49zrfsp	4	42	the	the	DT
cord-258787-n49zrfsp	4	43	acute	acute	JJ
cord-258787-n49zrfsp	4	44	phase	phase	NN
cord-258787-n49zrfsp	4	45	of	of	IN
cord-258787-n49zrfsp	4	46	the	the	DT
cord-258787-n49zrfsp	4	47	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	4	48	response	response	NN
cord-258787-n49zrfsp	4	49	.	.	.
cord-258787-n49zrfsp	5	1	However	however	RB
cord-258787-n49zrfsp	5	2	,	,	,
cord-258787-n49zrfsp	5	3	increasing	increase	VBG
cord-258787-n49zrfsp	5	4	number	number	NN
cord-258787-n49zrfsp	5	5	of	of	IN
cord-258787-n49zrfsp	5	6	investigations	investigation	NNS
cord-258787-n49zrfsp	5	7	showed	show	VBD
cord-258787-n49zrfsp	5	8	that	that	IN
cord-258787-n49zrfsp	5	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	5	10	are	be	VBP
cord-258787-n49zrfsp	5	11	endowed	endow	VBN
cord-258787-n49zrfsp	5	12	with	with	IN
cord-258787-n49zrfsp	5	13	plasticity	plasticity	NN
cord-258787-n49zrfsp	5	14	and	and	CC
cord-258787-n49zrfsp	5	15	can	can	MD
cord-258787-n49zrfsp	5	16	participate	participate	VB
cord-258787-n49zrfsp	5	17	in	in	IN
cord-258787-n49zrfsp	5	18	the	the	DT
cord-258787-n49zrfsp	5	19	orchestration	orchestration	NN
cord-258787-n49zrfsp	5	20	of	of	IN
cord-258787-n49zrfsp	5	21	both	both	DT
cord-258787-n49zrfsp	5	22	innate	innate	JJ
cord-258787-n49zrfsp	5	23	and	and	CC
cord-258787-n49zrfsp	5	24	adaptive	adaptive	JJ
cord-258787-n49zrfsp	5	25	immune	immune	JJ
cord-258787-n49zrfsp	5	26	responses	response	NNS
cord-258787-n49zrfsp	5	27	.	.	.
cord-258787-n49zrfsp	6	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	6	2	have	have	VBP
cord-258787-n49zrfsp	6	3	an	an	DT
cord-258787-n49zrfsp	6	4	impact	impact	NN
cord-258787-n49zrfsp	6	5	on	on	IN
cord-258787-n49zrfsp	6	6	a	a	DT
cord-258787-n49zrfsp	6	7	broad	broad	JJ
cord-258787-n49zrfsp	6	8	range	range	NN
cord-258787-n49zrfsp	6	9	of	of	IN
cord-258787-n49zrfsp	6	10	disorders	disorder	NNS
cord-258787-n49zrfsp	6	11	,	,	,
cord-258787-n49zrfsp	6	12	including	include	VBG
cord-258787-n49zrfsp	6	13	infections	infection	NNS
cord-258787-n49zrfsp	6	14	,	,	,
cord-258787-n49zrfsp	6	15	chronic	chronic	JJ
cord-258787-n49zrfsp	6	16	inflammations	inflammation	NNS
cord-258787-n49zrfsp	6	17	,	,	,
cord-258787-n49zrfsp	6	18	and	and	CC
cord-258787-n49zrfsp	6	19	cancer	cancer	NN
cord-258787-n49zrfsp	6	20	.	.	.
cord-258787-n49zrfsp	7	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	7	2	are	be	VBP
cord-258787-n49zrfsp	7	3	present	present	JJ
cord-258787-n49zrfsp	7	4	in	in	IN
cord-258787-n49zrfsp	7	5	the	the	DT
cord-258787-n49zrfsp	7	6	tumour	tumour	NN
cord-258787-n49zrfsp	7	7	microenvironment	microenvironment	NN
cord-258787-n49zrfsp	7	8	and	and	CC
cord-258787-n49zrfsp	7	9	have	have	VBP
cord-258787-n49zrfsp	7	10	been	be	VBN
cord-258787-n49zrfsp	7	11	reported	report	VBN
cord-258787-n49zrfsp	7	12	to	to	TO
cord-258787-n49zrfsp	7	13	mediate	mediate	VB
cord-258787-n49zrfsp	7	14	both	both	DT
cord-258787-n49zrfsp	7	15	pro	pro	JJ
cord-258787-n49zrfsp	7	16	-	-	JJ
cord-258787-n49zrfsp	7	17	tumour	tumour	JJ
cord-258787-n49zrfsp	7	18	and	and	CC
cord-258787-n49zrfsp	7	19	anti	anti	JJ
cord-258787-n49zrfsp	7	20	-	-	JJ
cord-258787-n49zrfsp	7	21	tumour	tumour	JJ
cord-258787-n49zrfsp	7	22	responses	response	NNS
cord-258787-n49zrfsp	7	23	.	.	.
cord-258787-n49zrfsp	8	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	8	2	can	can	MD
cord-258787-n49zrfsp	8	3	contribute	contribute	VB
cord-258787-n49zrfsp	8	4	to	to	IN
cord-258787-n49zrfsp	8	5	genetic	genetic	JJ
cord-258787-n49zrfsp	8	6	instability	instability	NN
cord-258787-n49zrfsp	8	7	,	,	,
cord-258787-n49zrfsp	8	8	tumour	tumour	NN
cord-258787-n49zrfsp	8	9	cell	cell	NN
cord-258787-n49zrfsp	8	10	proliferation	proliferation	NN
cord-258787-n49zrfsp	8	11	,	,	,
cord-258787-n49zrfsp	8	12	angiogenesis	angiogenesis	NN
cord-258787-n49zrfsp	8	13	and	and	CC
cord-258787-n49zrfsp	8	14	suppression	suppression	NN
cord-258787-n49zrfsp	8	15	of	of	IN
cord-258787-n49zrfsp	8	16	the	the	DT
cord-258787-n49zrfsp	8	17	anti	anti	JJ
cord-258787-n49zrfsp	8	18	-	-	JJ
cord-258787-n49zrfsp	8	19	tumour	tumour	JJ
cord-258787-n49zrfsp	8	20	immune	immune	JJ
cord-258787-n49zrfsp	8	21	response	response	NN
cord-258787-n49zrfsp	8	22	.	.	.
cord-258787-n49zrfsp	9	1	In	in	IN
cord-258787-n49zrfsp	9	2	contrast	contrast	NN
cord-258787-n49zrfsp	9	3	,	,	,
cord-258787-n49zrfsp	9	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	9	5	are	be	VBP
cord-258787-n49zrfsp	9	6	reported	report	VBN
cord-258787-n49zrfsp	9	7	to	to	TO
cord-258787-n49zrfsp	9	8	mediate	mediate	VB
cord-258787-n49zrfsp	9	9	anti	anti	JJ
cord-258787-n49zrfsp	9	10	-	-	JJ
cord-258787-n49zrfsp	9	11	tumour	tumour	JJ
cord-258787-n49zrfsp	9	12	resistance	resistance	NN
cord-258787-n49zrfsp	9	13	by	by	IN
cord-258787-n49zrfsp	9	14	direct	direct	JJ
cord-258787-n49zrfsp	9	15	killing	killing	NN
cord-258787-n49zrfsp	9	16	of	of	IN
cord-258787-n49zrfsp	9	17	tumour	tumour	NN
cord-258787-n49zrfsp	9	18	cells	cell	NNS
cord-258787-n49zrfsp	9	19	or	or	CC
cord-258787-n49zrfsp	9	20	by	by	IN
cord-258787-n49zrfsp	9	21	engaging	engage	VBG
cord-258787-n49zrfsp	9	22	cooperative	cooperative	JJ
cord-258787-n49zrfsp	9	23	interactions	interaction	NNS
cord-258787-n49zrfsp	9	24	with	with	IN
cord-258787-n49zrfsp	9	25	other	other	JJ
cord-258787-n49zrfsp	9	26	immune	immune	JJ
cord-258787-n49zrfsp	9	27	cells	cell	NNS
cord-258787-n49zrfsp	9	28	.	.	.
cord-258787-n49zrfsp	10	1	Here	here	RB
cord-258787-n49zrfsp	10	2	we	-PRON-	PRP
cord-258787-n49zrfsp	10	3	discuss	discuss	VBP
cord-258787-n49zrfsp	10	4	the	the	DT
cord-258787-n49zrfsp	10	5	current	current	JJ
cord-258787-n49zrfsp	10	6	understandings	understanding	NNS
cord-258787-n49zrfsp	10	7	of	of	IN
cord-258787-n49zrfsp	10	8	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	10	9	biology	biology	NN
cord-258787-n49zrfsp	10	10	and	and	CC
cord-258787-n49zrfsp	10	11	functions	function	NNS
cord-258787-n49zrfsp	10	12	in	in	IN
cord-258787-n49zrfsp	10	13	health	health	NN
cord-258787-n49zrfsp	10	14	and	and	CC
cord-258787-n49zrfsp	10	15	diseases	disease	NNS
cord-258787-n49zrfsp	10	16	,	,	,
cord-258787-n49zrfsp	10	17	with	with	IN
cord-258787-n49zrfsp	10	18	a	a	DT
cord-258787-n49zrfsp	10	19	specific	specific	JJ
cord-258787-n49zrfsp	10	20	focus	focus	NN
cord-258787-n49zrfsp	10	21	on	on	IN
cord-258787-n49zrfsp	10	22	their	-PRON-	PRP$
cord-258787-n49zrfsp	10	23	role	role	NN
cord-258787-n49zrfsp	10	24	in	in	IN
cord-258787-n49zrfsp	10	25	cancer	cancer	NN
cord-258787-n49zrfsp	10	26	biology	biology	NN
cord-258787-n49zrfsp	10	27	and	and	CC
cord-258787-n49zrfsp	10	28	their	-PRON-	PRP$
cord-258787-n49zrfsp	10	29	prognostic	prognostic	JJ
cord-258787-n49zrfsp	10	30	significance	significance	NN
cord-258787-n49zrfsp	10	31	in	in	IN
cord-258787-n49zrfsp	10	32	human	human	JJ
cord-258787-n49zrfsp	10	33	cancer	cancer	NN
cord-258787-n49zrfsp	10	34	.	.	.
cord-258787-n49zrfsp	11	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	11	2	are	be	VBP
cord-258787-n49zrfsp	11	3	the	the	DT
cord-258787-n49zrfsp	11	4	essential	essential	JJ
cord-258787-n49zrfsp	11	5	players	player	NNS
cord-258787-n49zrfsp	11	6	in	in	IN
cord-258787-n49zrfsp	11	7	the	the	DT
cord-258787-n49zrfsp	11	8	early	early	JJ
cord-258787-n49zrfsp	11	9	response	response	NN
cord-258787-n49zrfsp	11	10	against	against	IN
cord-258787-n49zrfsp	11	11	pathogens	pathogen	NNS
cord-258787-n49zrfsp	11	12	and	and	CC
cord-258787-n49zrfsp	11	13	during	during	IN
cord-258787-n49zrfsp	11	14	acute	acute	JJ
cord-258787-n49zrfsp	11	15	inflammation	inflammation	NN
cord-258787-n49zrfsp	11	16	[	[	-LRB-
cord-258787-n49zrfsp	11	17	1	1	CD
cord-258787-n49zrfsp	11	18	,	,	,
cord-258787-n49zrfsp	11	19	2	2	CD
cord-258787-n49zrfsp	11	20	]	]	-RRB-
cord-258787-n49zrfsp	11	21	.	.	.
cord-258787-n49zrfsp	12	1	In	in	IN
cord-258787-n49zrfsp	12	2	response	response	NN
cord-258787-n49zrfsp	12	3	to	to	IN
cord-258787-n49zrfsp	12	4	injury	injury	NN
cord-258787-n49zrfsp	12	5	and	and	CC
cord-258787-n49zrfsp	12	6	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	12	7	stimuli	stimulus	NNS
cord-258787-n49zrfsp	12	8	,	,	,
cord-258787-n49zrfsp	12	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	12	10	are	be	VBP
cord-258787-n49zrfsp	12	11	rapidly	rapidly	RB
cord-258787-n49zrfsp	12	12	recruited	recruit	VBN
cord-258787-n49zrfsp	12	13	in	in	IN
cord-258787-n49zrfsp	12	14	the	the	DT
cord-258787-n49zrfsp	12	15	tissues	tissue	NNS
cord-258787-n49zrfsp	12	16	[	[	-LRB-
cord-258787-n49zrfsp	12	17	3	3	CD
cord-258787-n49zrfsp	12	18	]	]	-RRB-
cord-258787-n49zrfsp	12	19	where	where	WRB
cord-258787-n49zrfsp	12	20	they	-PRON-	PRP
cord-258787-n49zrfsp	12	21	engage	engage	VBP
cord-258787-n49zrfsp	12	22	multiple	multiple	JJ
cord-258787-n49zrfsp	12	23	cross	cross	NN
cord-258787-n49zrfsp	12	24	-	-	NNS
cord-258787-n49zrfsp	12	25	talks	talk	NNS
cord-258787-n49zrfsp	12	26	with	with	IN
cord-258787-n49zrfsp	12	27	immune	immune	JJ
cord-258787-n49zrfsp	12	28	and	and	CC
cord-258787-n49zrfsp	12	29	non	non	JJ
cord-258787-n49zrfsp	12	30	-	-	JJ
cord-258787-n49zrfsp	12	31	immune	immune	JJ
cord-258787-n49zrfsp	12	32	cells	cell	NNS
cord-258787-n49zrfsp	12	33	[	[	-LRB-
cord-258787-n49zrfsp	12	34	4	4	CD
cord-258787-n49zrfsp	12	35	]	]	-RRB-
cord-258787-n49zrfsp	12	36	.	.	.
cord-258787-n49zrfsp	13	1	Accordingly	accordingly	RB
cord-258787-n49zrfsp	13	2	,	,	,
cord-258787-n49zrfsp	13	3	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	13	4	play	play	VBP
cord-258787-n49zrfsp	13	5	an	an	DT
cord-258787-n49zrfsp	13	6	important	important	JJ
cord-258787-n49zrfsp	13	7	role	role	NN
cord-258787-n49zrfsp	13	8	in	in	IN
cord-258787-n49zrfsp	13	9	the	the	DT
cord-258787-n49zrfsp	13	10	regulation	regulation	NN
cord-258787-n49zrfsp	13	11	of	of	IN
cord-258787-n49zrfsp	13	12	innate	innate	JJ
cord-258787-n49zrfsp	13	13	and	and	CC
cord-258787-n49zrfsp	13	14	adaptive	adaptive	JJ
cord-258787-n49zrfsp	13	15	immune	immune	JJ
cord-258787-n49zrfsp	13	16	responses	response	NNS
cord-258787-n49zrfsp	13	17	and	and	CC
cord-258787-n49zrfsp	13	18	are	be	VBP
cord-258787-n49zrfsp	13	19	part	part	NN
cord-258787-n49zrfsp	13	20	of	of	IN
cord-258787-n49zrfsp	13	21	the	the	DT
cord-258787-n49zrfsp	13	22	pathogenesis	pathogenesis	NN
cord-258787-n49zrfsp	13	23	of	of	IN
cord-258787-n49zrfsp	13	24	numerous	numerous	JJ
cord-258787-n49zrfsp	13	25	diseases	disease	NNS
cord-258787-n49zrfsp	13	26	[	[	-LRB-
cord-258787-n49zrfsp	13	27	2	2	CD
cord-258787-n49zrfsp	13	28	]	]	-RRB-
cord-258787-n49zrfsp	13	29	.	.	.
cord-258787-n49zrfsp	14	1	In	in	IN
cord-258787-n49zrfsp	14	2	addition	addition	NN
cord-258787-n49zrfsp	14	3	,	,	,
cord-258787-n49zrfsp	14	4	a	a	DT
cord-258787-n49zrfsp	14	5	growing	grow	VBG
cord-258787-n49zrfsp	14	6	number	number	NN
cord-258787-n49zrfsp	14	7	of	of	IN
cord-258787-n49zrfsp	14	8	studies	study	NNS
cord-258787-n49zrfsp	14	9	showed	show	VBD
cord-258787-n49zrfsp	14	10	that	that	IN
cord-258787-n49zrfsp	14	11	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	14	12	are	be	VBP
cord-258787-n49zrfsp	14	13	endowed	endow	VBN
cord-258787-n49zrfsp	14	14	with	with	IN
cord-258787-n49zrfsp	14	15	plasticity	plasticity	NN
cord-258787-n49zrfsp	14	16	and	and	CC
cord-258787-n49zrfsp	14	17	heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	14	18	which	which	WDT
cord-258787-n49zrfsp	14	19	have	have	VBP
cord-258787-n49zrfsp	14	20	long	long	RB
cord-258787-n49zrfsp	14	21	been	be	VBN
cord-258787-n49zrfsp	14	22	underestimated	underestimate	VBN
cord-258787-n49zrfsp	14	23	[	[	-LRB-
cord-258787-n49zrfsp	14	24	5	5	CD
cord-258787-n49zrfsp	14	25	]	]	-RRB-
cord-258787-n49zrfsp	14	26	[	[	-LRB-
cord-258787-n49zrfsp	14	27	6	6	CD
cord-258787-n49zrfsp	14	28	]	]	-RRB-
cord-258787-n49zrfsp	14	29	[	[	-LRB-
cord-258787-n49zrfsp	14	30	7	7	CD
cord-258787-n49zrfsp	14	31	]	]	-RRB-
cord-258787-n49zrfsp	14	32	[	[	-LRB-
cord-258787-n49zrfsp	14	33	8	8	CD
cord-258787-n49zrfsp	14	34	]	]	-RRB-
cord-258787-n49zrfsp	14	35	.	.	.
cord-258787-n49zrfsp	15	1	Cancer	cancer	NN
cord-258787-n49zrfsp	15	2	-	-	HYPH
cord-258787-n49zrfsp	15	3	related	relate	VBN
cord-258787-n49zrfsp	15	4	inflammation	inflammation	NN
cord-258787-n49zrfsp	15	5	has	have	VBZ
cord-258787-n49zrfsp	15	6	emerged	emerge	VBN
cord-258787-n49zrfsp	15	7	as	as	IN
cord-258787-n49zrfsp	15	8	a	a	DT
cord-258787-n49zrfsp	15	9	hallmark	hallmark	NN
cord-258787-n49zrfsp	15	10	of	of	IN
cord-258787-n49zrfsp	15	11	tumour	tumour	NN
cord-258787-n49zrfsp	15	12	biology	biology	NN
cord-258787-n49zrfsp	15	13	[	[	-LRB-
cord-258787-n49zrfsp	15	14	9	9	CD
cord-258787-n49zrfsp	15	15	,	,	,
cord-258787-n49zrfsp	15	16	10	10	CD
cord-258787-n49zrfsp	15	17	]	]	-RRB-
cord-258787-n49zrfsp	15	18	and	and	CC
cord-258787-n49zrfsp	15	19	the	the	DT
cord-258787-n49zrfsp	15	20	tumour	tumour	NN
cord-258787-n49zrfsp	15	21	microenvironment	microenvironment	NN
cord-258787-n49zrfsp	15	22	(	(	-LRB-
cord-258787-n49zrfsp	15	23	TME	TME	NNP
cord-258787-n49zrfsp	15	24	)	)	-RRB-
cord-258787-n49zrfsp	15	25	consists	consist	VBZ
cord-258787-n49zrfsp	15	26	of	of	IN
cord-258787-n49zrfsp	15	27	both	both	DT
cord-258787-n49zrfsp	15	28	stromal	stromal	JJ
cord-258787-n49zrfsp	15	29	and	and	CC
cord-258787-n49zrfsp	15	30	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	15	31	cells	cell	NNS
cord-258787-n49zrfsp	15	32	,	,	,
cord-258787-n49zrfsp	15	33	including	include	VBG
cord-258787-n49zrfsp	15	34	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	15	35	[	[	-LRB-
cord-258787-n49zrfsp	15	36	11	11	CD
cord-258787-n49zrfsp	15	37	]	]	-RRB-
cord-258787-n49zrfsp	15	38	.	.	.
cord-258787-n49zrfsp	16	1	The	the	DT
cord-258787-n49zrfsp	16	2	role	role	NN
cord-258787-n49zrfsp	16	3	of	of	IN
cord-258787-n49zrfsp	16	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	16	5	in	in	IN
cord-258787-n49zrfsp	16	6	tumour	tumour	NN
cord-258787-n49zrfsp	16	7	biology	biology	NN
cord-258787-n49zrfsp	16	8	has	have	VBZ
cord-258787-n49zrfsp	16	9	long	long	RB
cord-258787-n49zrfsp	16	10	been	be	VBN
cord-258787-n49zrfsp	16	11	underestimated	underestimate	VBN
cord-258787-n49zrfsp	16	12	while	while	IN
cord-258787-n49zrfsp	16	13	particular	particular	JJ
cord-258787-n49zrfsp	16	14	emphasis	emphasis	NN
cord-258787-n49zrfsp	16	15	has	have	VBZ
cord-258787-n49zrfsp	16	16	been	be	VBN
cord-258787-n49zrfsp	16	17	placed	place	VBN
cord-258787-n49zrfsp	16	18	on	on	IN
cord-258787-n49zrfsp	16	19	the	the	DT
cord-258787-n49zrfsp	16	20	role	role	NN
cord-258787-n49zrfsp	16	21	of	of	IN
cord-258787-n49zrfsp	16	22	other	other	JJ
cord-258787-n49zrfsp	16	23	myeloid	myeloid	NN
cord-258787-n49zrfsp	16	24	cells	cell	NNS
cord-258787-n49zrfsp	16	25	,	,	,
cord-258787-n49zrfsp	16	26	such	such	JJ
cord-258787-n49zrfsp	16	27	as	as	IN
cord-258787-n49zrfsp	16	28	macrophages	macrophage	NNS
cord-258787-n49zrfsp	16	29	[	[	-LRB-
cord-258787-n49zrfsp	16	30	12	12	CD
cord-258787-n49zrfsp	16	31	,	,	,
cord-258787-n49zrfsp	16	32	13	13	CD
cord-258787-n49zrfsp	16	33	]	]	-RRB-
cord-258787-n49zrfsp	16	34	.	.	.
cord-258787-n49zrfsp	17	1	However	however	RB
cord-258787-n49zrfsp	17	2	,	,	,
cord-258787-n49zrfsp	17	3	recent	recent	JJ
cord-258787-n49zrfsp	17	4	findings	finding	NNS
cord-258787-n49zrfsp	17	5	showed	show	VBD
cord-258787-n49zrfsp	17	6	that	that	IN
cord-258787-n49zrfsp	17	7	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	17	8	are	be	VBP
cord-258787-n49zrfsp	17	9	an	an	DT
cord-258787-n49zrfsp	17	10	important	important	JJ
cord-258787-n49zrfsp	17	11	component	component	NN
cord-258787-n49zrfsp	17	12	of	of	IN
cord-258787-n49zrfsp	17	13	the	the	DT
cord-258787-n49zrfsp	17	14	TME	TME	NNP
cord-258787-n49zrfsp	17	15	and	and	CC
cord-258787-n49zrfsp	17	16	have	have	VBP
cord-258787-n49zrfsp	17	17	highlighted	highlight	VBN
cord-258787-n49zrfsp	17	18	their	-PRON-	PRP$
cord-258787-n49zrfsp	17	19	importance	importance	NN
cord-258787-n49zrfsp	17	20	in	in	IN
cord-258787-n49zrfsp	17	21	tumour	tumour	NN
cord-258787-n49zrfsp	17	22	progression	progression	NN
cord-258787-n49zrfsp	17	23	as	as	RB
cord-258787-n49zrfsp	17	24	well	well	RB
cord-258787-n49zrfsp	17	25	as	as	IN
cord-258787-n49zrfsp	17	26	in	in	IN
cord-258787-n49zrfsp	17	27	the	the	DT
cord-258787-n49zrfsp	17	28	orchestration	orchestration	NN
cord-258787-n49zrfsp	17	29	of	of	IN
cord-258787-n49zrfsp	17	30	pathways	pathway	NNS
cord-258787-n49zrfsp	17	31	leading	lead	VBG
cord-258787-n49zrfsp	17	32	to	to	IN
cord-258787-n49zrfsp	17	33	tumour	tumour	NN
cord-258787-n49zrfsp	17	34	resistance	resistance	NN
cord-258787-n49zrfsp	17	35	[	[	-LRB-
cord-258787-n49zrfsp	17	36	14	14	CD
cord-258787-n49zrfsp	17	37	]	]	-RRB-
cord-258787-n49zrfsp	17	38	[	[	-LRB-
cord-258787-n49zrfsp	17	39	15	15	CD
cord-258787-n49zrfsp	17	40	]	]	-RRB-
cord-258787-n49zrfsp	17	41	[	[	-LRB-
cord-258787-n49zrfsp	17	42	16	16	CD
cord-258787-n49zrfsp	17	43	]	]	-RRB-
cord-258787-n49zrfsp	18	1	[	[	-LRB-
cord-258787-n49zrfsp	18	2	17	17	CD
cord-258787-n49zrfsp	18	3	]	]	-RRB-
cord-258787-n49zrfsp	18	4	[	[	-LRB-
cord-258787-n49zrfsp	18	5	18	18	CD
cord-258787-n49zrfsp	18	6	]	]	-RRB-
cord-258787-n49zrfsp	18	7	.	.	.
cord-258787-n49zrfsp	19	1	These	these	DT
cord-258787-n49zrfsp	19	2	contrasting	contrast	VBG
cord-258787-n49zrfsp	19	3	findings	finding	NNS
cord-258787-n49zrfsp	19	4	are	be	VBP
cord-258787-n49zrfsp	19	5	likely	likely	RB
cord-258787-n49zrfsp	19	6	the	the	DT
cord-258787-n49zrfsp	19	7	results	result	NNS
cord-258787-n49zrfsp	19	8	of	of	IN
cord-258787-n49zrfsp	19	9	the	the	DT
cord-258787-n49zrfsp	19	10	previously	previously	RB
cord-258787-n49zrfsp	19	11	underestimated	underestimate	VBN
cord-258787-n49zrfsp	19	12	plasticity	plasticity	NN
cord-258787-n49zrfsp	19	13	and	and	CC
cord-258787-n49zrfsp	19	14	heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	19	15	of	of	IN
cord-258787-n49zrfsp	19	16	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	19	17	in	in	IN
cord-258787-n49zrfsp	19	18	cancer	cancer	NN
cord-258787-n49zrfsp	19	19	[	[	-LRB-
cord-258787-n49zrfsp	19	20	8	8	CD
cord-258787-n49zrfsp	19	21	,	,	,
cord-258787-n49zrfsp	19	22	16	16	CD
cord-258787-n49zrfsp	19	23	,	,	,
cord-258787-n49zrfsp	19	24	19	19	CD
cord-258787-n49zrfsp	19	25	]	]	-RRB-
cord-258787-n49zrfsp	19	26	.	.	.
cord-258787-n49zrfsp	20	1	In	in	IN
cord-258787-n49zrfsp	20	2	humans	human	NNS
cord-258787-n49zrfsp	20	3	,	,	,
cord-258787-n49zrfsp	20	4	the	the	DT
cord-258787-n49zrfsp	20	5	density	density	NN
cord-258787-n49zrfsp	20	6	of	of	IN
cord-258787-n49zrfsp	20	7	tumour	tumour	NN
cord-258787-n49zrfsp	20	8	-	-	HYPH
cord-258787-n49zrfsp	20	9	associated	associate	VBN
cord-258787-n49zrfsp	20	10	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	20	11	(	(	-LRB-
cord-258787-n49zrfsp	20	12	TANs	tan	NNS
cord-258787-n49zrfsp	20	13	)	)	-RRB-
cord-258787-n49zrfsp	20	14	can	can	MD
cord-258787-n49zrfsp	20	15	have	have	VB
cord-258787-n49zrfsp	20	16	prognostic	prognostic	JJ
cord-258787-n49zrfsp	20	17	significance	significance	NN
cord-258787-n49zrfsp	20	18	for	for	IN
cord-258787-n49zrfsp	20	19	patient	patient	NN
cord-258787-n49zrfsp	20	20	's	's	POS
cord-258787-n49zrfsp	20	21	outcome	outcome	NN
cord-258787-n49zrfsp	20	22	[	[	-LRB-
cord-258787-n49zrfsp	20	23	20	20	CD
cord-258787-n49zrfsp	20	24	]	]	-RRB-
cord-258787-n49zrfsp	20	25	[	[	-LRB-
cord-258787-n49zrfsp	20	26	21	21	CD
cord-258787-n49zrfsp	20	27	]	]	-RRB-
cord-258787-n49zrfsp	20	28	[	[	-LRB-
cord-258787-n49zrfsp	20	29	22	22	CD
cord-258787-n49zrfsp	20	30	]	]	-RRB-
cord-258787-n49zrfsp	20	31	[	[	-LRB-
cord-258787-n49zrfsp	20	32	23	23	CD
cord-258787-n49zrfsp	20	33	]	]	-RRB-
cord-258787-n49zrfsp	20	34	.	.	.
cord-258787-n49zrfsp	21	1	Here	here	RB
cord-258787-n49zrfsp	21	2	we	-PRON-	PRP
cord-258787-n49zrfsp	21	3	review	review	VBP
cord-258787-n49zrfsp	21	4	the	the	DT
cord-258787-n49zrfsp	21	5	current	current	JJ
cord-258787-n49zrfsp	21	6	understandings	understanding	NNS
cord-258787-n49zrfsp	21	7	on	on	IN
cord-258787-n49zrfsp	21	8	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	21	9	biology	biology	NN
cord-258787-n49zrfsp	21	10	from	from	IN
cord-258787-n49zrfsp	21	11	their	-PRON-	PRP$
cord-258787-n49zrfsp	21	12	development	development	NN
cord-258787-n49zrfsp	21	13	to	to	IN
cord-258787-n49zrfsp	21	14	the	the	DT
cord-258787-n49zrfsp	21	15	mechanisms	mechanism	NNS
cord-258787-n49zrfsp	21	16	of	of	IN
cord-258787-n49zrfsp	21	17	their	-PRON-	PRP$
cord-258787-n49zrfsp	21	18	trafficking	trafficking	NN
cord-258787-n49zrfsp	21	19	and	and	CC
cord-258787-n49zrfsp	21	20	functions	function	NNS
cord-258787-n49zrfsp	21	21	in	in	IN
cord-258787-n49zrfsp	21	22	health	health	NN
cord-258787-n49zrfsp	21	23	and	and	CC
cord-258787-n49zrfsp	21	24	disease	disease	NN
cord-258787-n49zrfsp	21	25	,	,	,
cord-258787-n49zrfsp	21	26	with	with	IN
cord-258787-n49zrfsp	21	27	a	a	DT
cord-258787-n49zrfsp	21	28	focus	focus	NN
cord-258787-n49zrfsp	21	29	on	on	IN
cord-258787-n49zrfsp	21	30	their	-PRON-	PRP$
cord-258787-n49zrfsp	21	31	role	role	NN
cord-258787-n49zrfsp	21	32	in	in	IN
cord-258787-n49zrfsp	21	33	tumour	tumour	NN
cord-258787-n49zrfsp	21	34	biology	biology	NN
cord-258787-n49zrfsp	21	35	and	and	CC
cord-258787-n49zrfsp	21	36	their	-PRON-	PRP$
cord-258787-n49zrfsp	21	37	prognostic	prognostic	JJ
cord-258787-n49zrfsp	21	38	significance	significance	NN
cord-258787-n49zrfsp	21	39	in	in	IN
cord-258787-n49zrfsp	21	40	human	human	JJ
cord-258787-n49zrfsp	21	41	cancer	cancer	NN
cord-258787-n49zrfsp	21	42	.	.	.
cord-258787-n49zrfsp	22	1	Abbreviations	abbreviation	NNS
cord-258787-n49zrfsp	22	2	:	:	:
cord-258787-n49zrfsp	22	3	3-MCA	3-mca	ADD
cord-258787-n49zrfsp	22	4	,	,	,
cord-258787-n49zrfsp	22	5	3-methylcholathrene	3-methylcholathrene	CD
cord-258787-n49zrfsp	22	6	;	;	:
cord-258787-n49zrfsp	22	7	ACKR2	ackr2	NN
cord-258787-n49zrfsp	22	8	,	,	,
cord-258787-n49zrfsp	22	9	atypical	atypical	JJ
cord-258787-n49zrfsp	22	10	chemokine	chemokine	NN
cord-258787-n49zrfsp	22	11	receptor	receptor	NN
cord-258787-n49zrfsp	22	12	2	2	CD
cord-258787-n49zrfsp	22	13	;	;	:
cord-258787-n49zrfsp	22	14	APC	APC	NNP
cord-258787-n49zrfsp	22	15	,	,	,
cord-258787-n49zrfsp	22	16	antigen	antigen	NN
cord-258787-n49zrfsp	22	17	presenting	present	VBG
cord-258787-n49zrfsp	22	18	cell	cell	NN
cord-258787-n49zrfsp	22	19	;	;	:
cord-258787-n49zrfsp	22	20	G	G	NNP
cord-258787-n49zrfsp	22	21	-	-	HYPH
cord-258787-n49zrfsp	22	22	CSF	CSF	NNP
cord-258787-n49zrfsp	22	23	,	,	,
cord-258787-n49zrfsp	22	24	granulocytes	granulocyte	VBZ
cord-258787-n49zrfsp	22	25	colony	colony	NN
cord-258787-n49zrfsp	22	26	stimulating	stimulate	VBG
cord-258787-n49zrfsp	22	27	factor	factor	NN
cord-258787-n49zrfsp	22	28	;	;	:
cord-258787-n49zrfsp	22	29	G	g	NN
cord-258787-n49zrfsp	22	30	-	-	HYPH
cord-258787-n49zrfsp	22	31	MDSCs	mdsc	NNS
cord-258787-n49zrfsp	22	32	,	,	,
cord-258787-n49zrfsp	22	33	granulocytes	granulocyte	NNS
cord-258787-n49zrfsp	22	34	-	-	HYPH
cord-258787-n49zrfsp	22	35	myeloid	myeloid	NN
cord-258787-n49zrfsp	22	36	-	-	HYPH
cord-258787-n49zrfsp	22	37	derived	derive	VBN
cord-258787-n49zrfsp	22	38	suppressor	suppressor	NN
cord-258787-n49zrfsp	22	39	cells	cell	NNS
cord-258787-n49zrfsp	22	40	;	;	:
cord-258787-n49zrfsp	22	41	GM	GM	NNP
cord-258787-n49zrfsp	22	42	-	-	HYPH
cord-258787-n49zrfsp	22	43	CSF	CSF	NNP
cord-258787-n49zrfsp	22	44	,	,	,
cord-258787-n49zrfsp	22	45	granulocytes	granulocyte	NNS
cord-258787-n49zrfsp	22	46	-	-	HYPH
cord-258787-n49zrfsp	22	47	macrophages	macrophage	NNS
cord-258787-n49zrfsp	22	48	colony	colony	NN
cord-258787-n49zrfsp	22	49	stimulating	stimulate	VBG
cord-258787-n49zrfsp	22	50	factor	factor	NN
cord-258787-n49zrfsp	22	51	;	;	:
cord-258787-n49zrfsp	22	52	GMPs	GMPs	NNP
cord-258787-n49zrfsp	22	53	,	,	,
cord-258787-n49zrfsp	22	54	granulocyte	granulocyte	NNP
cord-258787-n49zrfsp	22	55	monocyte	monocyte	NNP
cord-258787-n49zrfsp	22	56	progenitors	progenitor	NNS
cord-258787-n49zrfsp	22	57	;	;	,
cord-258787-n49zrfsp	22	58	iNOS	inos	JJ
cord-258787-n49zrfsp	22	59	,	,	,
cord-258787-n49zrfsp	22	60	inducible	inducible	JJ
cord-258787-n49zrfsp	22	61	nitric	nitric	NN
cord-258787-n49zrfsp	22	62	oxide	oxide	NN
cord-258787-n49zrfsp	22	63	synthase	synthase	NN
cord-258787-n49zrfsp	22	64	;	;	:
cord-258787-n49zrfsp	22	65	M	M	NNP
cord-258787-n49zrfsp	22	66	-	-	HYPH
cord-258787-n49zrfsp	22	67	MDSCs	MDSCs	NNP
cord-258787-n49zrfsp	22	68	,	,	,
cord-258787-n49zrfsp	22	69	monocytes	monocyte	NNS
cord-258787-n49zrfsp	22	70	-	-	HYPH
cord-258787-n49zrfsp	22	71	myeloid	myeloid	NN
cord-258787-n49zrfsp	22	72	-	-	HYPH
cord-258787-n49zrfsp	22	73	derived	derive	VBN
cord-258787-n49zrfsp	22	74	suppressor	suppressor	NN
cord-258787-n49zrfsp	22	75	cells	cell	NNS
cord-258787-n49zrfsp	22	76	;	;	:
cord-258787-n49zrfsp	22	77	MMP-9	MMP-9	NNP
cord-258787-n49zrfsp	22	78	,	,	,
cord-258787-n49zrfsp	22	79	matrix	matrix	NN
cord-258787-n49zrfsp	22	80	metallopeptidase	metallopeptidase	NNP
cord-258787-n49zrfsp	22	81	9	9	CD
cord-258787-n49zrfsp	22	82	;	;	:
cord-258787-n49zrfsp	22	83	MPO	MPO	NNP
cord-258787-n49zrfsp	22	84	,	,	,
cord-258787-n49zrfsp	22	85	myeloperoxidase	myeloperoxidase	NN
cord-258787-n49zrfsp	22	86	;	;	:
cord-258787-n49zrfsp	22	87	NETs	net	NNS
cord-258787-n49zrfsp	22	88	,	,	,
cord-258787-n49zrfsp	22	89	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	22	90	extracellular	extracellular	JJ
cord-258787-n49zrfsp	22	91	traps	trap	NNS
cord-258787-n49zrfsp	22	92	;	;	:
cord-258787-n49zrfsp	22	93	NK	NK	NNP
cord-258787-n49zrfsp	22	94	,	,	,
cord-258787-n49zrfsp	22	95	natural	natural	JJ
cord-258787-n49zrfsp	22	96	killer	killer	NN
cord-258787-n49zrfsp	22	97	;	;	:
cord-258787-n49zrfsp	22	98	PRRs	PRRs	NNP
cord-258787-n49zrfsp	22	99	,	,	,
cord-258787-n49zrfsp	22	100	pattern	pattern	NN
cord-258787-n49zrfsp	22	101	recognition	recognition	NN
cord-258787-n49zrfsp	22	102	receptors	receptor	NNS
cord-258787-n49zrfsp	22	103	;	;	:
cord-258787-n49zrfsp	22	104	ROS	ROS	NNP
cord-258787-n49zrfsp	22	105	,	,	,
cord-258787-n49zrfsp	22	106	eactive	eactive	NN
cord-258787-n49zrfsp	22	107	oxygen	oxygen	NN
cord-258787-n49zrfsp	22	108	species	specie	NNS
cord-258787-n49zrfsp	22	109	;	;	:
cord-258787-n49zrfsp	22	110	TANs	tan	NNS
cord-258787-n49zrfsp	22	111	,	,	,
cord-258787-n49zrfsp	22	112	tumour	tumour	NN
cord-258787-n49zrfsp	22	113	-	-	HYPH
cord-258787-n49zrfsp	22	114	associated	associate	VBN
cord-258787-n49zrfsp	22	115	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	22	116	;	;	:
cord-258787-n49zrfsp	22	117	TCR	TCR	NNP
cord-258787-n49zrfsp	22	118	,	,	,
cord-258787-n49zrfsp	22	119	T	T	NNP
cord-258787-n49zrfsp	22	120	cell	cell	NN
cord-258787-n49zrfsp	22	121	receptor	receptor	NN
cord-258787-n49zrfsp	22	122	;	;	:
cord-258787-n49zrfsp	22	123	TILs	TILs	NNP
cord-258787-n49zrfsp	22	124	,	,	,
cord-258787-n49zrfsp	22	125	tumour	tumour	NN
cord-258787-n49zrfsp	22	126	infiltrating	infiltrate	VBG
cord-258787-n49zrfsp	22	127	leukocytes	leukocyte	NNS
cord-258787-n49zrfsp	22	128	;	;	:
cord-258787-n49zrfsp	22	129	TME	TME	NNP
cord-258787-n49zrfsp	22	130	,	,	,
cord-258787-n49zrfsp	22	131	tumour	tumour	NN
cord-258787-n49zrfsp	22	132	microenvironment	microenvironment	NN
cord-258787-n49zrfsp	22	133	;	;	:
cord-258787-n49zrfsp	22	134	TRAIL	TRAIL	NNP
cord-258787-n49zrfsp	22	135	,	,	,
cord-258787-n49zrfsp	22	136	TNF	TNF	NNP
cord-258787-n49zrfsp	22	137	-	-	HYPH
cord-258787-n49zrfsp	22	138	related	relate	VBN
cord-258787-n49zrfsp	22	139	apoptosis	apoptosis	NN
cord-258787-n49zrfsp	22	140	inducing	induce	VBG
cord-258787-n49zrfsp	22	141	ligand	ligand	NN
cord-258787-n49zrfsp	22	142	;	;	:
cord-258787-n49zrfsp	22	143	TRPM2	TRPM2	VBN
cord-258787-n49zrfsp	22	144	,	,	,
cord-258787-n49zrfsp	22	145	transient	transient	JJ
cord-258787-n49zrfsp	22	146	receptor	receptor	NN
cord-258787-n49zrfsp	22	147	potential	potential	JJ
cord-258787-n49zrfsp	22	148	cation	cation	NN
cord-258787-n49zrfsp	22	149	channel	channel	NN
cord-258787-n49zrfsp	22	150	subfamily	subfamily	NN
cord-258787-n49zrfsp	22	151	M	M	NNP
cord-258787-n49zrfsp	22	152	,	,	,
cord-258787-n49zrfsp	22	153	member	member	NN
cord-258787-n49zrfsp	22	154	2	2	CD
cord-258787-n49zrfsp	22	155	;	;	:
cord-258787-n49zrfsp	22	156	UTC	UTC	NNP
cord-258787-n49zrfsp	22	157	,	,	,
cord-258787-n49zrfsp	22	158	unconventional	unconventional	JJ
cord-258787-n49zrfsp	22	159	T	t	NN
cord-258787-n49zrfsp	22	160	cell	cell	NN
cord-258787-n49zrfsp	22	161	.	.	.
cord-258787-n49zrfsp	23	1	circulation	circulation	NN
cord-258787-n49zrfsp	23	2	requires	require	VBZ
cord-258787-n49zrfsp	23	3	a	a	DT
cord-258787-n49zrfsp	23	4	continuous	continuous	JJ
cord-258787-n49zrfsp	23	5	production	production	NN
cord-258787-n49zrfsp	23	6	in	in	IN
cord-258787-n49zrfsp	23	7	the	the	DT
cord-258787-n49zrfsp	23	8	bone	bone	NN
cord-258787-n49zrfsp	23	9	marrow	marrow	NN
cord-258787-n49zrfsp	23	10	(	(	-LRB-
cord-258787-n49zrfsp	23	11	BM	BM	NNP
cord-258787-n49zrfsp	23	12	)	)	-RRB-
cord-258787-n49zrfsp	23	13	,	,	,
cord-258787-n49zrfsp	23	14	which	which	WDT
cord-258787-n49zrfsp	23	15	is	be	VBZ
cord-258787-n49zrfsp	23	16	mainly	mainly	RB
cord-258787-n49zrfsp	23	17	regulated	regulate	VBN
cord-258787-n49zrfsp	23	18	by	by	IN
cord-258787-n49zrfsp	23	19	the	the	DT
cord-258787-n49zrfsp	23	20	production	production	NN
cord-258787-n49zrfsp	23	21	of	of	IN
cord-258787-n49zrfsp	23	22	granulocyte	granulocyte	NN
cord-258787-n49zrfsp	23	23	-	-	HYPH
cord-258787-n49zrfsp	23	24	colony	colony	NN
cord-258787-n49zrfsp	23	25	stimulating	stimulate	VBG
cord-258787-n49zrfsp	23	26	factor	factor	NN
cord-258787-n49zrfsp	23	27	(	(	-LRB-
cord-258787-n49zrfsp	23	28	G	G	NNP
cord-258787-n49zrfsp	23	29	-	-	HYPH
cord-258787-n49zrfsp	23	30	CSF	CSF	NNP
cord-258787-n49zrfsp	23	31	)	)	-RRB-
cord-258787-n49zrfsp	23	32	and	and	CC
cord-258787-n49zrfsp	23	33	granulocyte	granulocyte	NN
cord-258787-n49zrfsp	23	34	-	-	HYPH
cord-258787-n49zrfsp	23	35	macrophage	macrophage	NN
cord-258787-n49zrfsp	23	36	colony	colony	NN
cord-258787-n49zrfsp	23	37	-	-	HYPH
cord-258787-n49zrfsp	23	38	stimulating	stimulate	VBG
cord-258787-n49zrfsp	23	39	factor	factor	NN
cord-258787-n49zrfsp	23	40	(	(	-LRB-
cord-258787-n49zrfsp	23	41	GM	GM	NNP
cord-258787-n49zrfsp	23	42	-	-	HYPH
cord-258787-n49zrfsp	23	43	CSF	CSF	NNP
cord-258787-n49zrfsp	23	44	)	)	-RRB-
cord-258787-n49zrfsp	23	45	[	[	-LRB-
cord-258787-n49zrfsp	23	46	1	1	CD
cord-258787-n49zrfsp	23	47	,	,	,
cord-258787-n49zrfsp	23	48	[	[	-LRB-
cord-258787-n49zrfsp	23	49	24	24	CD
cord-258787-n49zrfsp	23	50	]	]	-RRB-
cord-258787-n49zrfsp	23	51	[	[	-LRB-
cord-258787-n49zrfsp	23	52	25	25	CD
cord-258787-n49zrfsp	23	53	]	]	-RRB-
cord-258787-n49zrfsp	23	54	[	[	-LRB-
cord-258787-n49zrfsp	23	55	26	26	CD
cord-258787-n49zrfsp	23	56	]	]	-RRB-
cord-258787-n49zrfsp	23	57	.	.	.
cord-258787-n49zrfsp	24	1	In	in	IN
cord-258787-n49zrfsp	24	2	humans	human	NNS
cord-258787-n49zrfsp	24	3	,	,	,
cord-258787-n49zrfsp	24	4	up	up	IN
cord-258787-n49zrfsp	24	5	to	to	TO
cord-258787-n49zrfsp	24	6	2	2	CD
cord-258787-n49zrfsp	24	7	×	×	CD
cord-258787-n49zrfsp	24	8	10	10	CD
cord-258787-n49zrfsp	24	9	11	11	CD
cord-258787-n49zrfsp	24	10	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	24	11	are	be	VBP
cord-258787-n49zrfsp	24	12	produced	produce	VBN
cord-258787-n49zrfsp	24	13	daily	daily	RB
cord-258787-n49zrfsp	24	14	during	during	IN
cord-258787-n49zrfsp	24	15	the	the	DT
cord-258787-n49zrfsp	24	16	process	process	NN
cord-258787-n49zrfsp	24	17	of	of	IN
cord-258787-n49zrfsp	24	18	granulopoiesis	granulopoiesis	NNP
cord-258787-n49zrfsp	24	19	in	in	IN
cord-258787-n49zrfsp	24	20	the	the	DT
cord-258787-n49zrfsp	24	21	BM	BM	NNP
cord-258787-n49zrfsp	24	22	and	and	CC
cord-258787-n49zrfsp	24	23	released	release	VBN
cord-258787-n49zrfsp	24	24	in	in	IN
cord-258787-n49zrfsp	24	25	the	the	DT
cord-258787-n49zrfsp	24	26	bloodstream	bloodstream	NN
cord-258787-n49zrfsp	24	27	[	[	-LRB-
cord-258787-n49zrfsp	24	28	1	1	CD
cord-258787-n49zrfsp	24	29	]	]	-RRB-
cord-258787-n49zrfsp	24	30	.	.	.
cord-258787-n49zrfsp	25	1	The	the	DT
cord-258787-n49zrfsp	25	2	process	process	NN
cord-258787-n49zrfsp	25	3	of	of	IN
cord-258787-n49zrfsp	25	4	granulopoiesis	granulopoiesis	NNP
cord-258787-n49zrfsp	25	5	has	have	VBZ
cord-258787-n49zrfsp	25	6	been	be	VBN
cord-258787-n49zrfsp	25	7	extensively	extensively	RB
cord-258787-n49zrfsp	25	8	studied	study	VBN
cord-258787-n49zrfsp	25	9	under	under	IN
cord-258787-n49zrfsp	25	10	both	both	DT
cord-258787-n49zrfsp	25	11	steady	steady	JJ
cord-258787-n49zrfsp	25	12	state	state	NN
cord-258787-n49zrfsp	25	13	and	and	CC
cord-258787-n49zrfsp	25	14	emergency	emergency	NN
cord-258787-n49zrfsp	25	15	conditions	condition	NNS
cord-258787-n49zrfsp	25	16	[	[	-LRB-
cord-258787-n49zrfsp	25	17	25	25	CD
cord-258787-n49zrfsp	25	18	,	,	,
cord-258787-n49zrfsp	25	19	27	27	CD
cord-258787-n49zrfsp	25	20	,	,	,
cord-258787-n49zrfsp	25	21	28	28	CD
cord-258787-n49zrfsp	25	22	]	]	-RRB-
cord-258787-n49zrfsp	25	23	.	.	.
cord-258787-n49zrfsp	26	1	In	in	IN
cord-258787-n49zrfsp	26	2	the	the	DT
cord-258787-n49zrfsp	26	3	BM	bm	NN
cord-258787-n49zrfsp	26	4	,	,	,
cord-258787-n49zrfsp	26	5	hematopoietic	hematopoietic	JJ
cord-258787-n49zrfsp	26	6	stem	stem	NN
cord-258787-n49zrfsp	26	7	cells	cell	NNS
cord-258787-n49zrfsp	26	8	(	(	-LRB-
cord-258787-n49zrfsp	26	9	HSC	HSC	NNP
cord-258787-n49zrfsp	26	10	)	)	-RRB-
cord-258787-n49zrfsp	26	11	differentiate	differentiate	VB
cord-258787-n49zrfsp	26	12	into	into	IN
cord-258787-n49zrfsp	26	13	lymphoid	lymphoid	JJ
cord-258787-n49zrfsp	26	14	-	-	HYPH
cord-258787-n49zrfsp	26	15	primed	prime	VBN
cord-258787-n49zrfsp	26	16	multipotent	multipotent	JJ
cord-258787-n49zrfsp	26	17	progenitors	progenitor	NNS
cord-258787-n49zrfsp	26	18	(	(	-LRB-
cord-258787-n49zrfsp	26	19	LMPPs	lmpp	NNS
cord-258787-n49zrfsp	26	20	)	)	-RRB-
cord-258787-n49zrfsp	26	21	or	or	CC
cord-258787-n49zrfsp	26	22	common	common	JJ
cord-258787-n49zrfsp	26	23	myeloid	myeloid	JJ
cord-258787-n49zrfsp	26	24	progenitors	progenitor	NNS
cord-258787-n49zrfsp	26	25	(	(	-LRB-
cord-258787-n49zrfsp	26	26	CMPs	CMPs	NNP
cord-258787-n49zrfsp	26	27	)	)	-RRB-
cord-258787-n49zrfsp	26	28	which	which	WDT
cord-258787-n49zrfsp	26	29	can	can	MD
cord-258787-n49zrfsp	26	30	both	both	DT
cord-258787-n49zrfsp	26	31	give	give	VB
cord-258787-n49zrfsp	26	32	rise	rise	NN
cord-258787-n49zrfsp	26	33	to	to	IN
cord-258787-n49zrfsp	26	34	granulocyte	granulocyte	NN
cord-258787-n49zrfsp	26	35	monocyte	monocyte	NNP
cord-258787-n49zrfsp	26	36	progenitors	progenitor	NNS
cord-258787-n49zrfsp	26	37	(	(	-LRB-
cord-258787-n49zrfsp	26	38	GMPs	GMPs	NNP
cord-258787-n49zrfsp	26	39	)	)	-RRB-
cord-258787-n49zrfsp	26	40	.	.	.
cord-258787-n49zrfsp	27	1	GMPs	GMPs	NNP
cord-258787-n49zrfsp	27	2	will	will	MD
cord-258787-n49zrfsp	27	3	commit	commit	VB
cord-258787-n49zrfsp	27	4	to	to	IN
cord-258787-n49zrfsp	27	5	the	the	DT
cord-258787-n49zrfsp	27	6	generation	generation	NN
cord-258787-n49zrfsp	27	7	of	of	IN
cord-258787-n49zrfsp	27	8	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	27	9	upon	upon	IN
cord-258787-n49zrfsp	27	10	receiving	receive	VBG
cord-258787-n49zrfsp	27	11	G	G	NNP
cord-258787-n49zrfsp	27	12	-	-	HYPH
cord-258787-n49zrfsp	27	13	CSF	CSF	NNP
cord-258787-n49zrfsp	27	14	and	and	CC
cord-258787-n49zrfsp	27	15	GM	GM	NNP
cord-258787-n49zrfsp	27	16	-	-	HYPH
cord-258787-n49zrfsp	27	17	CSF	CSF	NNP
cord-258787-n49zrfsp	27	18	signals	signal	NNS
cord-258787-n49zrfsp	27	19	produced	produce	VBN
cord-258787-n49zrfsp	27	20	by	by	IN
cord-258787-n49zrfsp	27	21	bone	bone	NN
cord-258787-n49zrfsp	27	22	marrow	marrow	NN
cord-258787-n49zrfsp	27	23	stromal	stromal	NN
cord-258787-n49zrfsp	27	24	cells	cell	NNS
cord-258787-n49zrfsp	27	25	[	[	-LRB-
cord-258787-n49zrfsp	27	26	15	15	CD
cord-258787-n49zrfsp	27	27	,	,	,
cord-258787-n49zrfsp	27	28	26	26	CD
cord-258787-n49zrfsp	27	29	,	,	,
cord-258787-n49zrfsp	27	30	29	29	CD
cord-258787-n49zrfsp	27	31	]	]	-RRB-
cord-258787-n49zrfsp	27	32	.	.	.
cord-258787-n49zrfsp	28	1	Accordingly	accordingly	RB
cord-258787-n49zrfsp	28	2	,	,	,
cord-258787-n49zrfsp	28	3	G	G	NNP
cord-258787-n49zrfsp	28	4	-	-	HYPH
cord-258787-n49zrfsp	28	5	CSF	CSF	NNP
cord-258787-n49zrfsp	28	6	−	−	NNP
cord-258787-n49zrfsp	28	7	/−	/−	.
cord-258787-n49zrfsp	29	1	and	and	CC
cord-258787-n49zrfsp	29	2	GM	GM	NNP
cord-258787-n49zrfsp	29	3	-	-	HYPH
cord-258787-n49zrfsp	29	4	CSF	CSF	NNP
cord-258787-n49zrfsp	29	5	-/mice	-/mice	NN
cord-258787-n49zrfsp	29	6	present	present	JJ
cord-258787-n49zrfsp	29	7	a	a	DT
cord-258787-n49zrfsp	29	8	severe	severe	JJ
cord-258787-n49zrfsp	29	9	and	and	CC
cord-258787-n49zrfsp	29	10	chronic	chronic	JJ
cord-258787-n49zrfsp	29	11	neutropenia	neutropenia	NN
cord-258787-n49zrfsp	29	12	[	[	-LRB-
cord-258787-n49zrfsp	29	13	30	30	CD
cord-258787-n49zrfsp	29	14	]	]	-RRB-
cord-258787-n49zrfsp	29	15	.	.	.
cord-258787-n49zrfsp	30	1	The	the	DT
cord-258787-n49zrfsp	30	2	process	process	NN
cord-258787-n49zrfsp	30	3	of	of	IN
cord-258787-n49zrfsp	30	4	granulopoiesis	granulopoiesis	NNP
cord-258787-n49zrfsp	30	5	is	be	VBZ
cord-258787-n49zrfsp	30	6	regulated	regulate	VBN
cord-258787-n49zrfsp	30	7	by	by	IN
cord-258787-n49zrfsp	30	8	the	the	DT
cord-258787-n49zrfsp	30	9	successive	successive	JJ
cord-258787-n49zrfsp	30	10	expression	expression	NN
cord-258787-n49zrfsp	30	11	of	of	IN
cord-258787-n49zrfsp	30	12	specific	specific	JJ
cord-258787-n49zrfsp	30	13	transcription	transcription	NN
cord-258787-n49zrfsp	30	14	factors	factor	NNS
cord-258787-n49zrfsp	30	15	(	(	-LRB-
cord-258787-n49zrfsp	30	16	TF	TF	NNP
cord-258787-n49zrfsp	30	17	)	)	-RRB-
cord-258787-n49zrfsp	30	18	and	and	CC
cord-258787-n49zrfsp	30	19	deficiency	deficiency	NN
cord-258787-n49zrfsp	30	20	in	in	IN
cord-258787-n49zrfsp	30	21	these	these	DT
cord-258787-n49zrfsp	30	22	TFs	tf	NNS
cord-258787-n49zrfsp	30	23	in	in	IN
cord-258787-n49zrfsp	30	24	mice	mouse	NNS
cord-258787-n49zrfsp	30	25	has	have	VBZ
cord-258787-n49zrfsp	30	26	been	be	VBN
cord-258787-n49zrfsp	30	27	associated	associate	VBN
cord-258787-n49zrfsp	30	28	with	with	IN
cord-258787-n49zrfsp	30	29	neutropenia	neutropenia	NN
cord-258787-n49zrfsp	30	30	[	[	-LRB-
cord-258787-n49zrfsp	30	31	31	31	CD
cord-258787-n49zrfsp	30	32	]	]	-RRB-
cord-258787-n49zrfsp	30	33	[	[	-LRB-
cord-258787-n49zrfsp	30	34	32	32	CD
cord-258787-n49zrfsp	30	35	]	]	-RRB-
cord-258787-n49zrfsp	30	36	[	[	-LRB-
cord-258787-n49zrfsp	30	37	33	33	CD
cord-258787-n49zrfsp	30	38	]	]	-RRB-
cord-258787-n49zrfsp	30	39	[	[	-LRB-
cord-258787-n49zrfsp	30	40	34	34	CD
cord-258787-n49zrfsp	30	41	]	]	-RRB-
cord-258787-n49zrfsp	30	42	[	[	-LRB-
cord-258787-n49zrfsp	30	43	35	35	CD
cord-258787-n49zrfsp	30	44	]	]	-RRB-
cord-258787-n49zrfsp	30	45	.	.	.
cord-258787-n49zrfsp	31	1	In	in	IN
cord-258787-n49zrfsp	31	2	particular	particular	JJ
cord-258787-n49zrfsp	31	3	,	,	,
cord-258787-n49zrfsp	31	4	CCAAT	CCAAT	NNP
cord-258787-n49zrfsp	31	5	/	/	SYM
cord-258787-n49zrfsp	31	6	enhancer	enhancer	NN
cord-258787-n49zrfsp	31	7	-	-	HYPH
cord-258787-n49zrfsp	31	8	binding	bind	VBG
cord-258787-n49zrfsp	31	9	proteins	protein	NNS
cord-258787-n49zrfsp	31	10	(	(	-LRB-
cord-258787-n49zrfsp	31	11	C	c	NN
cord-258787-n49zrfsp	31	12	/	/	SYM
cord-258787-n49zrfsp	31	13	EBPs	ebp	NNS
cord-258787-n49zrfsp	31	14	)	)	-RRB-
cord-258787-n49zrfsp	31	15	are	be	VBP
cord-258787-n49zrfsp	31	16	a	a	DT
cord-258787-n49zrfsp	31	17	family	family	NN
cord-258787-n49zrfsp	31	18	of	of	IN
cord-258787-n49zrfsp	31	19	six	six	CD
cord-258787-n49zrfsp	31	20	TFs	tf	NNS
cord-258787-n49zrfsp	31	21	among	among	IN
cord-258787-n49zrfsp	31	22	which	which	WDT
cord-258787-n49zrfsp	31	23	the	the	DT
cord-258787-n49zrfsp	31	24	members	member	NNS
cord-258787-n49zrfsp	31	25	C	C	NNP
cord-258787-n49zrfsp	31	26	/	/	SYM
cord-258787-n49zrfsp	31	27	EBPα	EBPα	NNS
cord-258787-n49zrfsp	31	28	,	,	,
cord-258787-n49zrfsp	31	29	C	C	NNP
cord-258787-n49zrfsp	31	30	/	/	SYM
cord-258787-n49zrfsp	31	31	EBPβ	EBPβ	NNS
cord-258787-n49zrfsp	31	32	and	and	CC
cord-258787-n49zrfsp	31	33	C	C	NNP
cord-258787-n49zrfsp	31	34	/	/	SYM
cord-258787-n49zrfsp	31	35	EBPε	EBPε	NNS
cord-258787-n49zrfsp	31	36	are	be	VBP
cord-258787-n49zrfsp	31	37	involved	involve	VBN
cord-258787-n49zrfsp	31	38	in	in	IN
cord-258787-n49zrfsp	31	39	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	31	40	development	development	NN
cord-258787-n49zrfsp	31	41	[	[	-LRB-
cord-258787-n49zrfsp	31	42	36	36	CD
cord-258787-n49zrfsp	31	43	]	]	-RRB-
cord-258787-n49zrfsp	31	44	[	[	-LRB-
cord-258787-n49zrfsp	31	45	37	37	CD
cord-258787-n49zrfsp	31	46	]	]	-RRB-
cord-258787-n49zrfsp	31	47	[	[	-LRB-
cord-258787-n49zrfsp	31	48	38	38	CD
cord-258787-n49zrfsp	31	49	]	]	-RRB-
cord-258787-n49zrfsp	31	50	[	[	-LRB-
cord-258787-n49zrfsp	31	51	39	39	CD
cord-258787-n49zrfsp	31	52	]	]	-RRB-
cord-258787-n49zrfsp	31	53	.	.	.
cord-258787-n49zrfsp	32	1	Specifically	specifically	RB
cord-258787-n49zrfsp	32	2	,	,	,
cord-258787-n49zrfsp	32	3	C	C	NNP
cord-258787-n49zrfsp	32	4	/	/	SYM
cord-258787-n49zrfsp	32	5	EBPα	EBPα	NNS
cord-258787-n49zrfsp	32	6	acts	act	VBZ
cord-258787-n49zrfsp	32	7	at	at	IN
cord-258787-n49zrfsp	32	8	the	the	DT
cord-258787-n49zrfsp	32	9	GMP	GMP	NNP
cord-258787-n49zrfsp	32	10	stage	stage	NN
cord-258787-n49zrfsp	32	11	of	of	IN
cord-258787-n49zrfsp	32	12	the	the	DT
cord-258787-n49zrfsp	32	13	process	process	NN
cord-258787-n49zrfsp	32	14	and	and	CC
cord-258787-n49zrfsp	32	15	its	-PRON-	PRP$
cord-258787-n49zrfsp	32	16	disruption	disruption	NN
cord-258787-n49zrfsp	32	17	in	in	IN
cord-258787-n49zrfsp	32	18	mice	mouse	NNS
cord-258787-n49zrfsp	32	19	lead	lead	VBP
cord-258787-n49zrfsp	32	20	to	to	IN
cord-258787-n49zrfsp	32	21	a	a	DT
cord-258787-n49zrfsp	32	22	complete	complete	JJ
cord-258787-n49zrfsp	32	23	loss	loss	NN
cord-258787-n49zrfsp	32	24	of	of	IN
cord-258787-n49zrfsp	32	25	mature	mature	JJ
cord-258787-n49zrfsp	32	26	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	32	27	by	by	IN
cord-258787-n49zrfsp	32	28	blocking	block	VBG
cord-258787-n49zrfsp	32	29	the	the	DT
cord-258787-n49zrfsp	32	30	transition	transition	NN
cord-258787-n49zrfsp	32	31	from	from	IN
cord-258787-n49zrfsp	32	32	CMPs	CMPs	NNP
cord-258787-n49zrfsp	32	33	to	to	IN
cord-258787-n49zrfsp	32	34	GMPs	GMPs	NNP
cord-258787-n49zrfsp	32	35	[	[	-LRB-
cord-258787-n49zrfsp	32	36	40	40	CD
cord-258787-n49zrfsp	32	37	]	]	-RRB-
cord-258787-n49zrfsp	32	38	.	.	.
cord-258787-n49zrfsp	33	1	C	C	NNP
cord-258787-n49zrfsp	33	2	/	/	SYM
cord-258787-n49zrfsp	33	3	EBPβ	EBPβ	NNS
cord-258787-n49zrfsp	33	4	is	be	VBZ
cord-258787-n49zrfsp	33	5	not	not	RB
cord-258787-n49zrfsp	33	6	necessary	necessary	JJ
cord-258787-n49zrfsp	33	7	for	for	IN
cord-258787-n49zrfsp	33	8	the	the	DT
cord-258787-n49zrfsp	33	9	development	development	NN
cord-258787-n49zrfsp	33	10	of	of	IN
cord-258787-n49zrfsp	33	11	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	33	12	in	in	IN
cord-258787-n49zrfsp	33	13	steady	steady	JJ
cord-258787-n49zrfsp	33	14	state	state	NN
cord-258787-n49zrfsp	33	15	but	but	CC
cord-258787-n49zrfsp	33	16	plays	play	VBZ
cord-258787-n49zrfsp	33	17	an	an	DT
cord-258787-n49zrfsp	33	18	important	important	JJ
cord-258787-n49zrfsp	33	19	role	role	NN
cord-258787-n49zrfsp	33	20	in	in	IN
cord-258787-n49zrfsp	33	21	emergency	emergency	NN
cord-258787-n49zrfsp	33	22	granulopoiesis	granulopoiesis	NNP
cord-258787-n49zrfsp	33	23	(	(	-LRB-
cord-258787-n49zrfsp	33	24	see	see	VB
cord-258787-n49zrfsp	33	25	below	below	RB
cord-258787-n49zrfsp	33	26	)	)	-RRB-
cord-258787-n49zrfsp	33	27	[	[	-LRB-
cord-258787-n49zrfsp	33	28	36	36	CD
cord-258787-n49zrfsp	33	29	,	,	,
cord-258787-n49zrfsp	33	30	37	37	CD
cord-258787-n49zrfsp	33	31	]	]	-RRB-
cord-258787-n49zrfsp	33	32	.	.	.
cord-258787-n49zrfsp	34	1	On	on	IN
cord-258787-n49zrfsp	34	2	the	the	DT
cord-258787-n49zrfsp	34	3	other	other	JJ
cord-258787-n49zrfsp	34	4	hand	hand	NN
cord-258787-n49zrfsp	34	5	,	,	,
cord-258787-n49zrfsp	34	6	C	C	NNP
cord-258787-n49zrfsp	34	7	/	/	SYM
cord-258787-n49zrfsp	34	8	EBPε	EBPε	NNS
cord-258787-n49zrfsp	34	9	drives	drive	VBZ
cord-258787-n49zrfsp	34	10	GMP	GMP	NNP
cord-258787-n49zrfsp	34	11	to	to	IN
cord-258787-n49zrfsp	34	12	myelocyte	myelocyte	NNP
cord-258787-n49zrfsp	34	13	transition	transition	NN
cord-258787-n49zrfsp	34	14	and	and	CC
cord-258787-n49zrfsp	34	15	may	may	MD
cord-258787-n49zrfsp	34	16	be	be	VB
cord-258787-n49zrfsp	34	17	important	important	JJ
cord-258787-n49zrfsp	34	18	in	in	IN
cord-258787-n49zrfsp	34	19	the	the	DT
cord-258787-n49zrfsp	34	20	terminal	terminal	JJ
cord-258787-n49zrfsp	34	21	step	step	NN
cord-258787-n49zrfsp	34	22	of	of	IN
cord-258787-n49zrfsp	34	23	the	the	DT
cord-258787-n49zrfsp	34	24	granulopoiesis	granulopoiesis	NNP
cord-258787-n49zrfsp	34	25	[	[	-LRB-
cord-258787-n49zrfsp	34	26	31	31	CD
cord-258787-n49zrfsp	34	27	,	,	,
cord-258787-n49zrfsp	34	28	41	41	CD
cord-258787-n49zrfsp	34	29	]	]	-RRB-
cord-258787-n49zrfsp	34	30	.	.	.
cord-258787-n49zrfsp	35	1	Other	other	JJ
cord-258787-n49zrfsp	35	2	TFs	tf	NNS
cord-258787-n49zrfsp	35	3	,	,	,
cord-258787-n49zrfsp	35	4	such	such	JJ
cord-258787-n49zrfsp	35	5	as	as	IN
cord-258787-n49zrfsp	35	6	the	the	DT
cord-258787-n49zrfsp	35	7	growth	growth	NN
cord-258787-n49zrfsp	35	8	factor	factor	NN
cord-258787-n49zrfsp	35	9	independent-1	independent-1	NNP
cord-258787-n49zrfsp	35	10	(	(	-LRB-
cord-258787-n49zrfsp	35	11	Gfi-1	Gfi-1	NNP
cord-258787-n49zrfsp	35	12	)	)	-RRB-
cord-258787-n49zrfsp	35	13	have	have	VBP
cord-258787-n49zrfsp	35	14	also	also	RB
cord-258787-n49zrfsp	35	15	been	be	VBN
cord-258787-n49zrfsp	35	16	implicated	implicate	VBN
cord-258787-n49zrfsp	35	17	in	in	IN
cord-258787-n49zrfsp	35	18	the	the	DT
cord-258787-n49zrfsp	35	19	process	process	NN
cord-258787-n49zrfsp	35	20	of	of	IN
cord-258787-n49zrfsp	35	21	granulopoiesis	granulopoiesis	NNP
cord-258787-n49zrfsp	35	22	[	[	-LRB-
cord-258787-n49zrfsp	35	23	33	33	CD
cord-258787-n49zrfsp	35	24	,	,	,
cord-258787-n49zrfsp	35	25	42	42	CD
cord-258787-n49zrfsp	35	26	]	]	-RRB-
cord-258787-n49zrfsp	35	27	.	.	.
cord-258787-n49zrfsp	36	1	Transcription	transcription	NN
cord-258787-n49zrfsp	36	2	factors	factor	NNS
cord-258787-n49zrfsp	36	3	control	control	VBP
cord-258787-n49zrfsp	36	4	gene	gene	NN
cord-258787-n49zrfsp	36	5	expression	expression	NN
cord-258787-n49zrfsp	36	6	profiles	profile	NNS
cord-258787-n49zrfsp	36	7	,	,	,
cord-258787-n49zrfsp	36	8	that	that	WDT
cord-258787-n49zrfsp	36	9	define	define	VBP
cord-258787-n49zrfsp	36	10	the	the	DT
cord-258787-n49zrfsp	36	11	molecular	molecular	JJ
cord-258787-n49zrfsp	36	12	signatures	signature	NNS
cord-258787-n49zrfsp	36	13	of	of	IN
cord-258787-n49zrfsp	36	14	immature	immature	JJ
cord-258787-n49zrfsp	36	15	cell	cell	NN
cord-258787-n49zrfsp	36	16	subsets	subset	NNS
cord-258787-n49zrfsp	36	17	revealing	reveal	VBG
cord-258787-n49zrfsp	36	18	their	-PRON-	PRP$
cord-258787-n49zrfsp	36	19	heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	36	20	[	[	-LRB-
cord-258787-n49zrfsp	36	21	36	36	CD
cord-258787-n49zrfsp	36	22	,	,	,
cord-258787-n49zrfsp	36	23	43	43	CD
cord-258787-n49zrfsp	36	24	]	]	-RRB-
cord-258787-n49zrfsp	36	25	.	.	.
cord-258787-n49zrfsp	37	1	State	state	NN
cord-258787-n49zrfsp	37	2	of	of	IN
cord-258787-n49zrfsp	37	3	the	the	DT
cord-258787-n49zrfsp	37	4	art	art	NN
cord-258787-n49zrfsp	37	5	technologies	technology	NNS
cord-258787-n49zrfsp	37	6	,	,	,
cord-258787-n49zrfsp	37	7	such	such	JJ
cord-258787-n49zrfsp	37	8	as	as	IN
cord-258787-n49zrfsp	37	9	total	total	JJ
cord-258787-n49zrfsp	37	10	and	and	CC
cord-258787-n49zrfsp	37	11	single	single	JJ
cord-258787-n49zrfsp	37	12	-	-	HYPH
cord-258787-n49zrfsp	37	13	cell	cell	NN
cord-258787-n49zrfsp	37	14	RNA	rna	NN
cord-258787-n49zrfsp	37	15	sequencing	sequencing	NN
cord-258787-n49zrfsp	37	16	(	(	-LRB-
cord-258787-n49zrfsp	37	17	scRNAseq	scRNAseq	NNP
cord-258787-n49zrfsp	37	18	)	)	-RRB-
cord-258787-n49zrfsp	37	19	and	and	CC
cord-258787-n49zrfsp	37	20	mass	mass	NN
cord-258787-n49zrfsp	37	21	cytometry	cytometry	NN
cord-258787-n49zrfsp	37	22	by	by	IN
cord-258787-n49zrfsp	37	23	time	time	NN
cord-258787-n49zrfsp	37	24	-	-	HYPH
cord-258787-n49zrfsp	37	25	of	of	IN
cord-258787-n49zrfsp	37	26	-	-	HYPH
cord-258787-n49zrfsp	37	27	flight	flight	NN
cord-258787-n49zrfsp	37	28	(	(	-LRB-
cord-258787-n49zrfsp	37	29	CyTOF	CyTOF	NNP
cord-258787-n49zrfsp	37	30	)	)	-RRB-
cord-258787-n49zrfsp	37	31	,	,	,
cord-258787-n49zrfsp	37	32	have	have	VBP
cord-258787-n49zrfsp	37	33	been	be	VBN
cord-258787-n49zrfsp	37	34	employed	employ	VBN
cord-258787-n49zrfsp	37	35	to	to	TO
cord-258787-n49zrfsp	37	36	characterize	characterize	VB
cord-258787-n49zrfsp	37	37	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	37	38	differentiation	differentiation	NN
cord-258787-n49zrfsp	37	39	and	and	CC
cord-258787-n49zrfsp	37	40	distinct	distinct	JJ
cord-258787-n49zrfsp	37	41	cellular	cellular	JJ
cord-258787-n49zrfsp	37	42	phenotypes	phenotype	NNS
cord-258787-n49zrfsp	37	43	have	have	VBP
cord-258787-n49zrfsp	37	44	been	be	VBN
cord-258787-n49zrfsp	37	45	identified	identify	VBN
cord-258787-n49zrfsp	37	46	from	from	IN
cord-258787-n49zrfsp	37	47	GMP	GMP	NNP
cord-258787-n49zrfsp	37	48	to	to	TO
cord-258787-n49zrfsp	37	49	mature	mature	VB
cord-258787-n49zrfsp	37	50	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	37	51	[	[	-LRB-
cord-258787-n49zrfsp	37	52	43	43	CD
cord-258787-n49zrfsp	37	53	]	]	-RRB-
cord-258787-n49zrfsp	37	54	[	[	-LRB-
cord-258787-n49zrfsp	37	55	44	44	CD
cord-258787-n49zrfsp	37	56	]	]	-RRB-
cord-258787-n49zrfsp	37	57	[	[	-LRB-
cord-258787-n49zrfsp	37	58	45	45	CD
cord-258787-n49zrfsp	37	59	]	]	-RRB-
cord-258787-n49zrfsp	37	60	[	[	-LRB-
cord-258787-n49zrfsp	37	61	46	46	CD
cord-258787-n49zrfsp	37	62	]	]	-RRB-
cord-258787-n49zrfsp	37	63	.	.	.
cord-258787-n49zrfsp	38	1	In	in	IN
cord-258787-n49zrfsp	38	2	particular	particular	JJ
cord-258787-n49zrfsp	38	3	,	,	,
cord-258787-n49zrfsp	38	4	a	a	DT
cord-258787-n49zrfsp	38	5	population	population	NN
cord-258787-n49zrfsp	38	6	of	of	IN
cord-258787-n49zrfsp	38	7	proliferative	proliferative	JJ
cord-258787-n49zrfsp	38	8	Gr1	gr1	NN
cord-258787-n49zrfsp	38	9	+	+	SYM
cord-258787-n49zrfsp	38	10	CD11b	CD11b	NNS
cord-258787-n49zrfsp	38	11	+	+	CC
cord-258787-n49zrfsp	39	1	CXCR4	CXCR4	NNP
cord-258787-n49zrfsp	40	1	hi	hi	UH
cord-258787-n49zrfsp	41	1	CD117	CD117	NNP
cord-258787-n49zrfsp	41	2	int	int	NN
cord-258787-n49zrfsp	41	3	CXCR2	CXCR2	NNS
cord-258787-n49zrfsp	41	4	−	−	CD
cord-258787-n49zrfsp	41	5	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	41	6	precursors	precursor	NNS
cord-258787-n49zrfsp	41	7	(	(	-LRB-
cord-258787-n49zrfsp	41	8	defined	define	VBN
cord-258787-n49zrfsp	41	9	as	as	IN
cord-258787-n49zrfsp	41	10	preNeu	preneu	NN
cord-258787-n49zrfsp	41	11	)	)	-RRB-
cord-258787-n49zrfsp	41	12	with	with	IN
cord-258787-n49zrfsp	41	13	a	a	DT
cord-258787-n49zrfsp	41	14	potential	potential	NN
cord-258787-n49zrfsp	41	15	to	to	TO
cord-258787-n49zrfsp	41	16	differentiate	differentiate	VB
cord-258787-n49zrfsp	41	17	into	into	IN
cord-258787-n49zrfsp	41	18	non	non	JJ
cord-258787-n49zrfsp	41	19	-	-	JJ
cord-258787-n49zrfsp	41	20	proliferative	proliferative	JJ
cord-258787-n49zrfsp	41	21	immature	immature	JJ
cord-258787-n49zrfsp	41	22	and	and	CC
cord-258787-n49zrfsp	41	23	then	then	RB
cord-258787-n49zrfsp	41	24	mature	mature	JJ
cord-258787-n49zrfsp	41	25	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	41	26	has	have	VBZ
cord-258787-n49zrfsp	41	27	been	be	VBN
cord-258787-n49zrfsp	41	28	identified	identify	VBN
cord-258787-n49zrfsp	41	29	in	in	IN
cord-258787-n49zrfsp	41	30	mouse	mouse	NN
cord-258787-n49zrfsp	41	31	BM	BM	NNP
cord-258787-n49zrfsp	41	32	[	[	-LRB-
cord-258787-n49zrfsp	41	33	47	47	CD
cord-258787-n49zrfsp	41	34	]	]	-RRB-
cord-258787-n49zrfsp	41	35	.	.	.
cord-258787-n49zrfsp	42	1	Recently	recently	RB
cord-258787-n49zrfsp	42	2	,	,	,
cord-258787-n49zrfsp	42	3	progenitors	progenitor	NNS
cord-258787-n49zrfsp	42	4	of	of	IN
cord-258787-n49zrfsp	42	5	the	the	DT
cord-258787-n49zrfsp	42	6	preNeu	preNeu	NNP
cord-258787-n49zrfsp	42	7	population	population	NN
cord-258787-n49zrfsp	42	8	have	have	VBP
cord-258787-n49zrfsp	42	9	been	be	VBN
cord-258787-n49zrfsp	42	10	described	describe	VBN
cord-258787-n49zrfsp	42	11	as	as	IN
cord-258787-n49zrfsp	42	12	early	early	JJ
cord-258787-n49zrfsp	42	13	committed	committed	JJ
cord-258787-n49zrfsp	42	14	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	42	15	progenitors	progenitor	NNS
cord-258787-n49zrfsp	42	16	(	(	-LRB-
cord-258787-n49zrfsp	42	17	proNeu1	proNeu1	NNS
cord-258787-n49zrfsp	42	18	)	)	-RRB-
cord-258787-n49zrfsp	42	19	,	,	,
cord-258787-n49zrfsp	42	20	which	which	WDT
cord-258787-n49zrfsp	42	21	gives	give	VBZ
cord-258787-n49zrfsp	42	22	rise	rise	NN
cord-258787-n49zrfsp	42	23	to	to	IN
cord-258787-n49zrfsp	42	24	an	an	DT
cord-258787-n49zrfsp	42	25	intermediate	intermediate	JJ
cord-258787-n49zrfsp	42	26	progeny	progeny	NN
cord-258787-n49zrfsp	42	27	(	(	-LRB-
cord-258787-n49zrfsp	42	28	proNeu2	proNeu2	NNS
cord-258787-n49zrfsp	42	29	)	)	-RRB-
cord-258787-n49zrfsp	42	30	and	and	CC
cord-258787-n49zrfsp	42	31	then	then	RB
cord-258787-n49zrfsp	42	32	to	to	IN
cord-258787-n49zrfsp	42	33	the	the	DT
cord-258787-n49zrfsp	42	34	subsequent	subsequent	JJ
cord-258787-n49zrfsp	42	35	populations	population	NNS
cord-258787-n49zrfsp	42	36	[	[	-LRB-
cord-258787-n49zrfsp	42	37	48	48	CD
cord-258787-n49zrfsp	42	38	]	]	-RRB-
cord-258787-n49zrfsp	42	39	.	.	.
cord-258787-n49zrfsp	43	1	These	these	DT
cord-258787-n49zrfsp	43	2	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	43	3	progenitors	progenitor	NNS
cord-258787-n49zrfsp	43	4	are	be	VBP
cord-258787-n49zrfsp	43	5	present	present	JJ
cord-258787-n49zrfsp	43	6	in	in	IN
cord-258787-n49zrfsp	43	7	mice	mouse	NNS
cord-258787-n49zrfsp	43	8	and	and	CC
cord-258787-n49zrfsp	43	9	humans	human	NNS
cord-258787-n49zrfsp	43	10	and	and	CC
cord-258787-n49zrfsp	43	11	their	-PRON-	PRP$
cord-258787-n49zrfsp	43	12	phenotypic	phenotypic	JJ
cord-258787-n49zrfsp	43	13	characteristics	characteristic	NNS
cord-258787-n49zrfsp	43	14	are	be	VBP
cord-258787-n49zrfsp	43	15	outlined	outline	VBN
cord-258787-n49zrfsp	43	16	in	in	IN
cord-258787-n49zrfsp	43	17	Table	Table	NNP
cord-258787-n49zrfsp	43	18	1	1	CD
cord-258787-n49zrfsp	43	19	.	.	.
cord-258787-n49zrfsp	44	1	A	a	DT
cord-258787-n49zrfsp	44	2	study	study	NN
cord-258787-n49zrfsp	44	3	previously	previously	RB
cord-258787-n49zrfsp	44	4	described	describe	VBD
cord-258787-n49zrfsp	44	5	an	an	DT
cord-258787-n49zrfsp	44	6	early	early	JJ
cord-258787-n49zrfsp	44	7	unipotent	unipotent	JJ
cord-258787-n49zrfsp	44	8	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	44	9	progenitor	progenitor	NN
cord-258787-n49zrfsp	44	10	(	(	-LRB-
cord-258787-n49zrfsp	44	11	defined	define	VBN
cord-258787-n49zrfsp	44	12	as	as	IN
cord-258787-n49zrfsp	44	13	NeP	nep	NN
cord-258787-n49zrfsp	44	14	)	)	-RRB-
cord-258787-n49zrfsp	44	15	,	,	,
cord-258787-n49zrfsp	44	16	comprising	comprise	VBG
cord-258787-n49zrfsp	44	17	different	different	JJ
cord-258787-n49zrfsp	44	18	clusters	cluster	NNS
cord-258787-n49zrfsp	44	19	of	of	IN
cord-258787-n49zrfsp	44	20	cells	cell	NNS
cord-258787-n49zrfsp	44	21	[	[	-LRB-
cord-258787-n49zrfsp	44	22	46	46	CD
cord-258787-n49zrfsp	44	23	]	]	-RRB-
cord-258787-n49zrfsp	44	24	.	.	.
cord-258787-n49zrfsp	45	1	It	-PRON-	PRP
cord-258787-n49zrfsp	45	2	is	be	VBZ
cord-258787-n49zrfsp	45	3	conceivable	conceivable	JJ
cord-258787-n49zrfsp	45	4	that	that	IN
cord-258787-n49zrfsp	45	5	this	this	DT
cord-258787-n49zrfsp	45	6	heterogenous	heterogenous	JJ
cord-258787-n49zrfsp	45	7	population	population	NN
cord-258787-n49zrfsp	45	8	represents	represent	VBZ
cord-258787-n49zrfsp	45	9	a	a	DT
cord-258787-n49zrfsp	45	10	mixture	mixture	NN
cord-258787-n49zrfsp	45	11	of	of	IN
cord-258787-n49zrfsp	45	12	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	45	13	progenitors	progenitor	NNS
cord-258787-n49zrfsp	45	14	described	describe	VBN
cord-258787-n49zrfsp	45	15	as	as	IN
cord-258787-n49zrfsp	45	16	proNeu1	proNeu1	NNS
cord-258787-n49zrfsp	45	17	,	,	,
cord-258787-n49zrfsp	45	18	proNeu2	proNeu2	NNS
cord-258787-n49zrfsp	45	19	and	and	CC
cord-258787-n49zrfsp	45	20	preNeu	preneu	NN
cord-258787-n49zrfsp	45	21	[	[	-LRB-
cord-258787-n49zrfsp	45	22	46	46	CD
cord-258787-n49zrfsp	45	23	]	]	-RRB-
cord-258787-n49zrfsp	45	24	[	[	-LRB-
cord-258787-n49zrfsp	45	25	47	47	CD
cord-258787-n49zrfsp	45	26	]	]	-RRB-
cord-258787-n49zrfsp	45	27	[	[	-LRB-
cord-258787-n49zrfsp	45	28	48	48	CD
cord-258787-n49zrfsp	45	29	]	]	-RRB-
cord-258787-n49zrfsp	45	30	.	.	.
cord-258787-n49zrfsp	46	1	The	the	DT
cord-258787-n49zrfsp	46	2	release	release	NN
cord-258787-n49zrfsp	46	3	of	of	IN
cord-258787-n49zrfsp	46	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	46	5	in	in	IN
cord-258787-n49zrfsp	46	6	the	the	DT
cord-258787-n49zrfsp	46	7	bloodstream	bloodstream	NN
cord-258787-n49zrfsp	46	8	is	be	VBZ
cord-258787-n49zrfsp	46	9	a	a	DT
cord-258787-n49zrfsp	46	10	process	process	NN
cord-258787-n49zrfsp	46	11	controlled	control	VBN
cord-258787-n49zrfsp	46	12	by	by	IN
cord-258787-n49zrfsp	46	13	the	the	DT
cord-258787-n49zrfsp	46	14	regulation	regulation	NN
cord-258787-n49zrfsp	46	15	of	of	IN
cord-258787-n49zrfsp	46	16	the	the	DT
cord-258787-n49zrfsp	46	17	expression	expression	NN
cord-258787-n49zrfsp	46	18	of	of	IN
cord-258787-n49zrfsp	46	19	genes	gene	NNS
cord-258787-n49zrfsp	46	20	coding	code	VBG
cord-258787-n49zrfsp	46	21	for	for	IN
cord-258787-n49zrfsp	46	22	CXCR4	CXCR4	NNS
cord-258787-n49zrfsp	46	23	and	and	CC
cord-258787-n49zrfsp	46	24	CXCR2	CXCR2	NNS
cord-258787-n49zrfsp	46	25	in	in	IN
cord-258787-n49zrfsp	46	26	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	46	27	precursors	precursor	NNS
cord-258787-n49zrfsp	46	28	[	[	-LRB-
cord-258787-n49zrfsp	46	29	49	49	CD
cord-258787-n49zrfsp	46	30	]	]	-RRB-
cord-258787-n49zrfsp	46	31	.	.	.
cord-258787-n49zrfsp	47	1	In	in	IN
cord-258787-n49zrfsp	47	2	steady	steady	JJ
cord-258787-n49zrfsp	47	3	state	state	NN
cord-258787-n49zrfsp	47	4	,	,	,
cord-258787-n49zrfsp	47	5	CXCL12	CXCL12	NNP
cord-258787-n49zrfsp	47	6	is	be	VBZ
cord-258787-n49zrfsp	47	7	constitutively	constitutively	RB
cord-258787-n49zrfsp	47	8	expressed	express	VBN
cord-258787-n49zrfsp	47	9	by	by	IN
cord-258787-n49zrfsp	47	10	BM	BM	NNP
cord-258787-n49zrfsp	47	11	stromal	stromal	NN
cord-258787-n49zrfsp	47	12	cells	cell	NNS
cord-258787-n49zrfsp	47	13	which	which	WDT
cord-258787-n49zrfsp	47	14	supports	support	VBZ
cord-258787-n49zrfsp	47	15	the	the	DT
cord-258787-n49zrfsp	47	16	retention	retention	NN
cord-258787-n49zrfsp	47	17	of	of	IN
cord-258787-n49zrfsp	47	18	CXCR4	CXCR4	NNS
cord-258787-n49zrfsp	47	19	+	+	CC
cord-258787-n49zrfsp	47	20	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	47	21	inside	inside	IN
cord-258787-n49zrfsp	47	22	the	the	DT
cord-258787-n49zrfsp	47	23	BM	BM	NNP
cord-258787-n49zrfsp	47	24	.	.	.
cord-258787-n49zrfsp	48	1	During	during	IN
cord-258787-n49zrfsp	48	2	their	-PRON-	PRP$
cord-258787-n49zrfsp	48	3	maturation	maturation	NN
cord-258787-n49zrfsp	48	4	,	,	,
cord-258787-n49zrfsp	48	5	expression	expression	NN
cord-258787-n49zrfsp	48	6	of	of	IN
cord-258787-n49zrfsp	48	7	CXCR4	CXCR4	NNS
cord-258787-n49zrfsp	48	8	on	on	IN
cord-258787-n49zrfsp	48	9	the	the	DT
cord-258787-n49zrfsp	48	10	surface	surface	NN
cord-258787-n49zrfsp	48	11	of	of	IN
cord-258787-n49zrfsp	48	12	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	48	13	is	be	VBZ
cord-258787-n49zrfsp	48	14	downregulated	downregulate	VBN
cord-258787-n49zrfsp	48	15	,	,	,
cord-258787-n49zrfsp	48	16	while	while	IN
cord-258787-n49zrfsp	48	17	the	the	DT
cord-258787-n49zrfsp	48	18	expression	expression	NN
cord-258787-n49zrfsp	48	19	of	of	IN
cord-258787-n49zrfsp	48	20	CXCR2	CXCR2	NNS
cord-258787-n49zrfsp	48	21	is	be	VBZ
cord-258787-n49zrfsp	48	22	increased	increase	VBN
cord-258787-n49zrfsp	48	23	,	,	,
cord-258787-n49zrfsp	48	24	leading	lead	VBG
cord-258787-n49zrfsp	48	25	to	to	IN
cord-258787-n49zrfsp	48	26	their	-PRON-	PRP$
cord-258787-n49zrfsp	48	27	release	release	NN
cord-258787-n49zrfsp	48	28	in	in	IN
cord-258787-n49zrfsp	48	29	the	the	DT
cord-258787-n49zrfsp	48	30	blood	blood	NN
cord-258787-n49zrfsp	48	31	via	via	IN
cord-258787-n49zrfsp	48	32	the	the	DT
cord-258787-n49zrfsp	48	33	interaction	interaction	NN
cord-258787-n49zrfsp	48	34	with	with	IN
cord-258787-n49zrfsp	48	35	CXC	CXC	NNP
cord-258787-n49zrfsp	48	36	chemokines	chemokine	NNS
cord-258787-n49zrfsp	48	37	(	(	-LRB-
cord-258787-n49zrfsp	48	38	e.g.	e.g.	RB
cord-258787-n49zrfsp	48	39	CXCL1	CXCL1	NNP
cord-258787-n49zrfsp	48	40	,	,	,
cord-258787-n49zrfsp	48	41	CXCL2	cxcl2	NN
cord-258787-n49zrfsp	48	42	)	)	-RRB-
cord-258787-n49zrfsp	49	1	present	present	JJ
cord-258787-n49zrfsp	49	2	in	in	IN
cord-258787-n49zrfsp	49	3	the	the	DT
cord-258787-n49zrfsp	49	4	circulation	circulation	NN
cord-258787-n49zrfsp	49	5	[	[	-LRB-
cord-258787-n49zrfsp	49	6	15	15	CD
cord-258787-n49zrfsp	49	7	,	,	,
cord-258787-n49zrfsp	49	8	24	24	CD
cord-258787-n49zrfsp	49	9	,	,	,
cord-258787-n49zrfsp	49	10	49	49	CD
cord-258787-n49zrfsp	49	11	,	,	,
cord-258787-n49zrfsp	49	12	50	50	CD
cord-258787-n49zrfsp	49	13	]	]	-RRB-
cord-258787-n49zrfsp	49	14	.	.	.
cord-258787-n49zrfsp	50	1	Circulating	circulate	VBG
cord-258787-n49zrfsp	50	2	aged	aged	JJ
cord-258787-n49zrfsp	50	3	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	50	4	upregulate	upregulate	VBP
cord-258787-n49zrfsp	50	5	the	the	DT
cord-258787-n49zrfsp	50	6	expression	expression	NN
cord-258787-n49zrfsp	50	7	of	of	IN
cord-258787-n49zrfsp	50	8	CXCR4	CXCR4	NNS
cord-258787-n49zrfsp	50	9	in	in	IN
cord-258787-n49zrfsp	50	10	order	order	NN
cord-258787-n49zrfsp	50	11	to	to	TO
cord-258787-n49zrfsp	50	12	migrate	migrate	VB
cord-258787-n49zrfsp	50	13	into	into	IN
cord-258787-n49zrfsp	50	14	the	the	DT
cord-258787-n49zrfsp	50	15	BM	bm	NN
cord-258787-n49zrfsp	50	16	where	where	WRB
cord-258787-n49zrfsp	50	17	they	-PRON-	PRP
cord-258787-n49zrfsp	50	18	are	be	VBP
cord-258787-n49zrfsp	50	19	eliminated	eliminate	VBN
cord-258787-n49zrfsp	50	20	by	by	IN
cord-258787-n49zrfsp	50	21	macrophages	macrophage	NNS
cord-258787-n49zrfsp	50	22	[	[	-LRB-
cord-258787-n49zrfsp	50	23	51	51	CD
cord-258787-n49zrfsp	50	24	]	]	-RRB-
cord-258787-n49zrfsp	50	25	.	.	.
cord-258787-n49zrfsp	51	1	In	in	IN
cord-258787-n49zrfsp	51	2	steady	steady	JJ
cord-258787-n49zrfsp	51	3	state	state	NN
cord-258787-n49zrfsp	51	4	,	,	,
cord-258787-n49zrfsp	51	5	BM	BM	NNP
cord-258787-n49zrfsp	51	6	is	be	VBZ
cord-258787-n49zrfsp	51	7	the	the	DT
cord-258787-n49zrfsp	51	8	unique	unique	JJ
cord-258787-n49zrfsp	51	9	site	site	NN
cord-258787-n49zrfsp	51	10	of	of	IN
cord-258787-n49zrfsp	51	11	haematopoiesis	haematopoiesis	NN
cord-258787-n49zrfsp	51	12	,	,	,
cord-258787-n49zrfsp	51	13	but	but	CC
cord-258787-n49zrfsp	51	14	during	during	IN
cord-258787-n49zrfsp	51	15	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	51	16	conditions	condition	NNS
cord-258787-n49zrfsp	51	17	,	,	,
cord-258787-n49zrfsp	51	18	such	such	JJ
cord-258787-n49zrfsp	51	19	as	as	IN
cord-258787-n49zrfsp	51	20	cancer	cancer	NN
cord-258787-n49zrfsp	51	21	and	and	CC
cord-258787-n49zrfsp	51	22	systemic	systemic	JJ
cord-258787-n49zrfsp	51	23	infection	infection	NN
cord-258787-n49zrfsp	51	24	,	,	,
cord-258787-n49zrfsp	51	25	the	the	DT
cord-258787-n49zrfsp	51	26	spleen	spleen	NN
cord-258787-n49zrfsp	51	27	can	can	MD
cord-258787-n49zrfsp	51	28	be	be	VB
cord-258787-n49zrfsp	51	29	involved	involve	VBN
cord-258787-n49zrfsp	51	30	in	in	IN
cord-258787-n49zrfsp	51	31	the	the	DT
cord-258787-n49zrfsp	51	32	generation	generation	NN
cord-258787-n49zrfsp	51	33	of	of	IN
cord-258787-n49zrfsp	51	34	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	51	35	[	[	-LRB-
cord-258787-n49zrfsp	51	36	52	52	CD
cord-258787-n49zrfsp	51	37	,	,	,
cord-258787-n49zrfsp	51	38	53	53	CD
cord-258787-n49zrfsp	51	39	]	]	-RRB-
cord-258787-n49zrfsp	51	40	.	.	.
cord-258787-n49zrfsp	52	1	In	in	IN
cord-258787-n49zrfsp	52	2	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	52	3	conditions	condition	NNS
cord-258787-n49zrfsp	52	4	,	,	,
cord-258787-n49zrfsp	52	5	expression	expression	NN
cord-258787-n49zrfsp	52	6	levels	level	NNS
cord-258787-n49zrfsp	52	7	of	of	IN
cord-258787-n49zrfsp	52	8	granulopoietic	granulopoietic	JJ
cord-258787-n49zrfsp	52	9	cytokines	cytokine	NNS
cord-258787-n49zrfsp	52	10	,	,	,
cord-258787-n49zrfsp	52	11	such	such	JJ
cord-258787-n49zrfsp	52	12	as	as	IN
cord-258787-n49zrfsp	52	13	G	G	NNP
cord-258787-n49zrfsp	52	14	-	-	HYPH
cord-258787-n49zrfsp	52	15	CSF	CSF	NNP
cord-258787-n49zrfsp	52	16	,	,	,
cord-258787-n49zrfsp	52	17	GM	GM	NNP
cord-258787-n49zrfsp	52	18	-	-	HYPH
cord-258787-n49zrfsp	52	19	CSF	CSF	NNP
cord-258787-n49zrfsp	52	20	and	and	CC
cord-258787-n49zrfsp	52	21	IL-6	IL-6	NNP
cord-258787-n49zrfsp	52	22	are	be	VBP
cord-258787-n49zrfsp	52	23	increased	increase	VBN
cord-258787-n49zrfsp	52	24	,	,	,
cord-258787-n49zrfsp	52	25	leading	lead	VBG
cord-258787-n49zrfsp	52	26	to	to	IN
cord-258787-n49zrfsp	52	27	the	the	DT
cord-258787-n49zrfsp	52	28	process	process	NN
cord-258787-n49zrfsp	52	29	of	of	IN
cord-258787-n49zrfsp	52	30	emergency	emergency	NN
cord-258787-n49zrfsp	52	31	granulopoiesis	granulopoiesis	NN
cord-258787-n49zrfsp	52	32	[	[	-LRB-
cord-258787-n49zrfsp	52	33	27	27	CD
cord-258787-n49zrfsp	52	34	,	,	,
cord-258787-n49zrfsp	52	35	54	54	CD
cord-258787-n49zrfsp	52	36	]	]	-RRB-
cord-258787-n49zrfsp	52	37	.	.	.
cord-258787-n49zrfsp	53	1	Interestingly	interestingly	RB
cord-258787-n49zrfsp	53	2	,	,	,
cord-258787-n49zrfsp	53	3	despite	despite	IN
cord-258787-n49zrfsp	53	4	that	that	DT
cord-258787-n49zrfsp	53	5	G	G	NNP
cord-258787-n49zrfsp	53	6	-	-	HYPH
cord-258787-n49zrfsp	53	7	CSF	CSF	NNP
cord-258787-n49zrfsp	53	8	−	−	NNP
cord-258787-n49zrfsp	53	9	/−	/−	.
cord-258787-n49zrfsp	53	10	and	and	CC
cord-258787-n49zrfsp	53	11	GM	GM	NNP
cord-258787-n49zrfsp	53	12	-	-	HYPH
cord-258787-n49zrfsp	53	13	CSF	CSF	NNP
cord-258787-n49zrfsp	53	14	-/mice	-/mice	NN
cord-258787-n49zrfsp	53	15	present	present	JJ
cord-258787-n49zrfsp	53	16	a	a	DT
cord-258787-n49zrfsp	53	17	severe	severe	JJ
cord-258787-n49zrfsp	53	18	neutropenia	neutropenia	NN
cord-258787-n49zrfsp	53	19	in	in	IN
cord-258787-n49zrfsp	53	20	steady	steady	JJ
cord-258787-n49zrfsp	53	21	state	state	NN
cord-258787-n49zrfsp	53	22	,	,	,
cord-258787-n49zrfsp	53	23	the	the	DT
cord-258787-n49zrfsp	53	24	expression	expression	NN
cord-258787-n49zrfsp	53	25	of	of	IN
cord-258787-n49zrfsp	53	26	IL-6	IL-6	NNP
cord-258787-n49zrfsp	53	27	in	in	IN
cord-258787-n49zrfsp	53	28	these	these	DT
cord-258787-n49zrfsp	53	29	mice	mouse	NNS
cord-258787-n49zrfsp	53	30	can	can	MD
cord-258787-n49zrfsp	53	31	be	be	VB
cord-258787-n49zrfsp	53	32	sufficient	sufficient	JJ
cord-258787-n49zrfsp	53	33	for	for	IN
cord-258787-n49zrfsp	53	34	the	the	DT
cord-258787-n49zrfsp	53	35	production	production	NN
cord-258787-n49zrfsp	53	36	of	of	IN
cord-258787-n49zrfsp	53	37	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	53	38	during	during	IN
cord-258787-n49zrfsp	53	39	emergency	emergency	NN
cord-258787-n49zrfsp	53	40	granulopoiesis	granulopoiesis	NNP
cord-258787-n49zrfsp	53	41	[	[	-LRB-
cord-258787-n49zrfsp	53	42	15	15	CD
cord-258787-n49zrfsp	53	43	,	,	,
cord-258787-n49zrfsp	53	44	30	30	CD
cord-258787-n49zrfsp	53	45	]	]	-RRB-
cord-258787-n49zrfsp	53	46	.	.	.
cord-258787-n49zrfsp	54	1	However	however	RB
cord-258787-n49zrfsp	54	2	,	,	,
cord-258787-n49zrfsp	54	3	the	the	DT
cord-258787-n49zrfsp	54	4	phenotype	phenotype	NN
cord-258787-n49zrfsp	54	5	and	and	CC
cord-258787-n49zrfsp	54	6	effector	effector	NN
cord-258787-n49zrfsp	54	7	functions	function	NNS
cord-258787-n49zrfsp	54	8	of	of	IN
cord-258787-n49zrfsp	54	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	54	10	produced	produce	VBN
cord-258787-n49zrfsp	54	11	in	in	IN
cord-258787-n49zrfsp	54	12	G	G	NNP
cord-258787-n49zrfsp	54	13	-	-	HYPH
cord-258787-n49zrfsp	54	14	CSF	CSF	NNP
cord-258787-n49zrfsp	54	15	−	−	NNP
cord-258787-n49zrfsp	54	16	/−	/−	.
cord-258787-n49zrfsp	54	17	and	and	CC
cord-258787-n49zrfsp	54	18	GM	GM	NNP
cord-258787-n49zrfsp	54	19	-	-	HYPH
cord-258787-n49zrfsp	54	20	CSF	CSF	NNP
cord-258787-n49zrfsp	54	21	-/mice	-/mice	NNS
cord-258787-n49zrfsp	54	22	remain	remain	JJ
cord-258787-n49zrfsp	54	23	to	to	TO
cord-258787-n49zrfsp	54	24	be	be	VB
cord-258787-n49zrfsp	54	25	fully	fully	RB
cord-258787-n49zrfsp	54	26	elucidated	elucidate	VBN
cord-258787-n49zrfsp	54	27	.	.	.
cord-258787-n49zrfsp	55	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	55	2	development	development	NN
cord-258787-n49zrfsp	55	3	during	during	IN
cord-258787-n49zrfsp	55	4	inflammation	inflammation	NN
cord-258787-n49zrfsp	55	5	is	be	VBZ
cord-258787-n49zrfsp	55	6	also	also	RB
cord-258787-n49zrfsp	55	7	controlled	control	VBN
cord-258787-n49zrfsp	55	8	by	by	IN
cord-258787-n49zrfsp	55	9	the	the	DT
cord-258787-n49zrfsp	55	10	expression	expression	NN
cord-258787-n49zrfsp	55	11	of	of	IN
cord-258787-n49zrfsp	55	12	specific	specific	JJ
cord-258787-n49zrfsp	55	13	transcription	transcription	NN
cord-258787-n49zrfsp	55	14	factors	factor	NNS
cord-258787-n49zrfsp	55	15	[	[	-LRB-
cord-258787-n49zrfsp	55	16	37	37	CD
cord-258787-n49zrfsp	55	17	,	,	,
cord-258787-n49zrfsp	55	18	55	55	CD
cord-258787-n49zrfsp	55	19	,	,	,
cord-258787-n49zrfsp	55	20	56	56	CD
cord-258787-n49zrfsp	55	21	]	]	-RRB-
cord-258787-n49zrfsp	55	22	.	.	.
cord-258787-n49zrfsp	56	1	Increased	increase	VBN
cord-258787-n49zrfsp	56	2	expression	expression	NN
cord-258787-n49zrfsp	56	3	of	of	IN
cord-258787-n49zrfsp	56	4	G	G	NNP
cord-258787-n49zrfsp	56	5	-	-	HYPH
cord-258787-n49zrfsp	56	6	CSF	CSF	NNP
cord-258787-n49zrfsp	56	7	and	and	CC
cord-258787-n49zrfsp	56	8	G	G	NNP
cord-258787-n49zrfsp	56	9	-	-	HYPH
cord-258787-n49zrfsp	56	10	CSF	csf	NN
cord-258787-n49zrfsp	56	11	receptor	receptor	NN
cord-258787-n49zrfsp	56	12	signalling	signal	VBG
cord-258787-n49zrfsp	56	13	triggers	trigger	VBZ
cord-258787-n49zrfsp	56	14	the	the	DT
cord-258787-n49zrfsp	56	15	phosphorylation	phosphorylation	NN
cord-258787-n49zrfsp	56	16	of	of	IN
cord-258787-n49zrfsp	56	17	signal	signal	NN
cord-258787-n49zrfsp	56	18	transducer	transducer	NN
cord-258787-n49zrfsp	56	19	and	and	CC
cord-258787-n49zrfsp	56	20	activator	activator	NN
cord-258787-n49zrfsp	56	21	of	of	IN
cord-258787-n49zrfsp	56	22	transcription	transcription	NN
cord-258787-n49zrfsp	56	23	3	3	CD
cord-258787-n49zrfsp	56	24	(	(	-LRB-
cord-258787-n49zrfsp	56	25	STAT3	STAT3	NNP
cord-258787-n49zrfsp	56	26	)	)	-RRB-
cord-258787-n49zrfsp	56	27	which	which	WDT
cord-258787-n49zrfsp	56	28	directly	directly	RB
cord-258787-n49zrfsp	56	29	enhances	enhance	VBZ
cord-258787-n49zrfsp	56	30	C	C	NNP
cord-258787-n49zrfsp	56	31	/	/	SYM
cord-258787-n49zrfsp	56	32	EBPβ	ebpβ	NN
cord-258787-n49zrfsp	56	33	expression	expression	NN
cord-258787-n49zrfsp	56	34	in	in	IN
cord-258787-n49zrfsp	56	35	progenitor	progenitor	NN
cord-258787-n49zrfsp	56	36	cells	cell	NNS
cord-258787-n49zrfsp	56	37	[	[	-LRB-
cord-258787-n49zrfsp	56	38	27	27	CD
cord-258787-n49zrfsp	56	39	]	]	-RRB-
cord-258787-n49zrfsp	56	40	.	.	.
cord-258787-n49zrfsp	57	1	In	in	IN
cord-258787-n49zrfsp	57	2	a	a	DT
cord-258787-n49zrfsp	57	3	negative	negative	JJ
cord-258787-n49zrfsp	57	4	feedback	feedback	NN
cord-258787-n49zrfsp	57	5	loop	loop	NN
cord-258787-n49zrfsp	57	6	,	,	,
cord-258787-n49zrfsp	57	7	the	the	DT
cord-258787-n49zrfsp	57	8	phosphorylation	phosphorylation	NN
cord-258787-n49zrfsp	57	9	of	of	IN
cord-258787-n49zrfsp	57	10	STAT3	STAT3	NNP
cord-258787-n49zrfsp	57	11	activates	activate	VBZ
cord-258787-n49zrfsp	57	12	the	the	DT
cord-258787-n49zrfsp	57	13	suppressor	suppressor	NN
cord-258787-n49zrfsp	57	14	of	of	IN
cord-258787-n49zrfsp	57	15	cytokine	cytokine	NN
cord-258787-n49zrfsp	57	16	signalling3	signalling3	NN
cord-258787-n49zrfsp	57	17	(	(	-LRB-
cord-258787-n49zrfsp	57	18	SOCS3	SOCS3	NNP
cord-258787-n49zrfsp	57	19	)	)	-RRB-
cord-258787-n49zrfsp	57	20	,	,	,
cord-258787-n49zrfsp	57	21	which	which	WDT
cord-258787-n49zrfsp	57	22	in	in	IN
cord-258787-n49zrfsp	57	23	turn	turn	NN
cord-258787-n49zrfsp	57	24	,	,	,
cord-258787-n49zrfsp	57	25	by	by	IN
cord-258787-n49zrfsp	57	26	inhibiting	inhibit	VBG
cord-258787-n49zrfsp	57	27	the	the	DT
cord-258787-n49zrfsp	57	28	activation	activation	NN
cord-258787-n49zrfsp	57	29	of	of	IN
cord-258787-n49zrfsp	57	30	STAT3	STAT3	NNP
cord-258787-n49zrfsp	57	31	,	,	,
cord-258787-n49zrfsp	57	32	prevents	prevent	VBZ
cord-258787-n49zrfsp	57	33	an	an	DT
cord-258787-n49zrfsp	57	34	excessive	excessive	JJ
cord-258787-n49zrfsp	57	35	production	production	NN
cord-258787-n49zrfsp	57	36	of	of	IN
cord-258787-n49zrfsp	57	37	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	57	38	[	[	-LRB-
cord-258787-n49zrfsp	57	39	27	27	CD
cord-258787-n49zrfsp	57	40	]	]	-RRB-
cord-258787-n49zrfsp	57	41	.	.	.
cord-258787-n49zrfsp	58	1	Elevated	elevated	JJ
cord-258787-n49zrfsp	58	2	number	number	NN
cord-258787-n49zrfsp	58	3	of	of	IN
cord-258787-n49zrfsp	58	4	circulating	circulate	VBG
cord-258787-n49zrfsp	58	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	58	6	have	have	VBP
cord-258787-n49zrfsp	58	7	been	be	VBN
cord-258787-n49zrfsp	58	8	reported	report	VBN
cord-258787-n49zrfsp	58	9	in	in	IN
cord-258787-n49zrfsp	58	10	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	58	11	conditions	condition	NNS
cord-258787-n49zrfsp	58	12	,	,	,
cord-258787-n49zrfsp	58	13	including	include	VBG
cord-258787-n49zrfsp	58	14	cancer	cancer	NN
cord-258787-n49zrfsp	58	15	[	[	-LRB-
cord-258787-n49zrfsp	58	16	7	7	CD
cord-258787-n49zrfsp	58	17	,	,	,
cord-258787-n49zrfsp	58	18	57	57	CD
cord-258787-n49zrfsp	58	19	,	,	,
cord-258787-n49zrfsp	58	20	58	58	CD
cord-258787-n49zrfsp	58	21	]	]	-RRB-
cord-258787-n49zrfsp	58	22	.	.	.
cord-258787-n49zrfsp	59	1	Accordingly	accordingly	RB
cord-258787-n49zrfsp	59	2	,	,	,
cord-258787-n49zrfsp	59	3	the	the	DT
cord-258787-n49zrfsp	59	4	 	 	_SP
cord-258787-n49zrfsp	59	5	production	production	NN
cord-258787-n49zrfsp	59	6	of	of	IN
cord-258787-n49zrfsp	59	7	cytokines	cytokine	NNS
cord-258787-n49zrfsp	59	8	and	and	CC
cord-258787-n49zrfsp	59	9	chemokines	chemokine	NNS
cord-258787-n49zrfsp	59	10	(	(	-LRB-
cord-258787-n49zrfsp	59	11	such	such	JJ
cord-258787-n49zrfsp	59	12	as	as	IN
cord-258787-n49zrfsp	59	13	Il-17	Il-17	NNP
cord-258787-n49zrfsp	59	14	,	,	,
cord-258787-n49zrfsp	59	15	IL-1β	IL-1β	NNP
cord-258787-n49zrfsp	59	16	,	,	,
cord-258787-n49zrfsp	59	17	G	G	NNP
cord-258787-n49zrfsp	59	18	-	-	HYPH
cord-258787-n49zrfsp	59	19	CSF	CSF	NNP
cord-258787-n49zrfsp	59	20	,	,	,
cord-258787-n49zrfsp	59	21	CXCL1	CXCL1	NNP
cord-258787-n49zrfsp	59	22	,	,	,
cord-258787-n49zrfsp	59	23	CXCL2	cxcl2	NN
cord-258787-n49zrfsp	59	24	)	)	-RRB-
cord-258787-n49zrfsp	59	25	involved	involve	VBN
cord-258787-n49zrfsp	59	26	in	in	IN
cord-258787-n49zrfsp	59	27	the	the	DT
cord-258787-n49zrfsp	59	28	development	development	NN
cord-258787-n49zrfsp	59	29	and	and	CC
cord-258787-n49zrfsp	59	30	mobilization	mobilization	NN
cord-258787-n49zrfsp	59	31	of	of	IN
cord-258787-n49zrfsp	59	32	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	59	33	is	be	VBZ
cord-258787-n49zrfsp	59	34	upregulated	upregulate	VBN
cord-258787-n49zrfsp	59	35	in	in	IN
cord-258787-n49zrfsp	59	36	tumour	tumour	NN
cord-258787-n49zrfsp	59	37	-	-	HYPH
cord-258787-n49zrfsp	59	38	bearing	bear	VBG
cord-258787-n49zrfsp	59	39	host	host	NN
cord-258787-n49zrfsp	59	40	[	[	-LRB-
cord-258787-n49zrfsp	59	41	15	15	CD
cord-258787-n49zrfsp	59	42	]	]	-RRB-
cord-258787-n49zrfsp	59	43	.	.	.
cord-258787-n49zrfsp	60	1	Tumour	tumour	NN
cord-258787-n49zrfsp	60	2	cells	cell	NNS
cord-258787-n49zrfsp	60	3	themselves	-PRON-	PRP
cord-258787-n49zrfsp	60	4	or	or	CC
cord-258787-n49zrfsp	60	5	tumour	tumour	NN
cord-258787-n49zrfsp	60	6	-	-	HYPH
cord-258787-n49zrfsp	60	7	associated	associate	VBN
cord-258787-n49zrfsp	60	8	immune	immune	JJ
cord-258787-n49zrfsp	60	9	cells	cell	NNS
cord-258787-n49zrfsp	60	10	can	can	MD
cord-258787-n49zrfsp	60	11	produce	produce	VB
cord-258787-n49zrfsp	60	12	these	these	DT
cord-258787-n49zrfsp	60	13	cytokines	cytokine	NNS
cord-258787-n49zrfsp	60	14	.	.	.
cord-258787-n49zrfsp	61	1	For	for	IN
cord-258787-n49zrfsp	61	2	instance	instance	NN
cord-258787-n49zrfsp	61	3	,	,	,
cord-258787-n49zrfsp	61	4	tumour	tumour	NN
cord-258787-n49zrfsp	61	5	-	-	HYPH
cord-258787-n49zrfsp	61	6	associated	associate	VBN
cord-258787-n49zrfsp	61	7	macrophages	macrophage	NNS
cord-258787-n49zrfsp	61	8	(	(	-LRB-
cord-258787-n49zrfsp	61	9	TAMs	tam	NNS
cord-258787-n49zrfsp	61	10	)	)	-RRB-
cord-258787-n49zrfsp	61	11	produce	produce	VBP
cord-258787-n49zrfsp	61	12	IL-1β	il-1β	NN
cord-258787-n49zrfsp	61	13	,	,	,
cord-258787-n49zrfsp	61	14	which	which	WDT
cord-258787-n49zrfsp	61	15	stimulates	stimulate	VBZ
cord-258787-n49zrfsp	61	16	T	t	NN
cord-258787-n49zrfsp	61	17	cells	cell	NNS
cord-258787-n49zrfsp	61	18	to	to	TO
cord-258787-n49zrfsp	61	19	produce	produce	VB
cord-258787-n49zrfsp	61	20	IL-17	IL-17	NNP
cord-258787-n49zrfsp	61	21	.	.	.
cord-258787-n49zrfsp	62	1	In	in	IN
cord-258787-n49zrfsp	62	2	turn	turn	NN
cord-258787-n49zrfsp	62	3	,	,	,
cord-258787-n49zrfsp	62	4	IL-17	IL-17	NNP
cord-258787-n49zrfsp	62	5	increases	increase	VBZ
cord-258787-n49zrfsp	62	6	the	the	DT
cord-258787-n49zrfsp	62	7	expression	expression	NN
cord-258787-n49zrfsp	62	8	of	of	IN
cord-258787-n49zrfsp	62	9	G	G	NNP
cord-258787-n49zrfsp	62	10	-	-	HYPH
cord-258787-n49zrfsp	62	11	CSF	CSF	NNP
cord-258787-n49zrfsp	62	12	and	and	CC
cord-258787-n49zrfsp	62	13	the	the	DT
cord-258787-n49zrfsp	62	14	release	release	NN
cord-258787-n49zrfsp	62	15	of	of	IN
cord-258787-n49zrfsp	62	16	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	62	17	in	in	IN
cord-258787-n49zrfsp	62	18	the	the	DT
cord-258787-n49zrfsp	62	19	circulation	circulation	NN
cord-258787-n49zrfsp	62	20	(	(	-LRB-
cord-258787-n49zrfsp	62	21	see	see	VB
cord-258787-n49zrfsp	62	22	also	also	RB
cord-258787-n49zrfsp	62	23	the	the	DT
cord-258787-n49zrfsp	62	24	paragraph	paragraph	NN
cord-258787-n49zrfsp	62	25	6.2	6.2	CD
cord-258787-n49zrfsp	62	26	)	)	-RRB-
cord-258787-n49zrfsp	63	1	[	[	-LRB-
cord-258787-n49zrfsp	63	2	15	15	CD
cord-258787-n49zrfsp	63	3	]	]	-RRB-
cord-258787-n49zrfsp	63	4	.	.	.
cord-258787-n49zrfsp	64	1	The	the	DT
cord-258787-n49zrfsp	64	2	pressure	pressure	NN
cord-258787-n49zrfsp	64	3	created	create	VBN
cord-258787-n49zrfsp	64	4	by	by	IN
cord-258787-n49zrfsp	64	5	the	the	DT
cord-258787-n49zrfsp	64	6	tumours	tumour	NNS
cord-258787-n49zrfsp	64	7	on	on	IN
cord-258787-n49zrfsp	64	8	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	64	9	mobilization	mobilization	NN
cord-258787-n49zrfsp	64	10	can	can	MD
cord-258787-n49zrfsp	64	11	lead	lead	VB
cord-258787-n49zrfsp	64	12	to	to	IN
cord-258787-n49zrfsp	64	13	the	the	DT
cord-258787-n49zrfsp	64	14	release	release	NN
cord-258787-n49zrfsp	64	15	of	of	IN
cord-258787-n49zrfsp	64	16	immature	immature	JJ
cord-258787-n49zrfsp	64	17	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	64	18	in	in	IN
cord-258787-n49zrfsp	64	19	the	the	DT
cord-258787-n49zrfsp	64	20	circulation	circulation	NN
cord-258787-n49zrfsp	64	21	[	[	-LRB-
cord-258787-n49zrfsp	64	22	8	8	CD
cord-258787-n49zrfsp	64	23	,	,	,
cord-258787-n49zrfsp	64	24	14	14	CD
cord-258787-n49zrfsp	64	25	,	,	,
cord-258787-n49zrfsp	64	26	59	59	CD
cord-258787-n49zrfsp	64	27	]	]	-RRB-
cord-258787-n49zrfsp	64	28	.	.	.
cord-258787-n49zrfsp	65	1	In	in	IN
cord-258787-n49zrfsp	65	2	mouse	mouse	NN
cord-258787-n49zrfsp	65	3	models	model	NNS
cord-258787-n49zrfsp	65	4	of	of	IN
cord-258787-n49zrfsp	65	5	cancer	cancer	NN
cord-258787-n49zrfsp	65	6	,	,	,
cord-258787-n49zrfsp	65	7	the	the	DT
cord-258787-n49zrfsp	65	8	frequency	frequency	NN
cord-258787-n49zrfsp	65	9	of	of	IN
cord-258787-n49zrfsp	65	10	Ly6	Ly6	NNP
cord-258787-n49zrfsp	65	11	G	G	NNP
cord-258787-n49zrfsp	65	12	high	high	JJ
cord-258787-n49zrfsp	65	13	CD101	CD101	NNP
cord-258787-n49zrfsp	65	14	−	−	CD
cord-258787-n49zrfsp	65	15	immature	immature	JJ
cord-258787-n49zrfsp	65	16	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	65	17	in	in	IN
cord-258787-n49zrfsp	65	18	the	the	DT
cord-258787-n49zrfsp	65	19	blood	blood	NN
cord-258787-n49zrfsp	65	20	has	have	VBZ
cord-258787-n49zrfsp	65	21	been	be	VBN
cord-258787-n49zrfsp	65	22	positively	positively	RB
cord-258787-n49zrfsp	65	23	correlated	correlate	VBN
cord-258787-n49zrfsp	65	24	with	with	IN
cord-258787-n49zrfsp	65	25	the	the	DT
cord-258787-n49zrfsp	65	26	tumour	tumour	NN
cord-258787-n49zrfsp	65	27	burden	burden	NN
cord-258787-n49zrfsp	65	28	[	[	-LRB-
cord-258787-n49zrfsp	65	29	47	47	CD
cord-258787-n49zrfsp	65	30	]	]	-RRB-
cord-258787-n49zrfsp	65	31	.	.	.
cord-258787-n49zrfsp	66	1	In	in	IN
cord-258787-n49zrfsp	66	2	both	both	DT
cord-258787-n49zrfsp	66	3	human	human	NN
cord-258787-n49zrfsp	66	4	and	and	CC
cord-258787-n49zrfsp	66	5	mice	mouse	NNS
cord-258787-n49zrfsp	66	6	,	,	,
cord-258787-n49zrfsp	66	7	NePs	NePs	NNP
cord-258787-n49zrfsp	66	8	(	(	-LRB-
cord-258787-n49zrfsp	66	9	see	see	VB
cord-258787-n49zrfsp	66	10	above	above	RB
cord-258787-n49zrfsp	66	11	)	)	-RRB-
cord-258787-n49zrfsp	66	12	,	,	,
cord-258787-n49zrfsp	66	13	are	be	VBP
cord-258787-n49zrfsp	66	14	reported	report	VBN
cord-258787-n49zrfsp	66	15	to	to	TO
cord-258787-n49zrfsp	66	16	infiltrate	infiltrate	VB
cord-258787-n49zrfsp	66	17	the	the	DT
cord-258787-n49zrfsp	66	18	tumour	tumour	NN
cord-258787-n49zrfsp	66	19	tissue	tissue	NN
cord-258787-n49zrfsp	66	20	[	[	-LRB-
cord-258787-n49zrfsp	66	21	14	14	CD
cord-258787-n49zrfsp	66	22	,	,	,
cord-258787-n49zrfsp	66	23	46	46	CD
cord-258787-n49zrfsp	66	24	,	,	,
cord-258787-n49zrfsp	66	25	47	47	CD
cord-258787-n49zrfsp	66	26	,	,	,
cord-258787-n49zrfsp	66	27	60	60	CD
cord-258787-n49zrfsp	66	28	]	]	-RRB-
cord-258787-n49zrfsp	66	29	.	.	.
cord-258787-n49zrfsp	67	1	In	in	IN
cord-258787-n49zrfsp	67	2	particular	particular	JJ
cord-258787-n49zrfsp	67	3	,	,	,
cord-258787-n49zrfsp	67	4	NePs	NePs	NNP
cord-258787-n49zrfsp	67	5	have	have	VBP
cord-258787-n49zrfsp	67	6	been	be	VBN
cord-258787-n49zrfsp	67	7	identified	identify	VBN
cord-258787-n49zrfsp	67	8	in	in	IN
cord-258787-n49zrfsp	67	9	the	the	DT
cord-258787-n49zrfsp	67	10	blood	blood	NN
cord-258787-n49zrfsp	67	11	and	and	CC
cord-258787-n49zrfsp	67	12	tumour	tumour	NN
cord-258787-n49zrfsp	67	13	of	of	IN
cord-258787-n49zrfsp	67	14	melanoma	melanoma	NN
cord-258787-n49zrfsp	67	15	patients	patient	NNS
cord-258787-n49zrfsp	67	16	and	and	CC
cord-258787-n49zrfsp	67	17	reported	report	VBD
cord-258787-n49zrfsp	67	18	to	to	TO
cord-258787-n49zrfsp	67	19	promote	promote	VB
cord-258787-n49zrfsp	67	20	tumour	tumour	NN
cord-258787-n49zrfsp	67	21	growth	growth	NN
cord-258787-n49zrfsp	67	22	in	in	IN
cord-258787-n49zrfsp	67	23	mice	mouse	NNS
cord-258787-n49zrfsp	67	24	through	through	IN
cord-258787-n49zrfsp	67	25	their	-PRON-	PRP$
cord-258787-n49zrfsp	67	26	immunosuppressive	immunosuppressive	JJ
cord-258787-n49zrfsp	67	27	activities	activity	NNS
cord-258787-n49zrfsp	67	28	(	(	-LRB-
cord-258787-n49zrfsp	67	29	see	see	VB
cord-258787-n49zrfsp	67	30	below	below	RB
cord-258787-n49zrfsp	67	31	)	)	-RRB-
cord-258787-n49zrfsp	68	1	[	[	-LRB-
cord-258787-n49zrfsp	68	2	46	46	CD
cord-258787-n49zrfsp	68	3	]	]	-RRB-
cord-258787-n49zrfsp	68	4	.	.	.
cord-258787-n49zrfsp	69	1	Studies	study	NNS
cord-258787-n49zrfsp	69	2	described	describe	VBD
cord-258787-n49zrfsp	69	3	pro	pro	JJ
cord-258787-n49zrfsp	69	4	-	-	JJ
cord-258787-n49zrfsp	69	5	tumoral	tumoral	JJ
cord-258787-n49zrfsp	69	6	capacity	capacity	NN
cord-258787-n49zrfsp	69	7	for	for	IN
cord-258787-n49zrfsp	69	8	immature	immature	JJ
cord-258787-n49zrfsp	69	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	69	10	through	through	IN
cord-258787-n49zrfsp	69	11	their	-PRON-	PRP$
cord-258787-n49zrfsp	69	12	T	t	NN
cord-258787-n49zrfsp	69	13	-	-	HYPH
cord-258787-n49zrfsp	69	14	cell	cell	NN
cord-258787-n49zrfsp	69	15	suppression	suppression	NN
cord-258787-n49zrfsp	69	16	ability	ability	NN
cord-258787-n49zrfsp	69	17	[	[	-LRB-
cord-258787-n49zrfsp	69	18	14	14	CD
cord-258787-n49zrfsp	69	19	,	,	,
cord-258787-n49zrfsp	69	20	61	61	CD
cord-258787-n49zrfsp	69	21	]	]	-RRB-
cord-258787-n49zrfsp	69	22	.	.	.
cord-258787-n49zrfsp	70	1	However	however	RB
cord-258787-n49zrfsp	70	2	,	,	,
cord-258787-n49zrfsp	70	3	not	not	RB
cord-258787-n49zrfsp	70	4	all	all	DT
cord-258787-n49zrfsp	70	5	immature	immature	JJ
cord-258787-n49zrfsp	70	6	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	70	7	show	show	VBP
cord-258787-n49zrfsp	70	8	immunosuppressive	immunosuppressive	JJ
cord-258787-n49zrfsp	70	9	proprieties	propriety	NNS
cord-258787-n49zrfsp	70	10	[	[	-LRB-
cord-258787-n49zrfsp	70	11	62	62	CD
cord-258787-n49zrfsp	70	12	,	,	,
cord-258787-n49zrfsp	70	13	63	63	CD
cord-258787-n49zrfsp	70	14	]	]	-RRB-
cord-258787-n49zrfsp	70	15	and	and	CC
cord-258787-n49zrfsp	70	16	further	further	JJ
cord-258787-n49zrfsp	70	17	investigations	investigation	NNS
cord-258787-n49zrfsp	70	18	are	be	VBP
cord-258787-n49zrfsp	70	19	needed	need	VBN
cord-258787-n49zrfsp	70	20	to	to	TO
cord-258787-n49zrfsp	70	21	fully	fully	RB
cord-258787-n49zrfsp	70	22	understand	understand	VB
cord-258787-n49zrfsp	70	23	the	the	DT
cord-258787-n49zrfsp	70	24	exact	exact	JJ
cord-258787-n49zrfsp	70	25	mechanism	mechanism	NN
cord-258787-n49zrfsp	70	26	in	in	IN
cord-258787-n49zrfsp	70	27	which	which	WDT
cord-258787-n49zrfsp	70	28	these	these	DT
cord-258787-n49zrfsp	70	29	cells	cell	NNS
cord-258787-n49zrfsp	70	30	affect	affect	VBP
cord-258787-n49zrfsp	70	31	tumour	tumour	NN
cord-258787-n49zrfsp	70	32	growth	growth	NN
cord-258787-n49zrfsp	70	33	.	.	.
cord-258787-n49zrfsp	71	1	Once	once	RB
cord-258787-n49zrfsp	71	2	in	in	IN
cord-258787-n49zrfsp	71	3	the	the	DT
cord-258787-n49zrfsp	71	4	circulation	circulation	NN
cord-258787-n49zrfsp	71	5	,	,	,
cord-258787-n49zrfsp	71	6	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	71	7	are	be	VBP
cord-258787-n49zrfsp	71	8	ready	ready	JJ
cord-258787-n49zrfsp	71	9	to	to	TO
cord-258787-n49zrfsp	71	10	migrate	migrate	VB
cord-258787-n49zrfsp	71	11	into	into	IN
cord-258787-n49zrfsp	71	12	the	the	DT
cord-258787-n49zrfsp	71	13	tissues	tissue	NNS
cord-258787-n49zrfsp	71	14	[	[	-LRB-
cord-258787-n49zrfsp	71	15	3	3	CD
cord-258787-n49zrfsp	71	16	]	]	-RRB-
cord-258787-n49zrfsp	71	17	.	.	.
cord-258787-n49zrfsp	72	1	Different	different	JJ
cord-258787-n49zrfsp	72	2	conditions	condition	NNS
cord-258787-n49zrfsp	72	3	provide	provide	VBP
cord-258787-n49zrfsp	72	4	chemotactic	chemotactic	JJ
cord-258787-n49zrfsp	72	5	gradients	gradient	NNS
cord-258787-n49zrfsp	72	6	for	for	IN
cord-258787-n49zrfsp	72	7	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	72	8	recruitment	recruitment	NN
cord-258787-n49zrfsp	72	9	.	.	.
cord-258787-n49zrfsp	73	1	In	in	IN
cord-258787-n49zrfsp	73	2	particular	particular	JJ
cord-258787-n49zrfsp	73	3	,	,	,
cord-258787-n49zrfsp	73	4	Neutrophils	Neutrophils	NNP
cord-258787-n49zrfsp	73	5	express	express	VBP
cord-258787-n49zrfsp	73	6	the	the	DT
cord-258787-n49zrfsp	73	7	chemokine	chemokine	NN
cord-258787-n49zrfsp	73	8	receptors	receptor	NNS
cord-258787-n49zrfsp	73	9	CXCR1	CXCR1	NNS
cord-258787-n49zrfsp	73	10	and	and	CC
cord-258787-n49zrfsp	73	11	CXCR2	CXCR2	NNS
cord-258787-n49zrfsp	73	12	and	and	CC
cord-258787-n49zrfsp	73	13	the	the	DT
cord-258787-n49zrfsp	73	14	presence	presence	NN
cord-258787-n49zrfsp	73	15	of	of	IN
cord-258787-n49zrfsp	73	16	their	-PRON-	PRP$
cord-258787-n49zrfsp	73	17	ligands	ligand	NNS
cord-258787-n49zrfsp	73	18	provides	provide	VBZ
cord-258787-n49zrfsp	73	19	important	important	JJ
cord-258787-n49zrfsp	73	20	chemotactic	chemotactic	JJ
cord-258787-n49zrfsp	73	21	pathways	pathway	NNS
cord-258787-n49zrfsp	73	22	for	for	IN
cord-258787-n49zrfsp	73	23	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	73	24	recruitment	recruitment	NN
cord-258787-n49zrfsp	73	25	to	to	IN
cord-258787-n49zrfsp	73	26	the	the	DT
cord-258787-n49zrfsp	73	27	tissues	tissue	NNS
cord-258787-n49zrfsp	73	28	[	[	-LRB-
cord-258787-n49zrfsp	73	29	64	64	CD
cord-258787-n49zrfsp	73	30	,	,	,
cord-258787-n49zrfsp	73	31	65	65	CD
cord-258787-n49zrfsp	73	32	]	]	-RRB-
cord-258787-n49zrfsp	73	33	.	.	.
cord-258787-n49zrfsp	74	1	Extravasation	extravasation	NN
cord-258787-n49zrfsp	74	2	of	of	IN
cord-258787-n49zrfsp	74	3	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	74	4	across	across	IN
cord-258787-n49zrfsp	74	5	the	the	DT
cord-258787-n49zrfsp	74	6	vascular	vascular	JJ
cord-258787-n49zrfsp	74	7	endothelium	endothelium	NN
cord-258787-n49zrfsp	74	8	is	be	VBZ
cord-258787-n49zrfsp	74	9	a	a	DT
cord-258787-n49zrfsp	74	10	multistep	multistep	JJ
cord-258787-n49zrfsp	74	11	process	process	NN
cord-258787-n49zrfsp	74	12	orchestrated	orchestrate	VBN
cord-258787-n49zrfsp	74	13	by	by	IN
cord-258787-n49zrfsp	74	14	adhesion	adhesion	NN
cord-258787-n49zrfsp	74	15	molecules	molecule	NNS
cord-258787-n49zrfsp	74	16	present	present	JJ
cord-258787-n49zrfsp	74	17	on	on	IN
cord-258787-n49zrfsp	74	18	vascular	vascular	JJ
cord-258787-n49zrfsp	74	19	endothelial	endothelial	JJ
cord-258787-n49zrfsp	74	20	cells	cell	NNS
cord-258787-n49zrfsp	74	21	and	and	CC
cord-258787-n49zrfsp	74	22	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	74	23	.	.	.
cord-258787-n49zrfsp	75	1	This	this	DT
cord-258787-n49zrfsp	75	2	process	process	NN
cord-258787-n49zrfsp	75	3	has	have	VBZ
cord-258787-n49zrfsp	75	4	been	be	VBN
cord-258787-n49zrfsp	75	5	extensively	extensively	RB
cord-258787-n49zrfsp	75	6	studied	study	VBN
cord-258787-n49zrfsp	75	7	and	and	CC
cord-258787-n49zrfsp	75	8	involves	involve	VBZ
cord-258787-n49zrfsp	75	9	the	the	DT
cord-258787-n49zrfsp	75	10	following	follow	VBG
cord-258787-n49zrfsp	75	11	steps	step	NNS
cord-258787-n49zrfsp	75	12	:	:	:
cord-258787-n49zrfsp	75	13	capture	capture	VB
cord-258787-n49zrfsp	75	14	,	,	,
cord-258787-n49zrfsp	75	15	rolling	roll	VBG
cord-258787-n49zrfsp	75	16	,	,	,
cord-258787-n49zrfsp	75	17	arrest	arrest	NN
cord-258787-n49zrfsp	75	18	,	,	,
cord-258787-n49zrfsp	75	19	firm	firm	JJ
cord-258787-n49zrfsp	75	20	adhesion	adhesion	NN
cord-258787-n49zrfsp	75	21	and	and	CC
cord-258787-n49zrfsp	75	22	transmigration	transmigration	NN
cord-258787-n49zrfsp	75	23	[	[	-LRB-
cord-258787-n49zrfsp	75	24	1	1	CD
cord-258787-n49zrfsp	75	25	]	]	-RRB-
cord-258787-n49zrfsp	75	26	.	.	.
cord-258787-n49zrfsp	76	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	76	2	capture	capture	NN
cord-258787-n49zrfsp	76	3	and	and	CC
cord-258787-n49zrfsp	76	4	rolling	roll	VBG
cord-258787-n49zrfsp	76	5	on	on	IN
cord-258787-n49zrfsp	76	6	endothelium	endothelium	NN
cord-258787-n49zrfsp	76	7	occur	occur	VBP
cord-258787-n49zrfsp	76	8	through	through	IN
cord-258787-n49zrfsp	76	9	the	the	DT
cord-258787-n49zrfsp	76	10	initial	initial	JJ
cord-258787-n49zrfsp	76	11	interaction	interaction	NN
cord-258787-n49zrfsp	76	12	of	of	IN
cord-258787-n49zrfsp	76	13	P	p	NN
cord-258787-n49zrfsp	76	14	-	-	HYPH
cord-258787-n49zrfsp	76	15	selectin	selectin	NNP
cord-258787-n49zrfsp	76	16	glycoprotein	glycoprotein	NN
cord-258787-n49zrfsp	76	17	ligand	ligand	NN
cord-258787-n49zrfsp	76	18	1	1	CD
cord-258787-n49zrfsp	76	19	(	(	-LRB-
cord-258787-n49zrfsp	76	20	PSGL1	PSGL1	NNP
cord-258787-n49zrfsp	76	21	)	)	-RRB-
cord-258787-n49zrfsp	76	22	expressed	express	VBN
cord-258787-n49zrfsp	76	23	on	on	IN
cord-258787-n49zrfsp	76	24	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	76	25	with	with	IN
cord-258787-n49zrfsp	76	26	P	p	NN
cord-258787-n49zrfsp	76	27	-	-	HYPH
cord-258787-n49zrfsp	76	28	selectin	selectin	NN
cord-258787-n49zrfsp	76	29	and	and	CC
cord-258787-n49zrfsp	76	30	E	e	NN
cord-258787-n49zrfsp	76	31	-	-	NN
cord-258787-n49zrfsp	76	32	selectin	selectin	JJ
cord-258787-n49zrfsp	77	1	expressed	express	VBN
cord-258787-n49zrfsp	77	2	on	on	IN
cord-258787-n49zrfsp	77	3	endothelial	endothelial	JJ
cord-258787-n49zrfsp	77	4	cells	cell	NNS
cord-258787-n49zrfsp	77	5	.	.	.
cord-258787-n49zrfsp	78	1	In	in	IN
cord-258787-n49zrfsp	78	2	addition	addition	NN
cord-258787-n49zrfsp	78	3	,	,	,
cord-258787-n49zrfsp	78	4	engagement	engagement	NN
cord-258787-n49zrfsp	78	5	of	of	IN
cord-258787-n49zrfsp	78	6	L	L	NNP
cord-258787-n49zrfsp	78	7	-	-	HYPH
cord-258787-n49zrfsp	78	8	selectin	selectin	NNP
cord-258787-n49zrfsp	78	9	expressed	express	VBN
cord-258787-n49zrfsp	78	10	by	by	IN
cord-258787-n49zrfsp	78	11	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	78	12	with	with	IN
cord-258787-n49zrfsp	78	13	sialylated	sialylated	JJ
cord-258787-n49zrfsp	78	14	ligands	ligand	NNS
cord-258787-n49zrfsp	78	15	on	on	IN
cord-258787-n49zrfsp	78	16	endothelial	endothelial	JJ
cord-258787-n49zrfsp	78	17	cells	cell	NNS
cord-258787-n49zrfsp	78	18	is	be	VBZ
cord-258787-n49zrfsp	78	19	also	also	RB
cord-258787-n49zrfsp	78	20	involved	involve	VBN
cord-258787-n49zrfsp	78	21	in	in	IN
cord-258787-n49zrfsp	78	22	the	the	DT
cord-258787-n49zrfsp	78	23	rolling	rolling	NN
cord-258787-n49zrfsp	78	24	of	of	IN
cord-258787-n49zrfsp	78	25	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	78	26	and	and	CC
cord-258787-n49zrfsp	78	27	activation	activation	NN
cord-258787-n49zrfsp	78	28	of	of	IN
cord-258787-n49zrfsp	78	29	integrins	integrin	NNS
cord-258787-n49zrfsp	78	30	[	[	-LRB-
cord-258787-n49zrfsp	78	31	66	66	CD
cord-258787-n49zrfsp	78	32	,	,	,
cord-258787-n49zrfsp	78	33	67	67	CD
cord-258787-n49zrfsp	78	34	]	]	-RRB-
cord-258787-n49zrfsp	78	35	.	.	.
cord-258787-n49zrfsp	79	1	Lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	79	2	function	function	NN
cord-258787-n49zrfsp	79	3	-	-	HYPH
cord-258787-n49zrfsp	79	4	associated	associate	VBN
cord-258787-n49zrfsp	79	5	antigen	antigen	NN
cord-258787-n49zrfsp	79	6	1	1	CD
cord-258787-n49zrfsp	80	1	(	(	-LRB-
cord-258787-n49zrfsp	80	2	LFA-1	LFA-1	NNP
cord-258787-n49zrfsp	80	3	)	)	-RRB-
cord-258787-n49zrfsp	80	4	is	be	VBZ
cord-258787-n49zrfsp	80	5	the	the	DT
cord-258787-n49zrfsp	80	6	principal	principal	JJ
cord-258787-n49zrfsp	80	7	integrin	integrin	NN
cord-258787-n49zrfsp	80	8	which	which	WDT
cord-258787-n49zrfsp	80	9	mediates	mediate	VBZ
cord-258787-n49zrfsp	80	10	arrest	arrest	NN
cord-258787-n49zrfsp	80	11	and	and	CC
cord-258787-n49zrfsp	80	12	firm	firm	JJ
cord-258787-n49zrfsp	80	13	adhesion	adhesion	NN
cord-258787-n49zrfsp	80	14	of	of	IN
cord-258787-n49zrfsp	80	15	rolling	rolling	JJ
cord-258787-n49zrfsp	80	16	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	80	17	.	.	.
cord-258787-n49zrfsp	81	1	LFA-1	LFA-1	NNP
cord-258787-n49zrfsp	81	2	binds	bind	VBZ
cord-258787-n49zrfsp	81	3	to	to	IN
cord-258787-n49zrfsp	81	4	its	-PRON-	PRP$
cord-258787-n49zrfsp	81	5	ligands	ligand	NNS
cord-258787-n49zrfsp	81	6	intercellular	intercellular	JJ
cord-258787-n49zrfsp	81	7	adhesion	adhesion	NN
cord-258787-n49zrfsp	81	8	molecule	molecule	NN
cord-258787-n49zrfsp	81	9	1	1	CD
cord-258787-n49zrfsp	81	10	(	(	-LRB-
cord-258787-n49zrfsp	81	11	ICAM1	ICAM1	NNP
cord-258787-n49zrfsp	81	12	)	)	-RRB-
cord-258787-n49zrfsp	81	13	and	and	CC
cord-258787-n49zrfsp	81	14	ICAM2	ICAM2	NNP
cord-258787-n49zrfsp	81	15	expressed	express	VBD
cord-258787-n49zrfsp	81	16	on	on	IN
cord-258787-n49zrfsp	81	17	the	the	DT
cord-258787-n49zrfsp	81	18	endothelium	endothelium	NN
cord-258787-n49zrfsp	81	19	[	[	-LRB-
cord-258787-n49zrfsp	81	20	68	68	CD
cord-258787-n49zrfsp	81	21	]	]	-RRB-
cord-258787-n49zrfsp	81	22	.	.	.
cord-258787-n49zrfsp	82	1	Once	once	IN
cord-258787-n49zrfsp	82	2	arrested	arrest	VBN
cord-258787-n49zrfsp	82	3	on	on	IN
cord-258787-n49zrfsp	82	4	the	the	DT
cord-258787-n49zrfsp	82	5	endothelium	endothelium	NN
cord-258787-n49zrfsp	82	6	,	,	,
cord-258787-n49zrfsp	82	7	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	82	8	are	be	VBP
cord-258787-n49zrfsp	82	9	ready	ready	JJ
cord-258787-n49zrfsp	82	10	to	to	TO
cord-258787-n49zrfsp	82	11	transmigrate	transmigrate	VB
cord-258787-n49zrfsp	82	12	from	from	IN
cord-258787-n49zrfsp	82	13	the	the	DT
cord-258787-n49zrfsp	82	14	vasculature	vasculature	NN
cord-258787-n49zrfsp	82	15	to	to	IN
cord-258787-n49zrfsp	82	16	the	the	DT
cord-258787-n49zrfsp	82	17	tissue	tissue	NN
cord-258787-n49zrfsp	82	18	where	where	WRB
cord-258787-n49zrfsp	82	19	they	-PRON-	PRP
cord-258787-n49zrfsp	82	20	can	can	MD
cord-258787-n49zrfsp	82	21	play	play	VB
cord-258787-n49zrfsp	82	22	different	different	JJ
cord-258787-n49zrfsp	82	23	roles	role	NNS
cord-258787-n49zrfsp	82	24	depending	depend	VBG
cord-258787-n49zrfsp	82	25	on	on	IN
cord-258787-n49zrfsp	82	26	the	the	DT
cord-258787-n49zrfsp	82	27	tissue	tissue	NN
cord-258787-n49zrfsp	82	28	context	context	NN
cord-258787-n49zrfsp	82	29	or	or	CC
cord-258787-n49zrfsp	82	30	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	82	31	situation	situation	NN
cord-258787-n49zrfsp	82	32	(	(	-LRB-
cord-258787-n49zrfsp	82	33	see	see	VB
cord-258787-n49zrfsp	82	34	below	below	RB
cord-258787-n49zrfsp	82	35	)	)	-RRB-
cord-258787-n49zrfsp	82	36	.	.	.
cord-258787-n49zrfsp	83	1	In	in	IN
cord-258787-n49zrfsp	83	2	addition	addition	NN
cord-258787-n49zrfsp	83	3	to	to	IN
cord-258787-n49zrfsp	83	4	their	-PRON-	PRP$
cord-258787-n49zrfsp	83	5	migration	migration	NN
cord-258787-n49zrfsp	83	6	in	in	IN
cord-258787-n49zrfsp	83	7	tissues	tissue	NNS
cord-258787-n49zrfsp	83	8	,	,	,
cord-258787-n49zrfsp	83	9	evidences	evidence	NNS
cord-258787-n49zrfsp	83	10	showed	show	VBD
cord-258787-n49zrfsp	83	11	that	that	IN
cord-258787-n49zrfsp	83	12	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	83	13	can	can	MD
cord-258787-n49zrfsp	83	14	migrate	migrate	VB
cord-258787-n49zrfsp	83	15	from	from	IN
cord-258787-n49zrfsp	83	16	the	the	DT
cord-258787-n49zrfsp	83	17	inflamed	inflamed	JJ
cord-258787-n49zrfsp	83	18	tissues	tissue	NNS
cord-258787-n49zrfsp	83	19	to	to	IN
cord-258787-n49zrfsp	83	20	the	the	DT
cord-258787-n49zrfsp	83	21	circulation	circulation	NN
cord-258787-n49zrfsp	83	22	through	through	IN
cord-258787-n49zrfsp	83	23	the	the	DT
cord-258787-n49zrfsp	83	24	process	process	NN
cord-258787-n49zrfsp	83	25	of	of	IN
cord-258787-n49zrfsp	83	26	reverse	reverse	JJ
cord-258787-n49zrfsp	83	27	migration	migration	NN
cord-258787-n49zrfsp	83	28	,	,	,
cord-258787-n49zrfsp	83	29	which	which	WDT
cord-258787-n49zrfsp	83	30	has	have	VBZ
cord-258787-n49zrfsp	83	31	been	be	VBN
cord-258787-n49zrfsp	83	32	associated	associate	VBN
cord-258787-n49zrfsp	83	33	with	with	IN
cord-258787-n49zrfsp	83	34	the	the	DT
cord-258787-n49zrfsp	83	35	disruption	disruption	NN
cord-258787-n49zrfsp	83	36	of	of	IN
cord-258787-n49zrfsp	83	37	endothelial	endothelial	JJ
cord-258787-n49zrfsp	83	38	cells	cell	NNS
cord-258787-n49zrfsp	83	39	tight	tight	JJ
cord-258787-n49zrfsp	83	40	junctions	junction	NNS
cord-258787-n49zrfsp	83	41	and	and	CC
cord-258787-n49zrfsp	83	42	an	an	DT
cord-258787-n49zrfsp	83	43	altered	altered	JJ
cord-258787-n49zrfsp	83	44	production	production	NN
cord-258787-n49zrfsp	83	45	of	of	IN
cord-258787-n49zrfsp	83	46	chemoattractant	chemoattractant	NN
cord-258787-n49zrfsp	83	47	molecules	molecule	NNS
cord-258787-n49zrfsp	83	48	[	[	-LRB-
cord-258787-n49zrfsp	83	49	69	69	CD
cord-258787-n49zrfsp	83	50	]	]	-RRB-
cord-258787-n49zrfsp	83	51	[	[	-LRB-
cord-258787-n49zrfsp	83	52	70	70	CD
cord-258787-n49zrfsp	83	53	]	]	-RRB-
cord-258787-n49zrfsp	83	54	[	[	-LRB-
cord-258787-n49zrfsp	83	55	71	71	CD
cord-258787-n49zrfsp	83	56	]	]	-RRB-
cord-258787-n49zrfsp	83	57	.	.	.
cord-258787-n49zrfsp	84	1	The	the	DT
cord-258787-n49zrfsp	84	2	process	process	NN
cord-258787-n49zrfsp	84	3	of	of	IN
cord-258787-n49zrfsp	84	4	reverse	reverse	JJ
cord-258787-n49zrfsp	84	5	migration	migration	NN
cord-258787-n49zrfsp	84	6	has	have	VBZ
cord-258787-n49zrfsp	84	7	been	be	VBN
cord-258787-n49zrfsp	84	8	proposed	propose	VBN
cord-258787-n49zrfsp	84	9	to	to	TO
cord-258787-n49zrfsp	84	10	prevent	prevent	VB
cord-258787-n49zrfsp	84	11	excessive	excessive	JJ
cord-258787-n49zrfsp	84	12	inflammation	inflammation	NN
cord-258787-n49zrfsp	84	13	and	and	CC
cord-258787-n49zrfsp	84	14	tissue	tissue	NN
cord-258787-n49zrfsp	84	15	damage	damage	NN
cord-258787-n49zrfsp	84	16	through	through	IN
cord-258787-n49zrfsp	84	17	the	the	DT
cord-258787-n49zrfsp	84	18	removal	removal	NN
cord-258787-n49zrfsp	84	19	of	of	IN
cord-258787-n49zrfsp	84	20	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	84	21	but	but	CC
cord-258787-n49zrfsp	84	22	could	could	MD
cord-258787-n49zrfsp	84	23	also	also	RB
cord-258787-n49zrfsp	84	24	act	act	VB
cord-258787-n49zrfsp	84	25	as	as	IN
cord-258787-n49zrfsp	84	26	a	a	DT
cord-258787-n49zrfsp	84	27	trigger	trigger	NN
cord-258787-n49zrfsp	84	28	of	of	IN
cord-258787-n49zrfsp	84	29	inflammation	inflammation	NN
cord-258787-n49zrfsp	84	30	in	in	IN
cord-258787-n49zrfsp	84	31	a	a	DT
cord-258787-n49zrfsp	84	32	secondary	secondary	JJ
cord-258787-n49zrfsp	84	33	site	site	NN
cord-258787-n49zrfsp	84	34	through	through	IN
cord-258787-n49zrfsp	84	35	the	the	DT
cord-258787-n49zrfsp	84	36	migration	migration	NN
cord-258787-n49zrfsp	84	37	of	of	IN
cord-258787-n49zrfsp	84	38	activated	activate	VBN
cord-258787-n49zrfsp	84	39	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	84	40	[	[	-LRB-
cord-258787-n49zrfsp	84	41	70	70	CD
cord-258787-n49zrfsp	84	42	,	,	,
cord-258787-n49zrfsp	84	43	72	72	CD
cord-258787-n49zrfsp	84	44	]	]	-RRB-
cord-258787-n49zrfsp	84	45	.	.	.
cord-258787-n49zrfsp	85	1	Therefore	therefore	RB
cord-258787-n49zrfsp	85	2	,	,	,
cord-258787-n49zrfsp	85	3	while	while	IN
cord-258787-n49zrfsp	85	4	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	85	5	trafficking	trafficking	NN
cord-258787-n49zrfsp	85	6	to	to	IN
cord-258787-n49zrfsp	85	7	inflamed	inflamed	JJ
cord-258787-n49zrfsp	85	8	tissues	tissue	NNS
cord-258787-n49zrfsp	85	9	has	have	VBZ
cord-258787-n49zrfsp	85	10	been	be	VBN
cord-258787-n49zrfsp	85	11	extensively	extensively	RB
cord-258787-n49zrfsp	85	12	studied	study	VBN
cord-258787-n49zrfsp	85	13	,	,	,
cord-258787-n49zrfsp	85	14	the	the	DT
cord-258787-n49zrfsp	85	15	mechanism	mechanism	NN
cord-258787-n49zrfsp	85	16	and	and	CC
cord-258787-n49zrfsp	85	17	role	role	NN
cord-258787-n49zrfsp	85	18	of	of	IN
cord-258787-n49zrfsp	85	19	reverse	reverse	JJ
cord-258787-n49zrfsp	85	20	migration	migration	NN
cord-258787-n49zrfsp	85	21	remain	remain	VBP
cord-258787-n49zrfsp	85	22	poorly	poorly	RB
cord-258787-n49zrfsp	85	23	understood	understand	VBN
cord-258787-n49zrfsp	85	24	and	and	CC
cord-258787-n49zrfsp	85	25	future	future	JJ
cord-258787-n49zrfsp	85	26	investigations	investigation	NNS
cord-258787-n49zrfsp	85	27	are	be	VBP
cord-258787-n49zrfsp	85	28	needed	need	VBN
cord-258787-n49zrfsp	85	29	to	to	TO
cord-258787-n49zrfsp	85	30	decipher	decipher	VB
cord-258787-n49zrfsp	85	31	the	the	DT
cord-258787-n49zrfsp	85	32	different	different	JJ
cord-258787-n49zrfsp	85	33	aspects	aspect	NNS
cord-258787-n49zrfsp	85	34	of	of	IN
cord-258787-n49zrfsp	85	35	this	this	DT
cord-258787-n49zrfsp	85	36	process	process	NN
cord-258787-n49zrfsp	85	37	.	.	.
cord-258787-n49zrfsp	86	1	As	as	IN
cord-258787-n49zrfsp	86	2	mentioned	mention	VBN
cord-258787-n49zrfsp	86	3	above	above	RB
cord-258787-n49zrfsp	86	4	,	,	,
cord-258787-n49zrfsp	86	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	86	6	express	express	VBP
cord-258787-n49zrfsp	86	7	CXCR1	CXCR1	NNP
cord-258787-n49zrfsp	86	8	and	and	CC
cord-258787-n49zrfsp	86	9	CXCR2	CXCR2	NNS
cord-258787-n49zrfsp	86	10	,	,	,
cord-258787-n49zrfsp	86	11	which	which	WDT
cord-258787-n49zrfsp	86	12	can	can	MD
cord-258787-n49zrfsp	86	13	bind	bind	VB
cord-258787-n49zrfsp	86	14	to	to	IN
cord-258787-n49zrfsp	86	15	their	-PRON-	PRP$
cord-258787-n49zrfsp	86	16	ligands	ligand	NNS
cord-258787-n49zrfsp	86	17	CXCL1	CXCL1	NNP
cord-258787-n49zrfsp	86	18	,	,	,
cord-258787-n49zrfsp	86	19	CXCL2	cxcl2	NN
cord-258787-n49zrfsp	86	20	,	,	,
cord-258787-n49zrfsp	86	21	CXCL5	CXCL5	NNP
cord-258787-n49zrfsp	86	22	,	,	,
cord-258787-n49zrfsp	86	23	CXCL6	cxcl6	NN
cord-258787-n49zrfsp	86	24	,	,	,
cord-258787-n49zrfsp	86	25	and	and	CC
cord-258787-n49zrfsp	86	26	CXCL8	CXCL8	NNP
cord-258787-n49zrfsp	86	27	released	release	VBN
cord-258787-n49zrfsp	86	28	by	by	IN
cord-258787-n49zrfsp	86	29	tumour	tumour	NN
cord-258787-n49zrfsp	86	30	cells	cell	NNS
cord-258787-n49zrfsp	86	31	,	,	,
cord-258787-n49zrfsp	86	32	stromal	stromal	JJ
cord-258787-n49zrfsp	86	33	cells	cell	NNS
cord-258787-n49zrfsp	86	34	and	and	CC
cord-258787-n49zrfsp	86	35	leukocytes	leukocyte	NNS
cord-258787-n49zrfsp	86	36	in	in	IN
cord-258787-n49zrfsp	86	37	the	the	DT
cord-258787-n49zrfsp	86	38	TME	TME	NNP
cord-258787-n49zrfsp	86	39	[	[	-LRB-
cord-258787-n49zrfsp	86	40	50	50	CD
cord-258787-n49zrfsp	86	41	,	,	,
cord-258787-n49zrfsp	86	42	73	73	CD
cord-258787-n49zrfsp	86	43	]	]	-RRB-
cord-258787-n49zrfsp	86	44	.	.	.
cord-258787-n49zrfsp	87	1	In	in	IN
cord-258787-n49zrfsp	87	2	addition	addition	NN
cord-258787-n49zrfsp	87	3	to	to	IN
cord-258787-n49zrfsp	87	4	chemokines	chemokine	NNS
cord-258787-n49zrfsp	87	5	,	,	,
cord-258787-n49zrfsp	87	6	tumour	tumour	NN
cord-258787-n49zrfsp	87	7	cells	cell	NNS
cord-258787-n49zrfsp	87	8	and	and	CC
cord-258787-n49zrfsp	87	9	tumour	tumour	NN
cord-258787-n49zrfsp	87	10	-	-	HYPH
cord-258787-n49zrfsp	87	11	infiltrating	infiltrate	VBG
cord-258787-n49zrfsp	87	12	leukocytes	leukocyte	NNS
cord-258787-n49zrfsp	87	13	are	be	VBP
cord-258787-n49zrfsp	87	14	reported	report	VBN
cord-258787-n49zrfsp	87	15	to	to	TO
cord-258787-n49zrfsp	87	16	produce	produce	VB
cord-258787-n49zrfsp	87	17	cytokines	cytokine	NNS
cord-258787-n49zrfsp	87	18	involved	involve	VBN
cord-258787-n49zrfsp	87	19	in	in	IN
cord-258787-n49zrfsp	87	20	the	the	DT
cord-258787-n49zrfsp	87	21	development	development	NN
cord-258787-n49zrfsp	87	22	,	,	,
cord-258787-n49zrfsp	87	23	mobilization	mobilization	NN
cord-258787-n49zrfsp	87	24	and	and	CC
cord-258787-n49zrfsp	87	25	recruitment	recruitment	NN
cord-258787-n49zrfsp	87	26	of	of	IN
cord-258787-n49zrfsp	87	27	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	87	28	.	.	.
cord-258787-n49zrfsp	88	1	For	for	IN
cord-258787-n49zrfsp	88	2	instance	instance	NN
cord-258787-n49zrfsp	88	3	,	,	,
cord-258787-n49zrfsp	88	4	T	t	NN
cord-258787-n49zrfsp	88	5	cells	cell	NNS
cord-258787-n49zrfsp	88	6	are	be	VBP
cord-258787-n49zrfsp	88	7	shown	show	VBN
cord-258787-n49zrfsp	88	8	to	to	TO
cord-258787-n49zrfsp	88	9	produce	produce	VB
cord-258787-n49zrfsp	88	10	GM	GM	NNP
cord-258787-n49zrfsp	88	11	-	-	HYPH
cord-258787-n49zrfsp	88	12	CSF	CSF	NNP
cord-258787-n49zrfsp	88	13	,	,	,
cord-258787-n49zrfsp	88	14	TNFα	TNFα	NNP
cord-258787-n49zrfsp	88	15	,	,	,
cord-258787-n49zrfsp	88	16	IL-17	IL-17	NNP
cord-258787-n49zrfsp	88	17	,	,	,
cord-258787-n49zrfsp	88	18	CXCL1	CXCL1	NNP
cord-258787-n49zrfsp	88	19	and	and	CC
cord-258787-n49zrfsp	88	20	CXCL2	CXCL2	NNS
cord-258787-n49zrfsp	88	21	,	,	,
cord-258787-n49zrfsp	88	22	which	which	WDT
cord-258787-n49zrfsp	88	23	can	can	MD
cord-258787-n49zrfsp	88	24	directly	directly	RB
cord-258787-n49zrfsp	88	25	or	or	CC
cord-258787-n49zrfsp	88	26	indirectly	indirectly	RB
cord-258787-n49zrfsp	88	27	recruit	recruit	VB
cord-258787-n49zrfsp	88	28	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	88	29	to	to	IN
cord-258787-n49zrfsp	88	30	the	the	DT
cord-258787-n49zrfsp	88	31	TME	TME	NNP
cord-258787-n49zrfsp	88	32	[	[	-LRB-
cord-258787-n49zrfsp	88	33	14	14	CD
cord-258787-n49zrfsp	88	34	,	,	,
cord-258787-n49zrfsp	88	35	15	15	CD
cord-258787-n49zrfsp	88	36	,	,	,
cord-258787-n49zrfsp	88	37	[	[	-LRB-
cord-258787-n49zrfsp	88	38	74	74	CD
cord-258787-n49zrfsp	88	39	]	]	-RRB-
cord-258787-n49zrfsp	88	40	[	[	-LRB-
cord-258787-n49zrfsp	88	41	75	75	CD
cord-258787-n49zrfsp	88	42	]	]	-RRB-
cord-258787-n49zrfsp	88	43	[	[	-LRB-
cord-258787-n49zrfsp	88	44	76	76	CD
cord-258787-n49zrfsp	88	45	]	]	-RRB-
cord-258787-n49zrfsp	88	46	.	.	.
cord-258787-n49zrfsp	89	1	Tumour	tumour	NN
cord-258787-n49zrfsp	89	2	-	-	HYPH
cord-258787-n49zrfsp	89	3	associated	associate	VBN
cord-258787-n49zrfsp	89	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	89	5	(	(	-LRB-
cord-258787-n49zrfsp	89	6	TANs	tan	NNS
cord-258787-n49zrfsp	89	7	)	)	-RRB-
cord-258787-n49zrfsp	89	8	themselves	-PRON-	PRP
cord-258787-n49zrfsp	89	9	produce	produce	VBP
cord-258787-n49zrfsp	89	10	CXCL1	cxcl1	NN
cord-258787-n49zrfsp	89	11	and	and	CC
cord-258787-n49zrfsp	89	12	CXCL2	cxcl2	NN
cord-258787-n49zrfsp	89	13	,	,	,
cord-258787-n49zrfsp	89	14	which	which	WDT
cord-258787-n49zrfsp	89	15	in	in	IN
cord-258787-n49zrfsp	89	16	turn	turn	NN
cord-258787-n49zrfsp	89	17	enhance	enhance	VBP
cord-258787-n49zrfsp	89	18	their	-PRON-	PRP$
cord-258787-n49zrfsp	89	19	recruitment	recruitment	NN
cord-258787-n49zrfsp	89	20	in	in	IN
cord-258787-n49zrfsp	89	21	the	the	DT
cord-258787-n49zrfsp	89	22	TME	TME	NNP
cord-258787-n49zrfsp	89	23	[	[	-LRB-
cord-258787-n49zrfsp	89	24	77	77	CD
cord-258787-n49zrfsp	89	25	]	]	-RRB-
cord-258787-n49zrfsp	89	26	.	.	.
cord-258787-n49zrfsp	90	1	In	in	IN
cord-258787-n49zrfsp	90	2	different	different	JJ
cord-258787-n49zrfsp	90	3	models	model	NNS
cord-258787-n49zrfsp	90	4	of	of	IN
cord-258787-n49zrfsp	90	5	primary	primary	JJ
cord-258787-n49zrfsp	90	6	carcinogenesis	carcinogenesis	NN
cord-258787-n49zrfsp	90	7	,	,	,
cord-258787-n49zrfsp	90	8	deficiency	deficiency	NN
cord-258787-n49zrfsp	90	9	in	in	IN
cord-258787-n49zrfsp	90	10	CXCR2	CXCR2	NNP
cord-258787-n49zrfsp	90	11	has	have	VBZ
cord-258787-n49zrfsp	90	12	been	be	VBN
cord-258787-n49zrfsp	90	13	associated	associate	VBN
cord-258787-n49zrfsp	90	14	with	with	IN
cord-258787-n49zrfsp	90	15	a	a	DT
cord-258787-n49zrfsp	90	16	dramatic	dramatic	JJ
cord-258787-n49zrfsp	90	17	reduction	reduction	NN
cord-258787-n49zrfsp	90	18	of	of	IN
cord-258787-n49zrfsp	90	19	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	90	20	recruitment	recruitment	NN
cord-258787-n49zrfsp	90	21	in	in	IN
cord-258787-n49zrfsp	90	22	the	the	DT
cord-258787-n49zrfsp	90	23	TME	TME	NNP
cord-258787-n49zrfsp	90	24	associated	associate	VBN
cord-258787-n49zrfsp	90	25	with	with	IN
cord-258787-n49zrfsp	90	26	reduction	reduction	NN
cord-258787-n49zrfsp	90	27	in	in	IN
cord-258787-n49zrfsp	90	28	tumour	tumour	NN
cord-258787-n49zrfsp	90	29	growth	growth	NN
cord-258787-n49zrfsp	90	30	[	[	-LRB-
cord-258787-n49zrfsp	90	31	78	78	CD
cord-258787-n49zrfsp	90	32	,	,	,
cord-258787-n49zrfsp	90	33	79	79	CD
cord-258787-n49zrfsp	90	34	]	]	-RRB-
cord-258787-n49zrfsp	90	35	.	.	.
cord-258787-n49zrfsp	91	1	In	in	IN
cord-258787-n49zrfsp	91	2	addition	addition	NN
cord-258787-n49zrfsp	91	3	to	to	IN
cord-258787-n49zrfsp	91	4	chemokines	chemokine	NNS
cord-258787-n49zrfsp	91	5	,	,	,
cord-258787-n49zrfsp	91	6	tumour	tumour	NN
cord-258787-n49zrfsp	91	7	-	-	HYPH
cord-258787-n49zrfsp	91	8	derived	derive	VBN
cord-258787-n49zrfsp	91	9	oxysterols	oxysterol	NNS
cord-258787-n49zrfsp	91	10	are	be	VBP
cord-258787-n49zrfsp	91	11	also	also	RB
cord-258787-n49zrfsp	91	12	shown	show	VBN
cord-258787-n49zrfsp	91	13	to	to	TO
cord-258787-n49zrfsp	91	14	trigger	trigger	VB
cord-258787-n49zrfsp	91	15	the	the	DT
cord-258787-n49zrfsp	91	16	recruitment	recruitment	NN
cord-258787-n49zrfsp	91	17	of	of	IN
cord-258787-n49zrfsp	91	18	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	91	19	to	to	IN
cord-258787-n49zrfsp	91	20	the	the	DT
cord-258787-n49zrfsp	91	21	TME	TME	NNP
cord-258787-n49zrfsp	91	22	through	through	IN
cord-258787-n49zrfsp	91	23	a	a	DT
cord-258787-n49zrfsp	91	24	CXCR2	cxcr2	NN
cord-258787-n49zrfsp	91	25	dependent	dependent	JJ
cord-258787-n49zrfsp	91	26	mechanism	mechanism	NN
cord-258787-n49zrfsp	91	27	[	[	-LRB-
cord-258787-n49zrfsp	91	28	80	80	CD
cord-258787-n49zrfsp	91	29	]	]	-RRB-
cord-258787-n49zrfsp	91	30	.	.	.
cord-258787-n49zrfsp	92	1	Recent	recent	JJ
cord-258787-n49zrfsp	92	2	investigations	investigation	NNS
cord-258787-n49zrfsp	92	3	showed	show	VBD
cord-258787-n49zrfsp	92	4	that	that	IN
cord-258787-n49zrfsp	92	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	92	6	were	be	VBD
cord-258787-n49zrfsp	92	7	present	present	JJ
cord-258787-n49zrfsp	92	8	in	in	IN
cord-258787-n49zrfsp	92	9	the	the	DT
cord-258787-n49zrfsp	92	10	TME	TME	NNP
cord-258787-n49zrfsp	92	11	at	at	IN
cord-258787-n49zrfsp	92	12	the	the	DT
cord-258787-n49zrfsp	92	13	very	very	RB
cord-258787-n49zrfsp	92	14	early	early	JJ
cord-258787-n49zrfsp	92	15	stages	stage	NNS
cord-258787-n49zrfsp	92	16	of	of	IN
cord-258787-n49zrfsp	92	17	tumour	tumour	NN
cord-258787-n49zrfsp	92	18	growth	growth	NN
cord-258787-n49zrfsp	92	19	.	.	.
cord-258787-n49zrfsp	93	1	Indeed	indeed	RB
cord-258787-n49zrfsp	93	2	,	,	,
cord-258787-n49zrfsp	93	3	intravital	intravital	NNP
cord-258787-n49zrfsp	93	4	multiphoton	multiphoton	NNP
cord-258787-n49zrfsp	93	5	imaging	image	VBG
cord-258787-n49zrfsp	93	6	in	in	IN
cord-258787-n49zrfsp	93	7	transplantable	transplantable	JJ
cord-258787-n49zrfsp	93	8	tumour	tumour	NN
cord-258787-n49zrfsp	93	9	models	model	NNS
cord-258787-n49zrfsp	93	10	of	of	IN
cord-258787-n49zrfsp	93	11	mice	mouse	NNS
cord-258787-n49zrfsp	93	12	with	with	IN
cord-258787-n49zrfsp	93	13	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	93	14	-	-	HYPH
cord-258787-n49zrfsp	93	15	specific	specific	JJ
cord-258787-n49zrfsp	93	16	fluorescence	fluorescence	NN
cord-258787-n49zrfsp	93	17	revealed	reveal	VBD
cord-258787-n49zrfsp	93	18	that	that	IN
cord-258787-n49zrfsp	93	19	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	93	20	were	be	VBD
cord-258787-n49zrfsp	93	21	present	present	JJ
cord-258787-n49zrfsp	93	22	in	in	IN
cord-258787-n49zrfsp	93	23	the	the	DT
cord-258787-n49zrfsp	93	24	TME	TME	NNP
cord-258787-n49zrfsp	93	25	as	as	RB
cord-258787-n49zrfsp	93	26	early	early	RB
cord-258787-n49zrfsp	93	27	as	as	IN
cord-258787-n49zrfsp	93	28	3	3	CD
cord-258787-n49zrfsp	93	29	h	h	NN
cord-258787-n49zrfsp	93	30	after	after	IN
cord-258787-n49zrfsp	93	31	tumour	tumour	NN
cord-258787-n49zrfsp	93	32	cell	cell	NN
cord-258787-n49zrfsp	93	33	injection	injection	NN
cord-258787-n49zrfsp	93	34	and	and	CC
cord-258787-n49zrfsp	93	35	were	be	VBD
cord-258787-n49zrfsp	93	36	present	present	JJ
cord-258787-n49zrfsp	93	37	in	in	IN
cord-258787-n49zrfsp	93	38	the	the	DT
cord-258787-n49zrfsp	93	39	tissue	tissue	NN
cord-258787-n49zrfsp	93	40	up	up	IN
cord-258787-n49zrfsp	93	41	to	to	TO
cord-258787-n49zrfsp	93	42	3	3	CD
cord-258787-n49zrfsp	93	43	days	day	NNS
cord-258787-n49zrfsp	93	44	after	after	IN
cord-258787-n49zrfsp	93	45	tumour	tumour	NN
cord-258787-n49zrfsp	93	46	cell	cell	NN
cord-258787-n49zrfsp	93	47	injection	injection	NN
cord-258787-n49zrfsp	93	48	[	[	-LRB-
cord-258787-n49zrfsp	93	49	81	81	CD
cord-258787-n49zrfsp	93	50	]	]	-RRB-
cord-258787-n49zrfsp	93	51	.	.	.
cord-258787-n49zrfsp	94	1	Here	here	RB
cord-258787-n49zrfsp	94	2	,	,	,
cord-258787-n49zrfsp	94	3	intra	intra	JJ
cord-258787-n49zrfsp	94	4	-	-	JJ
cord-258787-n49zrfsp	94	5	tumoral	tumoral	JJ
cord-258787-n49zrfsp	94	6	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	94	7	showed	show	VBD
cord-258787-n49zrfsp	94	8	lower	low	JJR
cord-258787-n49zrfsp	94	9	motility	motility	NN
cord-258787-n49zrfsp	94	10	compared	compare	VBN
cord-258787-n49zrfsp	94	11	to	to	IN
cord-258787-n49zrfsp	94	12	peri	peri	JJ
cord-258787-n49zrfsp	94	13	-	-	HYPH
cord-258787-n49zrfsp	94	14	tumoral	tumoral	JJ
cord-258787-n49zrfsp	94	15	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	94	16	,	,	,
cord-258787-n49zrfsp	94	17	suggesting	suggest	VBG
cord-258787-n49zrfsp	94	18	that	that	IN
cord-258787-n49zrfsp	94	19	the	the	DT
cord-258787-n49zrfsp	94	20	TME	TME	NNP
cord-258787-n49zrfsp	94	21	can	can	MD
cord-258787-n49zrfsp	94	22	affect	affect	VB
cord-258787-n49zrfsp	94	23	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	94	24	motility	motility	NN
cord-258787-n49zrfsp	94	25	and	and	CC
cord-258787-n49zrfsp	94	26	functions	function	NNS
cord-258787-n49zrfsp	94	27	[	[	-LRB-
cord-258787-n49zrfsp	94	28	81	81	CD
cord-258787-n49zrfsp	94	29	]	]	-RRB-
cord-258787-n49zrfsp	94	30	.	.	.
cord-258787-n49zrfsp	95	1	The	the	DT
cord-258787-n49zrfsp	95	2	classical	classical	JJ
cord-258787-n49zrfsp	95	3	view	view	NN
cord-258787-n49zrfsp	95	4	of	of	IN
cord-258787-n49zrfsp	95	5	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	95	6	roles	role	NNS
cord-258787-n49zrfsp	95	7	has	have	VBZ
cord-258787-n49zrfsp	95	8	long	long	RB
cord-258787-n49zrfsp	95	9	been	be	VBN
cord-258787-n49zrfsp	95	10	limited	limit	VBN
cord-258787-n49zrfsp	95	11	to	to	IN
cord-258787-n49zrfsp	95	12	their	-PRON-	PRP$
cord-258787-n49zrfsp	95	13	effector	effector	NN
cord-258787-n49zrfsp	95	14	functions	function	NNS
cord-258787-n49zrfsp	95	15	in	in	IN
cord-258787-n49zrfsp	95	16	the	the	DT
cord-258787-n49zrfsp	95	17	elimination	elimination	NN
cord-258787-n49zrfsp	95	18	of	of	IN
cord-258787-n49zrfsp	95	19	pathogens	pathogen	NNS
cord-258787-n49zrfsp	95	20	.	.	.
cord-258787-n49zrfsp	96	1	However	however	RB
cord-258787-n49zrfsp	96	2	,	,	,
cord-258787-n49zrfsp	96	3	a	a	DT
cord-258787-n49zrfsp	96	4	growing	grow	VBG
cord-258787-n49zrfsp	96	5	body	body	NN
cord-258787-n49zrfsp	96	6	of	of	IN
cord-258787-n49zrfsp	96	7	evidence	evidence	NN
cord-258787-n49zrfsp	96	8	showed	show	VBD
cord-258787-n49zrfsp	96	9	the	the	DT
cord-258787-n49zrfsp	96	10	recruitment	recruitment	NN
cord-258787-n49zrfsp	96	11	of	of	IN
cord-258787-n49zrfsp	96	12	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	96	13	into	into	IN
cord-258787-n49zrfsp	96	14	naive	naive	JJ
cord-258787-n49zrfsp	96	15	tissues	tissue	NNS
cord-258787-n49zrfsp	96	16	and	and	CC
cord-258787-n49zrfsp	96	17	their	-PRON-	PRP$
cord-258787-n49zrfsp	96	18	role	role	NN
cord-258787-n49zrfsp	96	19	in	in	IN
cord-258787-n49zrfsp	96	20	maintaining	maintain	VBG
cord-258787-n49zrfsp	96	21	tissue	tissue	NN
cord-258787-n49zrfsp	96	22	homeostasis	homeostasis	NN
cord-258787-n49zrfsp	96	23	,	,	,
cord-258787-n49zrfsp	96	24	such	such	JJ
cord-258787-n49zrfsp	96	25	as	as	IN
cord-258787-n49zrfsp	96	26	in	in	IN
cord-258787-n49zrfsp	96	27	the	the	DT
cord-258787-n49zrfsp	96	28	lung	lung	NN
cord-258787-n49zrfsp	96	29	where	where	WRB
cord-258787-n49zrfsp	96	30	pulmonary	pulmonary	JJ
cord-258787-n49zrfsp	96	31	endothelium	endothelium	NN
cord-258787-n49zrfsp	96	32	retains	retain	VBZ
cord-258787-n49zrfsp	96	33	CXCR4	CXCR4	NNS
cord-258787-n49zrfsp	96	34	+	+	CC
cord-258787-n49zrfsp	96	35	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	96	36	through	through	IN
cord-258787-n49zrfsp	96	37	the	the	DT
cord-258787-n49zrfsp	96	38	expression	expression	NN
cord-258787-n49zrfsp	96	39	of	of	IN
cord-258787-n49zrfsp	96	40	CXCL12	CXCL12	NNP
cord-258787-n49zrfsp	96	41	[	[	-LRB-
cord-258787-n49zrfsp	96	42	3	3	CD
cord-258787-n49zrfsp	96	43	,	,	,
cord-258787-n49zrfsp	96	44	82	82	CD
cord-258787-n49zrfsp	96	45	,	,	,
cord-258787-n49zrfsp	96	46	83	83	CD
cord-258787-n49zrfsp	96	47	]	]	-RRB-
cord-258787-n49zrfsp	96	48	.	.	.
cord-258787-n49zrfsp	97	1	Under	under	IN
cord-258787-n49zrfsp	97	2	homeostatic	homeostatic	JJ
cord-258787-n49zrfsp	97	3	condition	condition	NN
cord-258787-n49zrfsp	97	4	,	,	,
cord-258787-n49zrfsp	97	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	97	6	are	be	VBP
cord-258787-n49zrfsp	97	7	also	also	RB
cord-258787-n49zrfsp	97	8	found	find	VBN
cord-258787-n49zrfsp	97	9	in	in	IN
cord-258787-n49zrfsp	97	10	liver	liver	NN
cord-258787-n49zrfsp	97	11	,	,	,
cord-258787-n49zrfsp	97	12	spleen	spleen	NN
cord-258787-n49zrfsp	97	13	and	and	CC
cord-258787-n49zrfsp	97	14	lymph	lymph	NN
cord-258787-n49zrfsp	97	15	nodes	node	NNS
cord-258787-n49zrfsp	97	16	where	where	WRB
cord-258787-n49zrfsp	97	17	they	-PRON-	PRP
cord-258787-n49zrfsp	97	18	play	play	VBP
cord-258787-n49zrfsp	97	19	different	different	JJ
cord-258787-n49zrfsp	97	20	roles	role	NNS
cord-258787-n49zrfsp	97	21	[	[	-LRB-
cord-258787-n49zrfsp	97	22	3	3	CD
cord-258787-n49zrfsp	97	23	,	,	,
cord-258787-n49zrfsp	97	24	84	84	CD
cord-258787-n49zrfsp	97	25	,	,	,
cord-258787-n49zrfsp	97	26	85	85	CD
cord-258787-n49zrfsp	97	27	]	]	-RRB-
cord-258787-n49zrfsp	97	28	.	.	.
cord-258787-n49zrfsp	98	1	Indeed	indeed	RB
cord-258787-n49zrfsp	98	2	,	,	,
cord-258787-n49zrfsp	98	3	liver	liver	NN
cord-258787-n49zrfsp	98	4	infiltrating	infiltrate	VBG
cord-258787-n49zrfsp	98	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	98	6	can	can	MD
cord-258787-n49zrfsp	98	7	participate	participate	VB
cord-258787-n49zrfsp	98	8	in	in	IN
cord-258787-n49zrfsp	98	9	lipid	lipid	NN
cord-258787-n49zrfsp	98	10	metabolism	metabolism	NN
cord-258787-n49zrfsp	98	11	[	[	-LRB-
cord-258787-n49zrfsp	98	12	84	84	CD
cord-258787-n49zrfsp	98	13	]	]	-RRB-
cord-258787-n49zrfsp	98	14	,	,	,
cord-258787-n49zrfsp	98	15	whereas	whereas	IN
cord-258787-n49zrfsp	98	16	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	98	17	present	present	JJ
cord-258787-n49zrfsp	98	18	in	in	IN
cord-258787-n49zrfsp	98	19	the	the	DT
cord-258787-n49zrfsp	98	20	spleen	spleen	NNS
cord-258787-n49zrfsp	98	21	provide	provide	VBP
cord-258787-n49zrfsp	98	22	helper	helper	NN
cord-258787-n49zrfsp	98	23	signals	signal	NNS
cord-258787-n49zrfsp	98	24	to	to	IN
cord-258787-n49zrfsp	98	25	B	b	NN
cord-258787-n49zrfsp	98	26	cells	cell	NNS
cord-258787-n49zrfsp	98	27	through	through	IN
cord-258787-n49zrfsp	98	28	the	the	DT
cord-258787-n49zrfsp	98	29	production	production	NN
cord-258787-n49zrfsp	98	30	of	of	IN
cord-258787-n49zrfsp	98	31	B	b	NN
cord-258787-n49zrfsp	98	32	-	-	HYPH
cord-258787-n49zrfsp	98	33	cell	cell	NN
cord-258787-n49zrfsp	98	34	activating	activate	VBG
cord-258787-n49zrfsp	98	35	factor	factor	NN
cord-258787-n49zrfsp	98	36	(	(	-LRB-
cord-258787-n49zrfsp	98	37	BAFF	BAFF	NNP
cord-258787-n49zrfsp	98	38	)	)	-RRB-
cord-258787-n49zrfsp	98	39	,	,	,
cord-258787-n49zrfsp	98	40	a	a	DT
cord-258787-n49zrfsp	98	41	proliferation	proliferation	NN
cord-258787-n49zrfsp	98	42	-	-	HYPH
cord-258787-n49zrfsp	98	43	inducing	induce	VBG
cord-258787-n49zrfsp	98	44	ligand	ligand	NN
cord-258787-n49zrfsp	98	45	(	(	-LRB-
cord-258787-n49zrfsp	98	46	APRIL	APRIL	NNP
cord-258787-n49zrfsp	98	47	)	)	-RRB-
cord-258787-n49zrfsp	98	48	and	and	CC
cord-258787-n49zrfsp	98	49	IL-21	IL-21	NNP
cord-258787-n49zrfsp	98	50	[	[	-LRB-
cord-258787-n49zrfsp	98	51	85	85	CD
cord-258787-n49zrfsp	98	52	]	]	-RRB-
cord-258787-n49zrfsp	98	53	.	.	.
cord-258787-n49zrfsp	99	1	In	in	IN
cord-258787-n49zrfsp	99	2	lymph	lymph	NN
cord-258787-n49zrfsp	99	3	nodes	node	NNS
cord-258787-n49zrfsp	99	4	,	,	,
cord-258787-n49zrfsp	99	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	99	6	are	be	VBP
cord-258787-n49zrfsp	99	7	mostly	mostly	RB
cord-258787-n49zrfsp	99	8	located	locate	VBN
cord-258787-n49zrfsp	99	9	in	in	IN
cord-258787-n49zrfsp	99	10	proximity	proximity	NN
cord-258787-n49zrfsp	99	11	of	of	IN
cord-258787-n49zrfsp	99	12	T	t	NN
cord-258787-n49zrfsp	99	13	cells	cell	NNS
cord-258787-n49zrfsp	99	14	and	and	CC
cord-258787-n49zrfsp	99	15	natural	natural	JJ
cord-258787-n49zrfsp	99	16	killer	killer	NN
cord-258787-n49zrfsp	99	17	(	(	-LRB-
cord-258787-n49zrfsp	99	18	NK	NK	NNP
cord-258787-n49zrfsp	99	19	)	)	-RRB-
cord-258787-n49zrfsp	99	20	cells	cell	NNS
cord-258787-n49zrfsp	99	21	.	.	.
cord-258787-n49zrfsp	100	1	These	these	DT
cord-258787-n49zrfsp	100	2	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	100	3	express	express	VBP
cord-258787-n49zrfsp	100	4	high	high	JJ
cord-258787-n49zrfsp	100	5	amount	amount	NN
cord-258787-n49zrfsp	100	6	of	of	IN
cord-258787-n49zrfsp	100	7	major	major	JJ
cord-258787-n49zrfsp	100	8	histocompatibility	histocompatibility	NN
cord-258787-n49zrfsp	100	9	complex	complex	NN
cord-258787-n49zrfsp	100	10	II	II	NNP
cord-258787-n49zrfsp	100	11	(	(	-LRB-
cord-258787-n49zrfsp	100	12	MHCII	MHCII	NNP
cord-258787-n49zrfsp	100	13	)	)	-RRB-
cord-258787-n49zrfsp	100	14	,	,	,
cord-258787-n49zrfsp	100	15	suggesting	suggest	VBG
cord-258787-n49zrfsp	100	16	a	a	DT
cord-258787-n49zrfsp	100	17	role	role	NN
cord-258787-n49zrfsp	100	18	in	in	IN
cord-258787-n49zrfsp	100	19	CD4	CD4	NNP
cord-258787-n49zrfsp	100	20	+	+	CC
cord-258787-n49zrfsp	100	21	T	T	NNP
cord-258787-n49zrfsp	100	22	cell	cell	NN
cord-258787-n49zrfsp	100	23	activation	activation	NN
cord-258787-n49zrfsp	100	24	[	[	-LRB-
cord-258787-n49zrfsp	100	25	86	86	CD
cord-258787-n49zrfsp	100	26	]	]	-RRB-
cord-258787-n49zrfsp	100	27	.	.	.
cord-258787-n49zrfsp	101	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	101	2	have	have	VBP
cord-258787-n49zrfsp	101	3	been	be	VBN
cord-258787-n49zrfsp	101	4	also	also	RB
cord-258787-n49zrfsp	101	5	detected	detect	VBN
cord-258787-n49zrfsp	101	6	in	in	IN
cord-258787-n49zrfsp	101	7	other	other	JJ
cord-258787-n49zrfsp	101	8	tissues	tissue	NNS
cord-258787-n49zrfsp	101	9	,	,	,
cord-258787-n49zrfsp	101	10	such	such	JJ
cord-258787-n49zrfsp	101	11	as	as	IN
cord-258787-n49zrfsp	101	12	intestine	intestine	NN
cord-258787-n49zrfsp	101	13	,	,	,
cord-258787-n49zrfsp	101	14	white	white	JJ
cord-258787-n49zrfsp	101	15	adipose	adipose	JJ
cord-258787-n49zrfsp	101	16	tissue	tissue	NN
cord-258787-n49zrfsp	101	17	,	,	,
cord-258787-n49zrfsp	101	18	skin	skin	NN
cord-258787-n49zrfsp	101	19	,	,	,
cord-258787-n49zrfsp	101	20	and	and	CC
cord-258787-n49zrfsp	101	21	skeletal	skeletal	JJ
cord-258787-n49zrfsp	101	22	muscle	muscle	NN
cord-258787-n49zrfsp	101	23	but	but	CC
cord-258787-n49zrfsp	101	24	their	-PRON-	PRP$
cord-258787-n49zrfsp	101	25	role	role	NN
cord-258787-n49zrfsp	101	26	remains	remain	VBZ
cord-258787-n49zrfsp	101	27	to	to	TO
cord-258787-n49zrfsp	101	28	be	be	VB
cord-258787-n49zrfsp	101	29	elucidated	elucidate	VBN
cord-258787-n49zrfsp	101	30	[	[	-LRB-
cord-258787-n49zrfsp	101	31	3	3	CD
cord-258787-n49zrfsp	101	32	]	]	-RRB-
cord-258787-n49zrfsp	101	33	.	.	.
cord-258787-n49zrfsp	102	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	102	2	can	can	MD
cord-258787-n49zrfsp	102	3	detect	detect	VB
cord-258787-n49zrfsp	102	4	a	a	DT
cord-258787-n49zrfsp	102	5	wide	wide	JJ
cord-258787-n49zrfsp	102	6	range	range	NN
cord-258787-n49zrfsp	102	7	of	of	IN
cord-258787-n49zrfsp	102	8	ligands	ligand	NNS
cord-258787-n49zrfsp	102	9	expressed	express	VBN
cord-258787-n49zrfsp	102	10	by	by	IN
cord-258787-n49zrfsp	102	11	microbes	microbe	NNS
cord-258787-n49zrfsp	102	12	through	through	IN
cord-258787-n49zrfsp	102	13	their	-PRON-	PRP$
cord-258787-n49zrfsp	102	14	broad	broad	JJ
cord-258787-n49zrfsp	102	15	repertoire	repertoire	NN
cord-258787-n49zrfsp	102	16	of	of	IN
cord-258787-n49zrfsp	102	17	cell	cell	NN
cord-258787-n49zrfsp	102	18	associated	associate	VBN
cord-258787-n49zrfsp	102	19	and	and	CC
cord-258787-n49zrfsp	102	20	soluble	soluble	JJ
cord-258787-n49zrfsp	102	21	pattern	pattern	NN
cord-258787-n49zrfsp	102	22	recognition	recognition	NN
cord-258787-n49zrfsp	102	23	receptors	receptor	NNS
cord-258787-n49zrfsp	102	24	(	(	-LRB-
cord-258787-n49zrfsp	102	25	PRRs	PRRs	NNP
cord-258787-n49zrfsp	102	26	)	)	-RRB-
cord-258787-n49zrfsp	102	27	and	and	CC
cord-258787-n49zrfsp	102	28	represent	represent	VB
cord-258787-n49zrfsp	102	29	the	the	DT
cord-258787-n49zrfsp	102	30	first	first	JJ
cord-258787-n49zrfsp	102	31	line	line	NN
cord-258787-n49zrfsp	102	32	of	of	IN
cord-258787-n49zrfsp	102	33	defence	defence	NN
cord-258787-n49zrfsp	102	34	against	against	IN
cord-258787-n49zrfsp	102	35	invading	invade	VBG
cord-258787-n49zrfsp	102	36	pathogens	pathogen	NNS
cord-258787-n49zrfsp	102	37	[	[	-LRB-
cord-258787-n49zrfsp	102	38	2	2	CD
cord-258787-n49zrfsp	102	39	,	,	,
cord-258787-n49zrfsp	102	40	29	29	CD
cord-258787-n49zrfsp	102	41	,	,	,
cord-258787-n49zrfsp	102	42	87	87	CD
cord-258787-n49zrfsp	102	43	]	]	-RRB-
cord-258787-n49zrfsp	102	44	.	.	.
cord-258787-n49zrfsp	103	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	103	2	can	can	MD
cord-258787-n49zrfsp	103	3	eliminate	eliminate	VB
cord-258787-n49zrfsp	103	4	pathogens	pathogen	NNS
cord-258787-n49zrfsp	103	5	through	through	IN
cord-258787-n49zrfsp	103	6	phagocytosis	phagocytosis	NN
cord-258787-n49zrfsp	103	7	and	and	CC
cord-258787-n49zrfsp	103	8	production	production	NN
cord-258787-n49zrfsp	103	9	of	of	IN
cord-258787-n49zrfsp	103	10	ROS	ROS	NNP
cord-258787-n49zrfsp	103	11	into	into	IN
cord-258787-n49zrfsp	103	12	the	the	DT
cord-258787-n49zrfsp	103	13	phagocytic	phagocytic	JJ
cord-258787-n49zrfsp	103	14	vacuole	vacuole	NN
cord-258787-n49zrfsp	103	15	,	,	,
cord-258787-n49zrfsp	103	16	discharge	discharge	NN
cord-258787-n49zrfsp	103	17	of	of	IN
cord-258787-n49zrfsp	103	18	cytoplasmic	cytoplasmic	JJ
cord-258787-n49zrfsp	103	19	granules	granule	NNS
cord-258787-n49zrfsp	103	20	containing	contain	VBG
cord-258787-n49zrfsp	103	21	microbicidal	microbicidal	JJ
cord-258787-n49zrfsp	103	22	components	component	NNS
cord-258787-n49zrfsp	103	23	,	,	,
cord-258787-n49zrfsp	103	24	release	release	NN
cord-258787-n49zrfsp	103	25	of	of	IN
cord-258787-n49zrfsp	103	26	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	103	27	extracellular	extracellular	JJ
cord-258787-n49zrfsp	103	28	traps	trap	NNS
cord-258787-n49zrfsp	103	29	(	(	-LRB-
cord-258787-n49zrfsp	103	30	NETs	NETs	NNP
cord-258787-n49zrfsp	103	31	)	)	-RRB-
cord-258787-n49zrfsp	103	32	,	,	,
cord-258787-n49zrfsp	103	33	or	or	CC
cord-258787-n49zrfsp	103	34	indirectly	indirectly	RB
cord-258787-n49zrfsp	103	35	by	by	IN
cord-258787-n49zrfsp	103	36	secreting	secrete	VBG
cord-258787-n49zrfsp	103	37	pro	pro	JJ
cord-258787-n49zrfsp	103	38	-	-	JJ
cord-258787-n49zrfsp	103	39	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	103	40	cytokines	cytokine	NNS
cord-258787-n49zrfsp	103	41	and	and	CC
cord-258787-n49zrfsp	103	42	chemokines	chemokine	NNS
cord-258787-n49zrfsp	103	43	(	(	-LRB-
cord-258787-n49zrfsp	103	44	e.g.	e.g.	RB
cord-258787-n49zrfsp	103	45	TNFα	TNFα	NNP
cord-258787-n49zrfsp	103	46	,	,	,
cord-258787-n49zrfsp	103	47	IL-6	IL-6	NNP
cord-258787-n49zrfsp	103	48	,	,	,
cord-258787-n49zrfsp	103	49	IL-1β	IL-1β	NNP
cord-258787-n49zrfsp	103	50	and	and	CC
cord-258787-n49zrfsp	103	51	IL-8	IL-8	NNP
cord-258787-n49zrfsp	103	52	)	)	-RRB-
cord-258787-n49zrfsp	103	53	[	[	-LRB-
cord-258787-n49zrfsp	103	54	2	2	CD
cord-258787-n49zrfsp	103	55	,	,	,
cord-258787-n49zrfsp	103	56	88	88	CD
cord-258787-n49zrfsp	103	57	,	,	,
cord-258787-n49zrfsp	103	58	89	89	CD
cord-258787-n49zrfsp	103	59	]	]	-RRB-
cord-258787-n49zrfsp	103	60	,	,	,
cord-258787-n49zrfsp	103	61	which	which	WDT
cord-258787-n49zrfsp	103	62	promote	promote	VBP
cord-258787-n49zrfsp	103	63	the	the	DT
cord-258787-n49zrfsp	103	64	recruitment	recruitment	NN
cord-258787-n49zrfsp	103	65	and	and	CC
cord-258787-n49zrfsp	103	66	activation	activation	NN
cord-258787-n49zrfsp	103	67	of	of	IN
cord-258787-n49zrfsp	103	68	other	other	JJ
cord-258787-n49zrfsp	103	69	immune	immune	JJ
cord-258787-n49zrfsp	103	70	cells	cell	NNS
cord-258787-n49zrfsp	103	71	[	[	-LRB-
cord-258787-n49zrfsp	103	72	90	90	CD
cord-258787-n49zrfsp	103	73	]	]	-RRB-
cord-258787-n49zrfsp	103	74	[	[	-LRB-
cord-258787-n49zrfsp	103	75	91	91	CD
cord-258787-n49zrfsp	103	76	]	]	-RRB-
cord-258787-n49zrfsp	103	77	[	[	-LRB-
cord-258787-n49zrfsp	103	78	92	92	CD
cord-258787-n49zrfsp	103	79	]	]	-RRB-
cord-258787-n49zrfsp	103	80	[	[	-LRB-
cord-258787-n49zrfsp	103	81	93	93	CD
cord-258787-n49zrfsp	103	82	]	]	-RRB-
cord-258787-n49zrfsp	103	83	.	.	.
cord-258787-n49zrfsp	104	1	In	in	IN
cord-258787-n49zrfsp	104	2	addition	addition	NN
cord-258787-n49zrfsp	104	3	to	to	IN
cord-258787-n49zrfsp	104	4	their	-PRON-	PRP$
cord-258787-n49zrfsp	104	5	role	role	NN
cord-258787-n49zrfsp	104	6	in	in	IN
cord-258787-n49zrfsp	104	7	defence	defence	NN
cord-258787-n49zrfsp	104	8	against	against	IN
cord-258787-n49zrfsp	104	9	pathogens	pathogen	NNS
cord-258787-n49zrfsp	104	10	,	,	,
cord-258787-n49zrfsp	104	11	NETs	net	NNS
cord-258787-n49zrfsp	104	12	are	be	VBP
cord-258787-n49zrfsp	104	13	reported	report	VBN
cord-258787-n49zrfsp	104	14	to	to	TO
cord-258787-n49zrfsp	104	15	drive	drive	VB
cord-258787-n49zrfsp	104	16	thrombosis	thrombosis	NN
cord-258787-n49zrfsp	104	17	[	[	-LRB-
cord-258787-n49zrfsp	104	18	93	93	CD
cord-258787-n49zrfsp	104	19	,	,	,
cord-258787-n49zrfsp	104	20	94	94	CD
cord-258787-n49zrfsp	104	21	]	]	-RRB-
cord-258787-n49zrfsp	104	22	.	.	.
cord-258787-n49zrfsp	105	1	In	in	IN
cord-258787-n49zrfsp	105	2	Coronavirus	Coronavirus	NNP
cord-258787-n49zrfsp	105	3	disease	disease	NN
cord-258787-n49zrfsp	105	4	2019	2019	CD
cord-258787-n49zrfsp	105	5	(	(	-LRB-
cord-258787-n49zrfsp	105	6	COVID-19	COVID-19	NNP
cord-258787-n49zrfsp	105	7	)	)	-RRB-
cord-258787-n49zrfsp	105	8	patients	patient	NNS
cord-258787-n49zrfsp	105	9	,	,	,
cord-258787-n49zrfsp	105	10	increased	increase	VBN
cord-258787-n49zrfsp	105	11	plasma	plasma	NN
cord-258787-n49zrfsp	105	12	levels	level	NNS
cord-258787-n49zrfsp	105	13	of	of	IN
cord-258787-n49zrfsp	105	14	NETs	net	NNS
cord-258787-n49zrfsp	105	15	were	be	VBD
cord-258787-n49zrfsp	105	16	correlated	correlate	VBN
cord-258787-n49zrfsp	105	17	with	with	IN
cord-258787-n49zrfsp	105	18	the	the	DT
cord-258787-n49zrfsp	105	19	disease	disease	NN
cord-258787-n49zrfsp	105	20	severity	severity	NN
cord-258787-n49zrfsp	105	21	and	and	CC
cord-258787-n49zrfsp	105	22	in	in	IN
cord-258787-n49zrfsp	105	23	autopsy	autopsy	JJ
cord-258787-n49zrfsp	105	24	lung	lung	NN
cord-258787-n49zrfsp	105	25	samples	sample	NNS
cord-258787-n49zrfsp	105	26	from	from	IN
cord-258787-n49zrfsp	105	27	patients	patient	NNS
cord-258787-n49zrfsp	105	28	,	,	,
cord-258787-n49zrfsp	105	29	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	105	30	undergoing	undergo	VBG
cord-258787-n49zrfsp	105	31	NETosis	NETosis	NNP
cord-258787-n49zrfsp	105	32	were	be	VBD
cord-258787-n49zrfsp	105	33	shown	show	VBN
cord-258787-n49zrfsp	105	34	to	to	IN
cord-258787-n49zrfsp	105	35	colocalize	colocalize	NN
cord-258787-n49zrfsp	105	36	with	with	IN
cord-258787-n49zrfsp	105	37	platelets	platelet	NNS
cord-258787-n49zrfsp	105	38	in	in	IN
cord-258787-n49zrfsp	105	39	structures	structure	NNS
cord-258787-n49zrfsp	105	40	consistent	consistent	JJ
cord-258787-n49zrfsp	105	41	with	with	IN
cord-258787-n49zrfsp	105	42	blood	blood	NN
cord-258787-n49zrfsp	105	43	vessels	vessel	NNS
cord-258787-n49zrfsp	105	44	,	,	,
cord-258787-n49zrfsp	105	45	suggesting	suggest	VBG
cord-258787-n49zrfsp	105	46	the	the	DT
cord-258787-n49zrfsp	105	47	role	role	NN
cord-258787-n49zrfsp	105	48	of	of	IN
cord-258787-n49zrfsp	105	49	NETs	net	NNS
cord-258787-n49zrfsp	105	50	in	in	IN
cord-258787-n49zrfsp	105	51	COVID-19	covid-19	JJ
cord-258787-n49zrfsp	105	52	related	related	JJ
cord-258787-n49zrfsp	105	53	thrombosis	thrombosis	NN
cord-258787-n49zrfsp	105	54	[	[	-LRB-
cord-258787-n49zrfsp	105	55	95	95	CD
cord-258787-n49zrfsp	105	56	]	]	-RRB-
cord-258787-n49zrfsp	105	57	.	.	.
cord-258787-n49zrfsp	106	1	These	these	DT
cord-258787-n49zrfsp	106	2	results	result	NNS
cord-258787-n49zrfsp	106	3	suggest	suggest	VBP
cord-258787-n49zrfsp	106	4	NETs	net	NNS
cord-258787-n49zrfsp	106	5	formation	formation	NN
cord-258787-n49zrfsp	106	6	as	as	IN
cord-258787-n49zrfsp	106	7	a	a	DT
cord-258787-n49zrfsp	106	8	potential	potential	JJ
cord-258787-n49zrfsp	106	9	target	target	NN
cord-258787-n49zrfsp	106	10	for	for	IN
cord-258787-n49zrfsp	106	11	COVID-19	covid-19	JJ
cord-258787-n49zrfsp	106	12	treatment	treatment	NN
cord-258787-n49zrfsp	106	13	.	.	.
cord-258787-n49zrfsp	107	1	In	in	IN
cord-258787-n49zrfsp	107	2	a	a	DT
cord-258787-n49zrfsp	107	3	more	more	RBR
cord-258787-n49zrfsp	107	4	general	general	JJ
cord-258787-n49zrfsp	107	5	view	view	NN
cord-258787-n49zrfsp	107	6	,	,	,
cord-258787-n49zrfsp	107	7	these	these	DT
cord-258787-n49zrfsp	107	8	results	result	NNS
cord-258787-n49zrfsp	107	9	highlight	highlight	VBP
cord-258787-n49zrfsp	107	10	that	that	IN
cord-258787-n49zrfsp	107	11	an	an	DT
cord-258787-n49zrfsp	107	12	excessive	excessive	JJ
cord-258787-n49zrfsp	107	13	presence	presence	NN
cord-258787-n49zrfsp	107	14	of	of	IN
cord-258787-n49zrfsp	107	15	activated	activate	VBN
cord-258787-n49zrfsp	107	16	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	107	17	in	in	IN
cord-258787-n49zrfsp	107	18	tissues	tissue	NNS
cord-258787-n49zrfsp	107	19	can	can	MD
cord-258787-n49zrfsp	107	20	be	be	VB
cord-258787-n49zrfsp	107	21	deleterious	deleterious	JJ
cord-258787-n49zrfsp	107	22	for	for	IN
cord-258787-n49zrfsp	107	23	the	the	DT
cord-258787-n49zrfsp	107	24	host	host	NN
cord-258787-n49zrfsp	107	25	[	[	-LRB-
cord-258787-n49zrfsp	107	26	96	96	CD
cord-258787-n49zrfsp	107	27	,	,	,
cord-258787-n49zrfsp	107	28	97	97	CD
cord-258787-n49zrfsp	107	29	]	]	-RRB-
cord-258787-n49zrfsp	107	30	.	.	.
cord-258787-n49zrfsp	108	1	Thus	thus	RB
cord-258787-n49zrfsp	108	2	,	,	,
cord-258787-n49zrfsp	108	3	an	an	DT
cord-258787-n49zrfsp	108	4	efficient	efficient	JJ
cord-258787-n49zrfsp	108	5	resolution	resolution	NN
cord-258787-n49zrfsp	108	6	of	of	IN
cord-258787-n49zrfsp	108	7	inflammation	inflammation	NN
cord-258787-n49zrfsp	108	8	is	be	VBZ
cord-258787-n49zrfsp	108	9	crucial	crucial	JJ
cord-258787-n49zrfsp	108	10	for	for	IN
cord-258787-n49zrfsp	108	11	the	the	DT
cord-258787-n49zrfsp	108	12	restoration	restoration	NN
cord-258787-n49zrfsp	108	13	of	of	IN
cord-258787-n49zrfsp	108	14	tissue	tissue	NN
cord-258787-n49zrfsp	108	15	integrity	integrity	NN
cord-258787-n49zrfsp	108	16	and	and	CC
cord-258787-n49zrfsp	108	17	function	function	NN
cord-258787-n49zrfsp	108	18	after	after	IN
cord-258787-n49zrfsp	108	19	an	an	DT
cord-258787-n49zrfsp	108	20	infection	infection	NN
cord-258787-n49zrfsp	108	21	.	.	.
cord-258787-n49zrfsp	109	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	109	2	are	be	VBP
cord-258787-n49zrfsp	109	3	actively	actively	RB
cord-258787-n49zrfsp	109	4	involved	involve	VBN
cord-258787-n49zrfsp	109	5	in	in	IN
cord-258787-n49zrfsp	109	6	this	this	DT
cord-258787-n49zrfsp	109	7	process	process	NN
cord-258787-n49zrfsp	109	8	through	through	IN
cord-258787-n49zrfsp	109	9	the	the	DT
cord-258787-n49zrfsp	109	10	production	production	NN
cord-258787-n49zrfsp	109	11	of	of	IN
cord-258787-n49zrfsp	109	12	pro	pro	JJ
cord-258787-n49zrfsp	109	13	-	-	JJ
cord-258787-n49zrfsp	109	14	resolving	resolve	VBG
cord-258787-n49zrfsp	109	15	lipid	lipid	NN
cord-258787-n49zrfsp	109	16	mediators	mediator	NNS
cord-258787-n49zrfsp	109	17	(	(	-LRB-
cord-258787-n49zrfsp	109	18	including	include	VBG
cord-258787-n49zrfsp	109	19	resolvins	resolvins	NNP
cord-258787-n49zrfsp	109	20	and	and	CC
cord-258787-n49zrfsp	109	21	protectin	protectin	NNP
cord-258787-n49zrfsp	109	22	D1	D1	NNP
cord-258787-n49zrfsp	109	23	)	)	-RRB-
cord-258787-n49zrfsp	109	24	.	.	.
cord-258787-n49zrfsp	110	1	These	these	DT
cord-258787-n49zrfsp	110	2	molecules	molecule	NNS
cord-258787-n49zrfsp	110	3	can	can	MD
cord-258787-n49zrfsp	110	4	block	block	VB
cord-258787-n49zrfsp	110	5	the	the	DT
cord-258787-n49zrfsp	110	6	infiltration	infiltration	NN
cord-258787-n49zrfsp	110	7	of	of	IN
cord-258787-n49zrfsp	110	8	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	110	9	in	in	IN
cord-258787-n49zrfsp	110	10	tissues	tissue	NNS
cord-258787-n49zrfsp	110	11	and	and	CC
cord-258787-n49zrfsp	110	12	contribute	contribute	VB
cord-258787-n49zrfsp	110	13	to	to	IN
cord-258787-n49zrfsp	110	14	chemokines	chemokine	NNS
cord-258787-n49zrfsp	110	15	and	and	CC
cord-258787-n49zrfsp	110	16	cytokines	cytokine	NNS
cord-258787-n49zrfsp	110	17	scavenging	scavenge	VBG
cord-258787-n49zrfsp	110	18	[	[	-LRB-
cord-258787-n49zrfsp	110	19	2	2	CD
cord-258787-n49zrfsp	110	20	,	,	,
cord-258787-n49zrfsp	110	21	98	98	CD
cord-258787-n49zrfsp	110	22	,	,	,
cord-258787-n49zrfsp	110	23	99	99	CD
cord-258787-n49zrfsp	110	24	]	]	-RRB-
cord-258787-n49zrfsp	110	25	.	.	.
cord-258787-n49zrfsp	111	1	In	in	IN
cord-258787-n49zrfsp	111	2	addition	addition	NN
cord-258787-n49zrfsp	111	3	,	,	,
cord-258787-n49zrfsp	111	4	phagocytosis	phagocytosis	NN
cord-258787-n49zrfsp	111	5	of	of	IN
cord-258787-n49zrfsp	111	6	apoptotic	apoptotic	JJ
cord-258787-n49zrfsp	111	7	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	111	8	changes	change	VBZ
cord-258787-n49zrfsp	111	9	the	the	DT
cord-258787-n49zrfsp	111	10	phenotype	phenotype	NN
cord-258787-n49zrfsp	111	11	of	of	IN
cord-258787-n49zrfsp	111	12	macrophages	macrophage	NNS
cord-258787-n49zrfsp	111	13	to	to	TO
cord-258787-n49zrfsp	111	14	produce	produce	VB
cord-258787-n49zrfsp	111	15	anti	anti	JJ
cord-258787-n49zrfsp	111	16	-	-	JJ
cord-258787-n49zrfsp	111	17	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	111	18	cytokines	cytokine	NNS
cord-258787-n49zrfsp	111	19	such	such	JJ
cord-258787-n49zrfsp	111	20	as	as	IN
cord-258787-n49zrfsp	111	21	TGFβ	TGFβ	NNS
cord-258787-n49zrfsp	111	22	and	and	CC
cord-258787-n49zrfsp	111	23	IL-10	IL-10	NNP
cord-258787-n49zrfsp	111	24	[	[	-LRB-
cord-258787-n49zrfsp	111	25	100	100	CD
cord-258787-n49zrfsp	111	26	]	]	-RRB-
cord-258787-n49zrfsp	111	27	.	.	.
cord-258787-n49zrfsp	112	1	A	a	DT
cord-258787-n49zrfsp	112	2	growing	grow	VBG
cord-258787-n49zrfsp	112	3	number	number	NN
cord-258787-n49zrfsp	112	4	of	of	IN
cord-258787-n49zrfsp	112	5	studies	study	NNS
cord-258787-n49zrfsp	112	6	showed	show	VBD
cord-258787-n49zrfsp	112	7	that	that	IN
cord-258787-n49zrfsp	112	8	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	112	9	can	can	MD
cord-258787-n49zrfsp	112	10	be	be	VB
cord-258787-n49zrfsp	112	11	involved	involve	VBN
cord-258787-n49zrfsp	112	12	in	in	IN
cord-258787-n49zrfsp	112	13	different	different	JJ
cord-258787-n49zrfsp	112	14	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	112	15	and	and	CC
cord-258787-n49zrfsp	112	16	autoimmune	autoimmune	JJ
cord-258787-n49zrfsp	112	17	diseases	disease	NNS
cord-258787-n49zrfsp	112	18	,	,	,
cord-258787-n49zrfsp	112	19	such	such	JJ
cord-258787-n49zrfsp	112	20	as	as	IN
cord-258787-n49zrfsp	112	21	in	in	IN
cord-258787-n49zrfsp	112	22	cardiovascular	cardiovascular	JJ
cord-258787-n49zrfsp	112	23	disorders	disorder	NNS
cord-258787-n49zrfsp	112	24	,	,	,
cord-258787-n49zrfsp	112	25	multiple	multiple	JJ
cord-258787-n49zrfsp	112	26	sclerosis	sclerosis	NN
cord-258787-n49zrfsp	112	27	(	(	-LRB-
cord-258787-n49zrfsp	112	28	MS	MS	NNP
cord-258787-n49zrfsp	112	29	)	)	-RRB-
cord-258787-n49zrfsp	112	30	,	,	,
cord-258787-n49zrfsp	112	31	systemic	systemic	JJ
cord-258787-n49zrfsp	112	32	lupus	lupus	NN
cord-258787-n49zrfsp	112	33	erythematosus	erythematosus	NN
cord-258787-n49zrfsp	112	34	(	(	-LRB-
cord-258787-n49zrfsp	112	35	SLE	SLE	NNP
cord-258787-n49zrfsp	112	36	)	)	-RRB-
cord-258787-n49zrfsp	112	37	and	and	CC
cord-258787-n49zrfsp	112	38	rheumatoid	rheumatoid	NN
cord-258787-n49zrfsp	112	39	arthritis	arthritis	NN
cord-258787-n49zrfsp	112	40	(	(	-LRB-
cord-258787-n49zrfsp	112	41	RA	RA	NNP
cord-258787-n49zrfsp	112	42	)	)	-RRB-
cord-258787-n49zrfsp	112	43	[	[	-LRB-
cord-258787-n49zrfsp	112	44	2	2	CD
cord-258787-n49zrfsp	112	45	,	,	,
cord-258787-n49zrfsp	112	46	[	[	-LRB-
cord-258787-n49zrfsp	112	47	101	101	CD
cord-258787-n49zrfsp	112	48	]	]	-RRB-
cord-258787-n49zrfsp	112	49	[	[	-LRB-
cord-258787-n49zrfsp	112	50	102	102	CD
cord-258787-n49zrfsp	112	51	]	]	-RRB-
cord-258787-n49zrfsp	112	52	[	[	-LRB-
cord-258787-n49zrfsp	112	53	103	103	CD
cord-258787-n49zrfsp	112	54	]	]	-RRB-
cord-258787-n49zrfsp	112	55	[	[	-LRB-
cord-258787-n49zrfsp	112	56	104	104	CD
cord-258787-n49zrfsp	112	57	]	]	-RRB-
cord-258787-n49zrfsp	112	58	.	.	.
cord-258787-n49zrfsp	113	1	Proteins	protein	NNS
cord-258787-n49zrfsp	113	2	stored	store	VBN
cord-258787-n49zrfsp	113	3	in	in	IN
cord-258787-n49zrfsp	113	4	neutrophils	neutrophils	NN
cord-258787-n49zrfsp	113	5	granules	granule	NNS
cord-258787-n49zrfsp	113	6	,	,	,
cord-258787-n49zrfsp	113	7	such	such	JJ
cord-258787-n49zrfsp	113	8	as	as	IN
cord-258787-n49zrfsp	113	9	MPO	MPO	NNP
cord-258787-n49zrfsp	113	10	and	and	CC
cord-258787-n49zrfsp	113	11	LL-37	LL-37	NNP
cord-258787-n49zrfsp	113	12	have	have	VBP
cord-258787-n49zrfsp	113	13	been	be	VBN
cord-258787-n49zrfsp	113	14	associated	associate	VBN
cord-258787-n49zrfsp	113	15	with	with	IN
cord-258787-n49zrfsp	113	16	the	the	DT
cord-258787-n49zrfsp	113	17	process	process	NN
cord-258787-n49zrfsp	113	18	of	of	IN
cord-258787-n49zrfsp	113	19	atherosclerosis	atherosclerosis	NN
cord-258787-n49zrfsp	113	20	through	through	IN
cord-258787-n49zrfsp	113	21	the	the	DT
cord-258787-n49zrfsp	113	22	activation	activation	NN
cord-258787-n49zrfsp	113	23	of	of	IN
cord-258787-n49zrfsp	113	24	endothelial	endothelial	JJ
cord-258787-n49zrfsp	113	25	cells	cell	NNS
cord-258787-n49zrfsp	113	26	and	and	CC
cord-258787-n49zrfsp	113	27	the	the	DT
cord-258787-n49zrfsp	113	28	recruitment	recruitment	NN
cord-258787-n49zrfsp	113	29	of	of	IN
cord-258787-n49zrfsp	113	30	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	113	31	monocytes	monocyte	NNS
cord-258787-n49zrfsp	113	32	,	,	,
cord-258787-n49zrfsp	113	33	respectively	respectively	RB
cord-258787-n49zrfsp	113	34	[	[	-LRB-
cord-258787-n49zrfsp	113	35	105	105	CD
cord-258787-n49zrfsp	113	36	,	,	,
cord-258787-n49zrfsp	113	37	106	106	CD
cord-258787-n49zrfsp	113	38	]	]	-RRB-
cord-258787-n49zrfsp	113	39	.	.	.
cord-258787-n49zrfsp	114	1	NETs	net	NNS
cord-258787-n49zrfsp	114	2	have	have	VBP
cord-258787-n49zrfsp	114	3	also	also	RB
cord-258787-n49zrfsp	114	4	been	be	VBN
cord-258787-n49zrfsp	114	5	associated	associate	VBN
cord-258787-n49zrfsp	114	6	with	with	IN
cord-258787-n49zrfsp	114	7	cardiovascular	cardiovascular	JJ
cord-258787-n49zrfsp	114	8	diseases	disease	NNS
cord-258787-n49zrfsp	114	9	through	through	IN
cord-258787-n49zrfsp	114	10	different	different	JJ
cord-258787-n49zrfsp	114	11	mechanisms	mechanism	NNS
cord-258787-n49zrfsp	114	12	,	,	,
cord-258787-n49zrfsp	114	13	including	include	VBG
cord-258787-n49zrfsp	114	14	activation	activation	NN
cord-258787-n49zrfsp	114	15	of	of	IN
cord-258787-n49zrfsp	114	16	endothelial	endothelial	JJ
cord-258787-n49zrfsp	114	17	cells	cell	NNS
cord-258787-n49zrfsp	114	18	,	,	,
cord-258787-n49zrfsp	114	19	plasmacytoid	plasmacytoid	NNP
cord-258787-n49zrfsp	114	20	dendritic	dendritic	JJ
cord-258787-n49zrfsp	114	21	cells	cell	NNS
cord-258787-n49zrfsp	114	22	(	(	-LRB-
cord-258787-n49zrfsp	114	23	pDCs	pDCs	NNP
cord-258787-n49zrfsp	114	24	)	)	-RRB-
cord-258787-n49zrfsp	114	25	and	and	CC
cord-258787-n49zrfsp	114	26	macrophages	macrophage	NNS
cord-258787-n49zrfsp	114	27	[	[	-LRB-
cord-258787-n49zrfsp	114	28	107	107	CD
cord-258787-n49zrfsp	114	29	,	,	,
cord-258787-n49zrfsp	114	30	108	108	CD
cord-258787-n49zrfsp	114	31	]	]	-RRB-
cord-258787-n49zrfsp	114	32	.	.	.
cord-258787-n49zrfsp	115	1	Accordingly	accordingly	RB
cord-258787-n49zrfsp	115	2	,	,	,
cord-258787-n49zrfsp	115	3	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	115	4	depletion	depletion	NN
cord-258787-n49zrfsp	115	5	in	in	IN
cord-258787-n49zrfsp	115	6	mice	mouse	NNS
cord-258787-n49zrfsp	115	7	decreased	decrease	VBD
cord-258787-n49zrfsp	115	8	the	the	DT
cord-258787-n49zrfsp	115	9	number	number	NN
cord-258787-n49zrfsp	115	10	of	of	IN
cord-258787-n49zrfsp	115	11	monocytes	monocyte	NNS
cord-258787-n49zrfsp	115	12	in	in	IN
cord-258787-n49zrfsp	115	13	aortic	aortic	JJ
cord-258787-n49zrfsp	115	14	lysates	lysate	NNS
cord-258787-n49zrfsp	115	15	and	and	CC
cord-258787-n49zrfsp	115	16	reduced	reduce	VBD
cord-258787-n49zrfsp	115	17	the	the	DT
cord-258787-n49zrfsp	115	18	plaque	plaque	NN
cord-258787-n49zrfsp	115	19	sizes	size	NNS
cord-258787-n49zrfsp	115	20	[	[	-LRB-
cord-258787-n49zrfsp	115	21	109	109	CD
cord-258787-n49zrfsp	115	22	]	]	-RRB-
cord-258787-n49zrfsp	115	23	.	.	.
cord-258787-n49zrfsp	116	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	116	2	have	have	VBP
cord-258787-n49zrfsp	116	3	also	also	RB
cord-258787-n49zrfsp	116	4	been	be	VBN
cord-258787-n49zrfsp	116	5	involved	involve	VBN
cord-258787-n49zrfsp	116	6	in	in	IN
cord-258787-n49zrfsp	116	7	autoimmune	autoimmune	JJ
cord-258787-n49zrfsp	116	8	diseases	disease	NNS
cord-258787-n49zrfsp	116	9	[	[	-LRB-
cord-258787-n49zrfsp	116	10	104	104	CD
cord-258787-n49zrfsp	116	11	]	]	-RRB-
cord-258787-n49zrfsp	116	12	.	.	.
cord-258787-n49zrfsp	117	1	For	for	IN
cord-258787-n49zrfsp	117	2	instance	instance	NN
cord-258787-n49zrfsp	117	3	,	,	,
cord-258787-n49zrfsp	117	4	a	a	DT
cord-258787-n49zrfsp	117	5	population	population	NN
cord-258787-n49zrfsp	117	6	of	of	IN
cord-258787-n49zrfsp	117	7	low	low	JJ
cord-258787-n49zrfsp	117	8	density	density	NN
cord-258787-n49zrfsp	117	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	117	10	producing	produce	VBG
cord-258787-n49zrfsp	117	11	pro	pro	JJ
cord-258787-n49zrfsp	117	12	-	-	JJ
cord-258787-n49zrfsp	117	13	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	117	14	cytokines	cytokine	NNS
cord-258787-n49zrfsp	117	15	(	(	-LRB-
cord-258787-n49zrfsp	117	16	e.g.	e.g.	IN
cord-258787-n49zrfsp	117	17	IFNα	IFNα	NNP
cord-258787-n49zrfsp	117	18	,	,	,
cord-258787-n49zrfsp	117	19	TNFα	TNFα	NNP
cord-258787-n49zrfsp	117	20	)	)	-RRB-
cord-258787-n49zrfsp	117	21	and	and	CC
cord-258787-n49zrfsp	117	22	NETs	NETs	NNP
cord-258787-n49zrfsp	117	23	has	have	VBZ
cord-258787-n49zrfsp	117	24	been	be	VBN
cord-258787-n49zrfsp	117	25	identified	identify	VBN
cord-258787-n49zrfsp	117	26	in	in	IN
cord-258787-n49zrfsp	117	27	SLE	SLE	NNP
cord-258787-n49zrfsp	117	28	patients	patient	NNS
cord-258787-n49zrfsp	117	29	[	[	-LRB-
cord-258787-n49zrfsp	117	30	110	110	CD
cord-258787-n49zrfsp	117	31	]	]	-RRB-
cord-258787-n49zrfsp	117	32	.	.	.
cord-258787-n49zrfsp	118	1	Impaired	impaired	JJ
cord-258787-n49zrfsp	118	2	clearance	clearance	NN
cord-258787-n49zrfsp	118	3	of	of	IN
cord-258787-n49zrfsp	118	4	apoptotic	apoptotic	JJ
cord-258787-n49zrfsp	118	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	118	6	by	by	IN
cord-258787-n49zrfsp	118	7	macrophages	macrophage	NNS
cord-258787-n49zrfsp	118	8	is	be	VBZ
cord-258787-n49zrfsp	118	9	also	also	RB
cord-258787-n49zrfsp	118	10	observed	observe	VBN
cord-258787-n49zrfsp	118	11	in	in	IN
cord-258787-n49zrfsp	118	12	these	these	DT
cord-258787-n49zrfsp	118	13	patients	patient	NNS
cord-258787-n49zrfsp	118	14	[	[	-LRB-
cord-258787-n49zrfsp	118	15	111	111	CD
cord-258787-n49zrfsp	118	16	]	]	-RRB-
cord-258787-n49zrfsp	118	17	.	.	.
cord-258787-n49zrfsp	119	1	Interestingly	interestingly	RB
cord-258787-n49zrfsp	119	2	,	,	,
cord-258787-n49zrfsp	119	3	NETs	net	NNS
cord-258787-n49zrfsp	119	4	can	can	MD
cord-258787-n49zrfsp	119	5	activate	activate	VB
cord-258787-n49zrfsp	119	6	pDCs	pDCs	NNP
cord-258787-n49zrfsp	119	7	,	,	,
cord-258787-n49zrfsp	119	8	which	which	WDT
cord-258787-n49zrfsp	119	9	in	in	IN
cord-258787-n49zrfsp	119	10	turn	turn	NN
cord-258787-n49zrfsp	119	11	produce	produce	VBP
cord-258787-n49zrfsp	119	12	IFNα	IFNα	NNS
cord-258787-n49zrfsp	119	13	and	and	CC
cord-258787-n49zrfsp	119	14	IL-6	IL-6	NNP
cord-258787-n49zrfsp	119	15	to	to	TO
cord-258787-n49zrfsp	119	16	promote	promote	VB
cord-258787-n49zrfsp	119	17	B	b	NN
cord-258787-n49zrfsp	119	18	cell	cell	NN
cord-258787-n49zrfsp	119	19	differentiation	differentiation	NN
cord-258787-n49zrfsp	119	20	into	into	IN
cord-258787-n49zrfsp	119	21	plasma	plasma	NN
cord-258787-n49zrfsp	119	22	cells	cell	NNS
cord-258787-n49zrfsp	119	23	[	[	-LRB-
cord-258787-n49zrfsp	119	24	112	112	CD
cord-258787-n49zrfsp	119	25	,	,	,
cord-258787-n49zrfsp	119	26	113	113	CD
cord-258787-n49zrfsp	119	27	]	]	-RRB-
cord-258787-n49zrfsp	119	28	.	.	.
cord-258787-n49zrfsp	120	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	120	2	can	can	MD
cord-258787-n49zrfsp	120	3	also	also	RB
cord-258787-n49zrfsp	120	4	support	support	VB
cord-258787-n49zrfsp	120	5	the	the	DT
cord-258787-n49zrfsp	120	6	B	b	NN
cord-258787-n49zrfsp	120	7	cell	cell	NN
cord-258787-n49zrfsp	120	8	response	response	NN
cord-258787-n49zrfsp	120	9	through	through	IN
cord-258787-n49zrfsp	120	10	the	the	DT
cord-258787-n49zrfsp	120	11	production	production	NN
cord-258787-n49zrfsp	120	12	of	of	IN
cord-258787-n49zrfsp	120	13	BAFF	BAFF	NNP
cord-258787-n49zrfsp	120	14	[	[	-LRB-
cord-258787-n49zrfsp	120	15	114	114	CD
cord-258787-n49zrfsp	120	16	,	,	,
cord-258787-n49zrfsp	120	17	115	115	CD
cord-258787-n49zrfsp	120	18	]	]	-RRB-
cord-258787-n49zrfsp	120	19	.	.	.
cord-258787-n49zrfsp	121	1	Collectively	collectively	RB
cord-258787-n49zrfsp	121	2	,	,	,
cord-258787-n49zrfsp	121	3	these	these	DT
cord-258787-n49zrfsp	121	4	data	datum	NNS
cord-258787-n49zrfsp	121	5	suggest	suggest	VBP
cord-258787-n49zrfsp	121	6	that	that	IN
cord-258787-n49zrfsp	121	7	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	121	8	,	,	,
cord-258787-n49zrfsp	121	9	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	121	10	-	-	HYPH
cord-258787-n49zrfsp	121	11	derived	derive	VBN
cord-258787-n49zrfsp	121	12	molecules	molecule	NNS
cord-258787-n49zrfsp	121	13	and	and	CC
cord-258787-n49zrfsp	121	14	NETs	net	NNS
cord-258787-n49zrfsp	121	15	represent	represent	VBP
cord-258787-n49zrfsp	121	16	important	important	JJ
cord-258787-n49zrfsp	121	17	targets	target	NNS
cord-258787-n49zrfsp	121	18	for	for	IN
cord-258787-n49zrfsp	121	19	therapy	therapy	NN
cord-258787-n49zrfsp	121	20	in	in	IN
cord-258787-n49zrfsp	121	21	patients	patient	NNS
cord-258787-n49zrfsp	121	22	with	with	IN
cord-258787-n49zrfsp	121	23	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	121	24	and	and	CC
cord-258787-n49zrfsp	121	25	autoimmune	autoimmune	JJ
cord-258787-n49zrfsp	121	26	disorders	disorder	NNS
cord-258787-n49zrfsp	121	27	.	.	.
cord-258787-n49zrfsp	122	1	In	in	IN
cord-258787-n49zrfsp	122	2	steady	steady	JJ
cord-258787-n49zrfsp	122	3	state	state	NN
cord-258787-n49zrfsp	122	4	,	,	,
cord-258787-n49zrfsp	122	5	both	both	DT
cord-258787-n49zrfsp	122	6	circulating	circulate	VBG
cord-258787-n49zrfsp	122	7	and	and	CC
cord-258787-n49zrfsp	122	8	tissue	tissue	NN
cord-258787-n49zrfsp	122	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	122	10	are	be	VBP
cord-258787-n49zrfsp	122	11	endowed	endow	VBN
cord-258787-n49zrfsp	122	12	with	with	IN
cord-258787-n49zrfsp	122	13	functional	functional	JJ
cord-258787-n49zrfsp	122	14	and	and	CC
cord-258787-n49zrfsp	122	15	phenotypic	phenotypic	JJ
cord-258787-n49zrfsp	122	16	characteristics	characteristic	NNS
cord-258787-n49zrfsp	122	17	[	[	-LRB-
cord-258787-n49zrfsp	122	18	16	16	CD
cord-258787-n49zrfsp	122	19	,	,	,
cord-258787-n49zrfsp	122	20	116	116	CD
cord-258787-n49zrfsp	122	21	]	]	-RRB-
cord-258787-n49zrfsp	122	22	.	.	.
cord-258787-n49zrfsp	123	1	Accordingly	accordingly	RB
cord-258787-n49zrfsp	123	2	,	,	,
cord-258787-n49zrfsp	123	3	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	123	4	heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	123	5	has	have	VBZ
cord-258787-n49zrfsp	123	6	been	be	VBN
cord-258787-n49zrfsp	123	7	associated	associate	VBN
cord-258787-n49zrfsp	123	8	with	with	IN
cord-258787-n49zrfsp	123	9	different	different	JJ
cord-258787-n49zrfsp	123	10	parameters	parameter	NNS
cord-258787-n49zrfsp	123	11	,	,	,
cord-258787-n49zrfsp	123	12	such	such	JJ
cord-258787-n49zrfsp	123	13	as	as	IN
cord-258787-n49zrfsp	123	14	maturation	maturation	NN
cord-258787-n49zrfsp	123	15	,	,	,
cord-258787-n49zrfsp	123	16	ageing	age	VBG
cord-258787-n49zrfsp	123	17	or	or	CC
cord-258787-n49zrfsp	123	18	activation	activation	NN
cord-258787-n49zrfsp	123	19	states	state	NNS
cord-258787-n49zrfsp	123	20	in	in	IN
cord-258787-n49zrfsp	123	21	response	response	NN
cord-258787-n49zrfsp	123	22	to	to	IN
cord-258787-n49zrfsp	123	23	signals	signal	NNS
cord-258787-n49zrfsp	123	24	from	from	IN
cord-258787-n49zrfsp	123	25	the	the	DT
cord-258787-n49zrfsp	123	26	tissue	tissue	NN
cord-258787-n49zrfsp	123	27	microenvironment	microenvironment	NN
cord-258787-n49zrfsp	123	28	,	,	,
cord-258787-n49zrfsp	123	29	such	such	JJ
cord-258787-n49zrfsp	123	30	as	as	IN
cord-258787-n49zrfsp	123	31	cytokines	cytokine	NNS
cord-258787-n49zrfsp	123	32	[	[	-LRB-
cord-258787-n49zrfsp	123	33	19	19	CD
cord-258787-n49zrfsp	123	34	]	]	-RRB-
cord-258787-n49zrfsp	123	35	.	.	.
cord-258787-n49zrfsp	124	1	The	the	DT
cord-258787-n49zrfsp	124	2	BM	BM	NNP
cord-258787-n49zrfsp	124	3	is	be	VBZ
cord-258787-n49zrfsp	124	4	the	the	DT
cord-258787-n49zrfsp	124	5	principal	principal	JJ
cord-258787-n49zrfsp	124	6	site	site	NN
cord-258787-n49zrfsp	124	7	of	of	IN
cord-258787-n49zrfsp	124	8	granulopoiesis	granulopoiesis	NN
cord-258787-n49zrfsp	124	9	and	and	CC
cord-258787-n49zrfsp	124	10	elimination	elimination	NN
cord-258787-n49zrfsp	124	11	of	of	IN
cord-258787-n49zrfsp	124	12	aged	aged	JJ
cord-258787-n49zrfsp	124	13	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	124	14	.	.	.
cord-258787-n49zrfsp	125	1	Interestingly	interestingly	RB
cord-258787-n49zrfsp	125	2	,	,	,
cord-258787-n49zrfsp	125	3	in	in	IN
cord-258787-n49zrfsp	125	4	vivo	vivo	NNP
cord-258787-n49zrfsp	125	5	studies	study	NNS
cord-258787-n49zrfsp	125	6	revealed	reveal	VBD
cord-258787-n49zrfsp	125	7	specialized	specialized	JJ
cord-258787-n49zrfsp	125	8	subsets	subset	NNS
cord-258787-n49zrfsp	125	9	of	of	IN
cord-258787-n49zrfsp	125	10	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	125	11	in	in	IN
cord-258787-n49zrfsp	125	12	the	the	DT
cord-258787-n49zrfsp	125	13	BM	BM	NNP
cord-258787-n49zrfsp	125	14	displaying	display	VBG
cord-258787-n49zrfsp	125	15	niche	niche	NN
cord-258787-n49zrfsp	125	16	-	-	HYPH
cord-258787-n49zrfsp	125	17	supportive	supportive	JJ
cord-258787-n49zrfsp	125	18	and	and	CC
cord-258787-n49zrfsp	125	19	HSC	HSC	NNP
cord-258787-n49zrfsp	125	20	-	-	HYPH
cord-258787-n49zrfsp	125	21	supportive	supportive	JJ
cord-258787-n49zrfsp	125	22	functions	function	NNS
cord-258787-n49zrfsp	125	23	.	.	.
cord-258787-n49zrfsp	126	1	In	in	IN
cord-258787-n49zrfsp	126	2	particular	particular	JJ
cord-258787-n49zrfsp	126	3	,	,	,
cord-258787-n49zrfsp	126	4	a	a	DT
cord-258787-n49zrfsp	126	5	subset	subset	NN
cord-258787-n49zrfsp	126	6	of	of	IN
cord-258787-n49zrfsp	126	7	granulocytes	granulocyte	NNS
cord-258787-n49zrfsp	126	8	expressing	express	VBG
cord-258787-n49zrfsp	126	9	the	the	DT
cord-258787-n49zrfsp	126	10	histidine	histidine	NN
cord-258787-n49zrfsp	126	11	-	-	HYPH
cord-258787-n49zrfsp	126	12	decarboxylase	decarboxylase	NN
cord-258787-n49zrfsp	126	13	and	and	CC
cord-258787-n49zrfsp	126	14	histamine	histamine	NN
cord-258787-n49zrfsp	126	15	was	be	VBD
cord-258787-n49zrfsp	126	16	shown	show	VBN
cord-258787-n49zrfsp	126	17	to	to	TO
cord-258787-n49zrfsp	126	18	support	support	VB
cord-258787-n49zrfsp	126	19	the	the	DT
cord-258787-n49zrfsp	126	20	quiescence	quiescence	NN
cord-258787-n49zrfsp	126	21	of	of	IN
cord-258787-n49zrfsp	126	22	myeloid	myeloid	NN
cord-258787-n49zrfsp	126	23	-	-	HYPH
cord-258787-n49zrfsp	126	24	biased	bias	VBN
cord-258787-n49zrfsp	126	25	HSCs	HSCs	.
cord-258787-n49zrfsp	126	26	[	[	-LRB-
cord-258787-n49zrfsp	126	27	117	117	CD
cord-258787-n49zrfsp	126	28	]	]	-RRB-
cord-258787-n49zrfsp	126	29	.	.	.
cord-258787-n49zrfsp	127	1	Moreover	moreover	RB
cord-258787-n49zrfsp	127	2	,	,	,
cord-258787-n49zrfsp	127	3	BM	BM	NNP
cord-258787-n49zrfsp	127	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	127	5	can	can	MD
cord-258787-n49zrfsp	127	6	secrete	secrete	VB
cord-258787-n49zrfsp	127	7	prostaglandin	prostaglandin	NN
cord-258787-n49zrfsp	127	8	E	e	NN
cord-258787-n49zrfsp	127	9	2	2	CD
cord-258787-n49zrfsp	127	10	which	which	WDT
cord-258787-n49zrfsp	127	11	promotes	promote	VBZ
cord-258787-n49zrfsp	127	12	the	the	DT
cord-258787-n49zrfsp	127	13	retention	retention	NN
cord-258787-n49zrfsp	127	14	of	of	IN
cord-258787-n49zrfsp	127	15	HSC	HSC	NNP
cord-258787-n49zrfsp	127	16	in	in	IN
cord-258787-n49zrfsp	127	17	the	the	DT
cord-258787-n49zrfsp	127	18	BM	BM	NNP
cord-258787-n49zrfsp	127	19	through	through	IN
cord-258787-n49zrfsp	127	20	the	the	DT
cord-258787-n49zrfsp	127	21	production	production	NN
cord-258787-n49zrfsp	127	22	of	of	IN
cord-258787-n49zrfsp	127	23	osteopontin	osteopontin	NNP
cord-258787-n49zrfsp	127	24	by	by	IN
cord-258787-n49zrfsp	127	25	the	the	DT
cord-258787-n49zrfsp	127	26	preosteoblasts	preosteoblast	NNS
cord-258787-n49zrfsp	127	27	[	[	-LRB-
cord-258787-n49zrfsp	127	28	118	118	CD
cord-258787-n49zrfsp	127	29	]	]	-RRB-
cord-258787-n49zrfsp	127	30	.	.	.
cord-258787-n49zrfsp	128	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	128	2	are	be	VBP
cord-258787-n49zrfsp	128	3	released	release	VBN
cord-258787-n49zrfsp	128	4	in	in	IN
cord-258787-n49zrfsp	128	5	the	the	DT
cord-258787-n49zrfsp	128	6	blood	blood	NN
cord-258787-n49zrfsp	128	7	following	follow	VBG
cord-258787-n49zrfsp	128	8	a	a	DT
cord-258787-n49zrfsp	128	9	circadian	circadian	NN
cord-258787-n49zrfsp	128	10	rhythm	rhythm	NN
cord-258787-n49zrfsp	128	11	and	and	CC
cord-258787-n49zrfsp	128	12	circulating	circulate	VBG
cord-258787-n49zrfsp	128	13	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	128	14	present	present	VBP
cord-258787-n49zrfsp	128	15	different	different	JJ
cord-258787-n49zrfsp	128	16	phenotypes	phenotype	NNS
cord-258787-n49zrfsp	128	17	over	over	IN
cord-258787-n49zrfsp	128	18	the	the	DT
cord-258787-n49zrfsp	128	19	course	course	NN
cord-258787-n49zrfsp	128	20	of	of	IN
cord-258787-n49zrfsp	128	21	the	the	DT
cord-258787-n49zrfsp	128	22	day	day	NN
cord-258787-n49zrfsp	128	23	in	in	IN
cord-258787-n49zrfsp	128	24	both	both	DT
cord-258787-n49zrfsp	128	25	humans	human	NNS
cord-258787-n49zrfsp	128	26	and	and	CC
cord-258787-n49zrfsp	128	27	mice	mouse	NNS
cord-258787-n49zrfsp	128	28	[	[	-LRB-
cord-258787-n49zrfsp	128	29	19	19	CD
cord-258787-n49zrfsp	128	30	,	,	,
cord-258787-n49zrfsp	128	31	51	51	CD
cord-258787-n49zrfsp	128	32	,	,	,
cord-258787-n49zrfsp	128	33	119	119	CD
cord-258787-n49zrfsp	128	34	,	,	,
cord-258787-n49zrfsp	128	35	120	120	CD
cord-258787-n49zrfsp	128	36	]	]	-RRB-
cord-258787-n49zrfsp	128	37	.	.	.
cord-258787-n49zrfsp	129	1	In	in	IN
cord-258787-n49zrfsp	129	2	particular	particular	JJ
cord-258787-n49zrfsp	129	3	,	,	,
cord-258787-n49zrfsp	129	4	mature	mature	JJ
cord-258787-n49zrfsp	129	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	129	6	freshly	freshly	RB
cord-258787-n49zrfsp	129	7	released	release	VBN
cord-258787-n49zrfsp	129	8	from	from	IN
cord-258787-n49zrfsp	129	9	the	the	DT
cord-258787-n49zrfsp	129	10	BM	BM	NNP
cord-258787-n49zrfsp	129	11	are	be	VBP
cord-258787-n49zrfsp	129	12	described	describe	VBN
cord-258787-n49zrfsp	129	13	as	as	IN
cord-258787-n49zrfsp	129	14	CD62L	cd62l	NN
cord-258787-n49zrfsp	129	15	+	+	.
cord-258787-n49zrfsp	130	1	and	and	CC
cord-258787-n49zrfsp	130	2	CXCR2	CXCR2	NNS
cord-258787-n49zrfsp	130	3	+	+	CC
cord-258787-n49zrfsp	130	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	130	5	.	.	.
cord-258787-n49zrfsp	131	1	Within	within	IN
cord-258787-n49zrfsp	131	2	~6	~6	CD
cord-258787-n49zrfsp	131	3	h	h	NN
cord-258787-n49zrfsp	131	4	in	in	IN
cord-258787-n49zrfsp	131	5	the	the	DT
cord-258787-n49zrfsp	131	6	circulation	circulation	NN
cord-258787-n49zrfsp	131	7	,	,	,
cord-258787-n49zrfsp	131	8	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	131	9	downregulate	downregulate	VBP
cord-258787-n49zrfsp	131	10	the	the	DT
cord-258787-n49zrfsp	131	11	expression	expression	NN
cord-258787-n49zrfsp	131	12	of	of	IN
cord-258787-n49zrfsp	131	13	CD62	CD62	NNP
cord-258787-n49zrfsp	131	14	L	L	NNP
cord-258787-n49zrfsp	131	15	and	and	CC
cord-258787-n49zrfsp	131	16	upregulate	upregulate	VB
cord-258787-n49zrfsp	131	17	the	the	DT
cord-258787-n49zrfsp	131	18	expression	expression	NN
cord-258787-n49zrfsp	131	19	of	of	IN
cord-258787-n49zrfsp	131	20	CXCR4	CXCR4	NNS
cord-258787-n49zrfsp	131	21	and	and	CC
cord-258787-n49zrfsp	131	22	CD11b	CD11b	NNPS
cord-258787-n49zrfsp	131	23	and	and	CC
cord-258787-n49zrfsp	131	24	acquire	acquire	VB
cord-258787-n49zrfsp	131	25	a	a	DT
cord-258787-n49zrfsp	131	26	hypersegmented	hypersegmente	VBN
cord-258787-n49zrfsp	131	27	nuclei	nucleus	NNS
cord-258787-n49zrfsp	131	28	.	.	.
cord-258787-n49zrfsp	132	1	These	these	DT
cord-258787-n49zrfsp	132	2	CXCR4	CXCR4	NNS
cord-258787-n49zrfsp	133	1	+	+	CC
cord-258787-n49zrfsp	134	1	CD11b	CD11b	NNS
cord-258787-n49zrfsp	134	2	+	+	CC
cord-258787-n49zrfsp	135	1	CD62L	CD62L	VBD
cord-258787-n49zrfsp	135	2	low	low	JJ
cord-258787-n49zrfsp	135	3	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	135	4	exhibit	exhibit	NN
cord-258787-n49zrfsp	135	5	increased	increase	VBD
cord-258787-n49zrfsp	135	6	integrin	integrin	NN
cord-258787-n49zrfsp	135	7	activation	activation	NN
cord-258787-n49zrfsp	135	8	and	and	CC
cord-258787-n49zrfsp	135	9	a	a	DT
cord-258787-n49zrfsp	135	10	significant	significant	JJ
cord-258787-n49zrfsp	135	11	capacity	capacity	NN
cord-258787-n49zrfsp	135	12	to	to	TO
cord-258787-n49zrfsp	135	13	form	form	VB
cord-258787-n49zrfsp	135	14	NETs	net	NNS
cord-258787-n49zrfsp	135	15	in	in	IN
cord-258787-n49zrfsp	135	16	inflamed	inflamed	JJ
cord-258787-n49zrfsp	135	17	mouse	mouse	NN
cord-258787-n49zrfsp	135	18	venules	venule	NNS
cord-258787-n49zrfsp	135	19	[	[	-LRB-
cord-258787-n49zrfsp	135	20	119	119	CD
cord-258787-n49zrfsp	135	21	,	,	,
cord-258787-n49zrfsp	135	22	121	121	CD
cord-258787-n49zrfsp	135	23	]	]	-RRB-
cord-258787-n49zrfsp	135	24	.	.	.
cord-258787-n49zrfsp	136	1	These	these	DT
cord-258787-n49zrfsp	136	2	phenotypic	phenotypic	JJ
cord-258787-n49zrfsp	136	3	changes	change	NNS
cord-258787-n49zrfsp	136	4	were	be	VBD
cord-258787-n49zrfsp	136	5	linked	link	VBN
cord-258787-n49zrfsp	136	6	to	to	IN
cord-258787-n49zrfsp	136	7	a	a	DT
cord-258787-n49zrfsp	136	8	circadian	circadian	NN
cord-258787-n49zrfsp	136	9	transcriptional	transcriptional	JJ
cord-258787-n49zrfsp	136	10	oscillation	oscillation	NN
cord-258787-n49zrfsp	136	11	of	of	IN
cord-258787-n49zrfsp	136	12	the	the	DT
cord-258787-n49zrfsp	136	13	transcription	transcription	NN
cord-258787-n49zrfsp	136	14	factor	factor	NN
cord-258787-n49zrfsp	136	15	BMAL1	BMAL1	NNP
cord-258787-n49zrfsp	136	16	which	which	WDT
cord-258787-n49zrfsp	136	17	controls	control	VBZ
cord-258787-n49zrfsp	136	18	the	the	DT
cord-258787-n49zrfsp	136	19	expression	expression	NN
cord-258787-n49zrfsp	136	20	of	of	IN
cord-258787-n49zrfsp	136	21	CXCL2	cxcl2	NN
cord-258787-n49zrfsp	136	22	by	by	IN
cord-258787-n49zrfsp	136	23	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	136	24	.	.	.
cord-258787-n49zrfsp	137	1	In	in	IN
cord-258787-n49zrfsp	137	2	turn	turn	NN
cord-258787-n49zrfsp	137	3	,	,	,
cord-258787-n49zrfsp	137	4	CXCL2	cxcl2	NN
cord-258787-n49zrfsp	137	5	acts	act	NNS
cord-258787-n49zrfsp	137	6	on	on	IN
cord-258787-n49zrfsp	137	7	CXCR2	CXCR2	NNS
cord-258787-n49zrfsp	137	8	to	to	TO
cord-258787-n49zrfsp	137	9	drive	drive	VB
cord-258787-n49zrfsp	137	10	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	137	11	ageing	age	VBG
cord-258787-n49zrfsp	137	12	[	[	-LRB-
cord-258787-n49zrfsp	137	13	119	119	CD
cord-258787-n49zrfsp	137	14	]	]	-RRB-
cord-258787-n49zrfsp	137	15	.	.	.
cord-258787-n49zrfsp	138	1	Heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	138	2	and	and	CC
cord-258787-n49zrfsp	138	3	plasticity	plasticity	NN
cord-258787-n49zrfsp	138	4	of	of	IN
cord-258787-n49zrfsp	138	5	tumour	tumour	NN
cord-258787-n49zrfsp	138	6	infiltrating	infiltrate	VBG
cord-258787-n49zrfsp	138	7	leukocytes	leukocyte	NNS
cord-258787-n49zrfsp	138	8	(	(	-LRB-
cord-258787-n49zrfsp	138	9	TILs	TILs	NNP
cord-258787-n49zrfsp	138	10	)	)	-RRB-
cord-258787-n49zrfsp	138	11	have	have	VBP
cord-258787-n49zrfsp	138	12	been	be	VBN
cord-258787-n49zrfsp	138	13	well	well	RB
cord-258787-n49zrfsp	138	14	characterized	characterize	VBN
cord-258787-n49zrfsp	138	15	.	.	.
cord-258787-n49zrfsp	139	1	Macrophages	macrophage	NNS
cord-258787-n49zrfsp	139	2	served	serve	VBD
cord-258787-n49zrfsp	139	3	as	as	IN
cord-258787-n49zrfsp	139	4	a	a	DT
cord-258787-n49zrfsp	139	5	paradigm	paradigm	NN
cord-258787-n49zrfsp	139	6	for	for	IN
cord-258787-n49zrfsp	139	7	this	this	DT
cord-258787-n49zrfsp	139	8	phenomenon	phenomenon	NN
cord-258787-n49zrfsp	139	9	with	with	IN
cord-258787-n49zrfsp	139	10	classically	classically	RB
cord-258787-n49zrfsp	139	11	activated	activate	VBN
cord-258787-n49zrfsp	139	12	M1	M1	NNP
cord-258787-n49zrfsp	139	13	macrophages	macrophage	NNS
cord-258787-n49zrfsp	139	14	and	and	CC
cord-258787-n49zrfsp	139	15	alternatively	alternatively	RB
cord-258787-n49zrfsp	139	16	activated	activate	VBN
cord-258787-n49zrfsp	139	17	M2	M2	NNP
cord-258787-n49zrfsp	139	18	macrophages	macrophage	NNS
cord-258787-n49zrfsp	139	19	exerting	exert	VBG
cord-258787-n49zrfsp	139	20	anti	anti	JJ
cord-258787-n49zrfsp	139	21	-	-	JJ
cord-258787-n49zrfsp	139	22	tumour	tumour	JJ
cord-258787-n49zrfsp	139	23	and	and	CC
cord-258787-n49zrfsp	139	24	protumour	protumour	NN
cord-258787-n49zrfsp	139	25	activities	activity	NNS
cord-258787-n49zrfsp	139	26	,	,	,
cord-258787-n49zrfsp	139	27	respectively	respectively	RB
cord-258787-n49zrfsp	139	28	[	[	-LRB-
cord-258787-n49zrfsp	139	29	13	13	CD
cord-258787-n49zrfsp	139	30	,	,	,
cord-258787-n49zrfsp	139	31	122	122	CD
cord-258787-n49zrfsp	139	32	]	]	-RRB-
cord-258787-n49zrfsp	139	33	.	.	.
cord-258787-n49zrfsp	140	1	TANs	tan	NNS
cord-258787-n49zrfsp	140	2	can	can	MD
cord-258787-n49zrfsp	140	3	also	also	RB
cord-258787-n49zrfsp	140	4	undergo	undergo	VB
cord-258787-n49zrfsp	140	5	two	two	CD
cord-258787-n49zrfsp	140	6	different	different	JJ
cord-258787-n49zrfsp	140	7	polarization	polarization	NN
cord-258787-n49zrfsp	140	8	states	state	NNS
cord-258787-n49zrfsp	140	9	and	and	CC
cord-258787-n49zrfsp	140	10	by	by	IN
cord-258787-n49zrfsp	140	11	analogy	analogy	NN
cord-258787-n49zrfsp	140	12	with	with	IN
cord-258787-n49zrfsp	140	13	the	the	DT
cord-258787-n49zrfsp	140	14	nomenclature	nomenclature	NN
cord-258787-n49zrfsp	140	15	of	of	IN
cord-258787-n49zrfsp	140	16	M1	M1	NNP
cord-258787-n49zrfsp	140	17	and	and	CC
cord-258787-n49zrfsp	140	18	M2	M2	NNP
cord-258787-n49zrfsp	140	19	macrophages	macrophage	NNS
cord-258787-n49zrfsp	140	20	,	,	,
cord-258787-n49zrfsp	140	21	TANs	tan	NNS
cord-258787-n49zrfsp	140	22	are	be	VBP
cord-258787-n49zrfsp	140	23	classified	classify	VBN
cord-258787-n49zrfsp	140	24	into	into	IN
cord-258787-n49zrfsp	140	25	anti	anti	JJ
cord-258787-n49zrfsp	140	26	-	-	JJ
cord-258787-n49zrfsp	140	27	tumour	tumour	JJ
cord-258787-n49zrfsp	140	28	N1	n1	NN
cord-258787-n49zrfsp	140	29	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	140	30	and	and	CC
cord-258787-n49zrfsp	140	31	pro	pro	JJ
cord-258787-n49zrfsp	140	32	-	-	JJ
cord-258787-n49zrfsp	140	33	tumour	tumour	JJ
cord-258787-n49zrfsp	140	34	N2	n2	NN
cord-258787-n49zrfsp	140	35	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	140	36	.	.	.
cord-258787-n49zrfsp	141	1	Here	here	RB
cord-258787-n49zrfsp	141	2	,	,	,
cord-258787-n49zrfsp	141	3	TGFβ	TGFβ	NNP
cord-258787-n49zrfsp	141	4	presents	present	VBZ
cord-258787-n49zrfsp	141	5	in	in	IN
cord-258787-n49zrfsp	141	6	the	the	DT
cord-258787-n49zrfsp	141	7	TME	TME	NNP
cord-258787-n49zrfsp	141	8	drives	drive	VBZ
cord-258787-n49zrfsp	141	9	the	the	DT
cord-258787-n49zrfsp	141	10	polarization	polarization	NN
cord-258787-n49zrfsp	141	11	towards	towards	IN
cord-258787-n49zrfsp	141	12	the	the	DT
cord-258787-n49zrfsp	141	13	N2	N2	NNP
cord-258787-n49zrfsp	141	14	phenotype	phenotype	NN
cord-258787-n49zrfsp	141	15	[	[	-LRB-
cord-258787-n49zrfsp	141	16	44	44	CD
cord-258787-n49zrfsp	141	17	]	]	-RRB-
cord-258787-n49zrfsp	141	18	.	.	.
cord-258787-n49zrfsp	142	1	N1	n1	NN
cord-258787-n49zrfsp	142	2	TANs	tan	NNS
cord-258787-n49zrfsp	142	3	have	have	VBP
cord-258787-n49zrfsp	142	4	been	be	VBN
cord-258787-n49zrfsp	142	5	characterized	characterize	VBN
cord-258787-n49zrfsp	142	6	by	by	IN
cord-258787-n49zrfsp	142	7	their	-PRON-	PRP$
cord-258787-n49zrfsp	142	8	cytotoxic	cytotoxic	JJ
cord-258787-n49zrfsp	142	9	activity	activity	NN
cord-258787-n49zrfsp	142	10	towards	towards	IN
cord-258787-n49zrfsp	142	11	tumour	tumour	NN
cord-258787-n49zrfsp	142	12	cells	cell	NNS
cord-258787-n49zrfsp	142	13	,	,	,
cord-258787-n49zrfsp	142	14	their	-PRON-	PRP$
cord-258787-n49zrfsp	142	15	capacity	capacity	NN
cord-258787-n49zrfsp	142	16	to	to	TO
cord-258787-n49zrfsp	142	17	produce	produce	VB
cord-258787-n49zrfsp	142	18	T	T	NNP
cord-258787-n49zrfsp	142	19	cell	cell	NN
cord-258787-n49zrfsp	142	20	chemokines	chemokine	NNS
cord-258787-n49zrfsp	142	21	CCL3	CCL3	NNP
cord-258787-n49zrfsp	142	22	,	,	,
cord-258787-n49zrfsp	142	23	CXCL9	CXCL9	NNP
cord-258787-n49zrfsp	142	24	and	and	CC
cord-258787-n49zrfsp	142	25	CXCL10	CXCL10	NNP
cord-258787-n49zrfsp	142	26	and	and	CC
cord-258787-n49zrfsp	142	27	to	to	TO
cord-258787-n49zrfsp	142	28	sustain	sustain	VB
cord-258787-n49zrfsp	142	29	CD8	CD8	NNP
cord-258787-n49zrfsp	142	30	+	+	CC
cord-258787-n49zrfsp	142	31	T	T	NNP
cord-258787-n49zrfsp	142	32	cells	cell	NNS
cord-258787-n49zrfsp	142	33	activation	activation	VBP
cord-258787-n49zrfsp	142	34	[	[	-LRB-
cord-258787-n49zrfsp	142	35	77	77	CD
cord-258787-n49zrfsp	142	36	]	]	-RRB-
cord-258787-n49zrfsp	142	37	.	.	.
cord-258787-n49zrfsp	143	1	In	in	IN
cord-258787-n49zrfsp	143	2	contrast	contrast	NN
cord-258787-n49zrfsp	143	3	,	,	,
cord-258787-n49zrfsp	143	4	N2	N2	NNP
cord-258787-n49zrfsp	143	5	TANs	tan	NNS
cord-258787-n49zrfsp	143	6	showed	show	VBD
cord-258787-n49zrfsp	143	7	a	a	DT
cord-258787-n49zrfsp	143	8	pro	pro	JJ
cord-258787-n49zrfsp	143	9	-	-	JJ
cord-258787-n49zrfsp	143	10	tumour	tumour	JJ
cord-258787-n49zrfsp	143	11	phenotype	phenotype	NN
cord-258787-n49zrfsp	143	12	characterized	characterize	VBN
cord-258787-n49zrfsp	143	13	by	by	IN
cord-258787-n49zrfsp	143	14	the	the	DT
cord-258787-n49zrfsp	143	15	release	release	NN
cord-258787-n49zrfsp	143	16	of	of	IN
cord-258787-n49zrfsp	143	17	proangiogenic	proangiogenic	JJ
cord-258787-n49zrfsp	143	18	factors	factor	NNS
cord-258787-n49zrfsp	143	19	(	(	-LRB-
cord-258787-n49zrfsp	143	20	e.g.	e.g.	IN
cord-258787-n49zrfsp	143	21	matrix	matrix	NN
cord-258787-n49zrfsp	143	22	metallopeptidase	metallopeptidase	NNP
cord-258787-n49zrfsp	143	23	9	9	CD
cord-258787-n49zrfsp	143	24	(	(	-LRB-
cord-258787-n49zrfsp	143	25	MMP-9	MMP-9	NNP
cord-258787-n49zrfsp	143	26	)	)	-RRB-
cord-258787-n49zrfsp	143	27	)	)	-RRB-
cord-258787-n49zrfsp	143	28	and	and	CC
cord-258787-n49zrfsp	143	29	the	the	DT
cord-258787-n49zrfsp	143	30	inhibition	inhibition	NN
cord-258787-n49zrfsp	143	31	of	of	IN
cord-258787-n49zrfsp	143	32	CD8	CD8	NNP
cord-258787-n49zrfsp	143	33	+	+	CC
cord-258787-n49zrfsp	143	34	T	T	NNP
cord-258787-n49zrfsp	143	35	cells	cell	NNS
cord-258787-n49zrfsp	143	36	activation	activation	VBP
cord-258787-n49zrfsp	143	37	through	through	IN
cord-258787-n49zrfsp	143	38	secretion	secretion	NN
cord-258787-n49zrfsp	143	39	of	of	IN
cord-258787-n49zrfsp	143	40	arginase	arginase	NN
cord-258787-n49zrfsp	143	41	1	1	CD
cord-258787-n49zrfsp	143	42	(	(	-LRB-
cord-258787-n49zrfsp	143	43	Arg1	Arg1	NNP
cord-258787-n49zrfsp	143	44	)	)	-RRB-
cord-258787-n49zrfsp	143	45	[	[	-LRB-
cord-258787-n49zrfsp	143	46	44	44	CD
cord-258787-n49zrfsp	143	47	,	,	,
cord-258787-n49zrfsp	143	48	77	77	CD
cord-258787-n49zrfsp	143	49	]	]	-RRB-
cord-258787-n49zrfsp	143	50	.	.	.
cord-258787-n49zrfsp	144	1	Neutrophil	neutrophil	JJ
cord-258787-n49zrfsp	144	2	differentiation	differentiation	NN
cord-258787-n49zrfsp	144	3	and	and	CC
cord-258787-n49zrfsp	144	4	maturation	maturation	NN
cord-258787-n49zrfsp	144	5	trajectories	trajectory	NNS
cord-258787-n49zrfsp	144	6	are	be	VBP
cord-258787-n49zrfsp	144	7	profoundly	profoundly	RB
cord-258787-n49zrfsp	144	8	altered	alter	VBN
cord-258787-n49zrfsp	144	9	in	in	IN
cord-258787-n49zrfsp	144	10	tumour	tumour	NN
cord-258787-n49zrfsp	144	11	-	-	HYPH
cord-258787-n49zrfsp	144	12	bearing	bear	VBG
cord-258787-n49zrfsp	144	13	mice	mouse	NNS
cord-258787-n49zrfsp	144	14	[	[	-LRB-
cord-258787-n49zrfsp	144	15	57	57	CD
cord-258787-n49zrfsp	144	16	,	,	,
cord-258787-n49zrfsp	144	17	123	123	CD
cord-258787-n49zrfsp	144	18	]	]	-RRB-
cord-258787-n49zrfsp	144	19	.	.	.
cord-258787-n49zrfsp	145	1	In	in	IN
cord-258787-n49zrfsp	145	2	advanced	advanced	JJ
cord-258787-n49zrfsp	145	3	neoplasia	neoplasia	NN
cord-258787-n49zrfsp	145	4	,	,	,
cord-258787-n49zrfsp	145	5	immature	immature	JJ
cord-258787-n49zrfsp	145	6	myeloid	myeloid	NN
cord-258787-n49zrfsp	145	7	cells	cell	NNS
cord-258787-n49zrfsp	145	8	endowed	endow	VBN
cord-258787-n49zrfsp	145	9	with	with	IN
cord-258787-n49zrfsp	145	10	immunosuppressive	immunosuppressive	JJ
cord-258787-n49zrfsp	145	11	properties	property	NNS
cord-258787-n49zrfsp	145	12	appear	appear	VBP
cord-258787-n49zrfsp	145	13	in	in	IN
cord-258787-n49zrfsp	145	14	the	the	DT
cord-258787-n49zrfsp	145	15	circulation	circulation	NN
cord-258787-n49zrfsp	145	16	,	,	,
cord-258787-n49zrfsp	145	17	primary	primary	JJ
cord-258787-n49zrfsp	145	18	tumours	tumour	NNS
cord-258787-n49zrfsp	145	19	and	and	CC
cord-258787-n49zrfsp	145	20	metastases	metastasis	NNS
cord-258787-n49zrfsp	145	21	,	,	,
cord-258787-n49zrfsp	145	22	often	often	RB
cord-258787-n49zrfsp	145	23	referred	refer	VBD
cord-258787-n49zrfsp	145	24	to	to	IN
cord-258787-n49zrfsp	145	25	as	as	IN
cord-258787-n49zrfsp	145	26	monocytes	monocyte	NNS
cord-258787-n49zrfsp	145	27	or	or	CC
cord-258787-n49zrfsp	145	28	granulocytes	granulocyte	NNS
cord-258787-n49zrfsp	145	29	-	-	HYPH
cord-258787-n49zrfsp	145	30	myeloid	myeloid	NN
cord-258787-n49zrfsp	145	31	-	-	HYPH
cord-258787-n49zrfsp	145	32	derived	derive	VBN
cord-258787-n49zrfsp	145	33	suppressor	suppressor	NN
cord-258787-n49zrfsp	145	34	cells	cell	NNS
cord-258787-n49zrfsp	146	1	(	(	-LRB-
cord-258787-n49zrfsp	146	2	M	M	NNP
cord-258787-n49zrfsp	146	3	-	-	HYPH
cord-258787-n49zrfsp	146	4	MDSCs	MDSCs	NNP
cord-258787-n49zrfsp	146	5	or	or	CC
cord-258787-n49zrfsp	146	6	G	g	NN
cord-258787-n49zrfsp	146	7	-	-	HYPH
cord-258787-n49zrfsp	146	8	MDSCs	MDSCs	NNP
cord-258787-n49zrfsp	146	9	)	)	-RRB-
cord-258787-n49zrfsp	147	1	[	[	-LRB-
cord-258787-n49zrfsp	147	2	46	46	CD
cord-258787-n49zrfsp	147	3	,	,	,
cord-258787-n49zrfsp	147	4	124	124	CD
cord-258787-n49zrfsp	147	5	,	,	,
cord-258787-n49zrfsp	147	6	125	125	CD
cord-258787-n49zrfsp	147	7	]	]	-RRB-
cord-258787-n49zrfsp	147	8	.	.	.
cord-258787-n49zrfsp	148	1	G	g	NN
cord-258787-n49zrfsp	148	2	-	-	HYPH
cord-258787-n49zrfsp	148	3	MDSCs	MDSCs	NNP
cord-258787-n49zrfsp	148	4	are	be	VBP
cord-258787-n49zrfsp	148	5	functionally	functionally	RB
cord-258787-n49zrfsp	148	6	characterized	characterize	VBN
cord-258787-n49zrfsp	148	7	by	by	IN
cord-258787-n49zrfsp	148	8	their	-PRON-	PRP$
cord-258787-n49zrfsp	148	9	ability	ability	NN
cord-258787-n49zrfsp	148	10	to	to	TO
cord-258787-n49zrfsp	148	11	suppress	suppress	VB
cord-258787-n49zrfsp	148	12	T	t	NN
cord-258787-n49zrfsp	148	13	cells	cell	NNS
cord-258787-n49zrfsp	148	14	proliferation	proliferation	NN
cord-258787-n49zrfsp	148	15	and	and	CC
cord-258787-n49zrfsp	148	16	activation	activation	NN
cord-258787-n49zrfsp	148	17	ex	ex	NN
cord-258787-n49zrfsp	148	18	vivo	vivo	NN
cord-258787-n49zrfsp	148	19	[	[	-LRB-
cord-258787-n49zrfsp	148	20	126	126	CD
cord-258787-n49zrfsp	148	21	]	]	-RRB-
cord-258787-n49zrfsp	148	22	.	.	.
cord-258787-n49zrfsp	149	1	However	however	RB
cord-258787-n49zrfsp	149	2	,	,	,
cord-258787-n49zrfsp	149	3	there	there	EX
cord-258787-n49zrfsp	149	4	is	be	VBZ
cord-258787-n49zrfsp	149	5	no	no	DT
cord-258787-n49zrfsp	149	6	consensus	consensus	NN
cord-258787-n49zrfsp	149	7	regarding	regard	VBG
cord-258787-n49zrfsp	149	8	their	-PRON-	PRP$
cord-258787-n49zrfsp	149	9	phenotypic	phenotypic	JJ
cord-258787-n49zrfsp	149	10	characterization	characterization	NN
cord-258787-n49zrfsp	149	11	based	base	VBN
cord-258787-n49zrfsp	149	12	on	on	IN
cord-258787-n49zrfsp	149	13	surface	surface	NN
cord-258787-n49zrfsp	149	14	molecule	molecule	NN
cord-258787-n49zrfsp	149	15	expression	expression	NN
cord-258787-n49zrfsp	149	16	.	.	.
cord-258787-n49zrfsp	150	1	In	in	IN
cord-258787-n49zrfsp	150	2	human	human	NN
cord-258787-n49zrfsp	150	3	,	,	,
cord-258787-n49zrfsp	150	4	G	g	NN
cord-258787-n49zrfsp	150	5	-	-	HYPH
cord-258787-n49zrfsp	150	6	MDSCs	MDSCs	NNP
cord-258787-n49zrfsp	150	7	are	be	VBP
cord-258787-n49zrfsp	150	8	described	describe	VBN
cord-258787-n49zrfsp	150	9	as	as	IN
cord-258787-n49zrfsp	150	10	CD15	CD15	NNP
cord-258787-n49zrfsp	150	11	+	+	SYM
cord-258787-n49zrfsp	150	12	CD66b	cd66b	NN
cord-258787-n49zrfsp	150	13	+	+	CC
cord-258787-n49zrfsp	151	1	CD33	CD33	NNP
cord-258787-n49zrfsp	151	2	dim	dim	NN
cord-258787-n49zrfsp	151	3	HLA	HLA	NNP
cord-258787-n49zrfsp	151	4	-	-	HYPH
cord-258787-n49zrfsp	151	5	DR	DR	NNP
cord-258787-n49zrfsp	151	6	−	−	NNP
cord-258787-n49zrfsp	151	7	rendering	render	VBG
cord-258787-n49zrfsp	151	8	them	-PRON-	PRP
cord-258787-n49zrfsp	151	9	indistinguishable	indistinguishable	JJ
cord-258787-n49zrfsp	151	10	from	from	IN
cord-258787-n49zrfsp	151	11	the	the	DT
cord-258787-n49zrfsp	151	12	other	other	JJ
cord-258787-n49zrfsp	151	13	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	151	14	subsets	subset	NNS
cord-258787-n49zrfsp	151	15	[	[	-LRB-
cord-258787-n49zrfsp	151	16	127	127	CD
cord-258787-n49zrfsp	151	17	,	,	,
cord-258787-n49zrfsp	151	18	128	128	CD
cord-258787-n49zrfsp	151	19	]	]	-RRB-
cord-258787-n49zrfsp	151	20	.	.	.
cord-258787-n49zrfsp	152	1	Besides	besides	IN
cord-258787-n49zrfsp	152	2	their	-PRON-	PRP$
cord-258787-n49zrfsp	152	3	heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	152	4	in	in	IN
cord-258787-n49zrfsp	152	5	gene	gene	NN
cord-258787-n49zrfsp	152	6	expression	expression	NN
cord-258787-n49zrfsp	152	7	profile	profile	NN
cord-258787-n49zrfsp	152	8	and	and	CC
cord-258787-n49zrfsp	152	9	surface	surface	NN
cord-258787-n49zrfsp	152	10	molecule	molecule	NN
cord-258787-n49zrfsp	152	11	expression	expression	NN
cord-258787-n49zrfsp	152	12	,	,	,
cord-258787-n49zrfsp	152	13	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	152	14	were	be	VBD
cord-258787-n49zrfsp	152	15	classified	classify	VBN
cord-258787-n49zrfsp	152	16	by	by	IN
cord-258787-n49zrfsp	152	17	their	-PRON-	PRP$
cord-258787-n49zrfsp	152	18	sedimentation	sedimentation	NN
cord-258787-n49zrfsp	152	19	proprieties	propriety	NNS
cord-258787-n49zrfsp	152	20	into	into	IN
cord-258787-n49zrfsp	152	21	low	low	JJ
cord-258787-n49zrfsp	152	22	density	density	NN
cord-258787-n49zrfsp	152	23	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	152	24	(	(	-LRB-
cord-258787-n49zrfsp	152	25	LDNs	LDNs	NNP
cord-258787-n49zrfsp	152	26	)	)	-RRB-
cord-258787-n49zrfsp	152	27	,	,	,
cord-258787-n49zrfsp	152	28	normal	normal	JJ
cord-258787-n49zrfsp	152	29	density	density	NN
cord-258787-n49zrfsp	152	30	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	152	31	(	(	-LRB-
cord-258787-n49zrfsp	152	32	NDNs	ndns	NN
cord-258787-n49zrfsp	152	33	)	)	-RRB-
cord-258787-n49zrfsp	152	34	and	and	CC
cord-258787-n49zrfsp	152	35	high	high	JJ
cord-258787-n49zrfsp	152	36	density	density	NN
cord-258787-n49zrfsp	152	37	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	152	38	(	(	-LRB-
cord-258787-n49zrfsp	152	39	HDNs	hdns	NN
cord-258787-n49zrfsp	152	40	)	)	-RRB-
cord-258787-n49zrfsp	153	1	[	[	-LRB-
cord-258787-n49zrfsp	153	2	16	16	CD
cord-258787-n49zrfsp	153	3	,	,	,
cord-258787-n49zrfsp	153	4	17	17	CD
cord-258787-n49zrfsp	153	5	,	,	,
cord-258787-n49zrfsp	153	6	129	129	CD
cord-258787-n49zrfsp	153	7	]	]	-RRB-
cord-258787-n49zrfsp	153	8	.	.	.
cord-258787-n49zrfsp	154	1	LDNs	LDNs	NNP
cord-258787-n49zrfsp	154	2	were	be	VBD
cord-258787-n49zrfsp	154	3	reported	report	VBN
cord-258787-n49zrfsp	154	4	to	to	TO
cord-258787-n49zrfsp	154	5	include	include	VB
cord-258787-n49zrfsp	154	6	both	both	DT
cord-258787-n49zrfsp	154	7	immature	immature	JJ
cord-258787-n49zrfsp	154	8	and	and	CC
cord-258787-n49zrfsp	154	9	mature	mature	JJ
cord-258787-n49zrfsp	154	10	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	154	11	and	and	CC
cord-258787-n49zrfsp	154	12	to	to	TO
cord-258787-n49zrfsp	154	13	accumulate	accumulate	VB
cord-258787-n49zrfsp	154	14	in	in	IN
cord-258787-n49zrfsp	154	15	cancer	cancer	NN
cord-258787-n49zrfsp	154	16	[	[	-LRB-
cord-258787-n49zrfsp	154	17	8	8	CD
cord-258787-n49zrfsp	154	18	]	]	-RRB-
cord-258787-n49zrfsp	154	19	.	.	.
cord-258787-n49zrfsp	155	1	LDNs	LDNs	NNP
cord-258787-n49zrfsp	155	2	were	be	VBD
cord-258787-n49zrfsp	155	3	described	describe	VBN
cord-258787-n49zrfsp	155	4	to	to	TO
cord-258787-n49zrfsp	155	5	be	be	VB
cord-258787-n49zrfsp	155	6	generally	generally	RB
cord-258787-n49zrfsp	155	7	endowed	endow	VBN
cord-258787-n49zrfsp	155	8	with	with	IN
cord-258787-n49zrfsp	155	9	immunosuppressive	immunosuppressive	JJ
cord-258787-n49zrfsp	155	10	proprieties	propriety	NNS
cord-258787-n49zrfsp	155	11	[	[	-LRB-
cord-258787-n49zrfsp	155	12	8	8	CD
cord-258787-n49zrfsp	155	13	,	,	,
cord-258787-n49zrfsp	155	14	22	22	CD
cord-258787-n49zrfsp	155	15	,	,	,
cord-258787-n49zrfsp	155	16	130	130	CD
cord-258787-n49zrfsp	155	17	]	]	-RRB-
cord-258787-n49zrfsp	155	18	.	.	.
cord-258787-n49zrfsp	156	1	However	however	RB
cord-258787-n49zrfsp	156	2	,	,	,
cord-258787-n49zrfsp	156	3	immunosuppressive	immunosuppressive	JJ
cord-258787-n49zrfsp	156	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	156	5	(	(	-LRB-
cord-258787-n49zrfsp	156	6	CD66b	CD66b	NNS
cord-258787-n49zrfsp	156	7	+	+	SYM
cord-258787-n49zrfsp	156	8	,	,	,
cord-258787-n49zrfsp	156	9	CD10	CD10	NNP
cord-258787-n49zrfsp	156	10	+	+	CC
cord-258787-n49zrfsp	156	11	)	)	-RRB-
cord-258787-n49zrfsp	156	12	have	have	VBP
cord-258787-n49zrfsp	156	13	been	be	VBN
cord-258787-n49zrfsp	156	14	also	also	RB
cord-258787-n49zrfsp	156	15	observed	observe	VBN
cord-258787-n49zrfsp	156	16	in	in	IN
cord-258787-n49zrfsp	156	17	the	the	DT
cord-258787-n49zrfsp	156	18	HDN	HDN	NNP
cord-258787-n49zrfsp	156	19	fraction	fraction	NN
cord-258787-n49zrfsp	156	20	[	[	-LRB-
cord-258787-n49zrfsp	156	21	131	131	CD
cord-258787-n49zrfsp	156	22	]	]	-RRB-
cord-258787-n49zrfsp	156	23	,	,	,
cord-258787-n49zrfsp	156	24	highlighting	highlight	VBG
cord-258787-n49zrfsp	156	25	the	the	DT
cord-258787-n49zrfsp	156	26	urge	urge	NN
cord-258787-n49zrfsp	156	27	for	for	IN
cord-258787-n49zrfsp	156	28	an	an	DT
cord-258787-n49zrfsp	156	29	accurate	accurate	JJ
cord-258787-n49zrfsp	156	30	system	system	NN
cord-258787-n49zrfsp	156	31	to	to	TO
cord-258787-n49zrfsp	156	32	define	define	VB
cord-258787-n49zrfsp	156	33	the	the	DT
cord-258787-n49zrfsp	156	34	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	156	35	subsets	subset	NNS
cord-258787-n49zrfsp	156	36	in	in	IN
cord-258787-n49zrfsp	156	37	cancer	cancer	NN
cord-258787-n49zrfsp	156	38	.	.	.
cord-258787-n49zrfsp	157	1	Cancer	cancer	NN
cord-258787-n49zrfsp	157	2	-	-	HYPH
cord-258787-n49zrfsp	157	3	related	relate	VBN
cord-258787-n49zrfsp	157	4	inflammation	inflammation	NN
cord-258787-n49zrfsp	157	5	has	have	VBZ
cord-258787-n49zrfsp	157	6	emerged	emerge	VBN
cord-258787-n49zrfsp	157	7	as	as	IN
cord-258787-n49zrfsp	157	8	a	a	DT
cord-258787-n49zrfsp	157	9	hallmark	hallmark	NN
cord-258787-n49zrfsp	157	10	of	of	IN
cord-258787-n49zrfsp	157	11	cancer	cancer	NN
cord-258787-n49zrfsp	157	12	[	[	-LRB-
cord-258787-n49zrfsp	157	13	9	9	CD
cord-258787-n49zrfsp	157	14	,	,	,
cord-258787-n49zrfsp	157	15	10	10	CD
cord-258787-n49zrfsp	157	16	]	]	-RRB-
cord-258787-n49zrfsp	157	17	and	and	CC
cord-258787-n49zrfsp	157	18	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	157	19	were	be	VBD
cord-258787-n49zrfsp	157	20	found	find	VBN
cord-258787-n49zrfsp	157	21	to	to	TO
cord-258787-n49zrfsp	157	22	infiltrate	infiltrate	VB
cord-258787-n49zrfsp	157	23	different	different	JJ
cord-258787-n49zrfsp	157	24	types	type	NNS
cord-258787-n49zrfsp	157	25	of	of	IN
cord-258787-n49zrfsp	157	26	neoplasia	neoplasia	NN
cord-258787-n49zrfsp	157	27	,	,	,
cord-258787-n49zrfsp	157	28	including	include	VBG
cord-258787-n49zrfsp	157	29	non	non	JJ
cord-258787-n49zrfsp	157	30	-	-	JJ
cord-258787-n49zrfsp	157	31	small	small	JJ
cord-258787-n49zrfsp	157	32	cell	cell	NN
cord-258787-n49zrfsp	157	33	lung	lung	NN
cord-258787-n49zrfsp	157	34	cancer	cancer	NN
cord-258787-n49zrfsp	157	35	(	(	-LRB-
cord-258787-n49zrfsp	157	36	NSCLC	NSCLC	NNP
cord-258787-n49zrfsp	157	37	)	)	-RRB-
cord-258787-n49zrfsp	157	38	,	,	,
cord-258787-n49zrfsp	157	39	colorectal	colorectal	JJ
cord-258787-n49zrfsp	157	40	cancer	cancer	NN
cord-258787-n49zrfsp	157	41	(	(	-LRB-
cord-258787-n49zrfsp	157	42	CRC	CRC	NNP
cord-258787-n49zrfsp	157	43	)	)	-RRB-
cord-258787-n49zrfsp	157	44	,	,	,
cord-258787-n49zrfsp	157	45	gastric	gastric	JJ
cord-258787-n49zrfsp	157	46	cancer	cancer	NN
cord-258787-n49zrfsp	157	47	,	,	,
cord-258787-n49zrfsp	157	48	hepatocellular	hepatocellular	JJ
cord-258787-n49zrfsp	157	49	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	157	50	,	,	,
cord-258787-n49zrfsp	157	51	melanoma	melanoma	NN
cord-258787-n49zrfsp	157	52	,	,	,
cord-258787-n49zrfsp	157	53	breast	breast	NN
cord-258787-n49zrfsp	157	54	cancer	cancer	NN
cord-258787-n49zrfsp	157	55	and	and	CC
cord-258787-n49zrfsp	157	56	renal	renal	JJ
cord-258787-n49zrfsp	157	57	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	157	58	[	[	-LRB-
cord-258787-n49zrfsp	157	59	15	15	CD
cord-258787-n49zrfsp	157	60	,	,	,
cord-258787-n49zrfsp	157	61	16	16	CD
cord-258787-n49zrfsp	157	62	,	,	,
cord-258787-n49zrfsp	157	63	[	[	-LRB-
cord-258787-n49zrfsp	157	64	20	20	CD
cord-258787-n49zrfsp	157	65	]	]	-RRB-
cord-258787-n49zrfsp	157	66	[	[	-LRB-
cord-258787-n49zrfsp	157	67	21	21	CD
cord-258787-n49zrfsp	157	68	]	]	-RRB-
cord-258787-n49zrfsp	158	1	[	[	-LRB-
cord-258787-n49zrfsp	158	2	22	22	CD
cord-258787-n49zrfsp	158	3	]	]	-RRB-
cord-258787-n49zrfsp	158	4	132	132	CD
cord-258787-n49zrfsp	158	5	]	]	-RRB-
cord-258787-n49zrfsp	158	6	.	.	.
cord-258787-n49zrfsp	159	1	In	in	IN
cord-258787-n49zrfsp	159	2	the	the	DT
cord-258787-n49zrfsp	159	3	TME	TME	NNP
cord-258787-n49zrfsp	159	4	,	,	,
cord-258787-n49zrfsp	159	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	159	6	represent	represent	VBP
cord-258787-n49zrfsp	159	7	a	a	DT
cord-258787-n49zrfsp	159	8	source	source	NN
cord-258787-n49zrfsp	159	9	of	of	IN
cord-258787-n49zrfsp	159	10	cytokines	cytokine	NNS
cord-258787-n49zrfsp	159	11	,	,	,
cord-258787-n49zrfsp	159	12	chemokines	chemokine	NNS
cord-258787-n49zrfsp	159	13	and	and	CC
cord-258787-n49zrfsp	159	14	growth	growth	NN
cord-258787-n49zrfsp	159	15	factors	factor	NNS
cord-258787-n49zrfsp	159	16	that	that	WDT
cord-258787-n49zrfsp	159	17	sustain	sustain	VBP
cord-258787-n49zrfsp	159	18	tumour	tumour	NN
cord-258787-n49zrfsp	159	19	growth	growth	NN
cord-258787-n49zrfsp	159	20	and	and	CC
cord-258787-n49zrfsp	159	21	progression	progression	NN
cord-258787-n49zrfsp	159	22	including	include	VBG
cord-258787-n49zrfsp	159	23	epidermal	epidermal	JJ
cord-258787-n49zrfsp	159	24	growth	growth	NN
cord-258787-n49zrfsp	159	25	factor	factor	NN
cord-258787-n49zrfsp	159	26	(	(	-LRB-
cord-258787-n49zrfsp	159	27	EGF	EGF	NNP
cord-258787-n49zrfsp	159	28	)	)	-RRB-
cord-258787-n49zrfsp	159	29	,	,	,
cord-258787-n49zrfsp	159	30	hepatocytes	hepatocyte	VBZ
cord-258787-n49zrfsp	159	31	growth	growth	NN
cord-258787-n49zrfsp	159	32	factor	factor	NN
cord-258787-n49zrfsp	159	33	(	(	-LRB-
cord-258787-n49zrfsp	159	34	HGF	hgf	NN
cord-258787-n49zrfsp	159	35	)	)	-RRB-
cord-258787-n49zrfsp	159	36	and	and	CC
cord-258787-n49zrfsp	159	37	platelet	platelet	NN
cord-258787-n49zrfsp	159	38	-	-	HYPH
cord-258787-n49zrfsp	159	39	derived	derive	VBN
cord-258787-n49zrfsp	159	40	growth	growth	NN
cord-258787-n49zrfsp	159	41	factor	factor	NN
cord-258787-n49zrfsp	159	42	(	(	-LRB-
cord-258787-n49zrfsp	159	43	PDGF	PDGF	NNP
cord-258787-n49zrfsp	159	44	)	)	-RRB-
cord-258787-n49zrfsp	159	45	[	[	-LRB-
cord-258787-n49zrfsp	159	46	16	16	CD
cord-258787-n49zrfsp	159	47	,	,	,
cord-258787-n49zrfsp	159	48	133	133	CD
cord-258787-n49zrfsp	159	49	]	]	-RRB-
cord-258787-n49zrfsp	159	50	.	.	.
cord-258787-n49zrfsp	160	1	Other	other	JJ
cord-258787-n49zrfsp	160	2	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	160	3	-	-	HYPH
cord-258787-n49zrfsp	160	4	derived	derive	VBN
cord-258787-n49zrfsp	160	5	mediators	mediator	NNS
cord-258787-n49zrfsp	160	6	that	that	WDT
cord-258787-n49zrfsp	160	7	influence	influence	VBP
cord-258787-n49zrfsp	160	8	tumour	tumour	NN
cord-258787-n49zrfsp	160	9	progression	progression	NN
cord-258787-n49zrfsp	160	10	are	be	VBP
cord-258787-n49zrfsp	160	11	found	find	VBN
cord-258787-n49zrfsp	160	12	in	in	IN
cord-258787-n49zrfsp	160	13	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	160	14	granules	granule	NNS
cord-258787-n49zrfsp	160	15	.	.	.
cord-258787-n49zrfsp	161	1	For	for	IN
cord-258787-n49zrfsp	161	2	instance	instance	NN
cord-258787-n49zrfsp	161	3	,	,	,
cord-258787-n49zrfsp	161	4	NE	NE	NNP
cord-258787-n49zrfsp	161	5	has	have	VBZ
cord-258787-n49zrfsp	161	6	been	be	VBN
cord-258787-n49zrfsp	161	7	shown	show	VBN
cord-258787-n49zrfsp	161	8	to	to	TO
cord-258787-n49zrfsp	161	9	favour	favour	VB
cord-258787-n49zrfsp	161	10	the	the	DT
cord-258787-n49zrfsp	161	11	proliferation	proliferation	NN
cord-258787-n49zrfsp	161	12	of	of	IN
cord-258787-n49zrfsp	161	13	different	different	JJ
cord-258787-n49zrfsp	161	14	cancer	cancer	NN
cord-258787-n49zrfsp	161	15	cell	cell	NN
cord-258787-n49zrfsp	161	16	types	type	NNS
cord-258787-n49zrfsp	161	17	in	in	IN
cord-258787-n49zrfsp	161	18	vitro	vitro	FW
cord-258787-n49zrfsp	161	19	,	,	,
cord-258787-n49zrfsp	161	20	such	such	JJ
cord-258787-n49zrfsp	161	21	as	as	IN
cord-258787-n49zrfsp	161	22	human	human	JJ
cord-258787-n49zrfsp	161	23	oesophageal	oesophageal	JJ
cord-258787-n49zrfsp	161	24	cell	cell	NN
cord-258787-n49zrfsp	161	25	lines	line	NNS
cord-258787-n49zrfsp	161	26	and	and	CC
cord-258787-n49zrfsp	161	27	mammary	mammary	JJ
cord-258787-n49zrfsp	161	28	cell	cell	NN
cord-258787-n49zrfsp	161	29	lines	line	NNS
cord-258787-n49zrfsp	161	30	through	through	IN
cord-258787-n49zrfsp	161	31	the	the	DT
cord-258787-n49zrfsp	161	32	transactivation	transactivation	NN
cord-258787-n49zrfsp	161	33	of	of	IN
cord-258787-n49zrfsp	161	34	the	the	DT
cord-258787-n49zrfsp	161	35	EGF	EGF	NNP
cord-258787-n49zrfsp	161	36	receptor	receptor	NN
cord-258787-n49zrfsp	161	37	(	(	-LRB-
cord-258787-n49zrfsp	161	38	EGFR	EGFR	NNP
cord-258787-n49zrfsp	161	39	)	)	-RRB-
cord-258787-n49zrfsp	161	40	and	and	CC
cord-258787-n49zrfsp	161	41	TLR4	TLR4	NNP
cord-258787-n49zrfsp	161	42	,	,	,
cord-258787-n49zrfsp	161	43	and	and	CC
cord-258787-n49zrfsp	161	44	human	human	JJ
cord-258787-n49zrfsp	161	45	prostate	prostate	NN
cord-258787-n49zrfsp	161	46	cancer	cancer	NN
cord-258787-n49zrfsp	161	47	cell	cell	NN
cord-258787-n49zrfsp	161	48	lines	line	NNS
cord-258787-n49zrfsp	161	49	through	through	IN
cord-258787-n49zrfsp	161	50	the	the	DT
cord-258787-n49zrfsp	161	51	activation	activation	NN
cord-258787-n49zrfsp	161	52	of	of	IN
cord-258787-n49zrfsp	161	53	the	the	DT
cord-258787-n49zrfsp	161	54	mitogen	mitogen	NNP
cord-258787-n49zrfsp	161	55	activation	activation	NN
cord-258787-n49zrfsp	161	56	protein	protein	NN
cord-258787-n49zrfsp	161	57	kinase	kinase	NN
cord-258787-n49zrfsp	161	58	(	(	-LRB-
cord-258787-n49zrfsp	161	59	MAPK	MAPK	NNP
cord-258787-n49zrfsp	161	60	)	)	-RRB-
cord-258787-n49zrfsp	161	61	pathway	pathway	NN
cord-258787-n49zrfsp	161	62	[	[	-LRB-
cord-258787-n49zrfsp	161	63	134	134	CD
cord-258787-n49zrfsp	161	64	]	]	-RRB-
cord-258787-n49zrfsp	161	65	[	[	-LRB-
cord-258787-n49zrfsp	161	66	135	135	CD
cord-258787-n49zrfsp	161	67	]	]	-RRB-
cord-258787-n49zrfsp	161	68	[	[	-LRB-
cord-258787-n49zrfsp	161	69	136	136	CD
cord-258787-n49zrfsp	161	70	]	]	-RRB-
cord-258787-n49zrfsp	161	71	.	.	.
cord-258787-n49zrfsp	162	1	In	in	IN
cord-258787-n49zrfsp	162	2	a	a	DT
cord-258787-n49zrfsp	162	3	genetically	genetically	RB
cord-258787-n49zrfsp	162	4	engineered	engineer	VBN
cord-258787-n49zrfsp	162	5	mouse	mouse	NN
cord-258787-n49zrfsp	162	6	model	model	NN
cord-258787-n49zrfsp	162	7	of	of	IN
cord-258787-n49zrfsp	162	8	lung	lung	NN
cord-258787-n49zrfsp	162	9	adenocarcinoma	adenocarcinoma	NN
cord-258787-n49zrfsp	162	10	induced	induce	VBN
cord-258787-n49zrfsp	162	11	by	by	IN
cord-258787-n49zrfsp	162	12	oncogenic	oncogenic	JJ
cord-258787-n49zrfsp	162	13	Kras	Kras	NNP
cord-258787-n49zrfsp	162	14	,	,	,
cord-258787-n49zrfsp	162	15	NE	NE	NNP
cord-258787-n49zrfsp	162	16	-	-	HYPH
cord-258787-n49zrfsp	162	17	deficient	deficient	JJ
cord-258787-n49zrfsp	162	18	mice	mouse	NNS
cord-258787-n49zrfsp	162	19	displayed	display	VBD
cord-258787-n49zrfsp	162	20	reduced	reduced	JJ
cord-258787-n49zrfsp	162	21	tumour	tumour	NN
cord-258787-n49zrfsp	162	22	cells	cell	NNS
cord-258787-n49zrfsp	162	23	proliferation	proliferation	NN
cord-258787-n49zrfsp	162	24	and	and	CC
cord-258787-n49zrfsp	162	25	tumour	tumour	NN
cord-258787-n49zrfsp	162	26	growth	growth	NN
cord-258787-n49zrfsp	162	27	.	.	.
cord-258787-n49zrfsp	163	1	Mechanistically	mechanistically	RB
cord-258787-n49zrfsp	163	2	,	,	,
cord-258787-n49zrfsp	163	3	in	in	IN
cord-258787-n49zrfsp	163	4	vitro	vitro	FW
cord-258787-n49zrfsp	163	5	experiments	experiment	NNS
cord-258787-n49zrfsp	163	6	showed	show	VBD
cord-258787-n49zrfsp	163	7	that	that	IN
cord-258787-n49zrfsp	163	8	NE	NE	NNP
cord-258787-n49zrfsp	163	9	acted	act	VBD
cord-258787-n49zrfsp	163	10	by	by	IN
cord-258787-n49zrfsp	163	11	degrading	degrade	VBG
cord-258787-n49zrfsp	163	12	the	the	DT
cord-258787-n49zrfsp	163	13	insulin	insulin	NN
cord-258787-n49zrfsp	163	14	receptor	receptor	NN
cord-258787-n49zrfsp	163	15	substrate	substrate	NN
cord-258787-n49zrfsp	163	16	1	1	CD
cord-258787-n49zrfsp	163	17	(	(	-LRB-
cord-258787-n49zrfsp	163	18	IRS-1	IRS-1	NNP
cord-258787-n49zrfsp	163	19	)	)	-RRB-
cord-258787-n49zrfsp	163	20	,	,	,
cord-258787-n49zrfsp	163	21	which	which	WDT
cord-258787-n49zrfsp	163	22	usually	usually	RB
cord-258787-n49zrfsp	163	23	inhibits	inhibit	VBZ
cord-258787-n49zrfsp	163	24	the	the	DT
cord-258787-n49zrfsp	163	25	phosphoinositide	phosphoinositide	NN
cord-258787-n49zrfsp	163	26	3-kinase	3-kinase	CD
cord-258787-n49zrfsp	163	27	(	(	-LRB-
cord-258787-n49zrfsp	163	28	PI3	PI3	NNP
cord-258787-n49zrfsp	163	29	K	K	NNP
cord-258787-n49zrfsp	163	30	)	)	-RRB-
cord-258787-n49zrfsp	163	31	in	in	IN
cord-258787-n49zrfsp	163	32	tumour	tumour	NN
cord-258787-n49zrfsp	163	33	cells	cell	NNS
cord-258787-n49zrfsp	163	34	.	.	.
cord-258787-n49zrfsp	164	1	In	in	IN
cord-258787-n49zrfsp	164	2	turn	turn	NN
cord-258787-n49zrfsp	164	3	,	,	,
cord-258787-n49zrfsp	164	4	PI3	PI3	NNP
cord-258787-n49zrfsp	164	5	K	K	NNP
cord-258787-n49zrfsp	164	6	can	can	MD
cord-258787-n49zrfsp	164	7	interact	interact	VB
cord-258787-n49zrfsp	164	8	with	with	IN
cord-258787-n49zrfsp	164	9	the	the	DT
cord-258787-n49zrfsp	164	10	cytoplasmic	cytoplasmic	JJ
cord-258787-n49zrfsp	164	11	domain	domain	NN
cord-258787-n49zrfsp	164	12	of	of	IN
cord-258787-n49zrfsp	164	13	the	the	DT
cord-258787-n49zrfsp	164	14	PDGFR	PDGFR	NNP
cord-258787-n49zrfsp	164	15	,	,	,
cord-258787-n49zrfsp	164	16	which	which	WDT
cord-258787-n49zrfsp	164	17	has	have	VBZ
cord-258787-n49zrfsp	164	18	a	a	DT
cord-258787-n49zrfsp	164	19	potent	potent	JJ
cord-258787-n49zrfsp	164	20	mitogenic	mitogenic	JJ
cord-258787-n49zrfsp	164	21	action	action	NN
cord-258787-n49zrfsp	164	22	on	on	IN
cord-258787-n49zrfsp	164	23	human	human	NN
cord-258787-n49zrfsp	164	24	and	and	CC
cord-258787-n49zrfsp	164	25	mouse	mouse	NN
cord-258787-n49zrfsp	164	26	lung	lung	NN
cord-258787-n49zrfsp	164	27	cancer	cancer	NN
cord-258787-n49zrfsp	164	28	cells	cell	NNS
cord-258787-n49zrfsp	164	29	[	[	-LRB-
cord-258787-n49zrfsp	164	30	137	137	CD
cord-258787-n49zrfsp	164	31	]	]	-RRB-
cord-258787-n49zrfsp	165	1	(	(	-LRB-
cord-258787-n49zrfsp	165	2	Fig	Fig	NNP
cord-258787-n49zrfsp	165	3	.	.	.
cord-258787-n49zrfsp	166	1	1	1	LS
cord-258787-n49zrfsp	166	2	)	)	-RRB-
cord-258787-n49zrfsp	166	3	.	.	.
cord-258787-n49zrfsp	167	1	In	in	IN
cord-258787-n49zrfsp	167	2	addition	addition	NN
cord-258787-n49zrfsp	167	3	to	to	IN
cord-258787-n49zrfsp	167	4	their	-PRON-	PRP$
cord-258787-n49zrfsp	167	5	role	role	NN
cord-258787-n49zrfsp	167	6	against	against	IN
cord-258787-n49zrfsp	167	7	microbial	microbial	JJ
cord-258787-n49zrfsp	167	8	infections	infection	NNS
cord-258787-n49zrfsp	167	9	,	,	,
cord-258787-n49zrfsp	167	10	NETs	net	NNS
cord-258787-n49zrfsp	167	11	were	be	VBD
cord-258787-n49zrfsp	167	12	observed	observe	VBN
cord-258787-n49zrfsp	167	13	in	in	IN
cord-258787-n49zrfsp	167	14	different	different	JJ
cord-258787-n49zrfsp	167	15	tumours	tumour	NNS
cord-258787-n49zrfsp	167	16	(	(	-LRB-
cord-258787-n49zrfsp	167	17	e.g.	e.g.	IN
cord-258787-n49zrfsp	167	18	liver	liver	NN
cord-258787-n49zrfsp	167	19	,	,	,
cord-258787-n49zrfsp	167	20	breast	breast	NN
cord-258787-n49zrfsp	167	21	and	and	CC
cord-258787-n49zrfsp	167	22	intestinal	intestinal	JJ
cord-258787-n49zrfsp	167	23	)	)	-RRB-
cord-258787-n49zrfsp	167	24	and	and	CC
cord-258787-n49zrfsp	167	25	were	be	VBD
cord-258787-n49zrfsp	167	26	associated	associate	VBN
cord-258787-n49zrfsp	167	27	with	with	IN
cord-258787-n49zrfsp	167	28	the	the	DT
cord-258787-n49zrfsp	167	29	presence	presence	NN
cord-258787-n49zrfsp	167	30	of	of	IN
cord-258787-n49zrfsp	167	31	metastasis	metastasis	NN
cord-258787-n49zrfsp	167	32	(	(	-LRB-
cord-258787-n49zrfsp	167	33	see	see	VB
cord-258787-n49zrfsp	167	34	below	below	RB
cord-258787-n49zrfsp	167	35	)	)	-RRB-
cord-258787-n49zrfsp	168	1	[	[	-LRB-
cord-258787-n49zrfsp	168	2	138	138	CD
cord-258787-n49zrfsp	168	3	]	]	-RRB-
cord-258787-n49zrfsp	169	1	[	[	-LRB-
cord-258787-n49zrfsp	169	2	139	139	CD
cord-258787-n49zrfsp	169	3	]	]	-RRB-
cord-258787-n49zrfsp	169	4	[	[	-LRB-
cord-258787-n49zrfsp	169	5	140	140	CD
cord-258787-n49zrfsp	169	6	]	]	-RRB-
cord-258787-n49zrfsp	169	7	[	[	-LRB-
cord-258787-n49zrfsp	169	8	141	141	CD
cord-258787-n49zrfsp	169	9	]	]	-RRB-
cord-258787-n49zrfsp	169	10	[	[	-LRB-
cord-258787-n49zrfsp	169	11	142	142	CD
cord-258787-n49zrfsp	169	12	]	]	-RRB-
cord-258787-n49zrfsp	169	13	[	[	-LRB-
cord-258787-n49zrfsp	169	14	143	143	CD
cord-258787-n49zrfsp	169	15	]	]	-RRB-
cord-258787-n49zrfsp	169	16	.	.	.
cord-258787-n49zrfsp	170	1	A	a	DT
cord-258787-n49zrfsp	170	2	recent	recent	JJ
cord-258787-n49zrfsp	170	3	study	study	NN
cord-258787-n49zrfsp	170	4	showed	show	VBD
cord-258787-n49zrfsp	170	5	that	that	IN
cord-258787-n49zrfsp	170	6	NETs	net	NNS
cord-258787-n49zrfsp	170	7	were	be	VBD
cord-258787-n49zrfsp	170	8	able	able	JJ
cord-258787-n49zrfsp	170	9	to	to	TO
cord-258787-n49zrfsp	170	10	interfere	interfere	VB
cord-258787-n49zrfsp	170	11	with	with	IN
cord-258787-n49zrfsp	170	12	lymphocytes	lymphocyte	NNS
cord-258787-n49zrfsp	170	13	cytotoxicity	cytotoxicity	NN
cord-258787-n49zrfsp	170	14	in	in	IN
cord-258787-n49zrfsp	170	15	the	the	DT
cord-258787-n49zrfsp	170	16	primary	primary	JJ
cord-258787-n49zrfsp	170	17	tumour	tumour	NN
cord-258787-n49zrfsp	170	18	.	.	.
cord-258787-n49zrfsp	171	1	in	in	IN
cord-258787-n49zrfsp	171	2	vivo	vivo	NNP
cord-258787-n49zrfsp	171	3	and	and	CC
cord-258787-n49zrfsp	171	4	in	in	IN
cord-258787-n49zrfsp	171	5	vitro	vitro	FW
cord-258787-n49zrfsp	171	6	experiments	experiment	NNS
cord-258787-n49zrfsp	171	7	demonstrated	demonstrate	VBD
cord-258787-n49zrfsp	171	8	that	that	IN
cord-258787-n49zrfsp	171	9	NETs	net	NNS
cord-258787-n49zrfsp	171	10	can	can	MD
cord-258787-n49zrfsp	171	11	form	form	VB
cord-258787-n49zrfsp	171	12	a	a	DT
cord-258787-n49zrfsp	171	13	protective	protective	JJ
cord-258787-n49zrfsp	171	14	layer	layer	NN
cord-258787-n49zrfsp	171	15	on	on	IN
cord-258787-n49zrfsp	171	16	tumour	tumour	NN
cord-258787-n49zrfsp	171	17	cells	cell	NNS
cord-258787-n49zrfsp	171	18	that	that	WDT
cord-258787-n49zrfsp	171	19	acts	act	VBZ
cord-258787-n49zrfsp	171	20	as	as	IN
cord-258787-n49zrfsp	171	21	a	a	DT
cord-258787-n49zrfsp	171	22	shield	shield	NN
cord-258787-n49zrfsp	171	23	against	against	IN
cord-258787-n49zrfsp	171	24	the	the	DT
cord-258787-n49zrfsp	171	25	cytotoxic	cytotoxic	JJ
cord-258787-n49zrfsp	171	26	activity	activity	NN
cord-258787-n49zrfsp	171	27	of	of	IN
cord-258787-n49zrfsp	171	28	CD8	CD8	NNP
cord-258787-n49zrfsp	171	29	+	+	CC
cord-258787-n49zrfsp	171	30	T	T	NNP
cord-258787-n49zrfsp	171	31	cells	cell	NNS
cord-258787-n49zrfsp	171	32	and	and	CC
cord-258787-n49zrfsp	171	33	NK	NK	NNP
cord-258787-n49zrfsp	171	34	cells	cell	NNS
cord-258787-n49zrfsp	172	1	(	(	-LRB-
cord-258787-n49zrfsp	172	2	Fig	Fig	NNP
cord-258787-n49zrfsp	172	3	.	.	NNP
cord-258787-n49zrfsp	172	4	1	1	CD
cord-258787-n49zrfsp	172	5	)	)	-RRB-
cord-258787-n49zrfsp	172	6	.	.	.
cord-258787-n49zrfsp	173	1	Interestingly	interestingly	RB
cord-258787-n49zrfsp	173	2	,	,	,
cord-258787-n49zrfsp	173	3	pharmacological	pharmacological	JJ
cord-258787-n49zrfsp	173	4	inhibition	inhibition	NN
cord-258787-n49zrfsp	173	5	of	of	IN
cord-258787-n49zrfsp	173	6	NETs	net	NNS
cord-258787-n49zrfsp	173	7	synergized	synergize	VBN
cord-258787-n49zrfsp	173	8	with	with	IN
cord-258787-n49zrfsp	173	9	combination	combination	NN
cord-258787-n49zrfsp	173	10	immunotherapy	immunotherapy	NN
cord-258787-n49zrfsp	173	11	of	of	IN
cord-258787-n49zrfsp	173	12	anti	anti	JJ
cord-258787-n49zrfsp	173	13	-	-	JJ
cord-258787-n49zrfsp	173	14	PD1	pd1	JJ
cord-258787-n49zrfsp	173	15	plus	plus	CC
cord-258787-n49zrfsp	173	16	anti	anti	NNS
cord-258787-n49zrfsp	173	17	-	-	NNS
cord-258787-n49zrfsp	173	18	CTLA4	ctla4	JJ
cord-258787-n49zrfsp	173	19	to	to	TO
cord-258787-n49zrfsp	173	20	delay	delay	VB
cord-258787-n49zrfsp	173	21	tumour	tumour	NN
cord-258787-n49zrfsp	173	22	progression	progression	NN
cord-258787-n49zrfsp	173	23	in	in	IN
cord-258787-n49zrfsp	173	24	mice	mouse	NNS
cord-258787-n49zrfsp	173	25	injected	inject	VBN
cord-258787-n49zrfsp	173	26	with	with	IN
cord-258787-n49zrfsp	173	27	4T1	4t1	CD
cord-258787-n49zrfsp	173	28	breast	breast	NN
cord-258787-n49zrfsp	173	29	cancer	cancer	NN
cord-258787-n49zrfsp	173	30	cell	cell	NN
cord-258787-n49zrfsp	173	31	line	line	NN
cord-258787-n49zrfsp	173	32	[	[	-LRB-
cord-258787-n49zrfsp	173	33	144	144	CD
cord-258787-n49zrfsp	173	34	]	]	-RRB-
cord-258787-n49zrfsp	173	35	.	.	.
cord-258787-n49zrfsp	174	1	In	in	IN
cord-258787-n49zrfsp	174	2	tumour	tumour	NN
cord-258787-n49zrfsp	174	3	,	,	,
cord-258787-n49zrfsp	174	4	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	174	5	-	-	HYPH
cord-258787-n49zrfsp	174	6	derived	derive	VBN
cord-258787-n49zrfsp	174	7	ROS	ROS	NNP
cord-258787-n49zrfsp	174	8	have	have	VBP
cord-258787-n49zrfsp	174	9	been	be	VBN
cord-258787-n49zrfsp	174	10	associated	associate	VBN
cord-258787-n49zrfsp	174	11	with	with	IN
cord-258787-n49zrfsp	174	12	increased	increase	VBN
cord-258787-n49zrfsp	174	13	DNA	dna	NN
cord-258787-n49zrfsp	174	14	damage	damage	NN
cord-258787-n49zrfsp	174	15	and	and	CC
cord-258787-n49zrfsp	174	16	genetic	genetic	JJ
cord-258787-n49zrfsp	174	17	instability	instability	NN
cord-258787-n49zrfsp	174	18	in	in	IN
cord-258787-n49zrfsp	174	19	epithelial	epithelial	JJ
cord-258787-n49zrfsp	174	20	cells	cell	NNS
cord-258787-n49zrfsp	174	21	[	[	-LRB-
cord-258787-n49zrfsp	174	22	145	145	CD
cord-258787-n49zrfsp	174	23	]	]	-RRB-
cord-258787-n49zrfsp	174	24	suggesting	suggest	VBG
cord-258787-n49zrfsp	174	25	that	that	IN
cord-258787-n49zrfsp	174	26	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	174	27	were	be	VBD
cord-258787-n49zrfsp	174	28	involved	involve	VBN
cord-258787-n49zrfsp	174	29	in	in	IN
cord-258787-n49zrfsp	174	30	the	the	DT
cord-258787-n49zrfsp	174	31	initiation	initiation	NN
cord-258787-n49zrfsp	174	32	stage	stage	NN
cord-258787-n49zrfsp	174	33	of	of	IN
cord-258787-n49zrfsp	174	34	carcinogenesis	carcinogenesis	NN
cord-258787-n49zrfsp	174	35	(	(	-LRB-
cord-258787-n49zrfsp	174	36	Fig	fig	NN
cord-258787-n49zrfsp	174	37	.	.	.
cord-258787-n49zrfsp	174	38	1	1	CD
cord-258787-n49zrfsp	174	39	)	)	-RRB-
cord-258787-n49zrfsp	174	40	.	.	.
cord-258787-n49zrfsp	175	1	Accordingly	accordingly	RB
cord-258787-n49zrfsp	175	2	,	,	,
cord-258787-n49zrfsp	175	3	neutropenic	neutropenic	JJ
cord-258787-n49zrfsp	175	4	mice	mouse	NNS
cord-258787-n49zrfsp	175	5	(	(	-LRB-
cord-258787-n49zrfsp	175	6	Csf3	Csf3	NNP
cord-258787-n49zrfsp	175	7	−	−	NNS
cord-258787-n49zrfsp	175	8	/−	/−	.
cord-258787-n49zrfsp	175	9	mice	mouse	NNS
cord-258787-n49zrfsp	175	10	)	)	-RRB-
cord-258787-n49zrfsp	175	11	showed	show	VBD
cord-258787-n49zrfsp	175	12	reduced	reduced	JJ
cord-258787-n49zrfsp	175	13	urethane	urethane	NN
cord-258787-n49zrfsp	175	14	-	-	HYPH
cord-258787-n49zrfsp	175	15	induced	induce	VBN
cord-258787-n49zrfsp	175	16	lung	lung	NN
cord-258787-n49zrfsp	175	17	carcinogenesis	carcinogenesis	NN
cord-258787-n49zrfsp	175	18	and	and	CC
cord-258787-n49zrfsp	175	19	forcing	force	VBG
cord-258787-n49zrfsp	175	20	the	the	DT
cord-258787-n49zrfsp	175	21	recruitment	recruitment	NN
cord-258787-n49zrfsp	175	22	of	of	IN
cord-258787-n49zrfsp	175	23	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	175	24	in	in	IN
cord-258787-n49zrfsp	175	25	Csf3	Csf3	NNP
cord-258787-n49zrfsp	175	26	−	−	NNP
cord-258787-n49zrfsp	176	1	/−	/−	.
cord-258787-n49zrfsp	177	1	mice	mouse	NNS
cord-258787-n49zrfsp	177	2	by	by	IN
cord-258787-n49zrfsp	177	3	G	G	NNP
cord-258787-n49zrfsp	177	4	-	-	HYPH
cord-258787-n49zrfsp	177	5	CSF	CSF	NNP
cord-258787-n49zrfsp	177	6	was	be	VBD
cord-258787-n49zrfsp	177	7	sufficient	sufficient	JJ
cord-258787-n49zrfsp	177	8	to	to	TO
cord-258787-n49zrfsp	177	9	restore	restore	VB
cord-258787-n49zrfsp	177	10	tumour	tumour	NN
cord-258787-n49zrfsp	177	11	formation	formation	NN
cord-258787-n49zrfsp	177	12	in	in	IN
cord-258787-n49zrfsp	177	13	the	the	DT
cord-258787-n49zrfsp	177	14	lung	lung	NN
cord-258787-n49zrfsp	177	15	.	.	.
cord-258787-n49zrfsp	178	1	The	the	DT
cord-258787-n49zrfsp	178	2	detrimental	detrimental	JJ
cord-258787-n49zrfsp	178	3	activity	activity	NN
cord-258787-n49zrfsp	178	4	of	of	IN
cord-258787-n49zrfsp	178	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	178	6	was	be	VBD
cord-258787-n49zrfsp	178	7	linked	link	VBN
cord-258787-n49zrfsp	178	8	to	to	IN
cord-258787-n49zrfsp	178	9	the	the	DT
cord-258787-n49zrfsp	178	10	production	production	NN
cord-258787-n49zrfsp	178	11	of	of	IN
cord-258787-n49zrfsp	178	12	ROS	ROS	NNP
cord-258787-n49zrfsp	178	13	,	,	,
cord-258787-n49zrfsp	178	14	which	which	WDT
cord-258787-n49zrfsp	178	15	acts	act	VBZ
cord-258787-n49zrfsp	178	16	as	as	IN
cord-258787-n49zrfsp	178	17	an	an	DT
cord-258787-n49zrfsp	178	18	amplifier	amplifier	NN
cord-258787-n49zrfsp	178	19	of	of	IN
cord-258787-n49zrfsp	178	20	DNA	dna	NN
cord-258787-n49zrfsp	178	21	damage	damage	NN
cord-258787-n49zrfsp	178	22	induced	induce	VBN
cord-258787-n49zrfsp	178	23	by	by	IN
cord-258787-n49zrfsp	178	24	urethane	urethane	NN
cord-258787-n49zrfsp	178	25	carcinogenesis	carcinogenesis	NN
cord-258787-n49zrfsp	178	26	[	[	-LRB-
cord-258787-n49zrfsp	178	27	146	146	CD
cord-258787-n49zrfsp	178	28	]	]	-RRB-
cord-258787-n49zrfsp	178	29	.	.	.
cord-258787-n49zrfsp	179	1	In	in	IN
cord-258787-n49zrfsp	179	2	apparent	apparent	JJ
cord-258787-n49zrfsp	179	3	contrast	contrast	NN
cord-258787-n49zrfsp	179	4	,	,	,
cord-258787-n49zrfsp	179	5	in	in	IN
cord-258787-n49zrfsp	179	6	3-methylcholathrene(3-MCA)-induced	3-methylcholathrene(3-mca)-induced	CD
cord-258787-n49zrfsp	179	7	sarcomagenesis	sarcomagenesis	NN
cord-258787-n49zrfsp	179	8	,	,	,
cord-258787-n49zrfsp	179	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	179	10	were	be	VBD
cord-258787-n49zrfsp	179	11	found	find	VBN
cord-258787-n49zrfsp	179	12	to	to	TO
cord-258787-n49zrfsp	179	13	be	be	VB
cord-258787-n49zrfsp	179	14	crucial	crucial	JJ
cord-258787-n49zrfsp	179	15	for	for	IN
cord-258787-n49zrfsp	179	16	the	the	DT
cord-258787-n49zrfsp	179	17	initiation	initiation	NN
cord-258787-n49zrfsp	179	18	of	of	IN
cord-258787-n49zrfsp	179	19	an	an	DT
cord-258787-n49zrfsp	179	20	early	early	JJ
cord-258787-n49zrfsp	179	21	anti	anti	JJ
cord-258787-n49zrfsp	179	22	-	-	JJ
cord-258787-n49zrfsp	179	23	tumour	tumour	JJ
cord-258787-n49zrfsp	179	24	response	response	NN
cord-258787-n49zrfsp	179	25	.	.	.
cord-258787-n49zrfsp	180	1	Indeed	indeed	RB
cord-258787-n49zrfsp	180	2	,	,	,
cord-258787-n49zrfsp	180	3	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	180	4	amplified	amplify	VBD
cord-258787-n49zrfsp	180	5	the	the	DT
cord-258787-n49zrfsp	180	6	production	production	NN
cord-258787-n49zrfsp	180	7	of	of	IN
cord-258787-n49zrfsp	180	8	IL-12	IL-12	NNP
cord-258787-n49zrfsp	180	9	in	in	IN
cord-258787-n49zrfsp	180	10	macrophages	macrophage	NNS
cord-258787-n49zrfsp	180	11	,	,	,
cord-258787-n49zrfsp	180	12	which	which	WDT
cord-258787-n49zrfsp	180	13	induced	induce	VBD
cord-258787-n49zrfsp	180	14	type	type	NN
cord-258787-n49zrfsp	180	15	1	1	CD
cord-258787-n49zrfsp	180	16	polarization	polarization	NN
cord-258787-n49zrfsp	180	17	and	and	CC
cord-258787-n49zrfsp	180	18	IFNγ	IFNγ	NNS
cord-258787-n49zrfsp	180	19	production	production	NN
cord-258787-n49zrfsp	180	20	in	in	IN
cord-258787-n49zrfsp	180	21	a	a	DT
cord-258787-n49zrfsp	180	22	subset	subset	NN
cord-258787-n49zrfsp	180	23	of	of	IN
cord-258787-n49zrfsp	180	24	unconventional	unconventional	JJ
cord-258787-n49zrfsp	180	25	T	t	NN
cord-258787-n49zrfsp	180	26	cell	cell	NN
cord-258787-n49zrfsp	180	27	(	(	-LRB-
cord-258787-n49zrfsp	180	28	CD4-CD8-TCRβ	CD4-CD8-TCRβ	NNP
cord-258787-n49zrfsp	180	29	+	+	CC
cord-258787-n49zrfsp	180	30	)	)	-RRB-
cord-258787-n49zrfsp	181	1	[	[	-LRB-
cord-258787-n49zrfsp	181	2	17	17	CD
cord-258787-n49zrfsp	181	3	]	]	-RRB-
cord-258787-n49zrfsp	181	4	.	.	.
cord-258787-n49zrfsp	182	1	These	these	DT
cord-258787-n49zrfsp	182	2	contrasting	contrast	VBG
cord-258787-n49zrfsp	182	3	reports	report	NNS
cord-258787-n49zrfsp	182	4	are	be	VBP
cord-258787-n49zrfsp	182	5	likely	likely	RB
cord-258787-n49zrfsp	182	6	related	relate	VBN
cord-258787-n49zrfsp	182	7	to	to	IN
cord-258787-n49zrfsp	182	8	the	the	DT
cord-258787-n49zrfsp	182	9	plasticity	plasticity	NN
cord-258787-n49zrfsp	182	10	and	and	CC
cord-258787-n49zrfsp	182	11	heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	182	12	of	of	IN
cord-258787-n49zrfsp	182	13	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	182	14	in	in	IN
cord-258787-n49zrfsp	182	15	different	different	JJ
cord-258787-n49zrfsp	182	16	tissue	tissue	NN
cord-258787-n49zrfsp	182	17	contexts	context	NNS
cord-258787-n49zrfsp	182	18	and	and	CC
cord-258787-n49zrfsp	182	19	conditions	condition	NNS
cord-258787-n49zrfsp	182	20	.	.	.
cord-258787-n49zrfsp	183	1	ROS	ROS	NNP
cord-258787-n49zrfsp	183	2	were	be	VBD
cord-258787-n49zrfsp	183	3	shown	show	VBN
cord-258787-n49zrfsp	183	4	to	to	TO
cord-258787-n49zrfsp	183	5	be	be	VB
cord-258787-n49zrfsp	183	6	a	a	DT
cord-258787-n49zrfsp	183	7	potent	potent	JJ
cord-258787-n49zrfsp	183	8	arm	arm	NN
cord-258787-n49zrfsp	183	9	for	for	IN
cord-258787-n49zrfsp	183	10	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	183	11	anti	anti	JJ
cord-258787-n49zrfsp	183	12	-	-	JJ
cord-258787-n49zrfsp	183	13	tumour	tumour	JJ
cord-258787-n49zrfsp	183	14	activity	activity	NN
cord-258787-n49zrfsp	183	15	,	,	,
cord-258787-n49zrfsp	183	16	through	through	IN
cord-258787-n49zrfsp	183	17	which	which	WDT
cord-258787-n49zrfsp	183	18	they	-PRON-	PRP
cord-258787-n49zrfsp	183	19	can	can	MD
cord-258787-n49zrfsp	183	20	directly	directly	RB
cord-258787-n49zrfsp	183	21	kill	kill	VB
cord-258787-n49zrfsp	183	22	tumour	tumour	NN
cord-258787-n49zrfsp	183	23	cells	cell	NNS
cord-258787-n49zrfsp	183	24	[	[	-LRB-
cord-258787-n49zrfsp	183	25	44	44	CD
cord-258787-n49zrfsp	183	26	,	,	,
cord-258787-n49zrfsp	183	27	147	147	CD
cord-258787-n49zrfsp	183	28	]	]	-RRB-
cord-258787-n49zrfsp	183	29	.	.	.
cord-258787-n49zrfsp	184	1	in	in	IN
cord-258787-n49zrfsp	184	2	vivo	vivo	NNP
cord-258787-n49zrfsp	184	3	evidences	evidence	NNS
cord-258787-n49zrfsp	184	4	showed	show	VBD
cord-258787-n49zrfsp	184	5	that	that	IN
cord-258787-n49zrfsp	184	6	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	184	7	can	can	MD
cord-258787-n49zrfsp	184	8	kill	kill	VB
cord-258787-n49zrfsp	184	9	tumour	tumour	NN
cord-258787-n49zrfsp	184	10	cells	cell	NNS
cord-258787-n49zrfsp	184	11	through	through	IN
cord-258787-n49zrfsp	184	12	a	a	DT
cord-258787-n49zrfsp	184	13	cell	cell	NN
cord-258787-n49zrfsp	184	14	-	-	HYPH
cord-258787-n49zrfsp	184	15	contact	contact	NN
cord-258787-n49zrfsp	184	16	dependent	dependent	JJ
cord-258787-n49zrfsp	184	17	mechanism	mechanism	NN
cord-258787-n49zrfsp	184	18	and	and	CC
cord-258787-n49zrfsp	184	19	the	the	DT
cord-258787-n49zrfsp	184	20	generation	generation	NN
cord-258787-n49zrfsp	184	21	of	of	IN
cord-258787-n49zrfsp	184	22	ROS	ROS	NNP
cord-258787-n49zrfsp	184	23	(	(	-LRB-
cord-258787-n49zrfsp	184	24	i.e.	i.e.	FW
cord-258787-n49zrfsp	184	25	H	h	NN
cord-258787-n49zrfsp	184	26	2	2	CD
cord-258787-n49zrfsp	184	27	O	o	NN
cord-258787-n49zrfsp	184	28	2	2	CD
cord-258787-n49zrfsp	184	29	)	)	-RRB-
cord-258787-n49zrfsp	184	30	.	.	.
cord-258787-n49zrfsp	185	1	Cancer	cancer	NN
cord-258787-n49zrfsp	185	2	cells	cell	NNS
cord-258787-n49zrfsp	185	3	undergoing	undergo	VBG
cord-258787-n49zrfsp	185	4	epithelial	epithelial	JJ
cord-258787-n49zrfsp	185	5	-	-	HYPH
cord-258787-n49zrfsp	185	6	mesenchymal	mesenchymal	JJ
cord-258787-n49zrfsp	185	7	transition	transition	NN
cord-258787-n49zrfsp	185	8	(	(	-LRB-
cord-258787-n49zrfsp	185	9	EMT	EMT	NNP
cord-258787-n49zrfsp	185	10	)	)	-RRB-
cord-258787-n49zrfsp	185	11	upregulated	upregulate	VBD
cord-258787-n49zrfsp	185	12	the	the	DT
cord-258787-n49zrfsp	185	13	transient	transient	JJ
cord-258787-n49zrfsp	185	14	receptor	receptor	NN
cord-258787-n49zrfsp	185	15	potential	potential	JJ
cord-258787-n49zrfsp	185	16	cation	cation	NN
cord-258787-n49zrfsp	185	17	channel	channel	NN
cord-258787-n49zrfsp	185	18	,	,	,
cord-258787-n49zrfsp	185	19	subfamily	subfamily	NN
cord-258787-n49zrfsp	185	20	M	M	NNP
cord-258787-n49zrfsp	185	21	,	,	,
cord-258787-n49zrfsp	185	22	member	member	NN
cord-258787-n49zrfsp	185	23	2	2	CD
cord-258787-n49zrfsp	185	24	(	(	-LRB-
cord-258787-n49zrfsp	185	25	TRPM2	TRPM2	VBN
cord-258787-n49zrfsp	185	26	)	)	-RRB-
cord-258787-n49zrfsp	185	27	,	,	,
cord-258787-n49zrfsp	185	28	an	an	DT
cord-258787-n49zrfsp	185	29	H	h	NN
cord-258787-n49zrfsp	185	30	2	2	CD
cord-258787-n49zrfsp	185	31	O	o	NN
cord-258787-n49zrfsp	185	32	2	2	CD
cord-258787-n49zrfsp	185	33	-dependent	-dependent	CD
cord-258787-n49zrfsp	186	1	Ca	ca	NN
cord-258787-n49zrfsp	186	2	2	2	CD
cord-258787-n49zrfsp	186	3	+	+	SYM
cord-258787-n49zrfsp	186	4	channel	channel	NN
cord-258787-n49zrfsp	186	5	,	,	,
cord-258787-n49zrfsp	186	6	which	which	WDT
cord-258787-n49zrfsp	186	7	induces	induce	VBZ
cord-258787-n49zrfsp	186	8	a	a	DT
cord-258787-n49zrfsp	186	9	lethal	lethal	JJ
cord-258787-n49zrfsp	186	10	influx	influx	NN
cord-258787-n49zrfsp	186	11	of	of	IN
cord-258787-n49zrfsp	186	12	Ca	Ca	NNP
cord-258787-n49zrfsp	186	13	2	2	CD
cord-258787-n49zrfsp	186	14	+	+	CC
cord-258787-n49zrfsp	186	15	in	in	IN
cord-258787-n49zrfsp	186	16	target	target	NN
cord-258787-n49zrfsp	186	17	cells	cell	NNS
cord-258787-n49zrfsp	186	18	[	[	-LRB-
cord-258787-n49zrfsp	186	19	148	148	CD
cord-258787-n49zrfsp	186	20	]	]	-RRB-
cord-258787-n49zrfsp	187	1	(	(	-LRB-
cord-258787-n49zrfsp	187	2	Fig	Fig	NNP
cord-258787-n49zrfsp	187	3	.	.	NNP
cord-258787-n49zrfsp	187	4	2	2	CD
cord-258787-n49zrfsp	187	5	)	)	-RRB-
cord-258787-n49zrfsp	187	6	.	.	.
cord-258787-n49zrfsp	188	1	Accordingly	accordingly	RB
cord-258787-n49zrfsp	188	2	,	,	,
cord-258787-n49zrfsp	188	3	reduced	reduce	VBN
cord-258787-n49zrfsp	188	4	TRPM2	TRPM2	VBN
cord-258787-n49zrfsp	188	5	expression	expression	NN
cord-258787-n49zrfsp	188	6	in	in	IN
cord-258787-n49zrfsp	188	7	cancer	cancer	NN
cord-258787-n49zrfsp	188	8	cells	cell	NNS
cord-258787-n49zrfsp	188	9	protected	protect	VBD
cord-258787-n49zrfsp	188	10	them	-PRON-	PRP
cord-258787-n49zrfsp	188	11	from	from	IN
cord-258787-n49zrfsp	188	12	the	the	DT
cord-258787-n49zrfsp	188	13	cytotoxic	cytotoxic	JJ
cord-258787-n49zrfsp	188	14	activity	activity	NN
cord-258787-n49zrfsp	188	15	of	of	IN
cord-258787-n49zrfsp	188	16	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	188	17	.	.	.
cord-258787-n49zrfsp	189	1	Moreover	moreover	RB
cord-258787-n49zrfsp	189	2	,	,	,
cord-258787-n49zrfsp	189	3	the	the	DT
cord-258787-n49zrfsp	189	4	expression	expression	NN
cord-258787-n49zrfsp	189	5	of	of	IN
cord-258787-n49zrfsp	189	6	TRPM2	TRPM2	NNP
cord-258787-n49zrfsp	189	7	is	be	VBZ
cord-258787-n49zrfsp	189	8	associated	associate	VBN
cord-258787-n49zrfsp	189	9	with	with	IN
cord-258787-n49zrfsp	189	10	increased	increase	VBN
cord-258787-n49zrfsp	189	11	release	release	NN
cord-258787-n49zrfsp	189	12	of	of	IN
cord-258787-n49zrfsp	189	13	CXCL2	cxcl2	NN
cord-258787-n49zrfsp	189	14	,	,	,
cord-258787-n49zrfsp	189	15	a	a	DT
cord-258787-n49zrfsp	189	16	potent	potent	JJ
cord-258787-n49zrfsp	189	17	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	189	18	chemoattractant	chemoattractant	NN
cord-258787-n49zrfsp	189	19	.	.	.
cord-258787-n49zrfsp	190	1	These	these	DT
cord-258787-n49zrfsp	190	2	data	datum	NNS
cord-258787-n49zrfsp	190	3	suggest	suggest	VBP
cord-258787-n49zrfsp	190	4	that	that	IN
cord-258787-n49zrfsp	190	5	TRPM2	TRPM2	NNP
cord-258787-n49zrfsp	190	6	has	have	VBZ
cord-258787-n49zrfsp	190	7	a	a	DT
cord-258787-n49zrfsp	190	8	dual	dual	JJ
cord-258787-n49zrfsp	190	9	role	role	NN
cord-258787-n49zrfsp	190	10	in	in	IN
cord-258787-n49zrfsp	190	11	tumour	tumour	NN
cord-258787-n49zrfsp	190	12	,	,	,
cord-258787-n49zrfsp	190	13	by	by	IN
cord-258787-n49zrfsp	190	14	promoting	promote	VBG
cord-258787-n49zrfsp	190	15	the	the	DT
cord-258787-n49zrfsp	190	16	recruitment	recruitment	NN
cord-258787-n49zrfsp	190	17	of	of	IN
cord-258787-n49zrfsp	190	18	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	190	19	in	in	IN
cord-258787-n49zrfsp	190	20	the	the	DT
cord-258787-n49zrfsp	190	21	TME	TME	NNP
cord-258787-n49zrfsp	190	22	and	and	CC
cord-258787-n49zrfsp	190	23	the	the	DT
cord-258787-n49zrfsp	190	24	elimination	elimination	NN
cord-258787-n49zrfsp	190	25	of	of	IN
cord-258787-n49zrfsp	190	26	cancer	cancer	NN
cord-258787-n49zrfsp	190	27	cells	cell	NNS
cord-258787-n49zrfsp	190	28	[	[	-LRB-
cord-258787-n49zrfsp	190	29	149	149	CD
cord-258787-n49zrfsp	190	30	]	]	-RRB-
cord-258787-n49zrfsp	190	31	.	.	.
cord-258787-n49zrfsp	191	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	191	2	-	-	HYPH
cord-258787-n49zrfsp	191	3	mediated	mediate	VBN
cord-258787-n49zrfsp	191	4	killing	killing	NN
cord-258787-n49zrfsp	191	5	of	of	IN
cord-258787-n49zrfsp	191	6	tumour	tumour	NN
cord-258787-n49zrfsp	191	7	cells	cell	NNS
cord-258787-n49zrfsp	191	8	can	can	MD
cord-258787-n49zrfsp	191	9	also	also	RB
cord-258787-n49zrfsp	191	10	be	be	VB
cord-258787-n49zrfsp	191	11	induced	induce	VBN
cord-258787-n49zrfsp	191	12	by	by	IN
cord-258787-n49zrfsp	191	13	the	the	DT
cord-258787-n49zrfsp	191	14	expression	expression	NN
cord-258787-n49zrfsp	191	15	of	of	IN
cord-258787-n49zrfsp	191	16	TNF	tnf	NN
cord-258787-n49zrfsp	191	17	-	-	HYPH
cord-258787-n49zrfsp	191	18	related	relate	VBN
cord-258787-n49zrfsp	191	19	apoptosis	apoptosis	NN
cord-258787-n49zrfsp	191	20	inducing	induce	VBG
cord-258787-n49zrfsp	191	21	ligand	ligand	NN
cord-258787-n49zrfsp	191	22	(	(	-LRB-
cord-258787-n49zrfsp	191	23	TRAIL	TRAIL	NNP
cord-258787-n49zrfsp	191	24	)	)	-RRB-
cord-258787-n49zrfsp	191	25	by	by	IN
cord-258787-n49zrfsp	191	26	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	191	27	[	[	-LRB-
cord-258787-n49zrfsp	191	28	150	150	CD
cord-258787-n49zrfsp	191	29	]	]	-RRB-
cord-258787-n49zrfsp	191	30	and	and	CC
cord-258787-n49zrfsp	191	31	TNFα	TNFα	NNS
cord-258787-n49zrfsp	191	32	.	.	.
cord-258787-n49zrfsp	192	1	Tumour	tumour	NN
cord-258787-n49zrfsp	192	2	cell	cell	NN
cord-258787-n49zrfsp	192	3	-	-	HYPH
cord-258787-n49zrfsp	192	4	derived	derive	VBN
cord-258787-n49zrfsp	192	5	TNFα	TNFα	NNS
cord-258787-n49zrfsp	192	6	induced	induce	VBD
cord-258787-n49zrfsp	192	7	the	the	DT
cord-258787-n49zrfsp	192	8	expression	expression	NN
cord-258787-n49zrfsp	192	9	of	of	IN
cord-258787-n49zrfsp	192	10	the	the	DT
cord-258787-n49zrfsp	192	11	hepatocyte	hepatocyte	NN
cord-258787-n49zrfsp	192	12	growth	growth	NN
cord-258787-n49zrfsp	192	13	factor	factor	NN
cord-258787-n49zrfsp	192	14	receptor	receptor	NN
cord-258787-n49zrfsp	192	15	(	(	-LRB-
cord-258787-n49zrfsp	192	16	HGFR	HGFR	NNP
cord-258787-n49zrfsp	192	17	,	,	,
cord-258787-n49zrfsp	192	18	also	also	RB
cord-258787-n49zrfsp	192	19	called	call	VBN
cord-258787-n49zrfsp	192	20	MET	MET	NNP
cord-258787-n49zrfsp	192	21	)	)	-RRB-
cord-258787-n49zrfsp	192	22	in	in	IN
cord-258787-n49zrfsp	192	23	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	192	24	[	[	-LRB-
cord-258787-n49zrfsp	192	25	151	151	CD
cord-258787-n49zrfsp	192	26	]	]	-RRB-
cord-258787-n49zrfsp	192	27	.	.	.
cord-258787-n49zrfsp	193	1	This	this	DT
cord-258787-n49zrfsp	193	2	induction	induction	NN
cord-258787-n49zrfsp	193	3	is	be	VBZ
cord-258787-n49zrfsp	193	4	crucial	crucial	JJ
cord-258787-n49zrfsp	193	5	for	for	IN
cord-258787-n49zrfsp	193	6	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	193	7	transmigration	transmigration	NN
cord-258787-n49zrfsp	193	8	through	through	IN
cord-258787-n49zrfsp	193	9	inflamed	inflamed	JJ
cord-258787-n49zrfsp	193	10	endothelium	endothelium	NN
cord-258787-n49zrfsp	193	11	,	,	,
cord-258787-n49zrfsp	193	12	the	the	DT
cord-258787-n49zrfsp	193	13	production	production	NN
cord-258787-n49zrfsp	193	14	of	of	IN
cord-258787-n49zrfsp	193	15	inducible	inducible	JJ
cord-258787-n49zrfsp	193	16	nitric	nitric	NN
cord-258787-n49zrfsp	193	17	oxide	oxide	NN
cord-258787-n49zrfsp	193	18	synthase	synthase	NN
cord-258787-n49zrfsp	193	19	(	(	-LRB-
cord-258787-n49zrfsp	193	20	iNOS	inos	NN
cord-258787-n49zrfsp	193	21	)	)	-RRB-
cord-258787-n49zrfsp	193	22	and	and	CC
cord-258787-n49zrfsp	193	23	NO	no	RB
cord-258787-n49zrfsp	193	24	by	by	IN
cord-258787-n49zrfsp	193	25	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	193	26	in	in	IN
cord-258787-n49zrfsp	193	27	response	response	NN
cord-258787-n49zrfsp	193	28	to	to	IN
cord-258787-n49zrfsp	193	29	HGF	HGF	NNP
cord-258787-n49zrfsp	193	30	.	.	.
cord-258787-n49zrfsp	194	1	In	in	IN
cord-258787-n49zrfsp	194	2	turn	turn	NN
cord-258787-n49zrfsp	194	3	,	,	,
cord-258787-n49zrfsp	194	4	NO	no	DT
cord-258787-n49zrfsp	194	5	kills	kill	VBZ
cord-258787-n49zrfsp	194	6	cancer	cancer	NN
cord-258787-n49zrfsp	194	7	cells	cell	NNS
cord-258787-n49zrfsp	194	8	[	[	-LRB-
cord-258787-n49zrfsp	194	9	151	151	CD
cord-258787-n49zrfsp	194	10	]	]	-RRB-
cord-258787-n49zrfsp	195	1	(	(	-LRB-
cord-258787-n49zrfsp	195	2	Fig	Fig	NNP
cord-258787-n49zrfsp	195	3	.	.	NNP
cord-258787-n49zrfsp	195	4	2	2	CD
cord-258787-n49zrfsp	195	5	)	)	-RRB-
cord-258787-n49zrfsp	195	6	.	.	.
cord-258787-n49zrfsp	196	1	In	in	IN
cord-258787-n49zrfsp	196	2	contrast	contrast	NN
cord-258787-n49zrfsp	196	3	,	,	,
cord-258787-n49zrfsp	196	4	the	the	DT
cord-258787-n49zrfsp	196	5	HGF	HGF	NNP
cord-258787-n49zrfsp	196	6	-	-	HYPH
cord-258787-n49zrfsp	196	7	MET	MET	NNP
cord-258787-n49zrfsp	196	8	pathway	pathway	NN
cord-258787-n49zrfsp	196	9	was	be	VBD
cord-258787-n49zrfsp	196	10	also	also	RB
cord-258787-n49zrfsp	196	11	shown	show	VBN
cord-258787-n49zrfsp	196	12	to	to	TO
cord-258787-n49zrfsp	196	13	drive	drive	VB
cord-258787-n49zrfsp	196	14	an	an	DT
cord-258787-n49zrfsp	196	15	immunosuppressive	immunosuppressive	JJ
cord-258787-n49zrfsp	196	16	phenotype	phenotype	NN
cord-258787-n49zrfsp	196	17	in	in	IN
cord-258787-n49zrfsp	196	18	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	196	19	associated	associate	VBN
cord-258787-n49zrfsp	196	20	with	with	IN
cord-258787-n49zrfsp	196	21	limited	limited	JJ
cord-258787-n49zrfsp	196	22	expansion	expansion	NN
cord-258787-n49zrfsp	196	23	of	of	IN
cord-258787-n49zrfsp	196	24	anti	anti	JJ
cord-258787-n49zrfsp	196	25	-	-	JJ
cord-258787-n49zrfsp	196	26	tumour	tumour	NN
cord-258787-n49zrfsp	196	27	T	t	NN
cord-258787-n49zrfsp	196	28	cells	cell	NNS
cord-258787-n49zrfsp	196	29	[	[	-LRB-
cord-258787-n49zrfsp	196	30	152	152	CD
cord-258787-n49zrfsp	196	31	]	]	-RRB-
cord-258787-n49zrfsp	196	32	.	.	.
cord-258787-n49zrfsp	197	1	Therefore	therefore	RB
cord-258787-n49zrfsp	197	2	,	,	,
cord-258787-n49zrfsp	197	3	the	the	DT
cord-258787-n49zrfsp	197	4	impact	impact	NN
cord-258787-n49zrfsp	197	5	of	of	IN
cord-258787-n49zrfsp	197	6	MET	MET	NNP
cord-258787-n49zrfsp	197	7	expression	expression	NN
cord-258787-n49zrfsp	197	8	on	on	IN
cord-258787-n49zrfsp	197	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	197	10	and	and	CC
cord-258787-n49zrfsp	197	11	its	-PRON-	PRP$
cord-258787-n49zrfsp	197	12	possible	possible	JJ
cord-258787-n49zrfsp	197	13	therapeutic	therapeutic	JJ
cord-258787-n49zrfsp	197	14	applications	application	NNS
cord-258787-n49zrfsp	197	15	is	be	VBZ
cord-258787-n49zrfsp	197	16	still	still	RB
cord-258787-n49zrfsp	197	17	to	to	TO
cord-258787-n49zrfsp	197	18	be	be	VB
cord-258787-n49zrfsp	197	19	fully	fully	RB
cord-258787-n49zrfsp	197	20	clarified	clarify	VBN
cord-258787-n49zrfsp	197	21	.	.	.
cord-258787-n49zrfsp	198	1	The	the	DT
cord-258787-n49zrfsp	198	2	accumulation	accumulation	NN
cord-258787-n49zrfsp	198	3	of	of	IN
cord-258787-n49zrfsp	198	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	198	5	in	in	IN
cord-258787-n49zrfsp	198	6	tissues	tissue	NNS
cord-258787-n49zrfsp	198	7	distant	distant	JJ
cord-258787-n49zrfsp	198	8	from	from	IN
cord-258787-n49zrfsp	198	9	the	the	DT
cord-258787-n49zrfsp	198	10	primary	primary	JJ
cord-258787-n49zrfsp	198	11	tumour	tumour	NN
cord-258787-n49zrfsp	198	12	has	have	VBZ
cord-258787-n49zrfsp	198	13	been	be	VBN
cord-258787-n49zrfsp	198	14	shown	show	VBN
cord-258787-n49zrfsp	198	15	to	to	TO
cord-258787-n49zrfsp	198	16	contribute	contribute	VB
cord-258787-n49zrfsp	198	17	to	to	IN
cord-258787-n49zrfsp	198	18	the	the	DT
cord-258787-n49zrfsp	198	19	formation	formation	NN
cord-258787-n49zrfsp	198	20	of	of	IN
cord-258787-n49zrfsp	198	21	the	the	DT
cord-258787-n49zrfsp	198	22	premetastatic	premetastatic	JJ
cord-258787-n49zrfsp	198	23	niche	niche	NN
cord-258787-n49zrfsp	198	24	.	.	.
cord-258787-n49zrfsp	199	1	In	in	IN
cord-258787-n49zrfsp	199	2	the	the	DT
cord-258787-n49zrfsp	199	3	pre	pre	JJ
cord-258787-n49zrfsp	199	4	-	-	JJ
cord-258787-n49zrfsp	199	5	metastatic	metastatic	JJ
cord-258787-n49zrfsp	199	6	lung	lung	NN
cord-258787-n49zrfsp	199	7	,	,	,
cord-258787-n49zrfsp	199	8	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	199	9	were	be	VBD
cord-258787-n49zrfsp	199	10	found	find	VBN
cord-258787-n49zrfsp	199	11	to	to	TO
cord-258787-n49zrfsp	199	12	promote	promote	VB
cord-258787-n49zrfsp	199	13	the	the	DT
cord-258787-n49zrfsp	199	14	formation	formation	NN
cord-258787-n49zrfsp	199	15	of	of	IN
cord-258787-n49zrfsp	199	16	metastasis	metastasis	NN
cord-258787-n49zrfsp	199	17	via	via	IN
cord-258787-n49zrfsp	199	18	the	the	DT
cord-258787-n49zrfsp	199	19	secretion	secretion	NN
cord-258787-n49zrfsp	199	20	of	of	IN
cord-258787-n49zrfsp	199	21	several	several	JJ
cord-258787-n49zrfsp	199	22	mediators	mediator	NNS
cord-258787-n49zrfsp	199	23	,	,	,
cord-258787-n49zrfsp	199	24	such	such	JJ
cord-258787-n49zrfsp	199	25	as	as	IN
cord-258787-n49zrfsp	199	26	the	the	DT
cord-258787-n49zrfsp	199	27	proangiogenic	proangiogenic	NNP
cord-258787-n49zrfsp	199	28	factors	factor	NNS
cord-258787-n49zrfsp	199	29	Bv8	Bv8	NNP
cord-258787-n49zrfsp	199	30	(	(	-LRB-
cord-258787-n49zrfsp	199	31	also	also	RB
cord-258787-n49zrfsp	199	32	called	call	VBN
cord-258787-n49zrfsp	199	33	prokineticin	prokineticin	NNP
cord-258787-n49zrfsp	199	34	2	2	CD
cord-258787-n49zrfsp	199	35	)	)	-RRB-
cord-258787-n49zrfsp	199	36	and	and	CC
cord-258787-n49zrfsp	199	37	MMP-9	MMP-9	NNP
cord-258787-n49zrfsp	199	38	[	[	-LRB-
cord-258787-n49zrfsp	199	39	76	76	CD
cord-258787-n49zrfsp	199	40	]	]	-RRB-
cord-258787-n49zrfsp	199	41	,	,	,
cord-258787-n49zrfsp	199	42	the	the	DT
cord-258787-n49zrfsp	199	43	chemoattractant	chemoattractant	NN
cord-258787-n49zrfsp	199	44	molecules	molecule	NNS
cord-258787-n49zrfsp	199	45	S100A8	S100A8	NNP
cord-258787-n49zrfsp	199	46	and	and	CC
cord-258787-n49zrfsp	199	47	S100A9	S100A9	NNP
cord-258787-n49zrfsp	199	48	[	[	-LRB-
cord-258787-n49zrfsp	199	49	14	14	CD
cord-258787-n49zrfsp	199	50	]	]	-RRB-
cord-258787-n49zrfsp	199	51	,	,	,
cord-258787-n49zrfsp	199	52	NE	NE	NNP
cord-258787-n49zrfsp	199	53	and	and	CC
cord-258787-n49zrfsp	199	54	cathepsin	cathepsin	NN
cord-258787-n49zrfsp	199	55	G	g	NN
cord-258787-n49zrfsp	199	56	that	that	WDT
cord-258787-n49zrfsp	199	57	mediate	mediate	VBP
cord-258787-n49zrfsp	199	58	the	the	DT
cord-258787-n49zrfsp	199	59	degradation	degradation	NN
cord-258787-n49zrfsp	199	60	of	of	IN
cord-258787-n49zrfsp	199	61	thrombospondin-1	thrombospondin-1	NNP
cord-258787-n49zrfsp	199	62	(	(	-LRB-
cord-258787-n49zrfsp	199	63	Tsp-1	tsp-1	NN
cord-258787-n49zrfsp	199	64	)	)	-RRB-
cord-258787-n49zrfsp	199	65	[	[	-LRB-
cord-258787-n49zrfsp	199	66	153	153	CD
cord-258787-n49zrfsp	199	67	]	]	-RRB-
cord-258787-n49zrfsp	199	68	,	,	,
cord-258787-n49zrfsp	199	69	the	the	DT
cord-258787-n49zrfsp	199	70	pro	pro	JJ
cord-258787-n49zrfsp	199	71	-	-	JJ
cord-258787-n49zrfsp	199	72	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	199	73	cytokine	cytokine	NN
cord-258787-n49zrfsp	199	74	IL-1β	il-1β	NN
cord-258787-n49zrfsp	199	75	and	and	CC
cord-258787-n49zrfsp	199	76	the	the	DT
cord-258787-n49zrfsp	199	77	leukotriene	leukotriene	NN
cord-258787-n49zrfsp	199	78	B4	B4	NNP
cord-258787-n49zrfsp	199	79	(	(	-LRB-
cord-258787-n49zrfsp	199	80	LTB4	LTB4	NNP
cord-258787-n49zrfsp	199	81	)	)	-RRB-
cord-258787-n49zrfsp	200	1	[	[	-LRB-
cord-258787-n49zrfsp	200	2	18	18	CD
cord-258787-n49zrfsp	200	3	]	]	-RRB-
cord-258787-n49zrfsp	200	4	.	.	.
cord-258787-n49zrfsp	201	1	In	in	IN
cord-258787-n49zrfsp	201	2	particular	particular	JJ
cord-258787-n49zrfsp	201	3	,	,	,
cord-258787-n49zrfsp	201	4	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	201	5	-	-	HYPH
cord-258787-n49zrfsp	201	6	derived	derive	VBN
cord-258787-n49zrfsp	201	7	MMP-9	MMP-9	NNP
cord-258787-n49zrfsp	201	8	was	be	VBD
cord-258787-n49zrfsp	201	9	shown	show	VBN
cord-258787-n49zrfsp	201	10	to	to	TO
cord-258787-n49zrfsp	201	11	induce	induce	VB
cord-258787-n49zrfsp	201	12	the	the	DT
cord-258787-n49zrfsp	201	13	liberation	liberation	NN
cord-258787-n49zrfsp	201	14	and	and	CC
cord-258787-n49zrfsp	201	15	the	the	DT
cord-258787-n49zrfsp	201	16	activation	activation	NN
cord-258787-n49zrfsp	201	17	of	of	IN
cord-258787-n49zrfsp	201	18	VEGF	VEGF	NNP
cord-258787-n49zrfsp	201	19	and	and	CC
cord-258787-n49zrfsp	201	20	the	the	DT
cord-258787-n49zrfsp	201	21	subsequent	subsequent	JJ
cord-258787-n49zrfsp	201	22	production	production	NN
cord-258787-n49zrfsp	201	23	of	of	IN
cord-258787-n49zrfsp	201	24	new	new	JJ
cord-258787-n49zrfsp	201	25	vessels	vessel	NNS
cord-258787-n49zrfsp	201	26	.	.	.
cord-258787-n49zrfsp	202	1	in	in	IN
cord-258787-n49zrfsp	202	2	vivo	vivo	NNP
cord-258787-n49zrfsp	202	3	studies	study	NNS
cord-258787-n49zrfsp	202	4	have	have	VBP
cord-258787-n49zrfsp	202	5	shown	show	VBN
cord-258787-n49zrfsp	202	6	that	that	IN
cord-258787-n49zrfsp	202	7	Bv8	bv8	NN
cord-258787-n49zrfsp	202	8	,	,	,
cord-258787-n49zrfsp	202	9	produced	produce	VBN
cord-258787-n49zrfsp	202	10	by	by	IN
cord-258787-n49zrfsp	202	11	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	202	12	,	,	,
cord-258787-n49zrfsp	202	13	was	be	VBD
cord-258787-n49zrfsp	202	14	responsible	responsible	JJ
cord-258787-n49zrfsp	202	15	for	for	IN
cord-258787-n49zrfsp	202	16	the	the	DT
cord-258787-n49zrfsp	202	17	poor	poor	JJ
cord-258787-n49zrfsp	202	18	efficacy	efficacy	NN
cord-258787-n49zrfsp	202	19	of	of	IN
cord-258787-n49zrfsp	202	20	anti	anti	JJ
cord-258787-n49zrfsp	202	21	-	-	JJ
cord-258787-n49zrfsp	202	22	VEGF	vegf	JJ
cord-258787-n49zrfsp	202	23	therapy	therapy	NN
cord-258787-n49zrfsp	202	24	.	.	.
cord-258787-n49zrfsp	203	1	Thus	thus	RB
cord-258787-n49zrfsp	203	2	,	,	,
cord-258787-n49zrfsp	203	3	the	the	DT
cord-258787-n49zrfsp	203	4	inhibition	inhibition	NN
cord-258787-n49zrfsp	203	5	of	of	IN
cord-258787-n49zrfsp	203	6	IL-17\G	IL-17\G	NNP
cord-258787-n49zrfsp	203	7	-	-	HYPH
cord-258787-n49zrfsp	203	8	CSF	csf	NN
cord-258787-n49zrfsp	203	9	axis	axis	NN
cord-258787-n49zrfsp	203	10	was	be	VBD
cord-258787-n49zrfsp	203	11	shown	show	VBN
cord-258787-n49zrfsp	203	12	to	to	TO
cord-258787-n49zrfsp	203	13	increase	increase	VB
cord-258787-n49zrfsp	203	14	the	the	DT
cord-258787-n49zrfsp	203	15	therapeutic	therapeutic	JJ
cord-258787-n49zrfsp	203	16	efficacy	efficacy	NN
cord-258787-n49zrfsp	203	17	of	of	IN
cord-258787-n49zrfsp	203	18	anti	anti	JJ
cord-258787-n49zrfsp	203	19	-	-	JJ
cord-258787-n49zrfsp	203	20	VEGF	vegf	JJ
cord-258787-n49zrfsp	203	21	treatment	treatment	NN
cord-258787-n49zrfsp	203	22	[	[	-LRB-
cord-258787-n49zrfsp	203	23	154	154	CD
cord-258787-n49zrfsp	203	24	]	]	-RRB-
cord-258787-n49zrfsp	203	25	[	[	-LRB-
cord-258787-n49zrfsp	203	26	155	155	CD
cord-258787-n49zrfsp	203	27	]	]	-RRB-
cord-258787-n49zrfsp	203	28	[	[	-LRB-
cord-258787-n49zrfsp	203	29	156	156	CD
cord-258787-n49zrfsp	203	30	]	]	-RRB-
cord-258787-n49zrfsp	203	31	[	[	-LRB-
cord-258787-n49zrfsp	203	32	157	157	CD
cord-258787-n49zrfsp	203	33	]	]	-RRB-
cord-258787-n49zrfsp	203	34	.	.	.
cord-258787-n49zrfsp	204	1	The	the	DT
cord-258787-n49zrfsp	204	2	use	use	NN
cord-258787-n49zrfsp	204	3	of	of	IN
cord-258787-n49zrfsp	204	4	oncogene	oncogene	NN
cord-258787-n49zrfsp	204	5	-	-	HYPH
cord-258787-n49zrfsp	204	6	driven	drive	VBN
cord-258787-n49zrfsp	204	7	cancer	cancer	NN
cord-258787-n49zrfsp	204	8	model	model	NN
cord-258787-n49zrfsp	204	9	has	have	VBZ
cord-258787-n49zrfsp	204	10	highlighted	highlight	VBN
cord-258787-n49zrfsp	204	11	how	how	WRB
cord-258787-n49zrfsp	204	12	the	the	DT
cord-258787-n49zrfsp	204	13	interaction	interaction	NN
cord-258787-n49zrfsp	204	14	between	between	IN
cord-258787-n49zrfsp	204	15	tumour	tumour	NN
cord-258787-n49zrfsp	204	16	cells	cell	NNS
cord-258787-n49zrfsp	204	17	and	and	CC
cord-258787-n49zrfsp	204	18	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	204	19	was	be	VBD
cord-258787-n49zrfsp	204	20	involved	involve	VBN
cord-258787-n49zrfsp	204	21	in	in	IN
cord-258787-n49zrfsp	204	22	metastasis	metastasis	NN
cord-258787-n49zrfsp	204	23	formation	formation	NN
cord-258787-n49zrfsp	204	24	[	[	-LRB-
cord-258787-n49zrfsp	204	25	14	14	CD
cord-258787-n49zrfsp	204	26	,	,	,
cord-258787-n49zrfsp	204	27	18	18	CD
cord-258787-n49zrfsp	204	28	,	,	,
cord-258787-n49zrfsp	204	29	158	158	CD
cord-258787-n49zrfsp	204	30	,	,	,
cord-258787-n49zrfsp	204	31	159	159	CD
cord-258787-n49zrfsp	204	32	]	]	-RRB-
cord-258787-n49zrfsp	204	33	.	.	.
cord-258787-n49zrfsp	205	1	In	in	IN
cord-258787-n49zrfsp	205	2	K14	K14	NNP
cord-258787-n49zrfsp	205	3	cre	cre	NNP
cord-258787-n49zrfsp	205	4	;	;	:
cord-258787-n49zrfsp	205	5	Cdh1	Cdh1	NNP
cord-258787-n49zrfsp	205	6	fl	fl	NNP
cord-258787-n49zrfsp	205	7	/	/	SYM
cord-258787-n49zrfsp	205	8	fl	fl	NNP
cord-258787-n49zrfsp	205	9	;	;	:
cord-258787-n49zrfsp	205	10	Trp53	Trp53	NNP
cord-258787-n49zrfsp	205	11	fl	fl	NNP
cord-258787-n49zrfsp	205	12	/	/	SYM
cord-258787-n49zrfsp	205	13	fl	fl	NNP
cord-258787-n49zrfsp	205	14	(	(	-LRB-
cord-258787-n49zrfsp	205	15	KEP	KEP	NNP
cord-258787-n49zrfsp	205	16	)	)	-RRB-
cord-258787-n49zrfsp	205	17	mouse	mouse	NN
cord-258787-n49zrfsp	205	18	model	model	NN
cord-258787-n49zrfsp	205	19	of	of	IN
cord-258787-n49zrfsp	205	20	breast	breast	NN
cord-258787-n49zrfsp	205	21	cancer	cancer	NN
cord-258787-n49zrfsp	205	22	,	,	,
cord-258787-n49zrfsp	205	23	the	the	DT
cord-258787-n49zrfsp	205	24	accumulation	accumulation	NN
cord-258787-n49zrfsp	205	25	of	of	IN
cord-258787-n49zrfsp	205	26	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	205	27	in	in	IN
cord-258787-n49zrfsp	205	28	the	the	DT
cord-258787-n49zrfsp	205	29	pre	pre	JJ
cord-258787-n49zrfsp	205	30	-	-	JJ
cord-258787-n49zrfsp	205	31	metastatic	metastatic	JJ
cord-258787-n49zrfsp	205	32	lung	lung	NN
cord-258787-n49zrfsp	205	33	with	with	IN
cord-258787-n49zrfsp	205	34	immunosuppressive	immunosuppressive	JJ
cord-258787-n49zrfsp	205	35	features	feature	NNS
cord-258787-n49zrfsp	205	36	was	be	VBD
cord-258787-n49zrfsp	205	37	associated	associate	VBN
cord-258787-n49zrfsp	205	38	with	with	IN
cord-258787-n49zrfsp	205	39	the	the	DT
cord-258787-n49zrfsp	205	40	formation	formation	NN
cord-258787-n49zrfsp	205	41	of	of	IN
cord-258787-n49zrfsp	205	42	lung	lung	NN
cord-258787-n49zrfsp	205	43	metastasis	metastasis	NN
cord-258787-n49zrfsp	205	44	[	[	-LRB-
cord-258787-n49zrfsp	205	45	14	14	CD
cord-258787-n49zrfsp	205	46	]	]	-RRB-
cord-258787-n49zrfsp	205	47	.	.	.
cord-258787-n49zrfsp	206	1	Further	further	JJ
cord-258787-n49zrfsp	206	2	studies	study	NNS
cord-258787-n49zrfsp	206	3	have	have	VBP
cord-258787-n49zrfsp	206	4	demonstrated	demonstrate	VBN
cord-258787-n49zrfsp	206	5	that	that	IN
cord-258787-n49zrfsp	206	6	tumour	tumour	NN
cord-258787-n49zrfsp	206	7	cells	cell	NNS
cord-258787-n49zrfsp	206	8	,	,	,
cord-258787-n49zrfsp	206	9	through	through	IN
cord-258787-n49zrfsp	206	10	the	the	DT
cord-258787-n49zrfsp	206	11	secretion	secretion	NN
cord-258787-n49zrfsp	206	12	of	of	IN
cord-258787-n49zrfsp	206	13	WNT	wnt	NN
cord-258787-n49zrfsp	206	14	ligands	ligand	NNS
cord-258787-n49zrfsp	206	15	induced	induce	VBD
cord-258787-n49zrfsp	206	16	a	a	DT
cord-258787-n49zrfsp	206	17	systemic	systemic	JJ
cord-258787-n49zrfsp	206	18	pro	pro	JJ
cord-258787-n49zrfsp	206	19	-	-	JJ
cord-258787-n49zrfsp	206	20	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	206	21	cascade	cascade	NN
cord-258787-n49zrfsp	206	22	starting	start	VBG
cord-258787-n49zrfsp	206	23	by	by	IN
cord-258787-n49zrfsp	206	24	the	the	DT
cord-258787-n49zrfsp	206	25	secretion	secretion	NN
cord-258787-n49zrfsp	206	26	of	of	IN
cord-258787-n49zrfsp	206	27	IL-1β	il-1β	NN
cord-258787-n49zrfsp	206	28	by	by	IN
cord-258787-n49zrfsp	206	29	macrophages	macrophage	NNS
cord-258787-n49zrfsp	206	30	[	[	-LRB-
cord-258787-n49zrfsp	206	31	159	159	CD
cord-258787-n49zrfsp	206	32	]	]	-RRB-
cord-258787-n49zrfsp	206	33	.	.	.
cord-258787-n49zrfsp	207	1	In	in	IN
cord-258787-n49zrfsp	207	2	turn	turn	NN
cord-258787-n49zrfsp	207	3	,	,	,
cord-258787-n49zrfsp	207	4	IL-1β	IL-1β	NNP
cord-258787-n49zrfsp	207	5	induced	induce	VBD
cord-258787-n49zrfsp	207	6	the	the	DT
cord-258787-n49zrfsp	207	7	production	production	NN
cord-258787-n49zrfsp	207	8	of	of	IN
cord-258787-n49zrfsp	207	9	IL-17	IL-17	NNP
cord-258787-n49zrfsp	207	10	by	by	IN
cord-258787-n49zrfsp	207	11	γδ	γδ	NNP
cord-258787-n49zrfsp	207	12	T	t	NN
cord-258787-n49zrfsp	207	13	cells	cell	NNS
cord-258787-n49zrfsp	207	14	,	,	,
cord-258787-n49zrfsp	207	15	leading	lead	VBG
cord-258787-n49zrfsp	207	16	to	to	IN
cord-258787-n49zrfsp	207	17	a	a	DT
cord-258787-n49zrfsp	207	18	G	G	NNP
cord-258787-n49zrfsp	207	19	-	-	HYPH
cord-258787-n49zrfsp	207	20	CSF	csf	NN
cord-258787-n49zrfsp	207	21	-	-	HYPH
cord-258787-n49zrfsp	207	22	dependent	dependent	JJ
cord-258787-n49zrfsp	207	23	expansion	expansion	NN
cord-258787-n49zrfsp	207	24	of	of	IN
cord-258787-n49zrfsp	207	25	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	207	26	and	and	CC
cord-258787-n49zrfsp	207	27	their	-PRON-	PRP$
cord-258787-n49zrfsp	207	28	polarization	polarization	NN
cord-258787-n49zrfsp	207	29	in	in	IN
cord-258787-n49zrfsp	207	30	an	an	DT
cord-258787-n49zrfsp	207	31	immunosuppressive	immunosuppressive	JJ
cord-258787-n49zrfsp	207	32	phenotype	phenotype	NN
cord-258787-n49zrfsp	207	33	[	[	-LRB-
cord-258787-n49zrfsp	207	34	14	14	CD
cord-258787-n49zrfsp	207	35	,	,	,
cord-258787-n49zrfsp	207	36	160	160	CD
cord-258787-n49zrfsp	207	37	]	]	-RRB-
cord-258787-n49zrfsp	208	1	(	(	-LRB-
cord-258787-n49zrfsp	208	2	Fig	Fig	NNP
cord-258787-n49zrfsp	208	3	.	.	NNP
cord-258787-n49zrfsp	208	4	1	1	CD
cord-258787-n49zrfsp	208	5	)	)	-RRB-
cord-258787-n49zrfsp	208	6	.	.	.
cord-258787-n49zrfsp	209	1	Accordingly	accordingly	RB
cord-258787-n49zrfsp	209	2	,	,	,
cord-258787-n49zrfsp	209	3	IL-17	IL-17	NNP
cord-258787-n49zrfsp	209	4	derived	derive	VBN
cord-258787-n49zrfsp	209	5	from	from	IN
cord-258787-n49zrfsp	209	6	CD4	CD4	NNP
cord-258787-n49zrfsp	209	7	+	+	CC
cord-258787-n49zrfsp	209	8	T	T	NNP
cord-258787-n49zrfsp	209	9	cells	cell	NNS
cord-258787-n49zrfsp	209	10	or	or	CC
cord-258787-n49zrfsp	209	11	γδ	γδ	NN
cord-258787-n49zrfsp	209	12	T	t	NN
cord-258787-n49zrfsp	209	13	cells	cell	NNS
cord-258787-n49zrfsp	209	14	drives	drive	VBZ
cord-258787-n49zrfsp	209	15	most	most	JJS
cord-258787-n49zrfsp	209	16	of	of	IN
cord-258787-n49zrfsp	209	17	the	the	DT
cord-258787-n49zrfsp	209	18	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	209	19	-	-	HYPH
cord-258787-n49zrfsp	209	20	derived	derive	VBN
cord-258787-n49zrfsp	209	21	pro	pro	JJ
cord-258787-n49zrfsp	209	22	-	-	JJ
cord-258787-n49zrfsp	209	23	tumour	tumour	JJ
cord-258787-n49zrfsp	209	24	activities	activity	NNS
cord-258787-n49zrfsp	209	25	described	describe	VBN
cord-258787-n49zrfsp	209	26	above	above	RB
cord-258787-n49zrfsp	209	27	.	.	.
cord-258787-n49zrfsp	210	1	Studies	study	NNS
cord-258787-n49zrfsp	210	2	showed	show	VBD
cord-258787-n49zrfsp	210	3	that	that	IN
cord-258787-n49zrfsp	210	4	NETs	net	NNS
cord-258787-n49zrfsp	210	5	can	can	MD
cord-258787-n49zrfsp	210	6	support	support	VB
cord-258787-n49zrfsp	210	7	the	the	DT
cord-258787-n49zrfsp	210	8	formation	formation	NN
cord-258787-n49zrfsp	210	9	of	of	IN
cord-258787-n49zrfsp	210	10	metastasis	metastasis	NN
cord-258787-n49zrfsp	210	11	through	through	IN
cord-258787-n49zrfsp	210	12	their	-PRON-	PRP$
cord-258787-n49zrfsp	210	13	ability	ability	NN
cord-258787-n49zrfsp	210	14	to	to	TO
cord-258787-n49zrfsp	210	15	trap	trap	VB
cord-258787-n49zrfsp	210	16	disseminating	disseminate	VBG
cord-258787-n49zrfsp	210	17	cancer	cancer	NN
cord-258787-n49zrfsp	210	18	cells	cell	NNS
cord-258787-n49zrfsp	210	19	and	and	CC
cord-258787-n49zrfsp	210	20	to	to	TO
cord-258787-n49zrfsp	210	21	facilitate	facilitate	VB
cord-258787-n49zrfsp	210	22	their	-PRON-	PRP$
cord-258787-n49zrfsp	210	23	seeding	seeding	NN
cord-258787-n49zrfsp	210	24	and	and	CC
cord-258787-n49zrfsp	210	25	proliferation	proliferation	NN
cord-258787-n49zrfsp	210	26	in	in	IN
cord-258787-n49zrfsp	210	27	a	a	DT
cord-258787-n49zrfsp	210	28	distant	distant	JJ
cord-258787-n49zrfsp	210	29	anatomical	anatomical	JJ
cord-258787-n49zrfsp	210	30	site	site	NN
cord-258787-n49zrfsp	210	31	[	[	-LRB-
cord-258787-n49zrfsp	210	32	138	138	CD
cord-258787-n49zrfsp	210	33	]	]	-RRB-
cord-258787-n49zrfsp	211	1	[	[	-LRB-
cord-258787-n49zrfsp	211	2	139	139	CD
cord-258787-n49zrfsp	211	3	]	]	-RRB-
cord-258787-n49zrfsp	211	4	[	[	-LRB-
cord-258787-n49zrfsp	211	5	140	140	CD
cord-258787-n49zrfsp	211	6	]	]	-RRB-
cord-258787-n49zrfsp	211	7	[	[	-LRB-
cord-258787-n49zrfsp	211	8	141	141	CD
cord-258787-n49zrfsp	211	9	]	]	-RRB-
cord-258787-n49zrfsp	211	10	[	[	-LRB-
cord-258787-n49zrfsp	211	11	142	142	CD
cord-258787-n49zrfsp	211	12	]	]	-RRB-
cord-258787-n49zrfsp	211	13	[	[	-LRB-
cord-258787-n49zrfsp	211	14	143	143	CD
cord-258787-n49zrfsp	211	15	]	]	-RRB-
cord-258787-n49zrfsp	211	16	.	.	.
cord-258787-n49zrfsp	212	1	In	in	IN
cord-258787-n49zrfsp	212	2	an	an	DT
cord-258787-n49zrfsp	212	3	in	in	IN
cord-258787-n49zrfsp	212	4	vivo	vivo	NN
cord-258787-n49zrfsp	212	5	model	model	NN
cord-258787-n49zrfsp	212	6	of	of	IN
cord-258787-n49zrfsp	212	7	lung	lung	NN
cord-258787-n49zrfsp	212	8	metastasis	metastasis	NN
cord-258787-n49zrfsp	212	9	,	,	,
cord-258787-n49zrfsp	212	10	sustained	sustain	VBD
cord-258787-n49zrfsp	212	11	lung	lung	NN
cord-258787-n49zrfsp	212	12	inflammation	inflammation	NN
cord-258787-n49zrfsp	212	13	and	and	CC
cord-258787-n49zrfsp	212	14	cancer	cancer	NN
cord-258787-n49zrfsp	212	15	cell	cell	NN
cord-258787-n49zrfsp	212	16	-	-	HYPH
cord-258787-n49zrfsp	212	17	derived	derive	VBN
cord-258787-n49zrfsp	212	18	G	G	NNP
cord-258787-n49zrfsp	212	19	-	-	HYPH
cord-258787-n49zrfsp	212	20	CSF	CSF	NNP
cord-258787-n49zrfsp	212	21	induced	induced	NN
cord-258787-n49zrfsp	212	22	NETs	NETs	NNP
cord-258787-n49zrfsp	212	23	formation	formation	NN
cord-258787-n49zrfsp	212	24	,	,	,
cord-258787-n49zrfsp	212	25	which	which	WDT
cord-258787-n49zrfsp	212	26	in	in	IN
cord-258787-n49zrfsp	212	27	turn	turn	NN
cord-258787-n49zrfsp	212	28	promoted	promote	VBD
cord-258787-n49zrfsp	212	29	the	the	DT
cord-258787-n49zrfsp	212	30	proliferation	proliferation	NN
cord-258787-n49zrfsp	212	31	of	of	IN
cord-258787-n49zrfsp	212	32	dormant	dormant	JJ
cord-258787-n49zrfsp	212	33	cancer	cancer	NN
cord-258787-n49zrfsp	212	34	cells	cell	NNS
cord-258787-n49zrfsp	212	35	.	.	.
cord-258787-n49zrfsp	213	1	Accordingly	accordingly	RB
cord-258787-n49zrfsp	213	2	,	,	,
cord-258787-n49zrfsp	213	3	administration	administration	NN
cord-258787-n49zrfsp	213	4	of	of	IN
cord-258787-n49zrfsp	213	5	DNase	DNase	NNP
cord-258787-n49zrfsp	213	6	to	to	TO
cord-258787-n49zrfsp	213	7	eliminate	eliminate	VB
cord-258787-n49zrfsp	213	8	NETs	net	NNS
cord-258787-n49zrfsp	213	9	reduced	reduce	VBN
cord-258787-n49zrfsp	213	10	the	the	DT
cord-258787-n49zrfsp	213	11	formation	formation	NN
cord-258787-n49zrfsp	213	12	of	of	IN
cord-258787-n49zrfsp	213	13	lung	lung	NN
cord-258787-n49zrfsp	213	14	metastasis	metastasis	NN
cord-258787-n49zrfsp	213	15	[	[	-LRB-
cord-258787-n49zrfsp	213	16	142	142	CD
cord-258787-n49zrfsp	213	17	]	]	-RRB-
cord-258787-n49zrfsp	213	18	.	.	.
cord-258787-n49zrfsp	214	1	In	in	IN
cord-258787-n49zrfsp	214	2	ovarian	ovarian	JJ
cord-258787-n49zrfsp	214	3	cancer	cancer	NN
cord-258787-n49zrfsp	214	4	,	,	,
cord-258787-n49zrfsp	214	5	the	the	DT
cord-258787-n49zrfsp	214	6	formation	formation	NN
cord-258787-n49zrfsp	214	7	of	of	IN
cord-258787-n49zrfsp	214	8	new	new	JJ
cord-258787-n49zrfsp	214	9	metastasis	metastasis	NN
cord-258787-n49zrfsp	214	10	in	in	IN
cord-258787-n49zrfsp	214	11	the	the	DT
cord-258787-n49zrfsp	214	12	omentum	omentum	NN
cord-258787-n49zrfsp	214	13	was	be	VBD
cord-258787-n49zrfsp	214	14	also	also	RB
cord-258787-n49zrfsp	214	15	dependent	dependent	JJ
cord-258787-n49zrfsp	214	16	on	on	IN
cord-258787-n49zrfsp	214	17	the	the	DT
cord-258787-n49zrfsp	214	18	formation	formation	NN
cord-258787-n49zrfsp	214	19	of	of	IN
cord-258787-n49zrfsp	214	20	NETs	net	NNS
cord-258787-n49zrfsp	214	21	in	in	IN
cord-258787-n49zrfsp	214	22	the	the	DT
cord-258787-n49zrfsp	214	23	pre	pre	JJ
cord-258787-n49zrfsp	214	24	-	-	JJ
cord-258787-n49zrfsp	214	25	metastatic	metastatic	JJ
cord-258787-n49zrfsp	214	26	niche	niche	NN
cord-258787-n49zrfsp	214	27	[	[	-LRB-
cord-258787-n49zrfsp	214	28	141	141	CD
cord-258787-n49zrfsp	214	29	]	]	-RRB-
cord-258787-n49zrfsp	214	30	.	.	.
cord-258787-n49zrfsp	215	1	Mechanistically	mechanistically	RB
cord-258787-n49zrfsp	215	2	,	,	,
cord-258787-n49zrfsp	215	3	recent	recent	JJ
cord-258787-n49zrfsp	215	4	investigations	investigation	NNS
cord-258787-n49zrfsp	215	5	have	have	VBP
cord-258787-n49zrfsp	215	6	provided	provide	VBN
cord-258787-n49zrfsp	215	7	new	new	JJ
cord-258787-n49zrfsp	215	8	insights	insight	NNS
cord-258787-n49zrfsp	215	9	regarding	regard	VBG
cord-258787-n49zrfsp	215	10	the	the	DT
cord-258787-n49zrfsp	215	11	molecular	molecular	JJ
cord-258787-n49zrfsp	215	12	interaction	interaction	NN
cord-258787-n49zrfsp	215	13	between	between	IN
cord-258787-n49zrfsp	215	14	cancer	cancer	NN
cord-258787-n49zrfsp	215	15	cells	cell	NNS
cord-258787-n49zrfsp	215	16	and	and	CC
cord-258787-n49zrfsp	215	17	NETs	net	NNS
cord-258787-n49zrfsp	215	18	.	.	.
cord-258787-n49zrfsp	216	1	In	in	IN
cord-258787-n49zrfsp	216	2	particular	particular	JJ
cord-258787-n49zrfsp	216	3	,	,	,
cord-258787-n49zrfsp	216	4	cancer	cancer	NN
cord-258787-n49zrfsp	216	5	cells	cell	NNS
cord-258787-n49zrfsp	216	6	express	express	VBP
cord-258787-n49zrfsp	216	7	the	the	DT
cord-258787-n49zrfsp	216	8	coiled	coil	VBN
cord-258787-n49zrfsp	216	9	-	-	HYPH
cord-258787-n49zrfsp	216	10	coil	coil	NN
cord-258787-n49zrfsp	216	11	domain	domain	NN
cord-258787-n49zrfsp	216	12	containing	contain	VBG
cord-258787-n49zrfsp	216	13	protein-25	protein-25	CD
cord-258787-n49zrfsp	216	14	(	(	-LRB-
cord-258787-n49zrfsp	216	15	CCDC25	CCDC25	NNP
cord-258787-n49zrfsp	216	16	)	)	-RRB-
cord-258787-n49zrfsp	216	17	,	,	,
cord-258787-n49zrfsp	216	18	which	which	WDT
cord-258787-n49zrfsp	216	19	acts	act	VBZ
cord-258787-n49zrfsp	216	20	as	as	IN
cord-258787-n49zrfsp	216	21	an	an	DT
cord-258787-n49zrfsp	216	22	extracellular	extracellular	JJ
cord-258787-n49zrfsp	216	23	DNA	dna	NN
cord-258787-n49zrfsp	216	24	sensor	sensor	NN
cord-258787-n49zrfsp	216	25	and	and	CC
cord-258787-n49zrfsp	216	26	can	can	MD
cord-258787-n49zrfsp	216	27	activate	activate	VB
cord-258787-n49zrfsp	216	28	cell	cell	NN
cord-258787-n49zrfsp	216	29	motility	motility	NN
cord-258787-n49zrfsp	216	30	[	[	-LRB-
cord-258787-n49zrfsp	216	31	161	161	CD
cord-258787-n49zrfsp	216	32	]	]	-RRB-
cord-258787-n49zrfsp	216	33	.	.	.
cord-258787-n49zrfsp	217	1	Therefore	therefore	RB
cord-258787-n49zrfsp	217	2	,	,	,
cord-258787-n49zrfsp	217	3	the	the	DT
cord-258787-n49zrfsp	217	4	formation	formation	NN
cord-258787-n49zrfsp	217	5	of	of	IN
cord-258787-n49zrfsp	217	6	NETs	net	NNS
cord-258787-n49zrfsp	217	7	in	in	IN
cord-258787-n49zrfsp	217	8	the	the	DT
cord-258787-n49zrfsp	217	9	liver	liver	NN
cord-258787-n49zrfsp	217	10	or	or	CC
cord-258787-n49zrfsp	217	11	lung	lung	NN
cord-258787-n49zrfsp	217	12	induced	induce	VBD
cord-258787-n49zrfsp	217	13	the	the	DT
cord-258787-n49zrfsp	217	14	migration	migration	NN
cord-258787-n49zrfsp	217	15	of	of	IN
cord-258787-n49zrfsp	217	16	cancer	cancer	NN
cord-258787-n49zrfsp	217	17	cells	cell	NNS
cord-258787-n49zrfsp	217	18	and	and	CC
cord-258787-n49zrfsp	217	19	CCDC25-deficient	ccdc25-deficient	NN
cord-258787-n49zrfsp	217	20	mice	mouse	NNS
cord-258787-n49zrfsp	217	21	present	present	VBP
cord-258787-n49zrfsp	217	22	a	a	DT
cord-258787-n49zrfsp	217	23	reduced	reduce	VBN
cord-258787-n49zrfsp	217	24	formation	formation	NN
cord-258787-n49zrfsp	217	25	of	of	IN
cord-258787-n49zrfsp	217	26	metastasis	metastasis	NN
cord-258787-n49zrfsp	217	27	.	.	.
cord-258787-n49zrfsp	218	1	Moreover	moreover	RB
cord-258787-n49zrfsp	218	2	,	,	,
cord-258787-n49zrfsp	218	3	in	in	IN
cord-258787-n49zrfsp	218	4	silico	silico	NN
cord-258787-n49zrfsp	218	5	analyses	analysis	NNS
cord-258787-n49zrfsp	218	6	showed	show	VBD
cord-258787-n49zrfsp	218	7	that	that	IN
cord-258787-n49zrfsp	218	8	CCDC25	CCDC25	NNP
cord-258787-n49zrfsp	218	9	was	be	VBD
cord-258787-n49zrfsp	218	10	expressed	express	VBN
cord-258787-n49zrfsp	218	11	by	by	IN
cord-258787-n49zrfsp	218	12	several	several	JJ
cord-258787-n49zrfsp	218	13	cancer	cancer	NN
cord-258787-n49zrfsp	218	14	cells	cell	NNS
cord-258787-n49zrfsp	218	15	in	in	IN
cord-258787-n49zrfsp	218	16	human	human	JJ
cord-258787-n49zrfsp	218	17	and	and	CC
cord-258787-n49zrfsp	218	18	in	in	IN
cord-258787-n49zrfsp	218	19	cohorts	cohort	NNS
cord-258787-n49zrfsp	218	20	of	of	IN
cord-258787-n49zrfsp	218	21	patients	patient	NNS
cord-258787-n49zrfsp	218	22	with	with	IN
cord-258787-n49zrfsp	218	23	breast	breast	NN
cord-258787-n49zrfsp	218	24	cancer	cancer	NN
cord-258787-n49zrfsp	218	25	or	or	CC
cord-258787-n49zrfsp	218	26	colon	colon	NN
cord-258787-n49zrfsp	218	27	cancer	cancer	NN
cord-258787-n49zrfsp	218	28	,	,	,
cord-258787-n49zrfsp	218	29	the	the	DT
cord-258787-n49zrfsp	218	30	expression	expression	NN
cord-258787-n49zrfsp	218	31	of	of	IN
cord-258787-n49zrfsp	218	32	CCDC25	CCDC25	NNP
cord-258787-n49zrfsp	218	33	was	be	VBD
cord-258787-n49zrfsp	218	34	correlated	correlate	VBN
cord-258787-n49zrfsp	218	35	with	with	IN
cord-258787-n49zrfsp	218	36	poor	poor	JJ
cord-258787-n49zrfsp	218	37	clinical	clinical	JJ
cord-258787-n49zrfsp	218	38	outcome	outcome	NN
cord-258787-n49zrfsp	218	39	[	[	-LRB-
cord-258787-n49zrfsp	218	40	161	161	CD
cord-258787-n49zrfsp	218	41	]	]	-RRB-
cord-258787-n49zrfsp	218	42	.	.	.
cord-258787-n49zrfsp	219	1	In	in	IN
cord-258787-n49zrfsp	219	2	apparent	apparent	JJ
cord-258787-n49zrfsp	219	3	contrast	contrast	NN
cord-258787-n49zrfsp	219	4	with	with	IN
cord-258787-n49zrfsp	219	5	the	the	DT
cord-258787-n49zrfsp	219	6	previous	previous	JJ
cord-258787-n49zrfsp	219	7	findings	finding	NNS
cord-258787-n49zrfsp	219	8	,	,	,
cord-258787-n49zrfsp	219	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	219	10	recruitment	recruitment	NN
cord-258787-n49zrfsp	219	11	and	and	CC
cord-258787-n49zrfsp	219	12	activation	activation	NN
cord-258787-n49zrfsp	219	13	in	in	IN
cord-258787-n49zrfsp	219	14	the	the	DT
cord-258787-n49zrfsp	219	15	metastatic	metastatic	JJ
cord-258787-n49zrfsp	219	16	niche	niche	NN
cord-258787-n49zrfsp	219	17	was	be	VBD
cord-258787-n49zrfsp	219	18	found	find	VBN
cord-258787-n49zrfsp	219	19	to	to	TO
cord-258787-n49zrfsp	219	20	be	be	VB
cord-258787-n49zrfsp	219	21	important	important	JJ
cord-258787-n49zrfsp	219	22	for	for	IN
cord-258787-n49zrfsp	219	23	the	the	DT
cord-258787-n49zrfsp	219	24	reduction	reduction	NN
cord-258787-n49zrfsp	219	25	of	of	IN
cord-258787-n49zrfsp	219	26	metastasis	metastasis	NN
cord-258787-n49zrfsp	219	27	formation	formation	NN
cord-258787-n49zrfsp	219	28	through	through	IN
cord-258787-n49zrfsp	219	29	the	the	DT
cord-258787-n49zrfsp	219	30	killing	killing	NN
cord-258787-n49zrfsp	219	31	of	of	IN
cord-258787-n49zrfsp	219	32	cancer	cancer	NN
cord-258787-n49zrfsp	219	33	cells	cell	NNS
cord-258787-n49zrfsp	219	34	[	[	-LRB-
cord-258787-n49zrfsp	219	35	162	162	CD
cord-258787-n49zrfsp	219	36	,	,	,
cord-258787-n49zrfsp	219	37	163	163	CD
cord-258787-n49zrfsp	219	38	]	]	-RRB-
cord-258787-n49zrfsp	219	39	.	.	.
cord-258787-n49zrfsp	220	1	Genetic	genetic	JJ
cord-258787-n49zrfsp	220	2	ablation	ablation	NN
cord-258787-n49zrfsp	220	3	of	of	IN
cord-258787-n49zrfsp	220	4	the	the	DT
cord-258787-n49zrfsp	220	5	atypical	atypical	JJ
cord-258787-n49zrfsp	220	6	chemokine	chemokine	NN
cord-258787-n49zrfsp	220	7	receptor	receptor	NN
cord-258787-n49zrfsp	220	8	2	2	CD
cord-258787-n49zrfsp	220	9	(	(	-LRB-
cord-258787-n49zrfsp	220	10	ACKR2	ACKR2	NNP
cord-258787-n49zrfsp	220	11	)	)	-RRB-
cord-258787-n49zrfsp	220	12	resulted	result	VBD
cord-258787-n49zrfsp	220	13	in	in	IN
cord-258787-n49zrfsp	220	14	increased	increase	VBN
cord-258787-n49zrfsp	220	15	levels	level	NNS
cord-258787-n49zrfsp	220	16	of	of	IN
cord-258787-n49zrfsp	220	17	chemokine	chemokine	NN
cord-258787-n49zrfsp	220	18	receptors	receptor	NNS
cord-258787-n49zrfsp	220	19	(	(	-LRB-
cord-258787-n49zrfsp	220	20	i.e.	i.e.	FW
cord-258787-n49zrfsp	220	21	CCR1	CCR1	NNP
cord-258787-n49zrfsp	220	22	,	,	,
cord-258787-n49zrfsp	220	23	CCR2	CCR2	NNP
cord-258787-n49zrfsp	220	24	and	and	CC
cord-258787-n49zrfsp	220	25	CCR5	CCR5	NNP
cord-258787-n49zrfsp	220	26	)	)	-RRB-
cord-258787-n49zrfsp	220	27	in	in	IN
cord-258787-n49zrfsp	220	28	hematopoietic	hematopoietic	JJ
cord-258787-n49zrfsp	220	29	progenitors	progenitor	NNS
cord-258787-n49zrfsp	220	30	and	and	CC
cord-258787-n49zrfsp	220	31	the	the	DT
cord-258787-n49zrfsp	220	32	release	release	NN
cord-258787-n49zrfsp	220	33	from	from	IN
cord-258787-n49zrfsp	220	34	the	the	DT
cord-258787-n49zrfsp	220	35	BM	BM	NNP
cord-258787-n49zrfsp	220	36	of	of	IN
cord-258787-n49zrfsp	220	37	activated	activate	VBN
cord-258787-n49zrfsp	220	38	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	220	39	endowed	endow	VBN
cord-258787-n49zrfsp	220	40	with	with	IN
cord-258787-n49zrfsp	220	41	cytotoxic	cytotoxic	JJ
cord-258787-n49zrfsp	220	42	activity	activity	NN
cord-258787-n49zrfsp	220	43	towards	towards	IN
cord-258787-n49zrfsp	220	44	tumour	tumour	NN
cord-258787-n49zrfsp	220	45	cells	cell	NNS
cord-258787-n49zrfsp	220	46	and	and	CC
cord-258787-n49zrfsp	220	47	anti	anti	JJ
cord-258787-n49zrfsp	220	48	-	-	JJ
cord-258787-n49zrfsp	220	49	metastatic	metastatic	JJ
cord-258787-n49zrfsp	220	50	potential	potential	NN
cord-258787-n49zrfsp	220	51	[	[	-LRB-
cord-258787-n49zrfsp	220	52	163	163	CD
cord-258787-n49zrfsp	220	53	]	]	-RRB-
cord-258787-n49zrfsp	220	54	.	.	.
cord-258787-n49zrfsp	221	1	ACKR2	ACKR2	NNP
cord-258787-n49zrfsp	222	1	deficient	deficient	JJ
cord-258787-n49zrfsp	222	2	mice	mouse	NNS
cord-258787-n49zrfsp	222	3	transplanted	transplant	VBN
cord-258787-n49zrfsp	222	4	with	with	IN
cord-258787-n49zrfsp	222	5	4T1	4t1	CD
cord-258787-n49zrfsp	222	6	breast	breast	NN
cord-258787-n49zrfsp	222	7	cancer	cancer	NN
cord-258787-n49zrfsp	222	8	cell	cell	NN
cord-258787-n49zrfsp	222	9	lines	line	NNS
cord-258787-n49zrfsp	222	10	or	or	CC
cord-258787-n49zrfsp	222	11	intravenously	intravenously	RB
cord-258787-n49zrfsp	222	12	injected	inject	VBN
cord-258787-n49zrfsp	222	13	with	with	IN
cord-258787-n49zrfsp	222	14	B16F10	b16f10	JJ
cord-258787-n49zrfsp	222	15	melanoma	melanoma	NN
cord-258787-n49zrfsp	222	16	cell	cell	NN
cord-258787-n49zrfsp	222	17	lines	line	NNS
cord-258787-n49zrfsp	222	18	showed	show	VBD
cord-258787-n49zrfsp	222	19	protection	protection	NN
cord-258787-n49zrfsp	222	20	against	against	IN
cord-258787-n49zrfsp	222	21	metastasis	metastasis	NN
cord-258787-n49zrfsp	222	22	formation	formation	NN
cord-258787-n49zrfsp	222	23	[	[	-LRB-
cord-258787-n49zrfsp	222	24	163	163	CD
cord-258787-n49zrfsp	222	25	]	]	-RRB-
cord-258787-n49zrfsp	222	26	.	.	.
cord-258787-n49zrfsp	223	1	Thus	thus	RB
cord-258787-n49zrfsp	223	2	,	,	,
cord-258787-n49zrfsp	223	3	targeting	target	VBG
cord-258787-n49zrfsp	223	4	ACKR2	ackr2	IN
cord-258787-n49zrfsp	223	5	unleashed	unleash	VBN
cord-258787-n49zrfsp	223	6	anti	anti	JJ
cord-258787-n49zrfsp	223	7	-	-	JJ
cord-258787-n49zrfsp	223	8	metastatic	metastatic	JJ
cord-258787-n49zrfsp	223	9	potential	potential	NN
cord-258787-n49zrfsp	223	10	of	of	IN
cord-258787-n49zrfsp	223	11	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	223	12	and	and	CC
cord-258787-n49zrfsp	223	13	represents	represent	VBZ
cord-258787-n49zrfsp	223	14	an	an	DT
cord-258787-n49zrfsp	223	15	interesting	interesting	JJ
cord-258787-n49zrfsp	223	16	novel	novel	JJ
cord-258787-n49zrfsp	223	17	myeloid	myeloid	NN
cord-258787-n49zrfsp	223	18	checkpoint	checkpoint	NN
cord-258787-n49zrfsp	223	19	for	for	IN
cord-258787-n49zrfsp	223	20	innovative	innovative	JJ
cord-258787-n49zrfsp	223	21	therapeutic	therapeutic	JJ
cord-258787-n49zrfsp	223	22	strategies	strategy	NNS
cord-258787-n49zrfsp	223	23	.	.	.
cord-258787-n49zrfsp	224	1	A	a	DT
cord-258787-n49zrfsp	224	2	recent	recent	JJ
cord-258787-n49zrfsp	224	3	study	study	NN
cord-258787-n49zrfsp	224	4	has	have	VBZ
cord-258787-n49zrfsp	224	5	demonstrated	demonstrate	VBN
cord-258787-n49zrfsp	224	6	a	a	DT
cord-258787-n49zrfsp	224	7	mechanism	mechanism	NN
cord-258787-n49zrfsp	224	8	that	that	WDT
cord-258787-n49zrfsp	224	9	may	may	MD
cord-258787-n49zrfsp	224	10	explain	explain	VB
cord-258787-n49zrfsp	224	11	,	,	,
cord-258787-n49zrfsp	224	12	at	at	IN
cord-258787-n49zrfsp	224	13	least	least	JJS
cord-258787-n49zrfsp	224	14	in	in	IN
cord-258787-n49zrfsp	224	15	part	part	NN
cord-258787-n49zrfsp	224	16	,	,	,
cord-258787-n49zrfsp	224	17	why	why	WRB
cord-258787-n49zrfsp	224	18	breast	breast	NN
cord-258787-n49zrfsp	224	19	cancer	cancer	NN
cord-258787-n49zrfsp	224	20	patients	patient	NNS
cord-258787-n49zrfsp	224	21	develop	develop	VBP
cord-258787-n49zrfsp	224	22	metastasis	metastasis	NN
cord-258787-n49zrfsp	224	23	[	[	-LRB-
cord-258787-n49zrfsp	224	24	162	162	CD
cord-258787-n49zrfsp	224	25	]	]	-RRB-
cord-258787-n49zrfsp	224	26	.	.	.
cord-258787-n49zrfsp	225	1	The	the	DT
cord-258787-n49zrfsp	225	2	injection	injection	NN
cord-258787-n49zrfsp	225	3	of	of	IN
cord-258787-n49zrfsp	225	4	human	human	JJ
cord-258787-n49zrfsp	225	5	breast	breast	NN
cord-258787-n49zrfsp	225	6	cancer	cancer	NN
cord-258787-n49zrfsp	225	7	cells	cell	NNS
cord-258787-n49zrfsp	225	8	with	with	IN
cord-258787-n49zrfsp	225	9	low	low	JJ
cord-258787-n49zrfsp	225	10	spontaneous	spontaneous	JJ
cord-258787-n49zrfsp	225	11	metastatic	metastatic	JJ
cord-258787-n49zrfsp	225	12	potential	potential	NN
cord-258787-n49zrfsp	225	13	in	in	IN
cord-258787-n49zrfsp	225	14	non	non	JJ
cord-258787-n49zrfsp	225	15	-	-	JJ
cord-258787-n49zrfsp	225	16	obese	obese	JJ
cord-258787-n49zrfsp	225	17	diabetic	diabetic	JJ
cord-258787-n49zrfsp	225	18	(	(	-LRB-
cord-258787-n49zrfsp	225	19	NOD)/severe	nod)/severe	RB
cord-258787-n49zrfsp	225	20	combined	combine	VBN
cord-258787-n49zrfsp	225	21	immunodeficient	immunodeficient	JJ
cord-258787-n49zrfsp	225	22	(	(	-LRB-
cord-258787-n49zrfsp	225	23	SCID	SCID	NNP
cord-258787-n49zrfsp	225	24	)	)	-RRB-
cord-258787-n49zrfsp	225	25	mice	mouse	NNS
cord-258787-n49zrfsp	225	26	,	,	,
cord-258787-n49zrfsp	225	27	resulted	result	VBD
cord-258787-n49zrfsp	225	28	in	in	IN
cord-258787-n49zrfsp	225	29	reprogramming	reprogramming	NN
cord-258787-n49zrfsp	225	30	of	of	IN
cord-258787-n49zrfsp	225	31	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	225	32	in	in	IN
cord-258787-n49zrfsp	225	33	the	the	DT
cord-258787-n49zrfsp	225	34	pre	pre	JJ
cord-258787-n49zrfsp	225	35	-	-	JJ
cord-258787-n49zrfsp	225	36	metastatic	metastatic	JJ
cord-258787-n49zrfsp	225	37	lung	lung	NN
cord-258787-n49zrfsp	225	38	.	.	.
cord-258787-n49zrfsp	226	1	Breast	breast	NN
cord-258787-n49zrfsp	226	2	cancer	cancer	NN
cord-258787-n49zrfsp	226	3	cells	cell	NNS
cord-258787-n49zrfsp	226	4	with	with	IN
cord-258787-n49zrfsp	226	5	low	low	JJ
cord-258787-n49zrfsp	226	6	spontaneous	spontaneous	JJ
cord-258787-n49zrfsp	226	7	metastatic	metastatic	JJ
cord-258787-n49zrfsp	226	8	potential	potential	NN
cord-258787-n49zrfsp	226	9	secreted	secrete	VBN
cord-258787-n49zrfsp	226	10	high	high	JJ
cord-258787-n49zrfsp	226	11	amount	amount	NN
cord-258787-n49zrfsp	226	12	of	of	IN
cord-258787-n49zrfsp	226	13	CCL2	CCL2	NNP
cord-258787-n49zrfsp	226	14	compared	compare	VBN
cord-258787-n49zrfsp	226	15	to	to	IN
cord-258787-n49zrfsp	226	16	cancer	cancer	NN
cord-258787-n49zrfsp	226	17	cells	cell	NNS
cord-258787-n49zrfsp	226	18	with	with	IN
cord-258787-n49zrfsp	226	19	high	high	JJ
cord-258787-n49zrfsp	226	20	metastatic	metastatic	JJ
cord-258787-n49zrfsp	226	21	potential	potential	NN
cord-258787-n49zrfsp	226	22	.	.	.
cord-258787-n49zrfsp	227	1	CCL2	CCL2	NNP
cord-258787-n49zrfsp	227	2	induced	induce	VBD
cord-258787-n49zrfsp	227	3	the	the	DT
cord-258787-n49zrfsp	227	4	recruitment	recruitment	NN
cord-258787-n49zrfsp	227	5	of	of	IN
cord-258787-n49zrfsp	227	6	IFNγ	IFNγ	NNP
cord-258787-n49zrfsp	227	7	-	-	HYPH
cord-258787-n49zrfsp	227	8	producing	produce	VBG
cord-258787-n49zrfsp	227	9	CCR2	CCR2	NNP
cord-258787-n49zrfsp	227	10	+	+	CC
cord-258787-n49zrfsp	227	11	monocytes	monocyte	NNS
cord-258787-n49zrfsp	227	12	in	in	IN
cord-258787-n49zrfsp	227	13	the	the	DT
cord-258787-n49zrfsp	227	14	pre	pre	JJ
cord-258787-n49zrfsp	227	15	-	-	JJ
cord-258787-n49zrfsp	227	16	metastatic	metastatic	JJ
cord-258787-n49zrfsp	227	17	lung	lung	NN
cord-258787-n49zrfsp	227	18	,	,	,
cord-258787-n49zrfsp	227	19	leading	lead	VBG
cord-258787-n49zrfsp	227	20	to	to	IN
cord-258787-n49zrfsp	227	21	upregulation	upregulation	NN
cord-258787-n49zrfsp	227	22	of	of	IN
cord-258787-n49zrfsp	227	23	the	the	DT
cord-258787-n49zrfsp	227	24	transmembrane	transmembrane	NNP
cord-258787-n49zrfsp	227	25	protein	protein	NN
cord-258787-n49zrfsp	227	26	173	173	CD
cord-258787-n49zrfsp	227	27	(	(	-LRB-
cord-258787-n49zrfsp	227	28	TMEM173	TMEM173	NNP
cord-258787-n49zrfsp	227	29	,	,	,
cord-258787-n49zrfsp	227	30	also	also	RB
cord-258787-n49zrfsp	227	31	called	call	VBN
cord-258787-n49zrfsp	227	32	STING	STING	NNP
cord-258787-n49zrfsp	227	33	)	)	-RRB-
cord-258787-n49zrfsp	227	34	on	on	IN
cord-258787-n49zrfsp	227	35	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	227	36	and	and	CC
cord-258787-n49zrfsp	227	37	activation	activation	NN
cord-258787-n49zrfsp	227	38	of	of	IN
cord-258787-n49zrfsp	227	39	their	-PRON-	PRP$
cord-258787-n49zrfsp	227	40	cytotoxic	cytotoxic	JJ
cord-258787-n49zrfsp	227	41	activity	activity	NN
cord-258787-n49zrfsp	227	42	[	[	-LRB-
cord-258787-n49zrfsp	227	43	162	162	CD
cord-258787-n49zrfsp	227	44	]	]	-RRB-
cord-258787-n49zrfsp	227	45	.	.	.
cord-258787-n49zrfsp	228	1	Collectively	collectively	RB
cord-258787-n49zrfsp	228	2	,	,	,
cord-258787-n49zrfsp	228	3	these	these	DT
cord-258787-n49zrfsp	228	4	studies	study	NNS
cord-258787-n49zrfsp	228	5	underlined	underline	VBD
cord-258787-n49zrfsp	228	6	the	the	DT
cord-258787-n49zrfsp	228	7	relevance	relevance	NN
cord-258787-n49zrfsp	228	8	of	of	IN
cord-258787-n49zrfsp	228	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	228	10	in	in	IN
cord-258787-n49zrfsp	228	11	the	the	DT
cord-258787-n49zrfsp	228	12	TME	TME	NNP
cord-258787-n49zrfsp	228	13	,	,	,
cord-258787-n49zrfsp	228	14	both	both	CC
cord-258787-n49zrfsp	228	15	in	in	IN
cord-258787-n49zrfsp	228	16	the	the	DT
cord-258787-n49zrfsp	228	17	primary	primary	JJ
cord-258787-n49zrfsp	228	18	site	site	NN
cord-258787-n49zrfsp	228	19	and	and	CC
cord-258787-n49zrfsp	228	20	in	in	IN
cord-258787-n49zrfsp	228	21	the	the	DT
cord-258787-n49zrfsp	228	22	metastatic	metastatic	JJ
cord-258787-n49zrfsp	228	23	niche	niche	NN
cord-258787-n49zrfsp	228	24	.	.	.
cord-258787-n49zrfsp	229	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	229	2	with	with	IN
cord-258787-n49zrfsp	229	3	pro	pro	JJ
cord-258787-n49zrfsp	229	4	-	-	JJ
cord-258787-n49zrfsp	229	5	tumour	tumour	JJ
cord-258787-n49zrfsp	229	6	activities	activity	NNS
cord-258787-n49zrfsp	229	7	are	be	VBP
cord-258787-n49zrfsp	229	8	associated	associate	VBN
cord-258787-n49zrfsp	229	9	to	to	IN
cord-258787-n49zrfsp	229	10	all	all	DT
cord-258787-n49zrfsp	229	11	steps	step	NNS
cord-258787-n49zrfsp	229	12	of	of	IN
cord-258787-n49zrfsp	229	13	tumorigenesis	tumorigenesis	NN
cord-258787-n49zrfsp	229	14	,	,	,
cord-258787-n49zrfsp	229	15	from	from	IN
cord-258787-n49zrfsp	229	16	the	the	DT
cord-258787-n49zrfsp	229	17	promotion	promotion	NN
cord-258787-n49zrfsp	229	18	of	of	IN
cord-258787-n49zrfsp	229	19	genetic	genetic	JJ
cord-258787-n49zrfsp	229	20	instability	instability	NN
cord-258787-n49zrfsp	229	21	,	,	,
cord-258787-n49zrfsp	229	22	through	through	IN
cord-258787-n49zrfsp	229	23	the	the	DT
cord-258787-n49zrfsp	229	24	proliferation	proliferation	NN
cord-258787-n49zrfsp	229	25	,	,	,
cord-258787-n49zrfsp	229	26	dissemination	dissemination	NN
cord-258787-n49zrfsp	229	27	and	and	CC
cord-258787-n49zrfsp	229	28	implantation	implantation	NN
cord-258787-n49zrfsp	229	29	of	of	IN
cord-258787-n49zrfsp	229	30	cancer	cancer	NN
cord-258787-n49zrfsp	229	31	cells	cell	NNS
cord-258787-n49zrfsp	229	32	to	to	IN
cord-258787-n49zrfsp	229	33	distal	distal	JJ
cord-258787-n49zrfsp	229	34	anatomical	anatomical	JJ
cord-258787-n49zrfsp	229	35	sites	site	NNS
cord-258787-n49zrfsp	229	36	.	.	.
cord-258787-n49zrfsp	230	1	However	however	RB
cord-258787-n49zrfsp	230	2	,	,	,
cord-258787-n49zrfsp	230	3	when	when	WRB
cord-258787-n49zrfsp	230	4	properly	properly	RB
cord-258787-n49zrfsp	230	5	activated	activate	VBN
cord-258787-n49zrfsp	230	6	,	,	,
cord-258787-n49zrfsp	230	7	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	230	8	can	can	MD
cord-258787-n49zrfsp	230	9	kill	kill	VB
cord-258787-n49zrfsp	230	10	tumour	tumour	NN
cord-258787-n49zrfsp	230	11	cells	cell	NNS
cord-258787-n49zrfsp	230	12	and	and	CC
cord-258787-n49zrfsp	230	13	participate	participate	VB
cord-258787-n49zrfsp	230	14	to	to	IN
cord-258787-n49zrfsp	230	15	the	the	DT
cord-258787-n49zrfsp	230	16	anti	anti	JJ
cord-258787-n49zrfsp	230	17	-	-	JJ
cord-258787-n49zrfsp	230	18	tumour	tumour	JJ
cord-258787-n49zrfsp	230	19	response	response	NN
cord-258787-n49zrfsp	230	20	.	.	.
cord-258787-n49zrfsp	231	1	Thus	thus	RB
cord-258787-n49zrfsp	231	2	,	,	,
cord-258787-n49zrfsp	231	3	studies	study	NNS
cord-258787-n49zrfsp	231	4	aimed	aim	VBN
cord-258787-n49zrfsp	231	5	at	at	IN
cord-258787-n49zrfsp	231	6	clarifying	clarify	VBG
cord-258787-n49zrfsp	231	7	the	the	DT
cord-258787-n49zrfsp	231	8	pathways	pathway	NNS
cord-258787-n49zrfsp	231	9	that	that	WDT
cord-258787-n49zrfsp	231	10	trigger	trigger	VBP
cord-258787-n49zrfsp	231	11	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	231	12	cytotoxicity	cytotoxicity	NN
cord-258787-n49zrfsp	231	13	against	against	IN
cord-258787-n49zrfsp	231	14	cancer	cancer	NN
cord-258787-n49zrfsp	231	15	cells	cell	NNS
cord-258787-n49zrfsp	231	16	,	,	,
cord-258787-n49zrfsp	231	17	may	may	MD
cord-258787-n49zrfsp	231	18	be	be	VB
cord-258787-n49zrfsp	231	19	useful	useful	JJ
cord-258787-n49zrfsp	231	20	to	to	TO
cord-258787-n49zrfsp	231	21	pave	pave	VB
cord-258787-n49zrfsp	231	22	the	the	DT
cord-258787-n49zrfsp	231	23	way	way	NN
cord-258787-n49zrfsp	231	24	for	for	IN
cord-258787-n49zrfsp	231	25	new	new	JJ
cord-258787-n49zrfsp	231	26	therapeutic	therapeutic	JJ
cord-258787-n49zrfsp	231	27	strategies	strategy	NNS
cord-258787-n49zrfsp	231	28	targeting	target	VBG
cord-258787-n49zrfsp	231	29	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	231	30	.	.	.
cord-258787-n49zrfsp	232	1	Once	once	RB
cord-258787-n49zrfsp	232	2	recruited	recruit	VBN
cord-258787-n49zrfsp	232	3	into	into	IN
cord-258787-n49zrfsp	232	4	inflamed	inflamed	JJ
cord-258787-n49zrfsp	232	5	tissues	tissue	NNS
cord-258787-n49zrfsp	232	6	,	,	,
cord-258787-n49zrfsp	232	7	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	232	8	can	can	MD
cord-258787-n49zrfsp	232	9	engage	engage	VB
cord-258787-n49zrfsp	232	10	bidirectional	bidirectional	JJ
cord-258787-n49zrfsp	232	11	interactions	interaction	NNS
cord-258787-n49zrfsp	232	12	with	with	IN
cord-258787-n49zrfsp	232	13	non	non	JJ
cord-258787-n49zrfsp	232	14	-	-	JJ
cord-258787-n49zrfsp	232	15	immune	immune	JJ
cord-258787-n49zrfsp	232	16	(	(	-LRB-
cord-258787-n49zrfsp	232	17	e.g.	e.g.	RB
cord-258787-n49zrfsp	232	18	platelets	platelet	NNS
cord-258787-n49zrfsp	232	19	,	,	,
cord-258787-n49zrfsp	232	20	mesenchymal	mesenchymal	JJ
cord-258787-n49zrfsp	232	21	cells	cell	NNS
cord-258787-n49zrfsp	232	22	)	)	-RRB-
cord-258787-n49zrfsp	232	23	or	or	CC
cord-258787-n49zrfsp	232	24	immune	immune	JJ
cord-258787-n49zrfsp	232	25	cells	cell	NNS
cord-258787-n49zrfsp	232	26	(	(	-LRB-
cord-258787-n49zrfsp	232	27	e.g.	e.g.	IN
cord-258787-n49zrfsp	232	28	DCs	DCs	NNP
cord-258787-n49zrfsp	232	29	,	,	,
cord-258787-n49zrfsp	232	30	macrophages	macrophage	NNS
cord-258787-n49zrfsp	232	31	,	,	,
cord-258787-n49zrfsp	232	32	NK	NK	NNP
cord-258787-n49zrfsp	232	33	cells	cell	NNS
cord-258787-n49zrfsp	232	34	,	,	,
cord-258787-n49zrfsp	232	35	B	b	NN
cord-258787-n49zrfsp	232	36	cells	cell	NNS
cord-258787-n49zrfsp	232	37	,	,	,
cord-258787-n49zrfsp	232	38	T	t	NN
cord-258787-n49zrfsp	232	39	cells	cell	NNS
cord-258787-n49zrfsp	232	40	)	)	-RRB-
cord-258787-n49zrfsp	232	41	[	[	-LRB-
cord-258787-n49zrfsp	232	42	2	2	CD
cord-258787-n49zrfsp	232	43	]	]	-RRB-
cord-258787-n49zrfsp	232	44	.	.	.
cord-258787-n49zrfsp	233	1	These	these	DT
cord-258787-n49zrfsp	233	2	interactions	interaction	NNS
cord-258787-n49zrfsp	233	3	can	can	MD
cord-258787-n49zrfsp	233	4	occur	occur	VB
cord-258787-n49zrfsp	233	5	in	in	IN
cord-258787-n49zrfsp	233	6	a	a	DT
cord-258787-n49zrfsp	233	7	contact	contact	NN
cord-258787-n49zrfsp	233	8	-	-	HYPH
cord-258787-n49zrfsp	233	9	depend	depend	VB
cord-258787-n49zrfsp	233	10	manner	manner	JJ
cord-258787-n49zrfsp	233	11	or	or	CC
cord-258787-n49zrfsp	233	12	via	via	IN
cord-258787-n49zrfsp	233	13	the	the	DT
cord-258787-n49zrfsp	233	14	secretion	secretion	NN
cord-258787-n49zrfsp	233	15	of	of	IN
cord-258787-n49zrfsp	233	16	soluble	soluble	JJ
cord-258787-n49zrfsp	233	17	mediators	mediator	NNS
cord-258787-n49zrfsp	233	18	.	.	.
cord-258787-n49zrfsp	234	1	In	in	IN
cord-258787-n49zrfsp	234	2	these	these	DT
cord-258787-n49zrfsp	234	3	cross	cross	NN
cord-258787-n49zrfsp	234	4	-	-	NNS
cord-258787-n49zrfsp	234	5	talks	talk	NNS
cord-258787-n49zrfsp	234	6	,	,	,
cord-258787-n49zrfsp	234	7	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	234	8	receive	receive	VBP
cord-258787-n49zrfsp	234	9	signals	signal	NNS
cord-258787-n49zrfsp	234	10	that	that	WDT
cord-258787-n49zrfsp	234	11	modulate	modulate	VBP
cord-258787-n49zrfsp	234	12	their	-PRON-	PRP$
cord-258787-n49zrfsp	234	13	survival	survival	NN
cord-258787-n49zrfsp	234	14	or	or	CC
cord-258787-n49zrfsp	234	15	activation	activation	NN
cord-258787-n49zrfsp	234	16	status	status	NN
cord-258787-n49zrfsp	234	17	,	,	,
cord-258787-n49zrfsp	234	18	while	while	IN
cord-258787-n49zrfsp	234	19	on	on	IN
cord-258787-n49zrfsp	234	20	the	the	DT
cord-258787-n49zrfsp	234	21	other	other	JJ
cord-258787-n49zrfsp	234	22	hand	hand	NN
cord-258787-n49zrfsp	234	23	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	234	24	amplify	amplify	VBP
cord-258787-n49zrfsp	234	25	,	,	,
cord-258787-n49zrfsp	234	26	suppress	suppress	VBP
cord-258787-n49zrfsp	234	27	or	or	CC
cord-258787-n49zrfsp	234	28	initiate	initiate	VB
cord-258787-n49zrfsp	234	29	the	the	DT
cord-258787-n49zrfsp	234	30	innate	innate	JJ
cord-258787-n49zrfsp	234	31	and	and	CC
cord-258787-n49zrfsp	234	32	adaptive	adaptive	JJ
cord-258787-n49zrfsp	234	33	immune	immune	JJ
cord-258787-n49zrfsp	234	34	responses	response	NNS
cord-258787-n49zrfsp	234	35	[	[	-LRB-
cord-258787-n49zrfsp	234	36	4	4	CD
cord-258787-n49zrfsp	234	37	,	,	,
cord-258787-n49zrfsp	234	38	16	16	CD
cord-258787-n49zrfsp	234	39	]	]	-RRB-
cord-258787-n49zrfsp	234	40	.	.	.
cord-258787-n49zrfsp	235	1	These	these	DT
cord-258787-n49zrfsp	235	2	interactions	interaction	NNS
cord-258787-n49zrfsp	235	3	have	have	VBP
cord-258787-n49zrfsp	235	4	been	be	VBN
cord-258787-n49zrfsp	235	5	shown	show	VBN
cord-258787-n49zrfsp	235	6	to	to	TO
cord-258787-n49zrfsp	235	7	be	be	VB
cord-258787-n49zrfsp	235	8	relevant	relevant	JJ
cord-258787-n49zrfsp	235	9	in	in	IN
cord-258787-n49zrfsp	235	10	the	the	DT
cord-258787-n49zrfsp	235	11	TME	TME	NNP
cord-258787-n49zrfsp	235	12	.	.	.
cord-258787-n49zrfsp	236	1	For	for	IN
cord-258787-n49zrfsp	236	2	instance	instance	NN
cord-258787-n49zrfsp	236	3	,	,	,
cord-258787-n49zrfsp	236	4	tumour	tumour	NN
cord-258787-n49zrfsp	236	5	-	-	HYPH
cord-258787-n49zrfsp	236	6	entrained	entrain	VBN
cord-258787-n49zrfsp	236	7	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	236	8	can	can	MD
cord-258787-n49zrfsp	236	9	produce	produce	VB
cord-258787-n49zrfsp	236	10	chemokines	chemokine	NNS
cord-258787-n49zrfsp	236	11	,	,	,
cord-258787-n49zrfsp	236	12	including	include	VBG
cord-258787-n49zrfsp	236	13	CXCL10	cxcl10	CD
cord-258787-n49zrfsp	236	14	,	,	,
cord-258787-n49zrfsp	236	15	CCL2	CCL2	NNP
cord-258787-n49zrfsp	236	16	,	,	,
cord-258787-n49zrfsp	236	17	CCL3	CCL3	NNP
cord-258787-n49zrfsp	236	18	,	,	,
cord-258787-n49zrfsp	236	19	CXCL1	CXCL1	NNP
cord-258787-n49zrfsp	236	20	and	and	CC
cord-258787-n49zrfsp	236	21	CXCL2	CXCL2	NNS
cord-258787-n49zrfsp	236	22	,	,	,
cord-258787-n49zrfsp	236	23	responsible	responsible	JJ
cord-258787-n49zrfsp	236	24	for	for	IN
cord-258787-n49zrfsp	236	25	the	the	DT
cord-258787-n49zrfsp	236	26	recruitment	recruitment	NN
cord-258787-n49zrfsp	236	27	of	of	IN
cord-258787-n49zrfsp	236	28	T	T	NNP
cord-258787-n49zrfsp	236	29	cells	cell	NNS
cord-258787-n49zrfsp	236	30	and	and	CC
cord-258787-n49zrfsp	236	31	other	other	JJ
cord-258787-n49zrfsp	236	32	leukocytes	leukocyte	NNS
cord-258787-n49zrfsp	236	33	[	[	-LRB-
cord-258787-n49zrfsp	236	34	2	2	CD
cord-258787-n49zrfsp	236	35	,	,	,
cord-258787-n49zrfsp	236	36	16	16	CD
cord-258787-n49zrfsp	236	37	]	]	-RRB-
cord-258787-n49zrfsp	236	38	.	.	.
cord-258787-n49zrfsp	237	1	In	in	IN
cord-258787-n49zrfsp	237	2	non	non	JJ
cord-258787-n49zrfsp	237	3	-	-	JJ
cord-258787-n49zrfsp	237	4	small	small	JJ
cord-258787-n49zrfsp	237	5	cell	cell	NN
cord-258787-n49zrfsp	237	6	lung	lung	NN
cord-258787-n49zrfsp	237	7	cancer	cancer	NN
cord-258787-n49zrfsp	237	8	(	(	-LRB-
cord-258787-n49zrfsp	237	9	NSCLC	NSCLC	NNP
cord-258787-n49zrfsp	237	10	)	)	-RRB-
cord-258787-n49zrfsp	237	11	,	,	,
cord-258787-n49zrfsp	237	12	phenotypic	phenotypic	JJ
cord-258787-n49zrfsp	237	13	analysis	analysis	NN
cord-258787-n49zrfsp	237	14	of	of	IN
cord-258787-n49zrfsp	237	15	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	237	16	in	in	IN
cord-258787-n49zrfsp	237	17	early	early	JJ
cord-258787-n49zrfsp	237	18	stage	stage	NN
cord-258787-n49zrfsp	237	19	patients	patient	NNS
cord-258787-n49zrfsp	237	20	revealed	reveal	VBD
cord-258787-n49zrfsp	237	21	that	that	IN
cord-258787-n49zrfsp	237	22	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	237	23	can	can	MD
cord-258787-n49zrfsp	237	24	acquire	acquire	VB
cord-258787-n49zrfsp	237	25	antigen	antigen	NN
cord-258787-n49zrfsp	237	26	presenting	present	VBG
cord-258787-n49zrfsp	237	27	cell	cell	NN
cord-258787-n49zrfsp	237	28	(	(	-LRB-
cord-258787-n49zrfsp	237	29	APC)-like	apc)-like	IN
cord-258787-n49zrfsp	237	30	features	feature	NNS
cord-258787-n49zrfsp	237	31	and	and	CC
cord-258787-n49zrfsp	237	32	activate	activate	VBP
cord-258787-n49zrfsp	237	33	CD4	CD4	NNP
cord-258787-n49zrfsp	237	34	+	+	CC
cord-258787-n49zrfsp	237	35	T	t	NN
cord-258787-n49zrfsp	237	36	cells	cell	NNS
cord-258787-n49zrfsp	237	37	and	and	CC
cord-258787-n49zrfsp	237	38	CD8	CD8	NNP
cord-258787-n49zrfsp	237	39	+	+	CC
cord-258787-n49zrfsp	237	40	T	T	NNP
cord-258787-n49zrfsp	237	41	cells	cell	NNS
cord-258787-n49zrfsp	237	42	[	[	-LRB-
cord-258787-n49zrfsp	237	43	60	60	CD
cord-258787-n49zrfsp	237	44	]	]	-RRB-
cord-258787-n49zrfsp	237	45	.	.	.
cord-258787-n49zrfsp	238	1	These	these	DT
cord-258787-n49zrfsp	238	2	APC	APC	NNP
cord-258787-n49zrfsp	238	3	-	-	HYPH
cord-258787-n49zrfsp	238	4	like	like	JJ
cord-258787-n49zrfsp	238	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	238	6	derived	derive	VBN
cord-258787-n49zrfsp	238	7	from	from	IN
cord-258787-n49zrfsp	238	8	a	a	DT
cord-258787-n49zrfsp	238	9	subset	subset	NN
cord-258787-n49zrfsp	238	10	of	of	IN
cord-258787-n49zrfsp	238	11	immature	immature	JJ
cord-258787-n49zrfsp	238	12	progenitors	progenitor	NNS
cord-258787-n49zrfsp	238	13	(	(	-LRB-
cord-258787-n49zrfsp	238	14	CD11b	CD11b	NNS
cord-258787-n49zrfsp	238	15	+	+	CC
cord-258787-n49zrfsp	238	16	CD15	CD15	NNP
cord-258787-n49zrfsp	238	17	hi	hi	UH
cord-258787-n49zrfsp	238	18	CD10-CD16	CD10-CD16	NNP
cord-258787-n49zrfsp	238	19	int	int	NNP
cord-258787-n49zrfsp	238	20	/	/	SYM
cord-258787-n49zrfsp	238	21	low	low	NN
cord-258787-n49zrfsp	238	22	)	)	-RRB-
cord-258787-n49zrfsp	238	23	that	that	IN
cord-258787-n49zrfsp	238	24	in	in	IN
cord-258787-n49zrfsp	238	25	response	response	NN
cord-258787-n49zrfsp	238	26	to	to	IN
cord-258787-n49zrfsp	238	27	GM	GM	NNP
cord-258787-n49zrfsp	238	28	-	-	HYPH
cord-258787-n49zrfsp	238	29	CSF	CSF	NNP
cord-258787-n49zrfsp	238	30	and	and	CC
cord-258787-n49zrfsp	238	31	IFNγ	IFNγ	NNS
cord-258787-n49zrfsp	238	32	present	present	JJ
cord-258787-n49zrfsp	238	33	in	in	IN
cord-258787-n49zrfsp	238	34	the	the	DT
cord-258787-n49zrfsp	238	35	TME	TME	NNP
cord-258787-n49zrfsp	238	36	increased	increase	VBD
cord-258787-n49zrfsp	238	37	the	the	DT
cord-258787-n49zrfsp	238	38	expression	expression	NN
cord-258787-n49zrfsp	238	39	of	of	IN
cord-258787-n49zrfsp	238	40	MHCII	MHCII	NNP
cord-258787-n49zrfsp	238	41	and	and	CC
cord-258787-n49zrfsp	238	42	CD86	CD86	NNP
cord-258787-n49zrfsp	238	43	(	(	-LRB-
cord-258787-n49zrfsp	238	44	Fig	Fig	NNP
cord-258787-n49zrfsp	238	45	.	.	NNP
cord-258787-n49zrfsp	238	46	2	2	CD
cord-258787-n49zrfsp	238	47	)	)	-RRB-
cord-258787-n49zrfsp	238	48	.	.	.
cord-258787-n49zrfsp	239	1	On	on	IN
cord-258787-n49zrfsp	239	2	the	the	DT
cord-258787-n49zrfsp	239	3	same	same	JJ
cord-258787-n49zrfsp	239	4	line	line	NN
cord-258787-n49zrfsp	239	5	,	,	,
cord-258787-n49zrfsp	239	6	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	239	7	isolated	isolate	VBN
cord-258787-n49zrfsp	239	8	from	from	IN
cord-258787-n49zrfsp	239	9	colorectal	colorectal	JJ
cord-258787-n49zrfsp	239	10	cancer	cancer	NN
cord-258787-n49zrfsp	239	11	(	(	-LRB-
cord-258787-n49zrfsp	239	12	CRC	CRC	NNP
cord-258787-n49zrfsp	239	13	)	)	-RRB-
cord-258787-n49zrfsp	239	14	patients	patient	NNS
cord-258787-n49zrfsp	239	15	were	be	VBD
cord-258787-n49zrfsp	239	16	able	able	JJ
cord-258787-n49zrfsp	239	17	to	to	TO
cord-258787-n49zrfsp	239	18	enhance	enhance	VB
cord-258787-n49zrfsp	239	19	CD8	CD8	NNP
cord-258787-n49zrfsp	239	20	+	+	CC
cord-258787-n49zrfsp	239	21	T	T	NNP
cord-258787-n49zrfsp	239	22	cell	cell	NN
cord-258787-n49zrfsp	239	23	responsiveness	responsiveness	NN
cord-258787-n49zrfsp	239	24	to	to	IN
cord-258787-n49zrfsp	239	25	T	t	NN
cord-258787-n49zrfsp	239	26	cell	cell	NN
cord-258787-n49zrfsp	239	27	receptor	receptor	NN
cord-258787-n49zrfsp	239	28	(	(	-LRB-
cord-258787-n49zrfsp	239	29	TCR	TCR	NNP
cord-258787-n49zrfsp	239	30	)	)	-RRB-
cord-258787-n49zrfsp	239	31	triggering	trigger	VBG
cord-258787-n49zrfsp	239	32	[	[	-LRB-
cord-258787-n49zrfsp	239	33	164	164	CD
cord-258787-n49zrfsp	239	34	]	]	-RRB-
cord-258787-n49zrfsp	239	35	.	.	.
cord-258787-n49zrfsp	240	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	240	2	have	have	VBP
cord-258787-n49zrfsp	240	3	been	be	VBN
cord-258787-n49zrfsp	240	4	described	describe	VBN
cord-258787-n49zrfsp	240	5	to	to	TO
cord-258787-n49zrfsp	240	6	be	be	VB
cord-258787-n49zrfsp	240	7	important	important	JJ
cord-258787-n49zrfsp	240	8	in	in	IN
cord-258787-n49zrfsp	240	9	orchestrating	orchestrate	VBG
cord-258787-n49zrfsp	240	10	the	the	DT
cord-258787-n49zrfsp	240	11	establishment	establishment	NN
cord-258787-n49zrfsp	240	12	of	of	IN
cord-258787-n49zrfsp	240	13	an	an	DT
cord-258787-n49zrfsp	240	14	effective	effective	JJ
cord-258787-n49zrfsp	240	15	anti	anti	JJ
cord-258787-n49zrfsp	240	16	-	-	JJ
cord-258787-n49zrfsp	240	17	tumour	tumour	JJ
cord-258787-n49zrfsp	240	18	immunity	immunity	NN
cord-258787-n49zrfsp	240	19	in	in	IN
cord-258787-n49zrfsp	240	20	sarcoma	sarcoma	NN
cord-258787-n49zrfsp	240	21	[	[	-LRB-
cord-258787-n49zrfsp	240	22	17	17	CD
cord-258787-n49zrfsp	240	23	]	]	-RRB-
cord-258787-n49zrfsp	240	24	.	.	.
cord-258787-n49zrfsp	241	1	In	in	IN
cord-258787-n49zrfsp	241	2	a	a	DT
cord-258787-n49zrfsp	241	3	model	model	NN
cord-258787-n49zrfsp	241	4	of	of	IN
cord-258787-n49zrfsp	241	5	3-MCA	3-mca	CD
cord-258787-n49zrfsp	241	6	-	-	HYPH
cord-258787-n49zrfsp	241	7	induced	induce	VBN
cord-258787-n49zrfsp	241	8	sarcoma	sarcoma	NN
cord-258787-n49zrfsp	241	9	,	,	,
cord-258787-n49zrfsp	241	10	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	241	11	were	be	VBD
cord-258787-n49zrfsp	241	12	found	find	VBN
cord-258787-n49zrfsp	241	13	to	to	TO
cord-258787-n49zrfsp	241	14	engage	engage	VB
cord-258787-n49zrfsp	241	15	a	a	DT
cord-258787-n49zrfsp	241	16	tripartite	tripartite	JJ
cord-258787-n49zrfsp	241	17	interaction	interaction	NN
cord-258787-n49zrfsp	241	18	with	with	IN
cord-258787-n49zrfsp	241	19	macrophages	macrophage	NNS
cord-258787-n49zrfsp	241	20	and	and	CC
cord-258787-n49zrfsp	241	21	a	a	DT
cord-258787-n49zrfsp	241	22	subset	subset	NN
cord-258787-n49zrfsp	241	23	of	of	IN
cord-258787-n49zrfsp	241	24	UTC	utc	NN
cord-258787-n49zrfsp	241	25	αβ	αβ	NN
cord-258787-n49zrfsp	241	26	.	.	.
cord-258787-n49zrfsp	242	1	Neutrophils	neutrophils	NN
cord-258787-n49zrfsp	242	2	,	,	,
cord-258787-n49zrfsp	242	3	by	by	IN
cord-258787-n49zrfsp	242	4	amplifying	amplify	VBG
cord-258787-n49zrfsp	242	5	the	the	DT
cord-258787-n49zrfsp	242	6	production	production	NN
cord-258787-n49zrfsp	242	7	of	of	IN
cord-258787-n49zrfsp	242	8	IL-12	IL-12	NNP
cord-258787-n49zrfsp	242	9	by	by	IN
cord-258787-n49zrfsp	242	10	macrophages	macrophage	NNS
cord-258787-n49zrfsp	242	11	,	,	,
cord-258787-n49zrfsp	242	12	were	be	VBD
cord-258787-n49zrfsp	242	13	essential	essential	JJ
cord-258787-n49zrfsp	242	14	to	to	TO
cord-258787-n49zrfsp	242	15	promote	promote	VB
cord-258787-n49zrfsp	242	16	type	type	NN
cord-258787-n49zrfsp	242	17	I	-PRON-	PRP
cord-258787-n49zrfsp	242	18	polarization	polarization	NN
cord-258787-n49zrfsp	242	19	and	and	CC
cord-258787-n49zrfsp	242	20	IFNγ	IFNγ	NNS
cord-258787-n49zrfsp	242	21	production	production	NN
cord-258787-n49zrfsp	242	22	in	in	IN
cord-258787-n49zrfsp	242	23	UTC	UTC	NNP
cord-258787-n49zrfsp	242	24	αβ	αβ	NN
cord-258787-n49zrfsp	242	25	,	,	,
cord-258787-n49zrfsp	242	26	which	which	WDT
cord-258787-n49zrfsp	242	27	support	support	VBP
cord-258787-n49zrfsp	242	28	tumour	tumour	NN
cord-258787-n49zrfsp	242	29	resistance	resistance	NN
cord-258787-n49zrfsp	242	30	in	in	IN
cord-258787-n49zrfsp	242	31	vivo	vivo	FW
cord-258787-n49zrfsp	242	32	(	(	-LRB-
cord-258787-n49zrfsp	242	33	Fig	Fig	NNP
cord-258787-n49zrfsp	242	34	.	.	NNP
cord-258787-n49zrfsp	242	35	2	2	CD
cord-258787-n49zrfsp	242	36	)	)	-RRB-
cord-258787-n49zrfsp	242	37	.	.	.
cord-258787-n49zrfsp	243	1	Interestingly	interestingly	RB
cord-258787-n49zrfsp	243	2	,	,	,
cord-258787-n49zrfsp	243	3	in	in	IN
cord-258787-n49zrfsp	243	4	silico	silico	NN
cord-258787-n49zrfsp	243	5	analyses	analysis	NNS
cord-258787-n49zrfsp	243	6	indicated	indicate	VBD
cord-258787-n49zrfsp	243	7	that	that	IN
cord-258787-n49zrfsp	243	8	this	this	DT
cord-258787-n49zrfsp	243	9	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	243	10	dependent	dependent	JJ
cord-258787-n49zrfsp	243	11	anti	anti	JJ
cord-258787-n49zrfsp	243	12	-	-	JJ
cord-258787-n49zrfsp	243	13	tumour	tumour	JJ
cord-258787-n49zrfsp	243	14	axis	axis	NN
cord-258787-n49zrfsp	243	15	was	be	VBD
cord-258787-n49zrfsp	243	16	relevant	relevant	JJ
cord-258787-n49zrfsp	243	17	in	in	IN
cord-258787-n49zrfsp	243	18	selected	select	VBN
cord-258787-n49zrfsp	243	19	human	human	JJ
cord-258787-n49zrfsp	243	20	tumours	tumour	NNS
cord-258787-n49zrfsp	243	21	,	,	,
cord-258787-n49zrfsp	243	22	including	include	VBG
cord-258787-n49zrfsp	243	23	undifferentiated	undifferentiated	JJ
cord-258787-n49zrfsp	243	24	pleomorphic	pleomorphic	JJ
cord-258787-n49zrfsp	243	25	sarcoma	sarcoma	NN
cord-258787-n49zrfsp	243	26	(	(	-LRB-
cord-258787-n49zrfsp	243	27	UPS	UPS	NNP
cord-258787-n49zrfsp	243	28	)	)	-RRB-
cord-258787-n49zrfsp	243	29	,	,	,
cord-258787-n49zrfsp	243	30	CRC	CRC	NNP
cord-258787-n49zrfsp	243	31	and	and	CC
cord-258787-n49zrfsp	243	32	ovarian	ovarian	JJ
cord-258787-n49zrfsp	243	33	cancer	cancer	NN
cord-258787-n49zrfsp	243	34	[	[	-LRB-
cord-258787-n49zrfsp	243	35	17	17	CD
cord-258787-n49zrfsp	243	36	]	]	-RRB-
cord-258787-n49zrfsp	243	37	.	.	.
cord-258787-n49zrfsp	244	1	As	as	IN
cord-258787-n49zrfsp	244	2	mentioned	mention	VBN
cord-258787-n49zrfsp	244	3	above	above	RB
cord-258787-n49zrfsp	244	4	,	,	,
cord-258787-n49zrfsp	244	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	244	6	in	in	IN
cord-258787-n49zrfsp	244	7	the	the	DT
cord-258787-n49zrfsp	244	8	TME	TME	NNP
cord-258787-n49zrfsp	244	9	can	can	MD
cord-258787-n49zrfsp	244	10	produce	produce	VB
cord-258787-n49zrfsp	244	11	different	different	JJ
cord-258787-n49zrfsp	244	12	mediators	mediator	NNS
cord-258787-n49zrfsp	244	13	including	include	VBG
cord-258787-n49zrfsp	244	14	ROS	ROS	NNP
cord-258787-n49zrfsp	244	15	,	,	,
cord-258787-n49zrfsp	244	16	reactive	reactive	JJ
cord-258787-n49zrfsp	244	17	nitrogen	nitrogen	NN
cord-258787-n49zrfsp	244	18	intermediates	intermediate	NNS
cord-258787-n49zrfsp	244	19	(	(	-LRB-
cord-258787-n49zrfsp	244	20	RNI	RNI	NNP
cord-258787-n49zrfsp	244	21	)	)	-RRB-
cord-258787-n49zrfsp	244	22	and	and	CC
cord-258787-n49zrfsp	244	23	Arg1	Arg1	NNP
cord-258787-n49zrfsp	244	24	involved	involve	VBN
cord-258787-n49zrfsp	244	25	in	in	IN
cord-258787-n49zrfsp	244	26	the	the	DT
cord-258787-n49zrfsp	244	27	suppression	suppression	NN
cord-258787-n49zrfsp	244	28	of	of	IN
cord-258787-n49zrfsp	244	29	both	both	DT
cord-258787-n49zrfsp	244	30	innate	innate	JJ
cord-258787-n49zrfsp	244	31	and	and	CC
cord-258787-n49zrfsp	244	32	adaptive	adaptive	JJ
cord-258787-n49zrfsp	244	33	immune	immune	JJ
cord-258787-n49zrfsp	244	34	cells	cell	NNS
cord-258787-n49zrfsp	244	35	effector	effector	NN
cord-258787-n49zrfsp	244	36	functions	function	NNS
cord-258787-n49zrfsp	244	37	.	.	.
cord-258787-n49zrfsp	245	1	In	in	IN
cord-258787-n49zrfsp	245	2	a	a	DT
cord-258787-n49zrfsp	245	3	mammary	mammary	JJ
cord-258787-n49zrfsp	245	4	transplantable	transplantable	NN
cord-258787-n49zrfsp	245	5	tumour	tumour	NN
cord-258787-n49zrfsp	245	6	model	model	NN
cord-258787-n49zrfsp	245	7	,	,	,
cord-258787-n49zrfsp	245	8	c	c	NN
cord-258787-n49zrfsp	245	9	-	-	HYPH
cord-258787-n49zrfsp	245	10	Kit	kit	NN
cord-258787-n49zrfsp	245	11	+	+	CC
cord-258787-n49zrfsp	245	12	immature	immature	JJ
cord-258787-n49zrfsp	245	13	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	245	14	were	be	VBD
cord-258787-n49zrfsp	245	15	shown	show	VBN
cord-258787-n49zrfsp	245	16	to	to	TO
cord-258787-n49zrfsp	245	17	be	be	VB
cord-258787-n49zrfsp	245	18	sensitive	sensitive	JJ
cord-258787-n49zrfsp	245	19	to	to	IN
cord-258787-n49zrfsp	245	20	glucose	glucose	NN
cord-258787-n49zrfsp	245	21	limitation	limitation	NN
cord-258787-n49zrfsp	245	22	.	.	.
cord-258787-n49zrfsp	246	1	In	in	IN
cord-258787-n49zrfsp	246	2	this	this	DT
cord-258787-n49zrfsp	246	3	condition	condition	NN
cord-258787-n49zrfsp	246	4	,	,	,
cord-258787-n49zrfsp	246	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	246	6	use	use	VBP
cord-258787-n49zrfsp	246	7	mitochondrial	mitochondrial	JJ
cord-258787-n49zrfsp	246	8	fatty	fatty	JJ
cord-258787-n49zrfsp	246	9	acid	acid	NN
cord-258787-n49zrfsp	246	10	oxidation	oxidation	NN
cord-258787-n49zrfsp	246	11	to	to	TO
cord-258787-n49zrfsp	246	12	support	support	VB
cord-258787-n49zrfsp	246	13	NAPDH	NAPDH	NNP
cord-258787-n49zrfsp	246	14	oxidase	oxidase	NN
cord-258787-n49zrfsp	246	15	-	-	HYPH
cord-258787-n49zrfsp	246	16	dependent	dependent	JJ
cord-258787-n49zrfsp	246	17	ROS	ROS	NNP
cord-258787-n49zrfsp	246	18	production	production	NN
cord-258787-n49zrfsp	246	19	which	which	WDT
cord-258787-n49zrfsp	246	20	inhibits	inhibit	VBZ
cord-258787-n49zrfsp	246	21	the	the	DT
cord-258787-n49zrfsp	246	22	T	T	NNP
cord-258787-n49zrfsp	246	23	cells	cell	NNS
cord-258787-n49zrfsp	246	24	response	response	NN
cord-258787-n49zrfsp	246	25	[	[	-LRB-
cord-258787-n49zrfsp	246	26	165	165	CD
cord-258787-n49zrfsp	246	27	]	]	-RRB-
cord-258787-n49zrfsp	246	28	.	.	.
cord-258787-n49zrfsp	247	1	This	this	DT
cord-258787-n49zrfsp	247	2	mitochondrial	mitochondrial	JJ
cord-258787-n49zrfsp	247	3	fitness	fitness	NN
cord-258787-n49zrfsp	247	4	is	be	VBZ
cord-258787-n49zrfsp	247	5	driven	drive	VBN
cord-258787-n49zrfsp	247	6	by	by	IN
cord-258787-n49zrfsp	247	7	c	c	NN
cord-258787-n49zrfsp	247	8	-	-	HYPH
cord-258787-n49zrfsp	247	9	Kit	kit	NN
cord-258787-n49zrfsp	247	10	and	and	CC
cord-258787-n49zrfsp	247	11	was	be	VBD
cord-258787-n49zrfsp	247	12	especially	especially	RB
cord-258787-n49zrfsp	247	13	observed	observe	VBN
cord-258787-n49zrfsp	247	14	in	in	IN
cord-258787-n49zrfsp	247	15	splenic	splenic	JJ
cord-258787-n49zrfsp	247	16	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	247	17	[	[	-LRB-
cord-258787-n49zrfsp	247	18	165	165	CD
cord-258787-n49zrfsp	247	19	]	]	-RRB-
cord-258787-n49zrfsp	247	20	.	.	.
cord-258787-n49zrfsp	248	1	In	in	IN
cord-258787-n49zrfsp	248	2	response	response	NN
cord-258787-n49zrfsp	248	3	to	to	IN
cord-258787-n49zrfsp	248	4	TGFβ	TGFβ	NNS
cord-258787-n49zrfsp	248	5	found	find	VBN
cord-258787-n49zrfsp	248	6	in	in	IN
cord-258787-n49zrfsp	248	7	TME	TME	NNP
cord-258787-n49zrfsp	248	8	,	,	,
cord-258787-n49zrfsp	248	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	248	10	produced	produce	VBD
cord-258787-n49zrfsp	248	11	high	high	JJ
cord-258787-n49zrfsp	248	12	amount	amount	NN
cord-258787-n49zrfsp	248	13	of	of	IN
cord-258787-n49zrfsp	248	14	Arg1	Arg1	NNP
cord-258787-n49zrfsp	248	15	,	,	,
cord-258787-n49zrfsp	248	16	which	which	WDT
cord-258787-n49zrfsp	248	17	reduced	reduce	VBD
cord-258787-n49zrfsp	248	18	the	the	DT
cord-258787-n49zrfsp	248	19	availability	availability	NN
cord-258787-n49zrfsp	248	20	of	of	IN
cord-258787-n49zrfsp	248	21	L	l	NN
cord-258787-n49zrfsp	248	22	-	-	HYPH
cord-258787-n49zrfsp	248	23	arginine	arginine	NN
cord-258787-n49zrfsp	248	24	in	in	IN
cord-258787-n49zrfsp	248	25	the	the	DT
cord-258787-n49zrfsp	248	26	TME	TME	NNP
cord-258787-n49zrfsp	248	27	and	and	CC
cord-258787-n49zrfsp	248	28	lead	lead	NN
cord-258787-n49zrfsp	248	29	to	to	IN
cord-258787-n49zrfsp	248	30	T	T	NNP
cord-258787-n49zrfsp	248	31	cell	cell	NN
cord-258787-n49zrfsp	248	32	dysfunction	dysfunction	NN
cord-258787-n49zrfsp	248	33	and	and	CC
cord-258787-n49zrfsp	248	34	suppression	suppression	NN
cord-258787-n49zrfsp	248	35	of	of	IN
cord-258787-n49zrfsp	248	36	the	the	DT
cord-258787-n49zrfsp	248	37	T	T	NNP
cord-258787-n49zrfsp	248	38	cell	cell	NN
cord-258787-n49zrfsp	248	39	-	-	HYPH
cord-258787-n49zrfsp	248	40	mediated	mediate	VBN
cord-258787-n49zrfsp	248	41	anti	anti	JJ
cord-258787-n49zrfsp	248	42	-	-	JJ
cord-258787-n49zrfsp	248	43	tumour	tumour	JJ
cord-258787-n49zrfsp	248	44	response	response	NN
cord-258787-n49zrfsp	248	45	[	[	-LRB-
cord-258787-n49zrfsp	248	46	44	44	CD
cord-258787-n49zrfsp	248	47	]	]	-RRB-
cord-258787-n49zrfsp	249	1	(	(	-LRB-
cord-258787-n49zrfsp	249	2	Fig	Fig	NNP
cord-258787-n49zrfsp	249	3	.	.	NNP
cord-258787-n49zrfsp	249	4	1	1	CD
cord-258787-n49zrfsp	249	5	)	)	-RRB-
cord-258787-n49zrfsp	249	6	.	.	.
cord-258787-n49zrfsp	250	1	Notably	notably	RB
cord-258787-n49zrfsp	250	2	,	,	,
cord-258787-n49zrfsp	250	3	Arg1	Arg1	NNP
cord-258787-n49zrfsp	250	4	produced	produce	VBN
cord-258787-n49zrfsp	250	5	by	by	IN
cord-258787-n49zrfsp	250	6	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	250	7	from	from	IN
cord-258787-n49zrfsp	250	8	renal	renal	JJ
cord-258787-n49zrfsp	250	9	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	250	10	and	and	CC
cord-258787-n49zrfsp	250	11	NSCLC	NSCLC	NNP
cord-258787-n49zrfsp	250	12	cancer	cancer	NN
cord-258787-n49zrfsp	250	13	patients	patient	NNS
cord-258787-n49zrfsp	250	14	inhibited	inhibit	VBD
cord-258787-n49zrfsp	250	15	T	T	NNP
cord-258787-n49zrfsp	250	16	cell	cell	NN
cord-258787-n49zrfsp	250	17	response	response	NN
cord-258787-n49zrfsp	250	18	[	[	-LRB-
cord-258787-n49zrfsp	250	19	166	166	CD
cord-258787-n49zrfsp	250	20	,	,	,
cord-258787-n49zrfsp	250	21	167	167	CD
cord-258787-n49zrfsp	250	22	]	]	-RRB-
cord-258787-n49zrfsp	250	23	.	.	.
cord-258787-n49zrfsp	251	1	Recent	recent	JJ
cord-258787-n49zrfsp	251	2	investigations	investigation	NNS
cord-258787-n49zrfsp	251	3	showed	show	VBD
cord-258787-n49zrfsp	251	4	an	an	DT
cord-258787-n49zrfsp	251	5	interaction	interaction	NN
cord-258787-n49zrfsp	251	6	between	between	IN
cord-258787-n49zrfsp	251	7	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	251	8	and	and	CC
cord-258787-n49zrfsp	251	9	the	the	DT
cord-258787-n49zrfsp	251	10	microbiota	microbiota	NN
cord-258787-n49zrfsp	251	11	in	in	IN
cord-258787-n49zrfsp	251	12	cancer	cancer	NN
cord-258787-n49zrfsp	251	13	[	[	-LRB-
cord-258787-n49zrfsp	251	14	160	160	CD
cord-258787-n49zrfsp	251	15	,	,	,
cord-258787-n49zrfsp	251	16	[	[	-LRB-
cord-258787-n49zrfsp	251	17	168	168	CD
cord-258787-n49zrfsp	251	18	]	]	-RRB-
cord-258787-n49zrfsp	251	19	[	[	-LRB-
cord-258787-n49zrfsp	251	20	169	169	CD
cord-258787-n49zrfsp	251	21	]	]	-RRB-
cord-258787-n49zrfsp	251	22	[	[	-LRB-
cord-258787-n49zrfsp	251	23	170	170	CD
cord-258787-n49zrfsp	251	24	]	]	-RRB-
cord-258787-n49zrfsp	251	25	[	[	-LRB-
cord-258787-n49zrfsp	251	26	171	171	CD
cord-258787-n49zrfsp	251	27	]	]	-RRB-
cord-258787-n49zrfsp	251	28	.	.	.
cord-258787-n49zrfsp	252	1	Microbiota	Microbiota	NNP
cord-258787-n49zrfsp	252	2	can	can	MD
cord-258787-n49zrfsp	252	3	regulate	regulate	VB
cord-258787-n49zrfsp	252	4	the	the	DT
cord-258787-n49zrfsp	252	5	granulopoiesis	granulopoiesis	NN
cord-258787-n49zrfsp	252	6	through	through	IN
cord-258787-n49zrfsp	252	7	the	the	DT
cord-258787-n49zrfsp	252	8	activation	activation	NN
cord-258787-n49zrfsp	252	9	of	of	IN
cord-258787-n49zrfsp	252	10	the	the	DT
cord-258787-n49zrfsp	252	11	IL-17	IL-17	NNP
cord-258787-n49zrfsp	252	12	/	/	SYM
cord-258787-n49zrfsp	252	13	G	G	NNP
cord-258787-n49zrfsp	252	14	-	-	HYPH
cord-258787-n49zrfsp	252	15	CSF	CSF	NNP
cord-258787-n49zrfsp	252	16	pathway	pathway	NN
cord-258787-n49zrfsp	252	17	in	in	IN
cord-258787-n49zrfsp	252	18	the	the	DT
cord-258787-n49zrfsp	252	19	intestine	intestine	NN
cord-258787-n49zrfsp	252	20	[	[	-LRB-
cord-258787-n49zrfsp	252	21	172	172	CD
cord-258787-n49zrfsp	252	22	]	]	-RRB-
cord-258787-n49zrfsp	252	23	.	.	.
cord-258787-n49zrfsp	253	1	In	in	IN
cord-258787-n49zrfsp	253	2	CRC	CRC	NNP
cord-258787-n49zrfsp	253	3	,	,	,
cord-258787-n49zrfsp	253	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	253	5	were	be	VBD
cord-258787-n49zrfsp	253	6	reported	report	VBN
cord-258787-n49zrfsp	253	7	to	to	TO
cord-258787-n49zrfsp	253	8	have	have	VB
cord-258787-n49zrfsp	253	9	a	a	DT
cord-258787-n49zrfsp	253	10	tumour	tumour	NN
cord-258787-n49zrfsp	253	11	suppressive	suppressive	JJ
cord-258787-n49zrfsp	253	12	effect	effect	NN
cord-258787-n49zrfsp	253	13	through	through	IN
cord-258787-n49zrfsp	253	14	the	the	DT
cord-258787-n49zrfsp	253	15	expression	expression	NN
cord-258787-n49zrfsp	253	16	of	of	IN
cord-258787-n49zrfsp	253	17	antimicrobial	antimicrobial	JJ
cord-258787-n49zrfsp	253	18	peptides	peptide	NNS
cord-258787-n49zrfsp	253	19	,	,	,
cord-258787-n49zrfsp	253	20	which	which	WDT
cord-258787-n49zrfsp	253	21	limit	limit	VBP
cord-258787-n49zrfsp	253	22	the	the	DT
cord-258787-n49zrfsp	253	23	invasion	invasion	NN
cord-258787-n49zrfsp	253	24	of	of	IN
cord-258787-n49zrfsp	253	25	bacteria	bacteria	NNS
cord-258787-n49zrfsp	253	26	and	and	CC
cord-258787-n49zrfsp	253	27	the	the	DT
cord-258787-n49zrfsp	253	28	subsequent	subsequent	JJ
cord-258787-n49zrfsp	253	29	tumour	tumour	NN
cord-258787-n49zrfsp	253	30	-	-	HYPH
cord-258787-n49zrfsp	253	31	promoting	promote	VBG
cord-258787-n49zrfsp	253	32	inflammation	inflammation	NN
cord-258787-n49zrfsp	253	33	[	[	-LRB-
cord-258787-n49zrfsp	253	34	168	168	CD
cord-258787-n49zrfsp	253	35	]	]	-RRB-
cord-258787-n49zrfsp	254	1	[	[	-LRB-
cord-258787-n49zrfsp	254	2	169	169	CD
cord-258787-n49zrfsp	254	3	]	]	-RRB-
cord-258787-n49zrfsp	255	1	[	[	-LRB-
cord-258787-n49zrfsp	255	2	170	170	CD
cord-258787-n49zrfsp	255	3	]	]	-RRB-
cord-258787-n49zrfsp	256	1	(	(	-LRB-
cord-258787-n49zrfsp	256	2	Fig	Fig	NNP
cord-258787-n49zrfsp	256	3	.	.	NNP
cord-258787-n49zrfsp	256	4	2	2	CD
cord-258787-n49zrfsp	256	5	)	)	-RRB-
cord-258787-n49zrfsp	256	6	.	.	.
cord-258787-n49zrfsp	257	1	In	in	IN
cord-258787-n49zrfsp	257	2	addition	addition	NN
cord-258787-n49zrfsp	257	3	,	,	,
cord-258787-n49zrfsp	257	4	the	the	DT
cord-258787-n49zrfsp	257	5	process	process	NN
cord-258787-n49zrfsp	257	6	of	of	IN
cord-258787-n49zrfsp	257	7	lung	lung	NN
cord-258787-n49zrfsp	257	8	carcinogenesis	carcinogenesis	NN
cord-258787-n49zrfsp	257	9	induced	induce	VBN
cord-258787-n49zrfsp	257	10	by	by	IN
cord-258787-n49zrfsp	257	11	Kras	Kras	NNP
cord-258787-n49zrfsp	257	12	mutation	mutation	NN
cord-258787-n49zrfsp	257	13	coupled	couple	VBN
cord-258787-n49zrfsp	257	14	with	with	IN
cord-258787-n49zrfsp	257	15	p53	p53	NN
cord-258787-n49zrfsp	257	16	loss	loss	NN
cord-258787-n49zrfsp	257	17	has	have	VBZ
cord-258787-n49zrfsp	257	18	been	be	VBN
cord-258787-n49zrfsp	257	19	described	describe	VBN
cord-258787-n49zrfsp	257	20	to	to	TO
cord-258787-n49zrfsp	257	21	be	be	VB
cord-258787-n49zrfsp	257	22	associated	associate	VBN
cord-258787-n49zrfsp	257	23	with	with	IN
cord-258787-n49zrfsp	257	24	dysbiosis	dysbiosis	NN
cord-258787-n49zrfsp	257	25	of	of	IN
cord-258787-n49zrfsp	257	26	the	the	DT
cord-258787-n49zrfsp	257	27	airway	airway	NN
cord-258787-n49zrfsp	257	28	microbiota	microbiota	NN
cord-258787-n49zrfsp	257	29	,	,	,
cord-258787-n49zrfsp	257	30	which	which	WDT
cord-258787-n49zrfsp	257	31	stimulates	stimulate	VBZ
cord-258787-n49zrfsp	257	32	IL-17	IL-17	NNP
cord-258787-n49zrfsp	257	33	production	production	NN
cord-258787-n49zrfsp	257	34	by	by	IN
cord-258787-n49zrfsp	257	35	resident	resident	NN
cord-258787-n49zrfsp	257	36	γδ	γδ	NN
cord-258787-n49zrfsp	257	37	T	t	NN
cord-258787-n49zrfsp	257	38	cells	cell	NNS
cord-258787-n49zrfsp	257	39	resulting	result	VBG
cord-258787-n49zrfsp	257	40	in	in	IN
cord-258787-n49zrfsp	257	41	neutrophilia	neutrophilia	NNP
cord-258787-n49zrfsp	257	42	and	and	CC
cord-258787-n49zrfsp	257	43	tumour	tumour	NN
cord-258787-n49zrfsp	257	44	growth	growth	NN
cord-258787-n49zrfsp	257	45	[	[	-LRB-
cord-258787-n49zrfsp	257	46	160	160	CD
cord-258787-n49zrfsp	257	47	]	]	-RRB-
cord-258787-n49zrfsp	257	48	.	.	.
cord-258787-n49zrfsp	258	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	258	2	engage	engage	VBP
cord-258787-n49zrfsp	258	3	important	important	JJ
cord-258787-n49zrfsp	258	4	bi	bi	JJ
cord-258787-n49zrfsp	258	5	-	-	JJ
cord-258787-n49zrfsp	258	6	directional	directional	JJ
cord-258787-n49zrfsp	258	7	interactions	interaction	NNS
cord-258787-n49zrfsp	258	8	also	also	RB
cord-258787-n49zrfsp	258	9	with	with	IN
cord-258787-n49zrfsp	258	10	innate	innate	JJ
cord-258787-n49zrfsp	258	11	lymphoid	lymphoid	JJ
cord-258787-n49zrfsp	258	12	cells	cell	NNS
cord-258787-n49zrfsp	258	13	(	(	-LRB-
cord-258787-n49zrfsp	258	14	ILCs	ILCs	NNP
cord-258787-n49zrfsp	258	15	)	)	-RRB-
cord-258787-n49zrfsp	258	16	,	,	,
cord-258787-n49zrfsp	258	17	particularly	particularly	RB
cord-258787-n49zrfsp	258	18	with	with	IN
cord-258787-n49zrfsp	258	19	NK	NK	NNP
cord-258787-n49zrfsp	258	20	cells	cell	NNS
cord-258787-n49zrfsp	258	21	.	.	.
cord-258787-n49zrfsp	259	1	For	for	IN
cord-258787-n49zrfsp	259	2	instance	instance	NN
cord-258787-n49zrfsp	259	3	,	,	,
cord-258787-n49zrfsp	259	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	259	5	have	have	VBP
cord-258787-n49zrfsp	259	6	been	be	VBN
cord-258787-n49zrfsp	259	7	shown	show	VBN
cord-258787-n49zrfsp	259	8	to	to	TO
cord-258787-n49zrfsp	259	9	promote	promote	VB
cord-258787-n49zrfsp	259	10	the	the	DT
cord-258787-n49zrfsp	259	11	metastatic	metastatic	JJ
cord-258787-n49zrfsp	259	12	spread	spread	NN
cord-258787-n49zrfsp	259	13	by	by	IN
cord-258787-n49zrfsp	259	14	preventing	prevent	VBG
cord-258787-n49zrfsp	259	15	NK	NK	NNP
cord-258787-n49zrfsp	259	16	cells	cell	NNS
cord-258787-n49zrfsp	259	17	-	-	HYPH
cord-258787-n49zrfsp	259	18	mediated	mediate	VBN
cord-258787-n49zrfsp	259	19	clearance	clearance	NN
cord-258787-n49zrfsp	259	20	of	of	IN
cord-258787-n49zrfsp	259	21	disseminating	disseminate	VBG
cord-258787-n49zrfsp	259	22	cancer	cancer	NN
cord-258787-n49zrfsp	259	23	cells	cell	NNS
cord-258787-n49zrfsp	259	24	[	[	-LRB-
cord-258787-n49zrfsp	259	25	144	144	CD
cord-258787-n49zrfsp	259	26	,	,	,
cord-258787-n49zrfsp	259	27	173	173	CD
cord-258787-n49zrfsp	259	28	]	]	-RRB-
cord-258787-n49zrfsp	259	29	.	.	.
cord-258787-n49zrfsp	260	1	in	in	IN
cord-258787-n49zrfsp	260	2	vivo	vivo	NN
cord-258787-n49zrfsp	260	3	experiments	experiment	NNS
cord-258787-n49zrfsp	260	4	showed	show	VBD
cord-258787-n49zrfsp	260	5	that	that	IN
cord-258787-n49zrfsp	260	6	in	in	IN
cord-258787-n49zrfsp	260	7	the	the	DT
cord-258787-n49zrfsp	260	8	absence	absence	NN
cord-258787-n49zrfsp	260	9	of	of	IN
cord-258787-n49zrfsp	260	10	NK	NK	NNP
cord-258787-n49zrfsp	260	11	cells	cell	NNS
cord-258787-n49zrfsp	260	12	,	,	,
cord-258787-n49zrfsp	260	13	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	260	14	acquired	acquire	VBD
cord-258787-n49zrfsp	260	15	a	a	DT
cord-258787-n49zrfsp	260	16	pro	pro	JJ
cord-258787-n49zrfsp	260	17	-	-	JJ
cord-258787-n49zrfsp	260	18	tumour	tumour	JJ
cord-258787-n49zrfsp	260	19	phenotype	phenotype	NN
cord-258787-n49zrfsp	260	20	characterized	characterize	VBN
cord-258787-n49zrfsp	260	21	by	by	IN
cord-258787-n49zrfsp	260	22	increased	increase	VBN
cord-258787-n49zrfsp	260	23	expression	expression	NN
cord-258787-n49zrfsp	260	24	of	of	IN
cord-258787-n49zrfsp	260	25	VEGF	VEGF	NNP
cord-258787-n49zrfsp	260	26	-	-	:
cord-258787-n49zrfsp	260	27	A	A	NNP
cord-258787-n49zrfsp	260	28	[	[	-LRB-
cord-258787-n49zrfsp	260	29	174	174	CD
cord-258787-n49zrfsp	260	30	]	]	-RRB-
cord-258787-n49zrfsp	260	31	.	.	.
cord-258787-n49zrfsp	261	1	These	these	DT
cord-258787-n49zrfsp	261	2	results	result	NNS
cord-258787-n49zrfsp	261	3	suggest	suggest	VBP
cord-258787-n49zrfsp	261	4	that	that	IN
cord-258787-n49zrfsp	261	5	NK	NK	NNP
cord-258787-n49zrfsp	261	6	cells	cell	NNS
cord-258787-n49zrfsp	261	7	can	can	MD
cord-258787-n49zrfsp	261	8	control	control	VB
cord-258787-n49zrfsp	261	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	261	10	pro	pro	JJ
cord-258787-n49zrfsp	261	11	-	-	JJ
cord-258787-n49zrfsp	261	12	tumour	tumour	JJ
cord-258787-n49zrfsp	261	13	activities	activity	NNS
cord-258787-n49zrfsp	261	14	.	.	.
cord-258787-n49zrfsp	262	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	262	2	can	can	MD
cord-258787-n49zrfsp	262	3	express	express	VB
cord-258787-n49zrfsp	262	4	ligands	ligand	NNS
cord-258787-n49zrfsp	262	5	of	of	IN
cord-258787-n49zrfsp	262	6	checkpoint	checkpoint	NN
cord-258787-n49zrfsp	262	7	receptors	receptor	NNS
cord-258787-n49zrfsp	262	8	,	,	,
cord-258787-n49zrfsp	262	9	such	such	JJ
cord-258787-n49zrfsp	262	10	as	as	IN
cord-258787-n49zrfsp	262	11	PD	PD	NNP
cord-258787-n49zrfsp	262	12	-	-	HYPH
cord-258787-n49zrfsp	262	13	L1	L1	NNP
cord-258787-n49zrfsp	262	14	and	and	CC
cord-258787-n49zrfsp	262	15	V	v	NN
cord-258787-n49zrfsp	262	16	-	-	HYPH
cord-258787-n49zrfsp	262	17	domain	domain	NN
cord-258787-n49zrfsp	262	18	immunoglobulin	immunoglobulin	NN
cord-258787-n49zrfsp	262	19	suppressor	suppressor	NN
cord-258787-n49zrfsp	262	20	of	of	IN
cord-258787-n49zrfsp	262	21	T	t	NN
cord-258787-n49zrfsp	262	22	-	-	HYPH
cord-258787-n49zrfsp	262	23	cell	cell	NN
cord-258787-n49zrfsp	262	24	activation	activation	NN
cord-258787-n49zrfsp	262	25	(	(	-LRB-
cord-258787-n49zrfsp	262	26	VISTA	VISTA	NNP
cord-258787-n49zrfsp	262	27	)	)	-RRB-
cord-258787-n49zrfsp	262	28	involved	involve	VBN
cord-258787-n49zrfsp	262	29	in	in	IN
cord-258787-n49zrfsp	262	30	the	the	DT
cord-258787-n49zrfsp	262	31	suppression	suppression	NN
cord-258787-n49zrfsp	262	32	of	of	IN
cord-258787-n49zrfsp	262	33	the	the	DT
cord-258787-n49zrfsp	262	34	T	T	NNP
cord-258787-n49zrfsp	262	35	cell	cell	NN
cord-258787-n49zrfsp	262	36	response	response	NN
cord-258787-n49zrfsp	262	37	by	by	IN
cord-258787-n49zrfsp	262	38	driving	drive	VBG
cord-258787-n49zrfsp	262	39	checkpoint	checkpoint	NN
cord-258787-n49zrfsp	262	40	engagement	engagement	NN
cord-258787-n49zrfsp	262	41	and	and	CC
cord-258787-n49zrfsp	262	42	T	t	NN
cord-258787-n49zrfsp	262	43	cell	cell	NN
cord-258787-n49zrfsp	262	44	exhaustion	exhaustion	NN
cord-258787-n49zrfsp	263	1	(	(	-LRB-
cord-258787-n49zrfsp	263	2	Fig	Fig	NNP
cord-258787-n49zrfsp	263	3	.	.	NNP
cord-258787-n49zrfsp	263	4	1	1	CD
cord-258787-n49zrfsp	263	5	)	)	-RRB-
cord-258787-n49zrfsp	263	6	.	.	.
cord-258787-n49zrfsp	264	1	PD	PD	NNP
cord-258787-n49zrfsp	264	2	-	-	HYPH
cord-258787-n49zrfsp	264	3	L1	L1	NNP
cord-258787-n49zrfsp	264	4	expressing	express	VBG
cord-258787-n49zrfsp	264	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	264	6	were	be	VBD
cord-258787-n49zrfsp	264	7	found	find	VBN
cord-258787-n49zrfsp	264	8	in	in	IN
cord-258787-n49zrfsp	264	9	hepatocellular	hepatocellular	JJ
cord-258787-n49zrfsp	264	10	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	264	11	and	and	CC
cord-258787-n49zrfsp	264	12	gastric	gastric	JJ
cord-258787-n49zrfsp	264	13	cancer	cancer	NN
cord-258787-n49zrfsp	264	14	and	and	CC
cord-258787-n49zrfsp	264	15	were	be	VBD
cord-258787-n49zrfsp	264	16	associated	associate	VBN
cord-258787-n49zrfsp	264	17	with	with	IN
cord-258787-n49zrfsp	264	18	a	a	DT
cord-258787-n49zrfsp	264	19	bad	bad	JJ
cord-258787-n49zrfsp	264	20	prognosis	prognosis	NN
cord-258787-n49zrfsp	264	21	[	[	-LRB-
cord-258787-n49zrfsp	264	22	175	175	CD
cord-258787-n49zrfsp	264	23	,	,	,
cord-258787-n49zrfsp	264	24	176	176	CD
cord-258787-n49zrfsp	264	25	]	]	-RRB-
cord-258787-n49zrfsp	264	26	.	.	.
cord-258787-n49zrfsp	265	1	In	in	IN
cord-258787-n49zrfsp	265	2	a	a	DT
cord-258787-n49zrfsp	265	3	murine	murine	JJ
cord-258787-n49zrfsp	265	4	transplantable	transplantable	JJ
cord-258787-n49zrfsp	265	5	model	model	NN
cord-258787-n49zrfsp	265	6	of	of	IN
cord-258787-n49zrfsp	265	7	melanoma	melanoma	NN
cord-258787-n49zrfsp	265	8	,	,	,
cord-258787-n49zrfsp	265	9	blockade	blockade	NN
cord-258787-n49zrfsp	265	10	of	of	IN
cord-258787-n49zrfsp	265	11	VISTA	VISTA	NNP
cord-258787-n49zrfsp	265	12	induced	induce	VBD
cord-258787-n49zrfsp	265	13	the	the	DT
cord-258787-n49zrfsp	265	14	production	production	NN
cord-258787-n49zrfsp	265	15	of	of	IN
cord-258787-n49zrfsp	265	16	IL-12	IL-12	NNP
cord-258787-n49zrfsp	265	17	in	in	IN
cord-258787-n49zrfsp	265	18	tumour	tumour	NN
cord-258787-n49zrfsp	265	19	associated	associate	VBN
cord-258787-n49zrfsp	265	20	monocytes	monocyte	NNS
cord-258787-n49zrfsp	265	21	and	and	CC
cord-258787-n49zrfsp	265	22	dendritic	dendritic	JJ
cord-258787-n49zrfsp	265	23	cells	cell	NNS
cord-258787-n49zrfsp	265	24	,	,	,
cord-258787-n49zrfsp	265	25	via	via	IN
cord-258787-n49zrfsp	265	26	a	a	DT
cord-258787-n49zrfsp	265	27	MyD88-dependent	MyD88-dependent	NNP
cord-258787-n49zrfsp	265	28	pro	pro	JJ
cord-258787-n49zrfsp	265	29	-	-	JJ
cord-258787-n49zrfsp	265	30	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	265	31	response	response	NN
cord-258787-n49zrfsp	265	32	[	[	-LRB-
cord-258787-n49zrfsp	265	33	177	177	CD
cord-258787-n49zrfsp	265	34	]	]	-RRB-
cord-258787-n49zrfsp	265	35	.	.	.
cord-258787-n49zrfsp	266	1	However	however	RB
cord-258787-n49zrfsp	266	2	,	,	,
cord-258787-n49zrfsp	266	3	the	the	DT
cord-258787-n49zrfsp	266	4	inhibition	inhibition	NN
cord-258787-n49zrfsp	266	5	of	of	IN
cord-258787-n49zrfsp	266	6	VISTA	VISTA	NNP
cord-258787-n49zrfsp	266	7	on	on	IN
cord-258787-n49zrfsp	266	8	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	266	9	did	do	VBD
cord-258787-n49zrfsp	266	10	not	not	RB
cord-258787-n49zrfsp	266	11	alter	alter	VB
cord-258787-n49zrfsp	266	12	their	-PRON-	PRP$
cord-258787-n49zrfsp	266	13	immunosuppressive	immunosuppressive	JJ
cord-258787-n49zrfsp	266	14	phenotype	phenotype	NN
cord-258787-n49zrfsp	266	15	,	,	,
cord-258787-n49zrfsp	266	16	suggesting	suggest	VBG
cord-258787-n49zrfsp	266	17	that	that	IN
cord-258787-n49zrfsp	266	18	combination	combination	NN
cord-258787-n49zrfsp	266	19	therapy	therapy	NN
cord-258787-n49zrfsp	266	20	,	,	,
cord-258787-n49zrfsp	266	21	with	with	IN
cord-258787-n49zrfsp	266	22	VISTA	VISTA	NNP
cord-258787-n49zrfsp	266	23	inhibition	inhibition	NN
cord-258787-n49zrfsp	266	24	and	and	CC
cord-258787-n49zrfsp	266	25	reprogramming	reprogramming	NN
cord-258787-n49zrfsp	266	26	or	or	CC
cord-258787-n49zrfsp	266	27	depletion	depletion	NN
cord-258787-n49zrfsp	266	28	of	of	IN
cord-258787-n49zrfsp	266	29	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	266	30	,	,	,
cord-258787-n49zrfsp	266	31	should	should	MD
cord-258787-n49zrfsp	266	32	be	be	VB
cord-258787-n49zrfsp	266	33	considered	consider	VBN
cord-258787-n49zrfsp	266	34	in	in	IN
cord-258787-n49zrfsp	266	35	this	this	DT
cord-258787-n49zrfsp	266	36	model	model	NN
cord-258787-n49zrfsp	266	37	.	.	.
cord-258787-n49zrfsp	267	1	Collectively	collectively	RB
cord-258787-n49zrfsp	267	2	,	,	,
cord-258787-n49zrfsp	267	3	these	these	DT
cord-258787-n49zrfsp	267	4	findings	finding	NNS
cord-258787-n49zrfsp	267	5	suggest	suggest	VBP
cord-258787-n49zrfsp	267	6	that	that	IN
cord-258787-n49zrfsp	267	7	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	267	8	can	can	MD
cord-258787-n49zrfsp	267	9	amplify	amplify	VB
cord-258787-n49zrfsp	267	10	or	or	CC
cord-258787-n49zrfsp	267	11	suppress	suppress	VB
cord-258787-n49zrfsp	267	12	the	the	DT
cord-258787-n49zrfsp	267	13	immune	immune	JJ
cord-258787-n49zrfsp	267	14	anti	anti	JJ
cord-258787-n49zrfsp	267	15	-	-	JJ
cord-258787-n49zrfsp	267	16	tumour	tumour	JJ
cord-258787-n49zrfsp	267	17	immune	immune	JJ
cord-258787-n49zrfsp	267	18	response	response	NN
cord-258787-n49zrfsp	267	19	,	,	,
cord-258787-n49zrfsp	267	20	through	through	IN
cord-258787-n49zrfsp	267	21	different	different	JJ
cord-258787-n49zrfsp	267	22	mechanisms	mechanism	NNS
cord-258787-n49zrfsp	267	23	.	.	.
cord-258787-n49zrfsp	268	1	Deciphering	decipher	VBG
cord-258787-n49zrfsp	268	2	these	these	DT
cord-258787-n49zrfsp	268	3	mechanisms	mechanism	NNS
cord-258787-n49zrfsp	268	4	may	may	MD
cord-258787-n49zrfsp	268	5	provide	provide	VB
cord-258787-n49zrfsp	268	6	new	new	JJ
cord-258787-n49zrfsp	268	7	therapeutic	therapeutic	JJ
cord-258787-n49zrfsp	268	8	approaches	approach	NNS
cord-258787-n49zrfsp	268	9	to	to	TO
cord-258787-n49zrfsp	268	10	reprogram	reprogram	VB
cord-258787-n49zrfsp	268	11	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	268	12	in	in	IN
cord-258787-n49zrfsp	268	13	an	an	DT
cord-258787-n49zrfsp	268	14	anti	anti	JJ
cord-258787-n49zrfsp	268	15	-	-	JJ
cord-258787-n49zrfsp	268	16	tumour	tumour	JJ
cord-258787-n49zrfsp	268	17	activation	activation	NN
cord-258787-n49zrfsp	268	18	state	state	NN
cord-258787-n49zrfsp	268	19	.	.	.
cord-258787-n49zrfsp	269	1	High	high	JJ
cord-258787-n49zrfsp	269	2	density	density	NN
cord-258787-n49zrfsp	269	3	of	of	IN
cord-258787-n49zrfsp	269	4	TANs	tan	NNS
cord-258787-n49zrfsp	269	5	or	or	CC
cord-258787-n49zrfsp	269	6	a	a	DT
cord-258787-n49zrfsp	269	7	high	high	JJ
cord-258787-n49zrfsp	269	8	level	level	NN
cord-258787-n49zrfsp	269	9	of	of	IN
cord-258787-n49zrfsp	269	10	absolute	absolute	JJ
cord-258787-n49zrfsp	269	11	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	269	12	count	count	NN
cord-258787-n49zrfsp	269	13	(	(	-LRB-
cord-258787-n49zrfsp	269	14	ANC	ANC	NNP
cord-258787-n49zrfsp	269	15	)	)	-RRB-
cord-258787-n49zrfsp	269	16	in	in	IN
cord-258787-n49zrfsp	269	17	the	the	DT
cord-258787-n49zrfsp	269	18	blood	blood	NN
cord-258787-n49zrfsp	269	19	are	be	VBP
cord-258787-n49zrfsp	269	20	generally	generally	RB
cord-258787-n49zrfsp	269	21	associated	associate	VBN
cord-258787-n49zrfsp	269	22	with	with	IN
cord-258787-n49zrfsp	269	23	a	a	DT
cord-258787-n49zrfsp	269	24	poor	poor	JJ
cord-258787-n49zrfsp	269	25	prognosis	prognosis	NN
cord-258787-n49zrfsp	269	26	in	in	IN
cord-258787-n49zrfsp	269	27	cancer	cancer	NN
cord-258787-n49zrfsp	269	28	patients	patient	NNS
cord-258787-n49zrfsp	269	29	[	[	-LRB-
cord-258787-n49zrfsp	269	30	16	16	CD
cord-258787-n49zrfsp	269	31	,	,	,
cord-258787-n49zrfsp	269	32	[	[	-LRB-
cord-258787-n49zrfsp	269	33	20	20	CD
cord-258787-n49zrfsp	269	34	]	]	-RRB-
cord-258787-n49zrfsp	269	35	[	[	-LRB-
cord-258787-n49zrfsp	269	36	21	21	CD
cord-258787-n49zrfsp	269	37	]	]	-RRB-
cord-258787-n49zrfsp	269	38	[	[	-LRB-
cord-258787-n49zrfsp	269	39	22	22	CD
cord-258787-n49zrfsp	269	40	]	]	-RRB-
cord-258787-n49zrfsp	269	41	.	.	.
cord-258787-n49zrfsp	270	1	Accordingly	accordingly	RB
cord-258787-n49zrfsp	270	2	,	,	,
cord-258787-n49zrfsp	270	3	blood	blood	NN
cord-258787-n49zrfsp	270	4	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	270	5	to	to	IN
cord-258787-n49zrfsp	270	6	lymphocytes	lymphocytes	FW
cord-258787-n49zrfsp	270	7	ratio	ratio	NN
cord-258787-n49zrfsp	270	8	(	(	-LRB-
cord-258787-n49zrfsp	270	9	NLR	NLR	NNP
cord-258787-n49zrfsp	270	10	)	)	-RRB-
cord-258787-n49zrfsp	270	11	has	have	VBZ
cord-258787-n49zrfsp	270	12	been	be	VBN
cord-258787-n49zrfsp	270	13	proposed	propose	VBN
cord-258787-n49zrfsp	270	14	as	as	IN
cord-258787-n49zrfsp	270	15	a	a	DT
cord-258787-n49zrfsp	270	16	clinical	clinical	JJ
cord-258787-n49zrfsp	270	17	biomarker	biomarker	NN
cord-258787-n49zrfsp	270	18	in	in	IN
cord-258787-n49zrfsp	270	19	patients	patient	NNS
cord-258787-n49zrfsp	270	20	with	with	IN
cord-258787-n49zrfsp	270	21	cancer	cancer	NN
cord-258787-n49zrfsp	270	22	.	.	.
cord-258787-n49zrfsp	271	1	This	this	DT
cord-258787-n49zrfsp	271	2	parameter	parameter	NN
cord-258787-n49zrfsp	271	3	is	be	VBZ
cord-258787-n49zrfsp	271	4	easy	easy	JJ
cord-258787-n49zrfsp	271	5	to	to	TO
cord-258787-n49zrfsp	271	6	obtain	obtain	VB
cord-258787-n49zrfsp	271	7	in	in	IN
cord-258787-n49zrfsp	271	8	clinical	clinical	JJ
cord-258787-n49zrfsp	271	9	practice	practice	NN
cord-258787-n49zrfsp	271	10	and	and	CC
cord-258787-n49zrfsp	271	11	can	can	MD
cord-258787-n49zrfsp	271	12	be	be	VB
cord-258787-n49zrfsp	271	13	monitored	monitor	VBN
cord-258787-n49zrfsp	271	14	over	over	IN
cord-258787-n49zrfsp	271	15	time	time	NN
cord-258787-n49zrfsp	271	16	.	.	.
cord-258787-n49zrfsp	272	1	A	a	DT
cord-258787-n49zrfsp	272	2	systematic	systematic	JJ
cord-258787-n49zrfsp	272	3	review	review	NN
cord-258787-n49zrfsp	272	4	of	of	IN
cord-258787-n49zrfsp	272	5	electronic	electronic	JJ
cord-258787-n49zrfsp	272	6	databases	database	NNS
cord-258787-n49zrfsp	272	7	has	have	VBZ
cord-258787-n49zrfsp	272	8	been	be	VBN
cord-258787-n49zrfsp	272	9	conducted	conduct	VBN
cord-258787-n49zrfsp	272	10	to	to	TO
cord-258787-n49zrfsp	272	11	explore	explore	VB
cord-258787-n49zrfsp	272	12	the	the	DT
cord-258787-n49zrfsp	272	13	significance	significance	NN
cord-258787-n49zrfsp	272	14	of	of	IN
cord-258787-n49zrfsp	272	15	blood	blood	NN
cord-258787-n49zrfsp	272	16	NLR	NLR	NNP
cord-258787-n49zrfsp	272	17	in	in	IN
cord-258787-n49zrfsp	272	18	a	a	DT
cord-258787-n49zrfsp	272	19	variety	variety	NN
cord-258787-n49zrfsp	272	20	of	of	IN
cord-258787-n49zrfsp	272	21	solid	solid	JJ
cord-258787-n49zrfsp	272	22	tumours	tumour	NNS
cord-258787-n49zrfsp	272	23	.	.	.
cord-258787-n49zrfsp	273	1	In	in	IN
cord-258787-n49zrfsp	273	2	40,559	40,559	CD
cord-258787-n49zrfsp	273	3	patients	patient	NNS
cord-258787-n49zrfsp	273	4	,	,	,
cord-258787-n49zrfsp	273	5	with	with	IN
cord-258787-n49zrfsp	273	6	22	22	CD
cord-258787-n49zrfsp	273	7	different	different	JJ
cord-258787-n49zrfsp	273	8	types	type	NNS
cord-258787-n49zrfsp	273	9	of	of	IN
cord-258787-n49zrfsp	273	10	cancer	cancer	NN
cord-258787-n49zrfsp	273	11	,	,	,
cord-258787-n49zrfsp	273	12	blood	blood	NN
cord-258787-n49zrfsp	273	13	NLR	NLR	NNP
cord-258787-n49zrfsp	273	14	was	be	VBD
cord-258787-n49zrfsp	273	15	associated	associate	VBN
cord-258787-n49zrfsp	273	16	with	with	IN
cord-258787-n49zrfsp	273	17	faster	fast	JJR
cord-258787-n49zrfsp	273	18	tumour	tumour	NN
cord-258787-n49zrfsp	273	19	progression	progression	NN
cord-258787-n49zrfsp	273	20	and	and	CC
cord-258787-n49zrfsp	273	21	reduced	reduce	VBN
cord-258787-n49zrfsp	273	22	overall	overall	JJ
cord-258787-n49zrfsp	273	23	survival	survival	NN
cord-258787-n49zrfsp	273	24	(	(	-LRB-
cord-258787-n49zrfsp	273	25	OS	OS	NNP
cord-258787-n49zrfsp	273	26	)	)	-RRB-
cord-258787-n49zrfsp	273	27	of	of	IN
cord-258787-n49zrfsp	273	28	patients	patient	NNS
cord-258787-n49zrfsp	273	29	in	in	IN
cord-258787-n49zrfsp	273	30	the	the	DT
cord-258787-n49zrfsp	273	31	majority	majority	NN
cord-258787-n49zrfsp	273	32	of	of	IN
cord-258787-n49zrfsp	273	33	solid	solid	JJ
cord-258787-n49zrfsp	273	34	tumours	tumour	NNS
cord-258787-n49zrfsp	273	35	[	[	-LRB-
cord-258787-n49zrfsp	273	36	23	23	CD
cord-258787-n49zrfsp	273	37	]	]	-RRB-
cord-258787-n49zrfsp	273	38	.	.	.
cord-258787-n49zrfsp	274	1	However	however	RB
cord-258787-n49zrfsp	274	2	,	,	,
cord-258787-n49zrfsp	274	3	it	-PRON-	PRP
cord-258787-n49zrfsp	274	4	is	be	VBZ
cord-258787-n49zrfsp	274	5	important	important	JJ
cord-258787-n49zrfsp	274	6	to	to	TO
cord-258787-n49zrfsp	274	7	note	note	VB
cord-258787-n49zrfsp	274	8	that	that	IN
cord-258787-n49zrfsp	274	9	the	the	DT
cord-258787-n49zrfsp	274	10	validity	validity	NN
cord-258787-n49zrfsp	274	11	of	of	IN
cord-258787-n49zrfsp	274	12	the	the	DT
cord-258787-n49zrfsp	274	13	NLR	NLR	NNP
cord-258787-n49zrfsp	274	14	parameter	parameter	NN
cord-258787-n49zrfsp	274	15	has	have	VBZ
cord-258787-n49zrfsp	274	16	been	be	VBN
cord-258787-n49zrfsp	274	17	questioned	question	VBN
cord-258787-n49zrfsp	274	18	.	.	.
cord-258787-n49zrfsp	275	1	Indeed	indeed	RB
cord-258787-n49zrfsp	275	2	,	,	,
cord-258787-n49zrfsp	275	3	NLR	NLR	NNP
cord-258787-n49zrfsp	275	4	is	be	VBZ
cord-258787-n49zrfsp	275	5	a	a	DT
cord-258787-n49zrfsp	275	6	dynamic	dynamic	JJ
cord-258787-n49zrfsp	275	7	parameter	parameter	NN
cord-258787-n49zrfsp	275	8	that	that	WDT
cord-258787-n49zrfsp	275	9	can	can	MD
cord-258787-n49zrfsp	275	10	undergo	undergo	VB
cord-258787-n49zrfsp	275	11	variations	variation	NNS
cord-258787-n49zrfsp	275	12	over	over	IN
cord-258787-n49zrfsp	275	13	time	time	NN
cord-258787-n49zrfsp	275	14	and	and	CC
cord-258787-n49zrfsp	275	15	can	can	MD
cord-258787-n49zrfsp	275	16	be	be	VB
cord-258787-n49zrfsp	275	17	affected	affect	VBN
cord-258787-n49zrfsp	275	18	by	by	IN
cord-258787-n49zrfsp	275	19	other	other	JJ
cord-258787-n49zrfsp	275	20	clinical	clinical	JJ
cord-258787-n49zrfsp	275	21	parameters	parameter	NNS
cord-258787-n49zrfsp	275	22	,	,	,
cord-258787-n49zrfsp	275	23	such	such	JJ
cord-258787-n49zrfsp	275	24	as	as	IN
cord-258787-n49zrfsp	275	25	infections	infection	NNS
cord-258787-n49zrfsp	275	26	.	.	.
cord-258787-n49zrfsp	276	1	Therefore	therefore	RB
cord-258787-n49zrfsp	276	2	,	,	,
cord-258787-n49zrfsp	276	3	it	-PRON-	PRP
cord-258787-n49zrfsp	276	4	remains	remain	VBZ
cord-258787-n49zrfsp	276	5	to	to	TO
cord-258787-n49zrfsp	276	6	establish	establish	VB
cord-258787-n49zrfsp	276	7	an	an	DT
cord-258787-n49zrfsp	276	8	optimal	optimal	JJ
cord-258787-n49zrfsp	276	9	and	and	CC
cord-258787-n49zrfsp	276	10	uniform	uniform	JJ
cord-258787-n49zrfsp	276	11	threshold	threshold	NN
cord-258787-n49zrfsp	276	12	to	to	TO
cord-258787-n49zrfsp	276	13	define	define	VB
cord-258787-n49zrfsp	276	14	a	a	DT
cord-258787-n49zrfsp	276	15	low	low	JJ
cord-258787-n49zrfsp	276	16	,	,	,
cord-258787-n49zrfsp	276	17	normal	normal	JJ
cord-258787-n49zrfsp	276	18	and	and	CC
cord-258787-n49zrfsp	276	19	high	high	JJ
cord-258787-n49zrfsp	276	20	NLR	nlr	NN
cord-258787-n49zrfsp	276	21	in	in	IN
cord-258787-n49zrfsp	276	22	cancer	cancer	NN
cord-258787-n49zrfsp	276	23	patients	patient	NNS
cord-258787-n49zrfsp	276	24	[	[	-LRB-
cord-258787-n49zrfsp	276	25	178	178	CD
cord-258787-n49zrfsp	276	26	]	]	-RRB-
cord-258787-n49zrfsp	276	27	.	.	.
cord-258787-n49zrfsp	277	1	Beside	beside	IN
cord-258787-n49zrfsp	277	2	circulating	circulate	VBG
cord-258787-n49zrfsp	277	3	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	277	4	,	,	,
cord-258787-n49zrfsp	277	5	the	the	DT
cord-258787-n49zrfsp	277	6	density	density	NN
cord-258787-n49zrfsp	277	7	of	of	IN
cord-258787-n49zrfsp	277	8	TANs	tan	NNS
cord-258787-n49zrfsp	277	9	has	have	VBZ
cord-258787-n49zrfsp	277	10	been	be	VBN
cord-258787-n49zrfsp	277	11	also	also	RB
cord-258787-n49zrfsp	277	12	associated	associate	VBN
cord-258787-n49zrfsp	277	13	with	with	IN
cord-258787-n49zrfsp	277	14	outcome	outcome	NN
cord-258787-n49zrfsp	277	15	of	of	IN
cord-258787-n49zrfsp	277	16	patients	patient	NNS
cord-258787-n49zrfsp	277	17	with	with	IN
cord-258787-n49zrfsp	277	18	cancer	cancer	NN
cord-258787-n49zrfsp	277	19	.	.	.
cord-258787-n49zrfsp	278	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	278	2	represent	represent	VBP
cord-258787-n49zrfsp	278	3	a	a	DT
cord-258787-n49zrfsp	278	4	significant	significant	JJ
cord-258787-n49zrfsp	278	5	proportion	proportion	NN
cord-258787-n49zrfsp	278	6	of	of	IN
cord-258787-n49zrfsp	278	7	tumour	tumour	NN
cord-258787-n49zrfsp	278	8	-	-	HYPH
cord-258787-n49zrfsp	278	9	infiltrating	infiltrate	VBG
cord-258787-n49zrfsp	278	10	leukocytes	leukocyte	NNS
cord-258787-n49zrfsp	278	11	in	in	IN
cord-258787-n49zrfsp	278	12	different	different	JJ
cord-258787-n49zrfsp	278	13	subtype	subtype	NN
cord-258787-n49zrfsp	278	14	of	of	IN
cord-258787-n49zrfsp	278	15	solid	solid	JJ
cord-258787-n49zrfsp	278	16	tumours	tumour	NNS
cord-258787-n49zrfsp	278	17	,	,	,
cord-258787-n49zrfsp	278	18	including	include	VBG
cord-258787-n49zrfsp	278	19	NSCLC	NSCLC	NNP
cord-258787-n49zrfsp	278	20	,	,	,
cord-258787-n49zrfsp	278	21	hepatocellular	hepatocellular	JJ
cord-258787-n49zrfsp	278	22	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	278	23	,	,	,
cord-258787-n49zrfsp	278	24	renal	renal	JJ
cord-258787-n49zrfsp	278	25	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	278	26	,	,	,
cord-258787-n49zrfsp	278	27	CRC	CRC	NNP
cord-258787-n49zrfsp	278	28	and	and	CC
cord-258787-n49zrfsp	278	29	gastric	gastric	JJ
cord-258787-n49zrfsp	278	30	cancer	cancer	NN
cord-258787-n49zrfsp	278	31	[	[	-LRB-
cord-258787-n49zrfsp	278	32	20	20	CD
cord-258787-n49zrfsp	278	33	,	,	,
cord-258787-n49zrfsp	278	34	21	21	CD
cord-258787-n49zrfsp	278	35	,	,	,
cord-258787-n49zrfsp	278	36	132	132	CD
cord-258787-n49zrfsp	278	37	,	,	,
cord-258787-n49zrfsp	278	38	164	164	CD
cord-258787-n49zrfsp	278	39	,	,	,
cord-258787-n49zrfsp	278	40	175	175	CD
cord-258787-n49zrfsp	278	41	,	,	,
cord-258787-n49zrfsp	278	42	176	176	CD
cord-258787-n49zrfsp	278	43	,	,	,
cord-258787-n49zrfsp	278	44	[	[	-LRB-
cord-258787-n49zrfsp	278	45	179	179	CD
cord-258787-n49zrfsp	278	46	]	]	-RRB-
cord-258787-n49zrfsp	278	47	[	[	-LRB-
cord-258787-n49zrfsp	278	48	180	180	CD
cord-258787-n49zrfsp	278	49	]	]	-RRB-
cord-258787-n49zrfsp	278	50	[	[	-LRB-
cord-258787-n49zrfsp	278	51	181	181	CD
cord-258787-n49zrfsp	278	52	]	]	-RRB-
cord-258787-n49zrfsp	278	53	.	.	.
cord-258787-n49zrfsp	279	1	In	in	IN
cord-258787-n49zrfsp	279	2	most	most	JJS
cord-258787-n49zrfsp	279	3	cases	case	NNS
cord-258787-n49zrfsp	279	4	,	,	,
cord-258787-n49zrfsp	279	5	density	density	NN
cord-258787-n49zrfsp	279	6	of	of	IN
cord-258787-n49zrfsp	279	7	TANs	tan	NNS
cord-258787-n49zrfsp	279	8	has	have	VBZ
cord-258787-n49zrfsp	279	9	been	be	VBN
cord-258787-n49zrfsp	279	10	associated	associate	VBN
cord-258787-n49zrfsp	279	11	with	with	IN
cord-258787-n49zrfsp	279	12	a	a	DT
cord-258787-n49zrfsp	279	13	bad	bad	JJ
cord-258787-n49zrfsp	279	14	prognosis	prognosis	NN
cord-258787-n49zrfsp	279	15	,	,	,
cord-258787-n49zrfsp	279	16	likely	likely	RB
cord-258787-n49zrfsp	279	17	due	due	IN
cord-258787-n49zrfsp	279	18	to	to	IN
cord-258787-n49zrfsp	279	19	their	-PRON-	PRP$
cord-258787-n49zrfsp	279	20	immunosuppressive	immunosuppressive	JJ
cord-258787-n49zrfsp	279	21	features	feature	NNS
cord-258787-n49zrfsp	279	22	and	and	CC
cord-258787-n49zrfsp	279	23	their	-PRON-	PRP$
cord-258787-n49zrfsp	279	24	tumour	tumour	NN
cord-258787-n49zrfsp	279	25	promoting	promote	VBG
cord-258787-n49zrfsp	279	26	functions	function	NNS
cord-258787-n49zrfsp	279	27	(	(	-LRB-
cord-258787-n49zrfsp	279	28	see	see	VB
cord-258787-n49zrfsp	279	29	above	above	RB
cord-258787-n49zrfsp	279	30	)	)	-RRB-
cord-258787-n49zrfsp	279	31	.	.	.
cord-258787-n49zrfsp	280	1	For	for	IN
cord-258787-n49zrfsp	280	2	example	example	NN
cord-258787-n49zrfsp	280	3	,	,	,
cord-258787-n49zrfsp	280	4	TANs	tan	NNS
cord-258787-n49zrfsp	280	5	represent	represent	VBP
cord-258787-n49zrfsp	280	6	the	the	DT
cord-258787-n49zrfsp	280	7	dominant	dominant	JJ
cord-258787-n49zrfsp	280	8	leukocytes	leukocyte	NNS
cord-258787-n49zrfsp	280	9	population	population	NN
cord-258787-n49zrfsp	280	10	in	in	IN
cord-258787-n49zrfsp	280	11	NSCLC	NSCLC	NNP
cord-258787-n49zrfsp	280	12	and	and	CC
cord-258787-n49zrfsp	280	13	were	be	VBD
cord-258787-n49zrfsp	280	14	found	find	VBN
cord-258787-n49zrfsp	280	15	inversely	inversely	RB
cord-258787-n49zrfsp	280	16	associated	associate	VBN
cord-258787-n49zrfsp	280	17	with	with	IN
cord-258787-n49zrfsp	280	18	T	t	NN
cord-258787-n49zrfsp	280	19	cell	cell	NN
cord-258787-n49zrfsp	280	20	infiltration	infiltration	NN
cord-258787-n49zrfsp	280	21	[	[	-LRB-
cord-258787-n49zrfsp	280	22	180	180	CD
cord-258787-n49zrfsp	280	23	]	]	-RRB-
cord-258787-n49zrfsp	280	24	.	.	.
cord-258787-n49zrfsp	281	1	In	in	IN
cord-258787-n49zrfsp	281	2	other	other	JJ
cord-258787-n49zrfsp	281	3	tumour	tumour	NN
cord-258787-n49zrfsp	281	4	contexts	context	NNS
cord-258787-n49zrfsp	281	5	,	,	,
cord-258787-n49zrfsp	281	6	such	such	JJ
cord-258787-n49zrfsp	281	7	as	as	IN
cord-258787-n49zrfsp	281	8	in	in	IN
cord-258787-n49zrfsp	281	9	CRC	CRC	NNP
cord-258787-n49zrfsp	281	10	,	,	,
cord-258787-n49zrfsp	281	11	endometrial	endometrial	JJ
cord-258787-n49zrfsp	281	12	cancer	cancer	NN
cord-258787-n49zrfsp	281	13	,	,	,
cord-258787-n49zrfsp	281	14	invasive	invasive	JJ
cord-258787-n49zrfsp	281	15	ductal	ductal	JJ
cord-258787-n49zrfsp	281	16	breast	breast	NN
cord-258787-n49zrfsp	281	17	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	281	18	,	,	,
cord-258787-n49zrfsp	281	19	low	low	JJ
cord-258787-n49zrfsp	281	20	grade	grade	NN
cord-258787-n49zrfsp	281	21	glioma	glioma	NN
cord-258787-n49zrfsp	281	22	and	and	CC
cord-258787-n49zrfsp	281	23	undifferentiated	undifferentiated	JJ
cord-258787-n49zrfsp	281	24	pleomorphic	pleomorphic	JJ
cord-258787-n49zrfsp	281	25	sarcoma	sarcoma	NN
cord-258787-n49zrfsp	281	26	(	(	-LRB-
cord-258787-n49zrfsp	281	27	UPS	UPS	NNP
cord-258787-n49zrfsp	281	28	)	)	-RRB-
cord-258787-n49zrfsp	281	29	,	,	,
cord-258787-n49zrfsp	281	30	density	density	NN
cord-258787-n49zrfsp	281	31	of	of	IN
cord-258787-n49zrfsp	281	32	TANs	tan	NNS
cord-258787-n49zrfsp	281	33	appear	appear	VBP
cord-258787-n49zrfsp	281	34	to	to	TO
cord-258787-n49zrfsp	281	35	correlate	correlate	VB
cord-258787-n49zrfsp	281	36	with	with	IN
cord-258787-n49zrfsp	281	37	a	a	DT
cord-258787-n49zrfsp	281	38	good	good	JJ
cord-258787-n49zrfsp	281	39	prognosis	prognosis	NN
cord-258787-n49zrfsp	281	40	[	[	-LRB-
cord-258787-n49zrfsp	281	41	17	17	CD
cord-258787-n49zrfsp	281	42	,	,	,
cord-258787-n49zrfsp	281	43	60	60	CD
cord-258787-n49zrfsp	281	44	,	,	,
cord-258787-n49zrfsp	281	45	164	164	CD
cord-258787-n49zrfsp	281	46	,	,	,
cord-258787-n49zrfsp	281	47	179	179	CD
cord-258787-n49zrfsp	281	48	,	,	,
cord-258787-n49zrfsp	281	49	182	182	CD
cord-258787-n49zrfsp	281	50	,	,	,
cord-258787-n49zrfsp	281	51	183	183	CD
cord-258787-n49zrfsp	281	52	]	]	-RRB-
cord-258787-n49zrfsp	281	53	.	.	.
cord-258787-n49zrfsp	282	1	In	in	IN
cord-258787-n49zrfsp	282	2	CRC	CRC	NNP
cord-258787-n49zrfsp	282	3	patients	patient	NNS
cord-258787-n49zrfsp	282	4	,	,	,
cord-258787-n49zrfsp	282	5	TANs	tan	NNS
cord-258787-n49zrfsp	282	6	were	be	VBD
cord-258787-n49zrfsp	282	7	frequently	frequently	RB
cord-258787-n49zrfsp	282	8	colocalized	colocalize	VBN
cord-258787-n49zrfsp	282	9	with	with	IN
cord-258787-n49zrfsp	282	10	CD8	CD8	NNP
cord-258787-n49zrfsp	282	11	+	+	CC
cord-258787-n49zrfsp	282	12	T	T	NNP
cord-258787-n49zrfsp	282	13	cells	cell	NNS
cord-258787-n49zrfsp	282	14	and	and	CC
cord-258787-n49zrfsp	282	15	can	can	MD
cord-258787-n49zrfsp	282	16	enhance	enhance	VB
cord-258787-n49zrfsp	282	17	their	-PRON-	PRP$
cord-258787-n49zrfsp	282	18	responsiveness	responsiveness	NN
cord-258787-n49zrfsp	282	19	to	to	IN
cord-258787-n49zrfsp	282	20	TCR	TCR	NNP
cord-258787-n49zrfsp	282	21	triggering	trigger	VBG
cord-258787-n49zrfsp	282	22	[	[	-LRB-
cord-258787-n49zrfsp	282	23	164	164	CD
cord-258787-n49zrfsp	282	24	]	]	-RRB-
cord-258787-n49zrfsp	282	25	.	.	.
cord-258787-n49zrfsp	283	1	In	in	IN
cord-258787-n49zrfsp	283	2	patients	patient	NNS
cord-258787-n49zrfsp	283	3	with	with	IN
cord-258787-n49zrfsp	283	4	UPS	UPS	NNP
cord-258787-n49zrfsp	283	5	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	283	6	infiltration	infiltration	NN
cord-258787-n49zrfsp	283	7	and	and	CC
cord-258787-n49zrfsp	283	8	a	a	DT
cord-258787-n49zrfsp	283	9	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	283	10	signature	signature	NN
cord-258787-n49zrfsp	283	11	were	be	VBD
cord-258787-n49zrfsp	283	12	associated	associate	VBN
cord-258787-n49zrfsp	283	13	with	with	IN
cord-258787-n49zrfsp	283	14	a	a	DT
cord-258787-n49zrfsp	283	15	type	type	NN
cord-258787-n49zrfsp	283	16	I	-PRON-	PRP
cord-258787-n49zrfsp	283	17	immune	immune	VBP
cord-258787-n49zrfsp	283	18	response	response	NN
cord-258787-n49zrfsp	283	19	and	and	CC
cord-258787-n49zrfsp	283	20	a	a	DT
cord-258787-n49zrfsp	283	21	better	well	JJR
cord-258787-n49zrfsp	283	22	prognosis	prognosis	NN
cord-258787-n49zrfsp	283	23	[	[	-LRB-
cord-258787-n49zrfsp	283	24	17	17	CD
cord-258787-n49zrfsp	283	25	]	]	-RRB-
cord-258787-n49zrfsp	283	26	.	.	.
cord-258787-n49zrfsp	284	1	Thus	thus	RB
cord-258787-n49zrfsp	284	2	,	,	,
cord-258787-n49zrfsp	284	3	currently	currently	RB
cord-258787-n49zrfsp	284	4	available	available	JJ
cord-258787-n49zrfsp	284	5	data	datum	NNS
cord-258787-n49zrfsp	284	6	on	on	IN
cord-258787-n49zrfsp	284	7	the	the	DT
cord-258787-n49zrfsp	284	8	occurrence	occurrence	NN
cord-258787-n49zrfsp	284	9	and	and	CC
cord-258787-n49zrfsp	284	10	significance	significance	NN
cord-258787-n49zrfsp	284	11	of	of	IN
cord-258787-n49zrfsp	284	12	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	284	13	in	in	IN
cord-258787-n49zrfsp	284	14	human	human	JJ
cord-258787-n49zrfsp	284	15	cancer	cancer	NN
cord-258787-n49zrfsp	284	16	suggest	suggest	VBP
cord-258787-n49zrfsp	284	17	that	that	IN
cord-258787-n49zrfsp	284	18	circulating	circulate	VBG
cord-258787-n49zrfsp	284	19	and	and	CC
cord-258787-n49zrfsp	284	20	tumour	tumour	NN
cord-258787-n49zrfsp	284	21	infiltrating	infiltrate	VBG
cord-258787-n49zrfsp	284	22	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	284	23	may	may	MD
cord-258787-n49zrfsp	284	24	have	have	VB
cord-258787-n49zrfsp	284	25	opposite	opposite	JJ
cord-258787-n49zrfsp	284	26	prognostic	prognostic	JJ
cord-258787-n49zrfsp	284	27	significance	significance	NN
cord-258787-n49zrfsp	284	28	in	in	IN
cord-258787-n49zrfsp	284	29	different	different	JJ
cord-258787-n49zrfsp	284	30	tumour	tumour	NN
cord-258787-n49zrfsp	284	31	contexts	context	NNS
cord-258787-n49zrfsp	284	32	.	.	.
cord-258787-n49zrfsp	285	1	High	high	JJ
cord-258787-n49zrfsp	285	2	levels	level	NNS
cord-258787-n49zrfsp	285	3	of	of	IN
cord-258787-n49zrfsp	285	4	circulating	circulate	VBG
cord-258787-n49zrfsp	285	5	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	285	6	,	,	,
cord-258787-n49zrfsp	285	7	NLR	NLR	NNP
cord-258787-n49zrfsp	285	8	or	or	CC
cord-258787-n49zrfsp	285	9	density	density	NN
cord-258787-n49zrfsp	285	10	of	of	IN
cord-258787-n49zrfsp	285	11	TANs	tan	NNS
cord-258787-n49zrfsp	285	12	have	have	VBP
cord-258787-n49zrfsp	285	13	been	be	VBN
cord-258787-n49zrfsp	285	14	associated	associate	VBN
cord-258787-n49zrfsp	285	15	with	with	IN
cord-258787-n49zrfsp	285	16	a	a	DT
cord-258787-n49zrfsp	285	17	poor	poor	JJ
cord-258787-n49zrfsp	285	18	response	response	NN
cord-258787-n49zrfsp	285	19	to	to	IN
cord-258787-n49zrfsp	285	20	different	different	JJ
cord-258787-n49zrfsp	285	21	treatments	treatment	NNS
cord-258787-n49zrfsp	285	22	,	,	,
cord-258787-n49zrfsp	285	23	including	include	VBG
cord-258787-n49zrfsp	285	24	chemotherapy	chemotherapy	NN
cord-258787-n49zrfsp	285	25	,	,	,
cord-258787-n49zrfsp	285	26	radiotherapy	radiotherapy	NN
cord-258787-n49zrfsp	285	27	and	and	CC
cord-258787-n49zrfsp	285	28	immunotherapy	immunotherapy	NN
cord-258787-n49zrfsp	285	29	,	,	,
cord-258787-n49zrfsp	285	30	in	in	IN
cord-258787-n49zrfsp	285	31	the	the	DT
cord-258787-n49zrfsp	285	32	majority	majority	NN
cord-258787-n49zrfsp	285	33	of	of	IN
cord-258787-n49zrfsp	285	34	solid	solid	JJ
cord-258787-n49zrfsp	285	35	tumours	tumour	NNS
cord-258787-n49zrfsp	285	36	[	[	-LRB-
cord-258787-n49zrfsp	285	37	184	184	CD
cord-258787-n49zrfsp	285	38	]	]	-RRB-
cord-258787-n49zrfsp	285	39	[	[	-LRB-
cord-258787-n49zrfsp	285	40	185	185	CD
cord-258787-n49zrfsp	285	41	]	]	-RRB-
cord-258787-n49zrfsp	285	42	[	[	-LRB-
cord-258787-n49zrfsp	285	43	186	186	CD
cord-258787-n49zrfsp	285	44	]	]	-RRB-
cord-258787-n49zrfsp	285	45	[	[	-LRB-
cord-258787-n49zrfsp	285	46	187	187	CD
cord-258787-n49zrfsp	285	47	]	]	-RRB-
cord-258787-n49zrfsp	285	48	[	[	-LRB-
cord-258787-n49zrfsp	285	49	188	188	CD
cord-258787-n49zrfsp	285	50	]	]	-RRB-
cord-258787-n49zrfsp	285	51	[	[	-LRB-
cord-258787-n49zrfsp	285	52	189	189	CD
cord-258787-n49zrfsp	285	53	]	]	-RRB-
cord-258787-n49zrfsp	285	54	[	[	-LRB-
cord-258787-n49zrfsp	285	55	190	190	CD
cord-258787-n49zrfsp	285	56	]	]	-RRB-
cord-258787-n49zrfsp	285	57	.	.	.
cord-258787-n49zrfsp	286	1	Some	some	DT
cord-258787-n49zrfsp	286	2	exception	exception	NN
cord-258787-n49zrfsp	286	3	are	be	VBP
cord-258787-n49zrfsp	286	4	CRC	CRC	NNP
cord-258787-n49zrfsp	286	5	,	,	,
cord-258787-n49zrfsp	286	6	gastric	gastric	JJ
cord-258787-n49zrfsp	286	7	cancer	cancer	NN
cord-258787-n49zrfsp	286	8	and	and	CC
cord-258787-n49zrfsp	286	9	ovarian	ovarian	JJ
cord-258787-n49zrfsp	286	10	cancer	cancer	NN
cord-258787-n49zrfsp	286	11	where	where	WRB
cord-258787-n49zrfsp	286	12	higher	high	JJR
cord-258787-n49zrfsp	286	13	levels	level	NNS
cord-258787-n49zrfsp	286	14	of	of	IN
cord-258787-n49zrfsp	286	15	TANs	tan	NNS
cord-258787-n49zrfsp	286	16	have	have	VBP
cord-258787-n49zrfsp	286	17	been	be	VBN
cord-258787-n49zrfsp	286	18	associated	associate	VBN
cord-258787-n49zrfsp	286	19	with	with	IN
cord-258787-n49zrfsp	286	20	a	a	DT
cord-258787-n49zrfsp	286	21	good	good	JJ
cord-258787-n49zrfsp	286	22	response	response	NN
cord-258787-n49zrfsp	286	23	to	to	IN
cord-258787-n49zrfsp	286	24	therapy	therapy	NN
cord-258787-n49zrfsp	286	25	[	[	-LRB-
cord-258787-n49zrfsp	286	26	179	179	CD
cord-258787-n49zrfsp	286	27	,	,	,
cord-258787-n49zrfsp	286	28	183	183	CD
cord-258787-n49zrfsp	286	29	,	,	,
cord-258787-n49zrfsp	286	30	[	[	-LRB-
cord-258787-n49zrfsp	286	31	191	191	CD
cord-258787-n49zrfsp	286	32	]	]	-RRB-
cord-258787-n49zrfsp	286	33	[	[	-LRB-
cord-258787-n49zrfsp	286	34	192	192	CD
cord-258787-n49zrfsp	286	35	]	]	-RRB-
cord-258787-n49zrfsp	286	36	[	[	-LRB-
cord-258787-n49zrfsp	286	37	193	193	CD
cord-258787-n49zrfsp	286	38	]	]	-RRB-
cord-258787-n49zrfsp	286	39	[	[	-LRB-
cord-258787-n49zrfsp	286	40	194	194	CD
cord-258787-n49zrfsp	286	41	]	]	-RRB-
cord-258787-n49zrfsp	286	42	[	[	-LRB-
cord-258787-n49zrfsp	286	43	195	195	CD
cord-258787-n49zrfsp	286	44	]	]	-RRB-
cord-258787-n49zrfsp	286	45	[	[	-LRB-
cord-258787-n49zrfsp	286	46	196	196	CD
cord-258787-n49zrfsp	286	47	]	]	-RRB-
cord-258787-n49zrfsp	286	48	.	.	.
cord-258787-n49zrfsp	287	1	For	for	IN
cord-258787-n49zrfsp	287	2	instance	instance	NN
cord-258787-n49zrfsp	287	3	,	,	,
cord-258787-n49zrfsp	287	4	high	high	JJ
cord-258787-n49zrfsp	287	5	levels	level	NNS
cord-258787-n49zrfsp	287	6	of	of	IN
cord-258787-n49zrfsp	287	7	CD66b	CD66b	NNS
cord-258787-n49zrfsp	287	8	+	+	CC
cord-258787-n49zrfsp	287	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	287	10	infiltration	infiltration	NN
cord-258787-n49zrfsp	287	11	in	in	IN
cord-258787-n49zrfsp	287	12	stage	stage	NN
cord-258787-n49zrfsp	287	13	(	(	-LRB-
cord-258787-n49zrfsp	287	14	I	I	NNP
cord-258787-n49zrfsp	287	15	-	-	HYPH
cord-258787-n49zrfsp	287	16	IV	IV	NNP
cord-258787-n49zrfsp	287	17	)	)	-RRB-
cord-258787-n49zrfsp	288	1	CRC	CRC	NNP
cord-258787-n49zrfsp	288	2	patients	patient	NNS
cord-258787-n49zrfsp	288	3	were	be	VBD
cord-258787-n49zrfsp	288	4	found	find	VBN
cord-258787-n49zrfsp	288	5	to	to	TO
cord-258787-n49zrfsp	288	6	correlate	correlate	VB
cord-258787-n49zrfsp	288	7	with	with	IN
cord-258787-n49zrfsp	288	8	a	a	DT
cord-258787-n49zrfsp	288	9	better	well	JJR
cord-258787-n49zrfsp	288	10	clinical	clinical	JJ
cord-258787-n49zrfsp	288	11	outcome	outcome	NN
cord-258787-n49zrfsp	288	12	[	[	-LRB-
cord-258787-n49zrfsp	288	13	179	179	CD
cord-258787-n49zrfsp	288	14	,	,	,
cord-258787-n49zrfsp	288	15	183	183	CD
cord-258787-n49zrfsp	288	16	]	]	-RRB-
cord-258787-n49zrfsp	288	17	and	and	CC
cord-258787-n49zrfsp	288	18	in	in	IN
cord-258787-n49zrfsp	288	19	a	a	DT
cord-258787-n49zrfsp	288	20	cohort	cohort	NN
cord-258787-n49zrfsp	288	21	of	of	IN
cord-258787-n49zrfsp	288	22	stage	stage	NN
cord-258787-n49zrfsp	288	23	III	iii	CD
cord-258787-n49zrfsp	288	24	CRC	CRC	NNP
cord-258787-n49zrfsp	288	25	patients	patient	NNS
cord-258787-n49zrfsp	288	26	and	and	CC
cord-258787-n49zrfsp	288	27	gastric	gastric	JJ
cord-258787-n49zrfsp	288	28	cancer	cancer	NN
cord-258787-n49zrfsp	288	29	patients	patient	NNS
cord-258787-n49zrfsp	288	30	treated	treat	VBN
cord-258787-n49zrfsp	288	31	or	or	CC
cord-258787-n49zrfsp	288	32	not	not	RB
cord-258787-n49zrfsp	288	33	with	with	IN
cord-258787-n49zrfsp	288	34	5-FU	5-fu	CD
cord-258787-n49zrfsp	288	35	-	-	HYPH
cord-258787-n49zrfsp	288	36	based	base	VBN
cord-258787-n49zrfsp	288	37	chemotherapy	chemotherapy	NN
cord-258787-n49zrfsp	288	38	,	,	,
cord-258787-n49zrfsp	288	39	high	high	JJ
cord-258787-n49zrfsp	288	40	levels	level	NNS
cord-258787-n49zrfsp	288	41	of	of	IN
cord-258787-n49zrfsp	288	42	TANs	tan	NNS
cord-258787-n49zrfsp	288	43	infiltration	infiltration	NN
cord-258787-n49zrfsp	288	44	have	have	VBP
cord-258787-n49zrfsp	288	45	been	be	VBN
cord-258787-n49zrfsp	288	46	associated	associate	VBN
cord-258787-n49zrfsp	288	47	with	with	IN
cord-258787-n49zrfsp	288	48	a	a	DT
cord-258787-n49zrfsp	288	49	better	well	JJR
cord-258787-n49zrfsp	288	50	response	response	NN
cord-258787-n49zrfsp	288	51	to	to	IN
cord-258787-n49zrfsp	288	52	therapy	therapy	NN
cord-258787-n49zrfsp	288	53	[	[	-LRB-
cord-258787-n49zrfsp	288	54	179	179	CD
cord-258787-n49zrfsp	288	55	,	,	,
cord-258787-n49zrfsp	288	56	195	195	CD
cord-258787-n49zrfsp	288	57	]	]	-RRB-
cord-258787-n49zrfsp	288	58	.	.	.
cord-258787-n49zrfsp	289	1	Interestingly	interestingly	RB
cord-258787-n49zrfsp	289	2	,	,	,
cord-258787-n49zrfsp	289	3	similar	similar	JJ
cord-258787-n49zrfsp	289	4	findings	finding	NNS
cord-258787-n49zrfsp	289	5	have	have	VBP
cord-258787-n49zrfsp	289	6	been	be	VBN
cord-258787-n49zrfsp	289	7	observed	observe	VBN
cord-258787-n49zrfsp	289	8	in	in	IN
cord-258787-n49zrfsp	289	9	patients	patient	NNS
cord-258787-n49zrfsp	289	10	with	with	IN
cord-258787-n49zrfsp	289	11	ovarian	ovarian	JJ
cord-258787-n49zrfsp	289	12	cancer	cancer	NN
cord-258787-n49zrfsp	289	13	treated	treat	VBN
cord-258787-n49zrfsp	289	14	with	with	IN
cord-258787-n49zrfsp	289	15	a	a	DT
cord-258787-n49zrfsp	289	16	platinum	platinum	NN
cord-258787-n49zrfsp	289	17	-	-	HYPH
cord-258787-n49zrfsp	289	18	based	base	VBN
cord-258787-n49zrfsp	289	19	chemotherapy	chemotherapy	NN
cord-258787-n49zrfsp	289	20	[	[	-LRB-
cord-258787-n49zrfsp	289	21	193	193	CD
cord-258787-n49zrfsp	289	22	]	]	-RRB-
cord-258787-n49zrfsp	289	23	.	.	.
cord-258787-n49zrfsp	290	1	Therefore	therefore	RB
cord-258787-n49zrfsp	290	2	,	,	,
cord-258787-n49zrfsp	290	3	further	further	JJ
cord-258787-n49zrfsp	290	4	investigations	investigation	NNS
cord-258787-n49zrfsp	290	5	are	be	VBP
cord-258787-n49zrfsp	290	6	needed	need	VBN
cord-258787-n49zrfsp	290	7	to	to	TO
cord-258787-n49zrfsp	290	8	define	define	VB
cord-258787-n49zrfsp	290	9	the	the	DT
cord-258787-n49zrfsp	290	10	molecular	molecular	JJ
cord-258787-n49zrfsp	290	11	and	and	CC
cord-258787-n49zrfsp	290	12	cellular	cellular	JJ
cord-258787-n49zrfsp	290	13	mechanisms	mechanism	NNS
cord-258787-n49zrfsp	290	14	by	by	IN
cord-258787-n49zrfsp	290	15	which	which	WDT
cord-258787-n49zrfsp	290	16	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	290	17	can	can	MD
cord-258787-n49zrfsp	290	18	improve	improve	VB
cord-258787-n49zrfsp	290	19	the	the	DT
cord-258787-n49zrfsp	290	20	efficacy	efficacy	NN
cord-258787-n49zrfsp	290	21	of	of	IN
cord-258787-n49zrfsp	290	22	chemotherapy	chemotherapy	NN
cord-258787-n49zrfsp	290	23	in	in	IN
cord-258787-n49zrfsp	290	24	specific	specific	JJ
cord-258787-n49zrfsp	290	25	cancer	cancer	NN
cord-258787-n49zrfsp	290	26	subtypes	subtype	NNS
cord-258787-n49zrfsp	290	27	.	.	.
cord-258787-n49zrfsp	291	1	The	the	DT
cord-258787-n49zrfsp	291	2	role	role	NN
cord-258787-n49zrfsp	291	3	of	of	IN
cord-258787-n49zrfsp	291	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	291	5	has	have	VBZ
cord-258787-n49zrfsp	291	6	long	long	RB
cord-258787-n49zrfsp	291	7	been	be	VBN
cord-258787-n49zrfsp	291	8	considered	consider	VBN
cord-258787-n49zrfsp	291	9	restricted	restricted	JJ
cord-258787-n49zrfsp	291	10	to	to	IN
cord-258787-n49zrfsp	291	11	the	the	DT
cord-258787-n49zrfsp	291	12	elimination	elimination	NN
cord-258787-n49zrfsp	291	13	of	of	IN
cord-258787-n49zrfsp	291	14	invading	invade	VBG
cord-258787-n49zrfsp	291	15	pathogens	pathogen	NNS
cord-258787-n49zrfsp	291	16	and	and	CC
cord-258787-n49zrfsp	291	17	to	to	IN
cord-258787-n49zrfsp	291	18	the	the	DT
cord-258787-n49zrfsp	291	19	acute	acute	JJ
cord-258787-n49zrfsp	291	20	phase	phase	NN
cord-258787-n49zrfsp	291	21	of	of	IN
cord-258787-n49zrfsp	291	22	inflammation	inflammation	NN
cord-258787-n49zrfsp	291	23	.	.	.
cord-258787-n49zrfsp	292	1	However	however	RB
cord-258787-n49zrfsp	292	2	,	,	,
cord-258787-n49zrfsp	292	3	a	a	DT
cord-258787-n49zrfsp	292	4	large	large	JJ
cord-258787-n49zrfsp	292	5	number	number	NN
cord-258787-n49zrfsp	292	6	of	of	IN
cord-258787-n49zrfsp	292	7	studies	study	NNS
cord-258787-n49zrfsp	292	8	have	have	VBP
cord-258787-n49zrfsp	292	9	challenged	challenge	VBN
cord-258787-n49zrfsp	292	10	this	this	DT
cord-258787-n49zrfsp	292	11	view	view	NN
cord-258787-n49zrfsp	292	12	and	and	CC
cord-258787-n49zrfsp	292	13	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	292	14	are	be	VBP
cord-258787-n49zrfsp	292	15	now	now	RB
cord-258787-n49zrfsp	292	16	recognized	recognize	VBN
cord-258787-n49zrfsp	292	17	for	for	IN
cord-258787-n49zrfsp	292	18	their	-PRON-	PRP$
cord-258787-n49zrfsp	292	19	role	role	NN
cord-258787-n49zrfsp	292	20	in	in	IN
cord-258787-n49zrfsp	292	21	the	the	DT
cord-258787-n49zrfsp	292	22	activation	activation	NN
cord-258787-n49zrfsp	292	23	and	and	CC
cord-258787-n49zrfsp	292	24	orientation	orientation	NN
cord-258787-n49zrfsp	292	25	of	of	IN
cord-258787-n49zrfsp	292	26	both	both	CC
cord-258787-n49zrfsp	292	27	the	the	DT
cord-258787-n49zrfsp	292	28	innate	innate	JJ
cord-258787-n49zrfsp	292	29	and	and	CC
cord-258787-n49zrfsp	292	30	adaptive	adaptive	JJ
cord-258787-n49zrfsp	292	31	immune	immune	JJ
cord-258787-n49zrfsp	292	32	responses	response	NNS
cord-258787-n49zrfsp	292	33	.	.	.
cord-258787-n49zrfsp	293	1	Moreover	moreover	RB
cord-258787-n49zrfsp	293	2	,	,	,
cord-258787-n49zrfsp	293	3	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	293	4	are	be	VBP
cord-258787-n49zrfsp	293	5	endowed	endow	VBN
cord-258787-n49zrfsp	293	6	with	with	IN
cord-258787-n49zrfsp	293	7	a	a	DT
cord-258787-n49zrfsp	293	8	previously	previously	RB
cord-258787-n49zrfsp	293	9	underestimated	underestimate	VBN
cord-258787-n49zrfsp	293	10	plasticity	plasticity	NN
cord-258787-n49zrfsp	293	11	and	and	CC
cord-258787-n49zrfsp	293	12	can	can	MD
cord-258787-n49zrfsp	293	13	engage	engage	VB
cord-258787-n49zrfsp	293	14	complex	complex	JJ
cord-258787-n49zrfsp	293	15	cross	cross	NN
cord-258787-n49zrfsp	293	16	-	-	NNS
cord-258787-n49zrfsp	293	17	talks	talk	NNS
cord-258787-n49zrfsp	293	18	with	with	IN
cord-258787-n49zrfsp	293	19	immune	immune	JJ
cord-258787-n49zrfsp	293	20	and	and	CC
cord-258787-n49zrfsp	293	21	nonimmune	nonimmune	JJ
cord-258787-n49zrfsp	293	22	cells	cell	NNS
cord-258787-n49zrfsp	293	23	,	,	,
cord-258787-n49zrfsp	293	24	depending	depend	VBG
cord-258787-n49zrfsp	293	25	on	on	IN
cord-258787-n49zrfsp	293	26	the	the	DT
cord-258787-n49zrfsp	293	27	tissue	tissue	NN
cord-258787-n49zrfsp	293	28	and	and	CC
cord-258787-n49zrfsp	293	29	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	293	30	contexts	context	NNS
cord-258787-n49zrfsp	293	31	.	.	.
cord-258787-n49zrfsp	294	1	Accordingly	accordingly	RB
cord-258787-n49zrfsp	294	2	,	,	,
cord-258787-n49zrfsp	294	3	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	294	4	can	can	MD
cord-258787-n49zrfsp	294	5	participate	participate	VB
cord-258787-n49zrfsp	294	6	in	in	IN
cord-258787-n49zrfsp	294	7	the	the	DT
cord-258787-n49zrfsp	294	8	pathogenesis	pathogenesis	NN
cord-258787-n49zrfsp	294	9	of	of	IN
cord-258787-n49zrfsp	294	10	different	different	JJ
cord-258787-n49zrfsp	294	11	disorders	disorder	NNS
cord-258787-n49zrfsp	294	12	such	such	JJ
cord-258787-n49zrfsp	294	13	as	as	IN
cord-258787-n49zrfsp	294	14	infections	infection	NNS
cord-258787-n49zrfsp	294	15	,	,	,
cord-258787-n49zrfsp	294	16	chronic	chronic	JJ
cord-258787-n49zrfsp	294	17	inflammation	inflammation	NN
cord-258787-n49zrfsp	294	18	,	,	,
cord-258787-n49zrfsp	294	19	autoimmunity	autoimmunity	NN
cord-258787-n49zrfsp	294	20	and	and	CC
cord-258787-n49zrfsp	294	21	cancer	cancer	NN
cord-258787-n49zrfsp	294	22	.	.	.
cord-258787-n49zrfsp	295	1	The	the	DT
cord-258787-n49zrfsp	295	2	role	role	NN
cord-258787-n49zrfsp	295	3	of	of	IN
cord-258787-n49zrfsp	295	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	295	5	in	in	IN
cord-258787-n49zrfsp	295	6	cancer	cancer	NN
cord-258787-n49zrfsp	295	7	has	have	VBZ
cord-258787-n49zrfsp	295	8	long	long	RB
cord-258787-n49zrfsp	295	9	been	be	VBN
cord-258787-n49zrfsp	295	10	considered	consider	VBN
cord-258787-n49zrfsp	295	11	insignificant	insignificant	JJ
cord-258787-n49zrfsp	295	12	and	and	CC
cord-258787-n49zrfsp	295	13	was	be	VBD
cord-258787-n49zrfsp	295	14	neglected	neglect	VBN
cord-258787-n49zrfsp	295	15	.	.	.
cord-258787-n49zrfsp	296	1	However	however	RB
cord-258787-n49zrfsp	296	2	,	,	,
cord-258787-n49zrfsp	296	3	neutrophilia	neutrophilia	NNP
cord-258787-n49zrfsp	296	4	is	be	VBZ
cord-258787-n49zrfsp	296	5	observed	observe	VBN
cord-258787-n49zrfsp	296	6	in	in	IN
cord-258787-n49zrfsp	296	7	cancer	cancer	NN
cord-258787-n49zrfsp	296	8	and	and	CC
cord-258787-n49zrfsp	296	9	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	296	10	represent	represent	VBP
cord-258787-n49zrfsp	296	11	an	an	DT
cord-258787-n49zrfsp	296	12	important	important	JJ
cord-258787-n49zrfsp	296	13	component	component	NN
cord-258787-n49zrfsp	296	14	of	of	IN
cord-258787-n49zrfsp	296	15	the	the	DT
cord-258787-n49zrfsp	296	16	TME	TME	NNP
cord-258787-n49zrfsp	296	17	.	.	.
cord-258787-n49zrfsp	297	1	Therefore	therefore	RB
cord-258787-n49zrfsp	297	2	,	,	,
cord-258787-n49zrfsp	297	3	the	the	DT
cord-258787-n49zrfsp	297	4	clinical	clinical	JJ
cord-258787-n49zrfsp	297	5	significance	significance	NN
cord-258787-n49zrfsp	297	6	of	of	IN
cord-258787-n49zrfsp	297	7	circulating	circulate	VBG
cord-258787-n49zrfsp	297	8	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	297	9	,	,	,
cord-258787-n49zrfsp	297	10	NLR	NLR	NNP
cord-258787-n49zrfsp	297	11	and	and	CC
cord-258787-n49zrfsp	297	12	TANs	tan	NNS
cord-258787-n49zrfsp	297	13	has	have	VBZ
cord-258787-n49zrfsp	297	14	been	be	VBN
cord-258787-n49zrfsp	297	15	proposed	propose	VBN
cord-258787-n49zrfsp	297	16	in	in	IN
cord-258787-n49zrfsp	297	17	human	human	JJ
cord-258787-n49zrfsp	297	18	cancer	cancer	NN
cord-258787-n49zrfsp	297	19	and	and	CC
cord-258787-n49zrfsp	297	20	mostly	mostly	RB
cord-258787-n49zrfsp	297	21	associated	associate	VBN
cord-258787-n49zrfsp	297	22	with	with	IN
cord-258787-n49zrfsp	297	23	a	a	DT
cord-258787-n49zrfsp	297	24	poor	poor	JJ
cord-258787-n49zrfsp	297	25	prognosis	prognosis	NN
cord-258787-n49zrfsp	297	26	.	.	.
cord-258787-n49zrfsp	298	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	298	2	play	play	VBP
cord-258787-n49zrfsp	298	3	a	a	DT
cord-258787-n49zrfsp	298	4	dual	dual	JJ
cord-258787-n49zrfsp	298	5	role	role	NN
cord-258787-n49zrfsp	298	6	in	in	IN
cord-258787-n49zrfsp	298	7	cancer	cancer	NN
cord-258787-n49zrfsp	298	8	and	and	CC
cord-258787-n49zrfsp	298	9	can	can	MD
cord-258787-n49zrfsp	298	10	support	support	VB
cord-258787-n49zrfsp	298	11	both	both	DT
cord-258787-n49zrfsp	298	12	protumour	protumour	NN
cord-258787-n49zrfsp	298	13	and	and	CC
cord-258787-n49zrfsp	298	14	anti	anti	JJ
cord-258787-n49zrfsp	298	15	-	-	JJ
cord-258787-n49zrfsp	298	16	tumour	tumour	JJ
cord-258787-n49zrfsp	298	17	mechanisms	mechanism	NNS
cord-258787-n49zrfsp	298	18	.	.	.
cord-258787-n49zrfsp	299	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	299	2	can	can	MD
cord-258787-n49zrfsp	299	3	sustain	sustain	VB
cord-258787-n49zrfsp	299	4	genetic	genetic	JJ
cord-258787-n49zrfsp	299	5	instability	instability	NN
cord-258787-n49zrfsp	299	6	,	,	,
cord-258787-n49zrfsp	299	7	tumour	tumour	NN
cord-258787-n49zrfsp	299	8	cell	cell	NN
cord-258787-n49zrfsp	299	9	proliferation	proliferation	NN
cord-258787-n49zrfsp	299	10	and	and	CC
cord-258787-n49zrfsp	299	11	metastasis	metastasis	NN
cord-258787-n49zrfsp	299	12	and	and	CC
cord-258787-n49zrfsp	299	13	can	can	MD
cord-258787-n49zrfsp	299	14	suppress	suppress	VB
cord-258787-n49zrfsp	299	15	the	the	DT
cord-258787-n49zrfsp	299	16	immune	immune	JJ
cord-258787-n49zrfsp	299	17	response	response	NN
cord-258787-n49zrfsp	299	18	.	.	.
cord-258787-n49zrfsp	300	1	In	in	IN
cord-258787-n49zrfsp	300	2	contrast	contrast	NN
cord-258787-n49zrfsp	300	3	,	,	,
cord-258787-n49zrfsp	300	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	300	5	can	can	MD
cord-258787-n49zrfsp	300	6	kill	kill	VB
cord-258787-n49zrfsp	300	7	tumour	tumour	NN
cord-258787-n49zrfsp	300	8	cells	cell	NNS
cord-258787-n49zrfsp	300	9	and	and	CC
cord-258787-n49zrfsp	300	10	can	can	MD
cord-258787-n49zrfsp	300	11	be	be	VB
cord-258787-n49zrfsp	300	12	part	part	NN
cord-258787-n49zrfsp	300	13	of	of	IN
cord-258787-n49zrfsp	300	14	the	the	DT
cord-258787-n49zrfsp	300	15	anti	anti	JJ
cord-258787-n49zrfsp	300	16	-	-	JJ
cord-258787-n49zrfsp	300	17	tumour	tumour	JJ
cord-258787-n49zrfsp	300	18	immune	immune	JJ
cord-258787-n49zrfsp	300	19	response	response	NN
cord-258787-n49zrfsp	300	20	.	.	.
cord-258787-n49zrfsp	301	1	This	this	DT
cord-258787-n49zrfsp	301	2	dual	dual	JJ
cord-258787-n49zrfsp	301	3	role	role	NN
cord-258787-n49zrfsp	301	4	is	be	VBZ
cord-258787-n49zrfsp	301	5	probably	probably	RB
cord-258787-n49zrfsp	301	6	related	related	JJ
cord-258787-n49zrfsp	301	7	to	to	IN
cord-258787-n49zrfsp	301	8	the	the	DT
cord-258787-n49zrfsp	301	9	diversity	diversity	NN
cord-258787-n49zrfsp	301	10	and	and	CC
cord-258787-n49zrfsp	301	11	plasticity	plasticity	NN
cord-258787-n49zrfsp	301	12	of	of	IN
cord-258787-n49zrfsp	301	13	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	301	14	in	in	IN
cord-258787-n49zrfsp	301	15	different	different	JJ
cord-258787-n49zrfsp	301	16	tumour	tumour	NN
cord-258787-n49zrfsp	301	17	contexts	context	NNS
cord-258787-n49zrfsp	301	18	,	,	,
cord-258787-n49zrfsp	301	19	leading	lead	VBG
cord-258787-n49zrfsp	301	20	to	to	IN
cord-258787-n49zrfsp	301	21	the	the	DT
cord-258787-n49zrfsp	301	22	formation	formation	NN
cord-258787-n49zrfsp	301	23	of	of	IN
cord-258787-n49zrfsp	301	24	different	different	JJ
cord-258787-n49zrfsp	301	25	subtypes	subtype	NNS
cord-258787-n49zrfsp	301	26	of	of	IN
cord-258787-n49zrfsp	301	27	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	301	28	with	with	IN
cord-258787-n49zrfsp	301	29	opposite	opposite	JJ
cord-258787-n49zrfsp	301	30	functions	function	NNS
cord-258787-n49zrfsp	301	31	.	.	.
cord-258787-n49zrfsp	302	1	Therefore	therefore	RB
cord-258787-n49zrfsp	302	2	,	,	,
cord-258787-n49zrfsp	302	3	a	a	DT
cord-258787-n49zrfsp	302	4	better	well	JJR
cord-258787-n49zrfsp	302	5	dissection	dissection	NN
cord-258787-n49zrfsp	302	6	of	of	IN
cord-258787-n49zrfsp	302	7	TANs	tan	NNS
cord-258787-n49zrfsp	302	8	diversity	diversity	NN
cord-258787-n49zrfsp	302	9	in	in	IN
cord-258787-n49zrfsp	302	10	different	different	JJ
cord-258787-n49zrfsp	302	11	cancer	cancer	NN
cord-258787-n49zrfsp	302	12	subtypes	subtype	NNS
cord-258787-n49zrfsp	302	13	is	be	VBZ
cord-258787-n49zrfsp	302	14	required	require	VBN
cord-258787-n49zrfsp	302	15	to	to	TO
cord-258787-n49zrfsp	302	16	define	define	VB
cord-258787-n49zrfsp	302	17	a	a	DT
cord-258787-n49zrfsp	302	18	comprehensive	comprehensive	JJ
cord-258787-n49zrfsp	302	19	nomenclature	nomenclature	NN
cord-258787-n49zrfsp	302	20	of	of	IN
cord-258787-n49zrfsp	302	21	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	302	22	in	in	IN
cord-258787-n49zrfsp	302	23	cancer	cancer	NN
cord-258787-n49zrfsp	302	24	and	and	CC
cord-258787-n49zrfsp	302	25	to	to	TO
cord-258787-n49zrfsp	302	26	identify	identify	VB
cord-258787-n49zrfsp	302	27	the	the	DT
cord-258787-n49zrfsp	302	28	pathways	pathway	NNS
cord-258787-n49zrfsp	302	29	that	that	WDT
cord-258787-n49zrfsp	302	30	shape	shape	VBP
cord-258787-n49zrfsp	302	31	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	302	32	in	in	IN
cord-258787-n49zrfsp	302	33	an	an	DT
cord-258787-n49zrfsp	302	34	anti	anti	JJ
cord-258787-n49zrfsp	302	35	-	-	JJ
cord-258787-n49zrfsp	302	36	tumour	tumour	JJ
cord-258787-n49zrfsp	302	37	activation	activation	NN
cord-258787-n49zrfsp	302	38	state	state	NN
cord-258787-n49zrfsp	302	39	.	.	.
cord-258787-n49zrfsp	303	1	We	-PRON-	PRP
cord-258787-n49zrfsp	303	2	assume	assume	VBP
cord-258787-n49zrfsp	303	3	that	that	IN
cord-258787-n49zrfsp	303	4	further	further	JJ
cord-258787-n49zrfsp	303	5	therapeutic	therapeutic	JJ
cord-258787-n49zrfsp	303	6	approaches	approach	NNS
cord-258787-n49zrfsp	303	7	targeting	target	VBG
cord-258787-n49zrfsp	303	8	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	303	9	in	in	IN
cord-258787-n49zrfsp	303	10	cancer	cancer	NN
cord-258787-n49zrfsp	303	11	represent	represent	VBP
cord-258787-n49zrfsp	303	12	a	a	DT
cord-258787-n49zrfsp	303	13	new	new	JJ
cord-258787-n49zrfsp	303	14	frontier	frontier	NN
cord-258787-n49zrfsp	303	15	in	in	IN
cord-258787-n49zrfsp	303	16	cancer	cancer	NN
cord-258787-n49zrfsp	303	17	immunotherapy	immunotherapy	NN
cord-258787-n49zrfsp	303	18	.	.	.
cord-258787-n49zrfsp	304	1	Ministero	Ministero	NNP
cord-258787-n49zrfsp	304	2	dell'Istruzione	dell'Istruzione	NNP
cord-258787-n49zrfsp	304	3	,	,	,
cord-258787-n49zrfsp	304	4	dell'Università	dell'Università	NNP
cord-258787-n49zrfsp	304	5	e	e	NN
cord-258787-n49zrfsp	304	6	della	della	NNP
cord-258787-n49zrfsp	304	7	Ricerca	Ricerca	NNP
cord-258787-n49zrfsp	304	8	(	(	-LRB-
cord-258787-n49zrfsp	304	9	MIUR	MIUR	NNP
cord-258787-n49zrfsp	304	10	)	)	-RRB-
cord-258787-n49zrfsp	305	1	(	(	-LRB-
cord-258787-n49zrfsp	305	2	PRIN	PRIN	NNP
cord-258787-n49zrfsp	305	3	2017K7FSYBto	2017k7fsybto	CD
cord-258787-n49zrfsp	305	4	SJ	SJ	NNP
cord-258787-n49zrfsp	305	5	,	,	,
cord-258787-n49zrfsp	305	6	Ministero	Ministero	NNP
cord-258787-n49zrfsp	305	7	della	della	NNP
cord-258787-n49zrfsp	305	8	Salute	Salute	NNP
cord-258787-n49zrfsp	305	9	(	(	-LRB-
cord-258787-n49zrfsp	305	10	GR-2016	gr-2016	RB
cord-258787-n49zrfsp	305	11	-	-	HYPH
cord-258787-n49zrfsp	305	12	02361263to	02361263to	JJ
cord-258787-n49zrfsp	305	13	SJ	SJ	NNP
cord-258787-n49zrfsp	305	14	)	)	-RRB-
cord-258787-n49zrfsp	305	15	and	and	CC
cord-258787-n49zrfsp	305	16	Fondazione	Fondazione	NNP
cord-258787-n49zrfsp	305	17	AIRC	AIRC	NNP
cord-258787-n49zrfsp	305	18	per	per	IN
cord-258787-n49zrfsp	305	19	la	la	FW
cord-258787-n49zrfsp	305	20	ricerca	ricerca	FW
cord-258787-n49zrfsp	305	21	sul	sul	FW
cord-258787-n49zrfsp	305	22	cancro	cancro	NNP
cord-258787-n49zrfsp	305	23	(	(	-LRB-
cord-258787-n49zrfsp	305	24	AIRC	AIRC	NNP
cord-258787-n49zrfsp	305	25	IG-22815	IG-22815	NNP
cord-258787-n49zrfsp	305	26	to	to	IN
cord-258787-n49zrfsp	305	27	SJ	SJ	NNP
cord-258787-n49zrfsp	305	28	)	)	-RRB-
cord-258787-n49zrfsp	305	29	are	be	VBP
cord-258787-n49zrfsp	305	30	gratefully	gratefully	RB
cord-258787-n49zrfsp	305	31	acknowledged	acknowledge	VBN
cord-258787-n49zrfsp	305	32	.	.	.
cord-258787-n49zrfsp	306	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	306	2	recruitment	recruitment	NN
cord-258787-n49zrfsp	306	3	and	and	CC
cord-258787-n49zrfsp	306	4	function	function	NN
cord-258787-n49zrfsp	306	5	in	in	IN
cord-258787-n49zrfsp	306	6	health	health	NN
cord-258787-n49zrfsp	306	7	and	and	CC
cord-258787-n49zrfsp	306	8	inflammation	inflammation	NN
cord-258787-n49zrfsp	306	9	Neutrophils	Neutrophils	NNP
cord-258787-n49zrfsp	306	10	in	in	IN
cord-258787-n49zrfsp	306	11	the	the	DT
cord-258787-n49zrfsp	306	12	activation	activation	NN
cord-258787-n49zrfsp	306	13	and	and	CC
cord-258787-n49zrfsp	306	14	regulation	regulation	NN
cord-258787-n49zrfsp	306	15	of	of	IN
cord-258787-n49zrfsp	307	1	innate	innate	JJ
cord-258787-n49zrfsp	307	2	and	and	CC
cord-258787-n49zrfsp	307	3	adaptive	adaptive	JJ
cord-258787-n49zrfsp	307	4	immunity	immunity	NN
cord-258787-n49zrfsp	307	5	Neutrophils	Neutrophils	NNPS
cord-258787-n49zrfsp	307	6	instruct	instruct	VBP
cord-258787-n49zrfsp	307	7	homeostatic	homeostatic	JJ
cord-258787-n49zrfsp	307	8	and	and	CC
cord-258787-n49zrfsp	307	9	pathological	pathological	JJ
cord-258787-n49zrfsp	307	10	states	state	NNS
cord-258787-n49zrfsp	307	11	in	in	IN
cord-258787-n49zrfsp	307	12	naive	naive	JJ
cord-258787-n49zrfsp	307	13	tissues	tissue	NNS
cord-258787-n49zrfsp	307	14	Social	social	JJ
cord-258787-n49zrfsp	307	15	networking	networking	NN
cord-258787-n49zrfsp	307	16	of	of	IN
cord-258787-n49zrfsp	307	17	human	human	JJ
cord-258787-n49zrfsp	307	18	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	307	19	within	within	IN
cord-258787-n49zrfsp	307	20	the	the	DT
cord-258787-n49zrfsp	307	21	immune	immune	JJ
cord-258787-n49zrfsp	307	22	system	system	NN
cord-258787-n49zrfsp	307	23	Heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	307	24	among	among	IN
cord-258787-n49zrfsp	307	25	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	307	26	Current	current	JJ
cord-258787-n49zrfsp	307	27	understanding	understanding	NN
cord-258787-n49zrfsp	307	28	in	in	IN
cord-258787-n49zrfsp	307	29	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	307	30	differentiation	differentiation	NN
cord-258787-n49zrfsp	307	31	and	and	CC
cord-258787-n49zrfsp	307	32	heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	307	33	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	307	34	heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	307	35	in	in	IN
cord-258787-n49zrfsp	307	36	Cancer	cancer	NN
cord-258787-n49zrfsp	307	37	:	:	:
cord-258787-n49zrfsp	307	38	from	from	IN
cord-258787-n49zrfsp	307	39	biology	biology	NN
cord-258787-n49zrfsp	307	40	to	to	IN
cord-258787-n49zrfsp	307	41	therapies	therapy	NNS
cord-258787-n49zrfsp	307	42	Phenotypic	phenotypic	JJ
cord-258787-n49zrfsp	307	43	diversity	diversity	NN
cord-258787-n49zrfsp	307	44	and	and	CC
cord-258787-n49zrfsp	307	45	plasticity	plasticity	NN
cord-258787-n49zrfsp	307	46	in	in	IN
cord-258787-n49zrfsp	307	47	circulating	circulate	VBG
cord-258787-n49zrfsp	307	48	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	307	49	subpopulations	subpopulation	NNS
cord-258787-n49zrfsp	307	50	in	in	IN
cord-258787-n49zrfsp	307	51	cancer	cancer	NN
cord-258787-n49zrfsp	307	52	Hallmarks	Hallmarks	NNP
cord-258787-n49zrfsp	307	53	of	of	IN
cord-258787-n49zrfsp	307	54	cancer	cancer	NN
cord-258787-n49zrfsp	307	55	:	:	:
cord-258787-n49zrfsp	307	56	the	the	DT
cord-258787-n49zrfsp	307	57	next	next	JJ
cord-258787-n49zrfsp	307	58	generation	generation	NN
cord-258787-n49zrfsp	307	59	Cancer	cancer	NN
cord-258787-n49zrfsp	307	60	-	-	HYPH
cord-258787-n49zrfsp	307	61	related	relate	VBN
cord-258787-n49zrfsp	307	62	inflammation	inflammation	NN
cord-258787-n49zrfsp	308	1	The	the	DT
cord-258787-n49zrfsp	308	2	immune	immune	JJ
cord-258787-n49zrfsp	308	3	contexture	contexture	NN
cord-258787-n49zrfsp	308	4	in	in	IN
cord-258787-n49zrfsp	308	5	cancer	cancer	NN
cord-258787-n49zrfsp	308	6	prognosis	prognosis	NN
cord-258787-n49zrfsp	308	7	and	and	CC
cord-258787-n49zrfsp	308	8	treatment	treatment	NN
cord-258787-n49zrfsp	308	9	Macrophages	macrophage	NNS
cord-258787-n49zrfsp	308	10	at	at	IN
cord-258787-n49zrfsp	308	11	the	the	DT
cord-258787-n49zrfsp	308	12	crossroads	crossroad	NNS
cord-258787-n49zrfsp	308	13	of	of	IN
cord-258787-n49zrfsp	308	14	anticancer	anticancer	JJ
cord-258787-n49zrfsp	308	15	strategies	strategy	NNS
cord-258787-n49zrfsp	308	16	Tumour	tumour	NN
cord-258787-n49zrfsp	308	17	-	-	HYPH
cord-258787-n49zrfsp	308	18	associated	associate	VBN
cord-258787-n49zrfsp	308	19	macrophages	macrophage	NNS
cord-258787-n49zrfsp	308	20	as	as	IN
cord-258787-n49zrfsp	308	21	treatment	treatment	NN
cord-258787-n49zrfsp	308	22	targets	target	NNS
cord-258787-n49zrfsp	308	23	in	in	IN
cord-258787-n49zrfsp	308	24	oncology	oncology	NN
cord-258787-n49zrfsp	308	25	IL-17-producing	IL-17-producing	NNP
cord-258787-n49zrfsp	308	26	gammadelta	gammadelta	NNP
cord-258787-n49zrfsp	308	27	T	t	NN
cord-258787-n49zrfsp	308	28	cells	cell	NNS
cord-258787-n49zrfsp	308	29	and	and	CC
cord-258787-n49zrfsp	308	30	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	308	31	conspire	conspire	VBP
cord-258787-n49zrfsp	308	32	to	to	TO
cord-258787-n49zrfsp	308	33	promote	promote	VB
cord-258787-n49zrfsp	308	34	breast	breast	NN
cord-258787-n49zrfsp	308	35	cancer	cancer	NN
cord-258787-n49zrfsp	308	36	metastasis	metastasis	NN
cord-258787-n49zrfsp	308	37	Neutrophils	Neutrophils	NNP
cord-258787-n49zrfsp	308	38	in	in	IN
cord-258787-n49zrfsp	308	39	cancer	cancer	NN
cord-258787-n49zrfsp	308	40	:	:	:
cord-258787-n49zrfsp	309	1	neutral	neutral	JJ
cord-258787-n49zrfsp	309	2	no	no	DT
cord-258787-n49zrfsp	309	3	more	more	JJR
cord-258787-n49zrfsp	309	4	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	309	5	diversity	diversity	NN
cord-258787-n49zrfsp	309	6	and	and	CC
cord-258787-n49zrfsp	309	7	plasticity	plasticity	NN
cord-258787-n49zrfsp	309	8	in	in	IN
cord-258787-n49zrfsp	309	9	tumour	tumour	NN
cord-258787-n49zrfsp	309	10	progression	progression	NN
cord-258787-n49zrfsp	309	11	and	and	CC
cord-258787-n49zrfsp	309	12	therapy	therapy	NN
cord-258787-n49zrfsp	309	13	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	309	14	driving	drive	VBG
cord-258787-n49zrfsp	309	15	unconventional	unconventional	JJ
cord-258787-n49zrfsp	309	16	t	t	NN
cord-258787-n49zrfsp	309	17	cells	cell	NNS
cord-258787-n49zrfsp	309	18	mediate	mediate	VBP
cord-258787-n49zrfsp	309	19	resistance	resistance	NN
cord-258787-n49zrfsp	309	20	against	against	IN
cord-258787-n49zrfsp	309	21	murine	murine	JJ
cord-258787-n49zrfsp	309	22	sarcomas	sarcoma	NNS
cord-258787-n49zrfsp	309	23	and	and	CC
cord-258787-n49zrfsp	309	24	selected	select	VBN
cord-258787-n49zrfsp	309	25	human	human	JJ
cord-258787-n49zrfsp	309	26	tumors	tumor	NNS
cord-258787-n49zrfsp	309	27	Neutrophils	Neutrophils	NNP
cord-258787-n49zrfsp	309	28	support	support	VBP
cord-258787-n49zrfsp	309	29	lung	lung	NN
cord-258787-n49zrfsp	309	30	colonization	colonization	NN
cord-258787-n49zrfsp	309	31	of	of	IN
cord-258787-n49zrfsp	309	32	metastasisinitiating	metastasisinitiate	VBG
cord-258787-n49zrfsp	309	33	breast	breast	NN
cord-258787-n49zrfsp	309	34	cancer	cancer	NN
cord-258787-n49zrfsp	309	35	cells	cell	NNS
cord-258787-n49zrfsp	309	36	Heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	309	37	of	of	IN
cord-258787-n49zrfsp	309	38	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	309	39	Spatiotemporal	spatiotemporal	JJ
cord-258787-n49zrfsp	309	40	dynamics	dynamic	NNS
cord-258787-n49zrfsp	309	41	of	of	IN
cord-258787-n49zrfsp	309	42	intratumoral	intratumoral	JJ
cord-258787-n49zrfsp	309	43	immune	immune	JJ
cord-258787-n49zrfsp	309	44	cells	cell	NNS
cord-258787-n49zrfsp	309	45	reveal	reveal	VBP
cord-258787-n49zrfsp	309	46	the	the	DT
cord-258787-n49zrfsp	309	47	immune	immune	JJ
cord-258787-n49zrfsp	309	48	landscape	landscape	NN
cord-258787-n49zrfsp	309	49	in	in	IN
cord-258787-n49zrfsp	309	50	human	human	JJ
cord-258787-n49zrfsp	309	51	cancer	cancer	NN
cord-258787-n49zrfsp	310	1	The	the	DT
cord-258787-n49zrfsp	310	2	prognostic	prognostic	JJ
cord-258787-n49zrfsp	310	3	landscape	landscape	NN
cord-258787-n49zrfsp	310	4	of	of	IN
cord-258787-n49zrfsp	310	5	genes	gene	NNS
cord-258787-n49zrfsp	310	6	and	and	CC
cord-258787-n49zrfsp	310	7	infiltrating	infiltrate	VBG
cord-258787-n49zrfsp	310	8	immune	immune	JJ
cord-258787-n49zrfsp	310	9	cells	cell	NNS
cord-258787-n49zrfsp	310	10	across	across	IN
cord-258787-n49zrfsp	310	11	human	human	JJ
cord-258787-n49zrfsp	310	12	cancers	cancer	NNS
cord-258787-n49zrfsp	310	13	Tumour	tumour	NN
cord-258787-n49zrfsp	310	14	-	-	HYPH
cord-258787-n49zrfsp	310	15	associated	associate	VBN
cord-258787-n49zrfsp	310	16	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	310	17	in	in	IN
cord-258787-n49zrfsp	310	18	patients	patient	NNS
cord-258787-n49zrfsp	310	19	with	with	IN
cord-258787-n49zrfsp	310	20	cancer	cancer	NN
cord-258787-n49zrfsp	310	21	Prognostic	prognostic	JJ
cord-258787-n49zrfsp	310	22	role	role	NN
cord-258787-n49zrfsp	310	23	of	of	IN
cord-258787-n49zrfsp	310	24	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	310	25	-	-	HYPH
cord-258787-n49zrfsp	310	26	to	to	IN
cord-258787-n49zrfsp	310	27	-	-	HYPH
cord-258787-n49zrfsp	310	28	lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	310	29	ratio	ratio	NN
cord-258787-n49zrfsp	310	30	in	in	IN
cord-258787-n49zrfsp	310	31	solid	solid	JJ
cord-258787-n49zrfsp	310	32	tumors	tumor	NNS
cord-258787-n49zrfsp	310	33	:	:	:
cord-258787-n49zrfsp	310	34	a	a	DT
cord-258787-n49zrfsp	310	35	systematic	systematic	JJ
cord-258787-n49zrfsp	310	36	review	review	NN
cord-258787-n49zrfsp	310	37	and	and	CC
cord-258787-n49zrfsp	310	38	meta	meta	NNP
cord-258787-n49zrfsp	310	39	-	-	HYPH
cord-258787-n49zrfsp	310	40	analysis	analysis	NN
cord-258787-n49zrfsp	310	41	Circadian	circadian	NN
cord-258787-n49zrfsp	310	42	features	feature	NNS
cord-258787-n49zrfsp	310	43	of	of	IN
cord-258787-n49zrfsp	310	44	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	310	45	biology	biology	NN
cord-258787-n49zrfsp	311	1	The	the	DT
cord-258787-n49zrfsp	311	2	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	311	3	life	life	NN
cord-258787-n49zrfsp	311	4	cycle	cycle	NN
cord-258787-n49zrfsp	312	1	The	the	DT
cord-258787-n49zrfsp	312	2	ontogeny	ontogeny	NN
cord-258787-n49zrfsp	312	3	of	of	IN
cord-258787-n49zrfsp	312	4	a	a	DT
cord-258787-n49zrfsp	312	5	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	312	6	:	:	:
cord-258787-n49zrfsp	312	7	mechanisms	mechanism	NNS
cord-258787-n49zrfsp	312	8	of	of	IN
cord-258787-n49zrfsp	312	9	granulopoiesis	granulopoiesis	NN
cord-258787-n49zrfsp	312	10	and	and	CC
cord-258787-n49zrfsp	312	11	homeostasis	homeostasis	NN
cord-258787-n49zrfsp	312	12	,	,	,
cord-258787-n49zrfsp	312	13	Microbiol	Microbiol	NNP
cord-258787-n49zrfsp	312	14	Emergency	Emergency	NNP
cord-258787-n49zrfsp	312	15	granulopoiesis	granulopoiesis	NN
cord-258787-n49zrfsp	312	16	Granulopoiesis	Granulopoiesis	NNP
cord-258787-n49zrfsp	312	17	and	and	CC
cord-258787-n49zrfsp	312	18	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	312	19	Homeostasis	Homeostasis	NNP
cord-258787-n49zrfsp	312	20	:	:	:
cord-258787-n49zrfsp	313	1	A	a	DT
cord-258787-n49zrfsp	313	2	Metabolic	Metabolic	NNP
cord-258787-n49zrfsp	313	3	,	,	,
cord-258787-n49zrfsp	313	4	Daily	Daily	NNP
cord-258787-n49zrfsp	313	5	Balancing	Balancing	NNP
cord-258787-n49zrfsp	313	6	Act	Act	NNP
cord-258787-n49zrfsp	313	7	Neutrophils	Neutrophils	NNP
cord-258787-n49zrfsp	313	8	,	,	,
cord-258787-n49zrfsp	313	9	from	from	IN
cord-258787-n49zrfsp	313	10	marrow	marrow	NN
cord-258787-n49zrfsp	313	11	to	to	IN
cord-258787-n49zrfsp	313	12	microbes	microbe	NNS
cord-258787-n49zrfsp	313	13	IL6	IL6	NNP
cord-258787-n49zrfsp	313	14	/	/	SYM
cord-258787-n49zrfsp	313	15	sIL6R	sil6r	CD
cord-258787-n49zrfsp	313	16	complex	complex	NN
cord-258787-n49zrfsp	313	17	contributes	contribute	VBZ
cord-258787-n49zrfsp	313	18	to	to	IN
cord-258787-n49zrfsp	313	19	emergency	emergency	NN
cord-258787-n49zrfsp	313	20	granulopoietic	granulopoietic	JJ
cord-258787-n49zrfsp	313	21	responses	response	NNS
cord-258787-n49zrfsp	313	22	in	in	IN
cord-258787-n49zrfsp	313	23	G	G	NNP
cord-258787-n49zrfsp	313	24	-	-	HYPH
cord-258787-n49zrfsp	313	25	CSF	csf	NN
cord-258787-n49zrfsp	313	26	-	-	,
cord-258787-n49zrfsp	313	27	and	and	CC
cord-258787-n49zrfsp	313	28	GM	GM	NNP
cord-258787-n49zrfsp	313	29	-	-	HYPH
cord-258787-n49zrfsp	313	30	CSF	csf	NN
cord-258787-n49zrfsp	313	31	-	-	HYPH
cord-258787-n49zrfsp	313	32	deficient	deficient	JJ
cord-258787-n49zrfsp	313	33	mice	mouse	NNS
cord-258787-n49zrfsp	313	34	Transcriptional	Transcriptional	NNP
cord-258787-n49zrfsp	313	35	regulation	regulation	NN
cord-258787-n49zrfsp	313	36	of	of	IN
cord-258787-n49zrfsp	313	37	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	313	38	differentiation	differentiation	NN
cord-258787-n49zrfsp	313	39	and	and	CC
cord-258787-n49zrfsp	313	40	function	function	NN
cord-258787-n49zrfsp	313	41	during	during	IN
cord-258787-n49zrfsp	313	42	inflammation	inflammation	NN
cord-258787-n49zrfsp	313	43	Granulopoiesis	granulopoiesis	NN
cord-258787-n49zrfsp	313	44	and	and	CC
cord-258787-n49zrfsp	313	45	granules	granule	NNS
cord-258787-n49zrfsp	313	46	of	of	IN
cord-258787-n49zrfsp	313	47	human	human	JJ
cord-258787-n49zrfsp	313	48	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	313	49	Intrinsic	intrinsic	JJ
cord-258787-n49zrfsp	313	50	requirement	requirement	NN
cord-258787-n49zrfsp	313	51	for	for	IN
cord-258787-n49zrfsp	313	52	zinc	zinc	NN
cord-258787-n49zrfsp	313	53	finger	finger	NN
cord-258787-n49zrfsp	313	54	transcription	transcription	NN
cord-258787-n49zrfsp	313	55	factor	factor	NN
cord-258787-n49zrfsp	314	1	Gfi-1	Gfi-1	NNP
cord-258787-n49zrfsp	314	2	in	in	IN
cord-258787-n49zrfsp	314	3	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	314	4	differentiation	differentiation	NN
cord-258787-n49zrfsp	315	1	Gfi-1	Gfi-1	NNP
cord-258787-n49zrfsp	315	2	inhibits	inhibit	VBZ
cord-258787-n49zrfsp	315	3	the	the	DT
cord-258787-n49zrfsp	315	4	expression	expression	NN
cord-258787-n49zrfsp	315	5	of	of	IN
cord-258787-n49zrfsp	315	6	eosinophil	eosinophil	JJ
cord-258787-n49zrfsp	315	7	major	major	JJ
cord-258787-n49zrfsp	315	8	basic	basic	JJ
cord-258787-n49zrfsp	315	9	protein	protein	NN
cord-258787-n49zrfsp	315	10	(	(	-LRB-
cord-258787-n49zrfsp	315	11	MBP	MBP	NNP
cord-258787-n49zrfsp	315	12	)	)	-RRB-
cord-258787-n49zrfsp	315	13	during	during	IN
cord-258787-n49zrfsp	315	14	G	G	NNP
cord-258787-n49zrfsp	315	15	-	-	HYPH
cord-258787-n49zrfsp	315	16	CSF	CSF	NNP
cord-258787-n49zrfsp	315	17	-	-	HYPH
cord-258787-n49zrfsp	315	18	induced	induce	VBN
cord-258787-n49zrfsp	315	19	neutrophilic	neutrophilic	NNP
cord-258787-n49zrfsp	315	20	differentiation	differentiation	NN
cord-258787-n49zrfsp	315	21	Transcriptional	Transcriptional	NNP
cord-258787-n49zrfsp	315	22	heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	315	23	and	and	CC
cord-258787-n49zrfsp	315	24	lineage	lineage	NN
cord-258787-n49zrfsp	315	25	commitment	commitment	NN
cord-258787-n49zrfsp	315	26	in	in	IN
cord-258787-n49zrfsp	315	27	myeloid	myeloid	JJ
cord-258787-n49zrfsp	315	28	progenitors	progenitor	NNS
cord-258787-n49zrfsp	316	1	The	the	DT
cord-258787-n49zrfsp	316	2	in	in	IN
cord-258787-n49zrfsp	316	3	vivo	vivo	NN
cord-258787-n49zrfsp	316	4	profile	profile	NN
cord-258787-n49zrfsp	316	5	of	of	IN
cord-258787-n49zrfsp	316	6	transcription	transcription	NN
cord-258787-n49zrfsp	316	7	factors	factor	NNS
cord-258787-n49zrfsp	316	8	during	during	IN
cord-258787-n49zrfsp	316	9	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	316	10	differentiation	differentiation	NN
cord-258787-n49zrfsp	316	11	in	in	IN
cord-258787-n49zrfsp	316	12	human	human	JJ
cord-258787-n49zrfsp	316	13	bone	bone	NN
cord-258787-n49zrfsp	316	14	marrow	marrow	NN
cord-258787-n49zrfsp	316	15	C	C	NNP
cord-258787-n49zrfsp	316	16	/	/	SYM
cord-258787-n49zrfsp	316	17	EBPbeta	EBPbeta	NNP
cord-258787-n49zrfsp	316	18	is	be	VBZ
cord-258787-n49zrfsp	316	19	required	require	VBN
cord-258787-n49zrfsp	316	20	for	for	IN
cord-258787-n49zrfsp	316	21	'	'	``
cord-258787-n49zrfsp	316	22	emergency	emergency	NN
cord-258787-n49zrfsp	316	23	'	'	''
cord-258787-n49zrfsp	316	24	granulopoiesis	granulopoiesis	NN
cord-258787-n49zrfsp	317	1	A	a	DT
cord-258787-n49zrfsp	317	2	novel	novel	NN
cord-258787-n49zrfsp	317	3	,	,	,
cord-258787-n49zrfsp	317	4	myeloid	myeloid	JJ
cord-258787-n49zrfsp	317	5	transcription	transcription	NN
cord-258787-n49zrfsp	317	6	factor	factor	NN
cord-258787-n49zrfsp	317	7	,	,	,
cord-258787-n49zrfsp	317	8	C	C	NNP
cord-258787-n49zrfsp	317	9	/	/	SYM
cord-258787-n49zrfsp	317	10	EBP	ebp	NN
cord-258787-n49zrfsp	317	11	epsilon	epsilon	NN
cord-258787-n49zrfsp	317	12	,	,	,
cord-258787-n49zrfsp	317	13	is	be	VBZ
cord-258787-n49zrfsp	317	14	upregulated	upregulate	VBN
cord-258787-n49zrfsp	317	15	during	during	IN
cord-258787-n49zrfsp	317	16	granulocytic	granulocytic	JJ
cord-258787-n49zrfsp	317	17	,	,	,
cord-258787-n49zrfsp	317	18	but	but	CC
cord-258787-n49zrfsp	317	19	not	not	RB
cord-258787-n49zrfsp	317	20	monocytic	monocytic	JJ
cord-258787-n49zrfsp	317	21	,	,	,
cord-258787-n49zrfsp	317	22	differentiation	differentiation	NN
cord-258787-n49zrfsp	318	1	The	the	DT
cord-258787-n49zrfsp	318	2	multifaceted	multifaceted	JJ
cord-258787-n49zrfsp	318	3	functions	function	NNS
cord-258787-n49zrfsp	318	4	of	of	IN
cord-258787-n49zrfsp	318	5	C	c	NN
cord-258787-n49zrfsp	318	6	/	/	SYM
cord-258787-n49zrfsp	318	7	EBPalpha	EBPalpha	NNS
cord-258787-n49zrfsp	318	8	in	in	IN
cord-258787-n49zrfsp	318	9	normal	normal	JJ
cord-258787-n49zrfsp	318	10	and	and	CC
cord-258787-n49zrfsp	318	11	malignant	malignant	JJ
cord-258787-n49zrfsp	318	12	haematopoiesis	haematopoiesis	NN
cord-258787-n49zrfsp	318	13	Enhancement	enhancement	NN
cord-258787-n49zrfsp	318	14	of	of	IN
cord-258787-n49zrfsp	318	15	hematopoietic	hematopoietic	JJ
cord-258787-n49zrfsp	318	16	stem	stem	NN
cord-258787-n49zrfsp	318	17	cell	cell	NN
cord-258787-n49zrfsp	318	18	repopulating	repopulate	VBG
cord-258787-n49zrfsp	318	19	capacity	capacity	NN
cord-258787-n49zrfsp	318	20	and	and	CC
cord-258787-n49zrfsp	318	21	self	self	NN
cord-258787-n49zrfsp	318	22	-	-	HYPH
cord-258787-n49zrfsp	318	23	renewal	renewal	NN
cord-258787-n49zrfsp	318	24	in	in	IN
cord-258787-n49zrfsp	318	25	the	the	DT
cord-258787-n49zrfsp	318	26	absence	absence	NN
cord-258787-n49zrfsp	318	27	of	of	IN
cord-258787-n49zrfsp	318	28	the	the	DT
cord-258787-n49zrfsp	318	29	transcription	transcription	NN
cord-258787-n49zrfsp	318	30	factor	factor	NN
cord-258787-n49zrfsp	319	1	C	C	NNP
cord-258787-n49zrfsp	319	2	/	/	SYM
cord-258787-n49zrfsp	319	3	EBP	ebp	NN
cord-258787-n49zrfsp	319	4	alpha	alpha	NN
cord-258787-n49zrfsp	319	5	C	c	NN
cord-258787-n49zrfsp	319	6	/	/	SYM
cord-258787-n49zrfsp	319	7	EBPepsilon	EBPepsilon	NNP
cord-258787-n49zrfsp	319	8	interacts	interact	VBZ
cord-258787-n49zrfsp	319	9	with	with	IN
cord-258787-n49zrfsp	319	10	retinoblastoma	retinoblastoma	NN
cord-258787-n49zrfsp	319	11	and	and	CC
cord-258787-n49zrfsp	319	12	E2F1	E2F1	NNP
cord-258787-n49zrfsp	319	13	during	during	IN
cord-258787-n49zrfsp	319	14	granulopoiesis	granulopoiesis	NNP
cord-258787-n49zrfsp	319	15	Gfi-1	Gfi-1	NNP
cord-258787-n49zrfsp	319	16	restricts	restrict	VBZ
cord-258787-n49zrfsp	319	17	proliferation	proliferation	NN
cord-258787-n49zrfsp	319	18	and	and	CC
cord-258787-n49zrfsp	319	19	preserves	preserve	VBZ
cord-258787-n49zrfsp	319	20	functional	functional	JJ
cord-258787-n49zrfsp	319	21	integrity	integrity	NN
cord-258787-n49zrfsp	319	22	of	of	IN
cord-258787-n49zrfsp	319	23	haematopoietic	haematopoietic	JJ
cord-258787-n49zrfsp	319	24	stem	stem	NN
cord-258787-n49zrfsp	319	25	cells	cell	NNS
cord-258787-n49zrfsp	319	26	Dynamics	dynamic	NNS
cord-258787-n49zrfsp	319	27	of	of	IN
cord-258787-n49zrfsp	319	28	transcription	transcription	NN
cord-258787-n49zrfsp	319	29	regulation	regulation	NN
cord-258787-n49zrfsp	319	30	in	in	IN
cord-258787-n49zrfsp	319	31	human	human	JJ
cord-258787-n49zrfsp	319	32	bone	bone	NN
cord-258787-n49zrfsp	319	33	marrow	marrow	NN
cord-258787-n49zrfsp	319	34	myeloid	myeloid	NN
cord-258787-n49zrfsp	319	35	differentiation	differentiation	NN
cord-258787-n49zrfsp	319	36	to	to	TO
cord-258787-n49zrfsp	319	37	mature	mature	VB
cord-258787-n49zrfsp	319	38	blood	blood	NN
cord-258787-n49zrfsp	319	39	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	319	40	Polarization	polarization	NN
cord-258787-n49zrfsp	319	41	of	of	IN
cord-258787-n49zrfsp	319	42	tumor	tumor	NN
cord-258787-n49zrfsp	319	43	-	-	HYPH
cord-258787-n49zrfsp	319	44	associated	associate	VBN
cord-258787-n49zrfsp	319	45	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	319	46	phenotype	phenotype	NN
cord-258787-n49zrfsp	319	47	by	by	IN
cord-258787-n49zrfsp	319	48	TGF	TGF	NNP
cord-258787-n49zrfsp	319	49	-	-	HYPH
cord-258787-n49zrfsp	319	50	beta	beta	NN
cord-258787-n49zrfsp	319	51	:	:	:
cord-258787-n49zrfsp	319	52	"	"	``
cord-258787-n49zrfsp	319	53	N1	N1	NNP
cord-258787-n49zrfsp	319	54	"	"	''
cord-258787-n49zrfsp	319	55	versus	versus	IN
cord-258787-n49zrfsp	319	56	"	"	``
cord-258787-n49zrfsp	319	57	N2	N2	NNP
cord-258787-n49zrfsp	319	58	"	"	''
cord-258787-n49zrfsp	319	59	TAN	TAN	NNP
cord-258787-n49zrfsp	319	60	Single	single	JJ
cord-258787-n49zrfsp	319	61	-	-	HYPH
cord-258787-n49zrfsp	319	62	cell	cell	NN
cord-258787-n49zrfsp	319	63	characterization	characterization	NN
cord-258787-n49zrfsp	319	64	of	of	IN
cord-258787-n49zrfsp	319	65	haematopoietic	haematopoietic	JJ
cord-258787-n49zrfsp	319	66	progenitors	progenitor	NNS
cord-258787-n49zrfsp	319	67	and	and	CC
cord-258787-n49zrfsp	319	68	their	-PRON-	PRP$
cord-258787-n49zrfsp	319	69	trajectories	trajectory	NNS
cord-258787-n49zrfsp	319	70	in	in	IN
cord-258787-n49zrfsp	319	71	homeostasis	homeostasis	NN
cord-258787-n49zrfsp	319	72	and	and	CC
cord-258787-n49zrfsp	319	73	perturbed	perturb	VBD
cord-258787-n49zrfsp	319	74	haematopoiesis	haematopoiesis	NN
cord-258787-n49zrfsp	319	75	Identification	identification	NN
cord-258787-n49zrfsp	319	76	of	of	IN
cord-258787-n49zrfsp	319	77	an	an	DT
cord-258787-n49zrfsp	319	78	early	early	JJ
cord-258787-n49zrfsp	319	79	unipotent	unipotent	JJ
cord-258787-n49zrfsp	319	80	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	319	81	progenitor	progenitor	NN
cord-258787-n49zrfsp	319	82	with	with	IN
cord-258787-n49zrfsp	319	83	pro	pro	JJ
cord-258787-n49zrfsp	319	84	-	-	JJ
cord-258787-n49zrfsp	319	85	tumoral	tumoral	JJ
cord-258787-n49zrfsp	319	86	activity	activity	NN
cord-258787-n49zrfsp	319	87	in	in	IN
cord-258787-n49zrfsp	319	88	mouse	mouse	NN
cord-258787-n49zrfsp	319	89	and	and	CC
cord-258787-n49zrfsp	319	90	human	human	JJ
cord-258787-n49zrfsp	319	91	bone	bone	NN
cord-258787-n49zrfsp	319	92	marrow	marrow	NN
cord-258787-n49zrfsp	319	93	Developmental	developmental	JJ
cord-258787-n49zrfsp	319	94	analysis	analysis	NN
cord-258787-n49zrfsp	319	95	of	of	IN
cord-258787-n49zrfsp	319	96	bone	bone	NN
cord-258787-n49zrfsp	319	97	marrow	marrow	NN
cord-258787-n49zrfsp	319	98	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	319	99	reveals	reveal	VBZ
cord-258787-n49zrfsp	319	100	populations	population	NNS
cord-258787-n49zrfsp	319	101	specialized	specialize	VBN
cord-258787-n49zrfsp	319	102	in	in	IN
cord-258787-n49zrfsp	319	103	expansion	expansion	NN
cord-258787-n49zrfsp	319	104	,	,	,
cord-258787-n49zrfsp	319	105	trafficking	trafficking	NN
cord-258787-n49zrfsp	319	106	,	,	,
cord-258787-n49zrfsp	319	107	and	and	CC
cord-258787-n49zrfsp	319	108	effector	effector	NN
cord-258787-n49zrfsp	319	109	functions	function	NNS
cord-258787-n49zrfsp	320	1	Combinatorial	combinatorial	JJ
cord-258787-n49zrfsp	320	2	single	single	JJ
cord-258787-n49zrfsp	320	3	-	-	HYPH
cord-258787-n49zrfsp	320	4	cell	cell	NN
cord-258787-n49zrfsp	320	5	analyses	analysis	NNS
cord-258787-n49zrfsp	320	6	of	of	IN
cord-258787-n49zrfsp	320	7	granulocyte	granulocyte	NN
cord-258787-n49zrfsp	320	8	-	-	HYPH
cord-258787-n49zrfsp	320	9	monocyte	monocyte	JJ
cord-258787-n49zrfsp	320	10	progenitor	progenitor	NN
cord-258787-n49zrfsp	320	11	heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	320	12	reveals	reveal	VBZ
cord-258787-n49zrfsp	320	13	an	an	DT
cord-258787-n49zrfsp	320	14	early	early	JJ
cord-258787-n49zrfsp	320	15	unipotent	unipotent	JJ
cord-258787-n49zrfsp	320	16	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	320	17	progenitor	progenitor	NN
cord-258787-n49zrfsp	320	18	CXCR2	CXCR2	NNS
cord-258787-n49zrfsp	320	19	and	and	CC
cord-258787-n49zrfsp	320	20	CXCR4	CXCR4	NNS
cord-258787-n49zrfsp	321	1	antagonistically	antagonistically	RB
cord-258787-n49zrfsp	321	2	regulate	regulate	VB
cord-258787-n49zrfsp	321	3	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	321	4	trafficking	trafficking	NN
cord-258787-n49zrfsp	321	5	from	from	IN
cord-258787-n49zrfsp	321	6	murine	murine	JJ
cord-258787-n49zrfsp	321	7	bone	bone	NN
cord-258787-n49zrfsp	321	8	marrow	marrow	NN
cord-258787-n49zrfsp	321	9	Multiple	multiple	JJ
cord-258787-n49zrfsp	321	10	roles	role	NNS
cord-258787-n49zrfsp	321	11	for	for	IN
cord-258787-n49zrfsp	321	12	chemokines	chemokine	NNS
cord-258787-n49zrfsp	321	13	in	in	IN
cord-258787-n49zrfsp	321	14	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	321	15	biology	biology	NN
cord-258787-n49zrfsp	321	16	Rhythmic	rhythmic	JJ
cord-258787-n49zrfsp	321	17	modulation	modulation	NN
cord-258787-n49zrfsp	321	18	of	of	IN
cord-258787-n49zrfsp	321	19	the	the	DT
cord-258787-n49zrfsp	321	20	hematopoietic	hematopoietic	JJ
cord-258787-n49zrfsp	321	21	niche	niche	NN
cord-258787-n49zrfsp	321	22	through	through	IN
cord-258787-n49zrfsp	321	23	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	321	24	clearance	clearance	NN
cord-258787-n49zrfsp	322	1	The	the	DT
cord-258787-n49zrfsp	322	2	spleen	spleen	NNS
cord-258787-n49zrfsp	322	3	in	in	IN
cord-258787-n49zrfsp	322	4	local	local	JJ
cord-258787-n49zrfsp	322	5	and	and	CC
cord-258787-n49zrfsp	322	6	systemic	systemic	JJ
cord-258787-n49zrfsp	322	7	regulation	regulation	NN
cord-258787-n49zrfsp	322	8	of	of	IN
cord-258787-n49zrfsp	322	9	immunity	immunity	NN
cord-258787-n49zrfsp	322	10	Origins	origin	NNS
cord-258787-n49zrfsp	322	11	of	of	IN
cord-258787-n49zrfsp	322	12	tumorassociated	tumorassociated	JJ
cord-258787-n49zrfsp	322	13	macrophages	macrophage	NNS
cord-258787-n49zrfsp	322	14	and	and	CC
cord-258787-n49zrfsp	322	15	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	322	16	Regulation	regulation	NN
cord-258787-n49zrfsp	322	17	of	of	IN
cord-258787-n49zrfsp	322	18	inflammation	inflammation	NN
cord-258787-n49zrfsp	322	19	-	-	HYPH
cord-258787-n49zrfsp	322	20	and	and	CC
cord-258787-n49zrfsp	322	21	infection	infection	NN
cord-258787-n49zrfsp	322	22	-	-	HYPH
cord-258787-n49zrfsp	322	23	driven	drive	VBN
cord-258787-n49zrfsp	322	24	hematopoiesis	hematopoiesis	NN
cord-258787-n49zrfsp	323	1	Non	non	JJ
cord-258787-n49zrfsp	323	2	-	-	JJ
cord-258787-n49zrfsp	323	3	steady	steady	JJ
cord-258787-n49zrfsp	323	4	-	-	HYPH
cord-258787-n49zrfsp	323	5	state	state	NN
cord-258787-n49zrfsp	323	6	hematopoiesis	hematopoiesis	NN
cord-258787-n49zrfsp	323	7	regulated	regulate	VBN
cord-258787-n49zrfsp	323	8	by	by	IN
cord-258787-n49zrfsp	323	9	the	the	DT
cord-258787-n49zrfsp	323	10	C	C	NNP
cord-258787-n49zrfsp	323	11	/	/	SYM
cord-258787-n49zrfsp	323	12	EBPbeta	ebpbeta	NN
cord-258787-n49zrfsp	323	13	transcription	transcription	NN
cord-258787-n49zrfsp	323	14	factor	factor	NN
cord-258787-n49zrfsp	323	15	C/	C/	NNP
cord-258787-n49zrfsp	323	16	EBPbeta	ebpbeta	NN
cord-258787-n49zrfsp	323	17	is	be	VBZ
cord-258787-n49zrfsp	323	18	involved	involve	VBN
cord-258787-n49zrfsp	323	19	in	in	IN
cord-258787-n49zrfsp	323	20	the	the	DT
cord-258787-n49zrfsp	323	21	amplification	amplification	NN
cord-258787-n49zrfsp	323	22	of	of	IN
cord-258787-n49zrfsp	323	23	early	early	JJ
cord-258787-n49zrfsp	323	24	granulocyte	granulocyte	NN
cord-258787-n49zrfsp	323	25	precursors	precursor	NNS
cord-258787-n49zrfsp	323	26	during	during	IN
cord-258787-n49zrfsp	323	27	candidemia	candidemia	NN
cord-258787-n49zrfsp	323	28	-	-	HYPH
cord-258787-n49zrfsp	323	29	induced	induce	VBN
cord-258787-n49zrfsp	323	30	"	"	``
cord-258787-n49zrfsp	323	31	emergency	emergency	NN
cord-258787-n49zrfsp	323	32	"	"	''
cord-258787-n49zrfsp	323	33	granulopoiesis	granulopoiesis	NNP
cord-258787-n49zrfsp	323	34	Invasive	invasive	JJ
cord-258787-n49zrfsp	323	35	breast	breast	NN
cord-258787-n49zrfsp	323	36	cancer	cancer	NN
cord-258787-n49zrfsp	323	37	reprograms	reprogram	VBZ
cord-258787-n49zrfsp	323	38	early	early	JJ
cord-258787-n49zrfsp	323	39	myeloid	myeloid	JJ
cord-258787-n49zrfsp	323	40	differentiation	differentiation	NN
cord-258787-n49zrfsp	323	41	in	in	IN
cord-258787-n49zrfsp	323	42	the	the	DT
cord-258787-n49zrfsp	323	43	bone	bone	NN
cord-258787-n49zrfsp	323	44	marrow	marrow	NN
cord-258787-n49zrfsp	323	45	to	to	TO
cord-258787-n49zrfsp	323	46	generate	generate	VB
cord-258787-n49zrfsp	323	47	immunosuppressive	immunosuppressive	JJ
cord-258787-n49zrfsp	323	48	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	323	49	Elevated	elevated	JJ
cord-258787-n49zrfsp	323	50	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	323	51	and	and	CC
cord-258787-n49zrfsp	323	52	monocyte	monocyte	NN
cord-258787-n49zrfsp	323	53	counts	count	NNS
cord-258787-n49zrfsp	323	54	in	in	IN
cord-258787-n49zrfsp	323	55	peripheral	peripheral	JJ
cord-258787-n49zrfsp	323	56	blood	blood	NN
cord-258787-n49zrfsp	323	57	are	be	VBP
cord-258787-n49zrfsp	323	58	associated	associate	VBN
cord-258787-n49zrfsp	323	59	with	with	IN
cord-258787-n49zrfsp	323	60	poor	poor	JJ
cord-258787-n49zrfsp	323	61	survival	survival	NN
cord-258787-n49zrfsp	323	62	in	in	IN
cord-258787-n49zrfsp	323	63	patients	patient	NNS
cord-258787-n49zrfsp	323	64	with	with	IN
cord-258787-n49zrfsp	323	65	metastatic	metastatic	JJ
cord-258787-n49zrfsp	323	66	melanoma	melanoma	NN
cord-258787-n49zrfsp	323	67	:	:	:
cord-258787-n49zrfsp	323	68	a	a	DT
cord-258787-n49zrfsp	323	69	prognostic	prognostic	JJ
cord-258787-n49zrfsp	323	70	model	model	NN
cord-258787-n49zrfsp	323	71	Origin	origin	NN
cord-258787-n49zrfsp	323	72	and	and	CC
cord-258787-n49zrfsp	323	73	role	role	NN
cord-258787-n49zrfsp	323	74	of	of	IN
cord-258787-n49zrfsp	323	75	a	a	DT
cord-258787-n49zrfsp	323	76	subset	subset	NN
cord-258787-n49zrfsp	323	77	of	of	IN
cord-258787-n49zrfsp	323	78	tumor	tumor	NN
cord-258787-n49zrfsp	323	79	-	-	HYPH
cord-258787-n49zrfsp	323	80	associated	associate	VBN
cord-258787-n49zrfsp	323	81	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	323	82	with	with	IN
cord-258787-n49zrfsp	323	83	antigen	antigen	NN
cord-258787-n49zrfsp	323	84	-	-	HYPH
cord-258787-n49zrfsp	323	85	presenting	present	VBG
cord-258787-n49zrfsp	323	86	cell	cell	NN
cord-258787-n49zrfsp	323	87	features	feature	NNS
cord-258787-n49zrfsp	323	88	in	in	IN
cord-258787-n49zrfsp	323	89	early	early	JJ
cord-258787-n49zrfsp	323	90	-	-	HYPH
cord-258787-n49zrfsp	323	91	stage	stage	NN
cord-258787-n49zrfsp	323	92	human	human	JJ
cord-258787-n49zrfsp	323	93	lung	lung	NN
cord-258787-n49zrfsp	323	94	Cancer	Cancer	NNP
cord-258787-n49zrfsp	324	1	Their	-PRON-	PRP$
cord-258787-n49zrfsp	324	2	biological	biological	JJ
cord-258787-n49zrfsp	324	3	role	role	NN
cord-258787-n49zrfsp	324	4	and	and	CC
cord-258787-n49zrfsp	324	5	interaction	interaction	NN
cord-258787-n49zrfsp	324	6	with	with	IN
cord-258787-n49zrfsp	324	7	stromal	stromal	NN
cord-258787-n49zrfsp	324	8	cells	cell	NNS
cord-258787-n49zrfsp	324	9	FcRgamma	FcRgamma	NNP
cord-258787-n49zrfsp	324	10	activation	activation	NN
cord-258787-n49zrfsp	324	11	regulates	regulate	VBZ
cord-258787-n49zrfsp	324	12	inflammation	inflammation	NN
cord-258787-n49zrfsp	324	13	-	-	HYPH
cord-258787-n49zrfsp	324	14	associated	associate	VBN
cord-258787-n49zrfsp	324	15	squamous	squamous	JJ
cord-258787-n49zrfsp	324	16	carcinogenesis	carcinogenesis	NN
cord-258787-n49zrfsp	324	17	Antigen	antigen	NN
cord-258787-n49zrfsp	324	18	-	-	HYPH
cord-258787-n49zrfsp	324	19	specific	specific	JJ
cord-258787-n49zrfsp	324	20	immunity	immunity	NN
cord-258787-n49zrfsp	324	21	and	and	CC
cord-258787-n49zrfsp	324	22	cross	cross	NN
cord-258787-n49zrfsp	324	23	-	-	NN
cord-258787-n49zrfsp	324	24	priming	priming	NN
cord-258787-n49zrfsp	324	25	by	by	IN
cord-258787-n49zrfsp	324	26	epithelial	epithelial	JJ
cord-258787-n49zrfsp	324	27	ovarian	ovarian	JJ
cord-258787-n49zrfsp	324	28	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	324	29	-	-	HYPH
cord-258787-n49zrfsp	324	30	induced	induce	VBN
cord-258787-n49zrfsp	324	31	CD11b(+)Gr-1(+	CD11b(+)Gr-1(+	''
cord-258787-n49zrfsp	324	32	)	)	-RRB-
cord-258787-n49zrfsp	325	1	cells	cell	NNS
cord-258787-n49zrfsp	326	1	Role	role	NN
cord-258787-n49zrfsp	326	2	of	of	IN
cord-258787-n49zrfsp	326	3	the	the	DT
cord-258787-n49zrfsp	326	4	CXCL8-CXCR1/2	CXCL8-CXCR1/2	NNP
cord-258787-n49zrfsp	326	5	Axis	Axis	NNP
cord-258787-n49zrfsp	326	6	in	in	IN
cord-258787-n49zrfsp	326	7	Cancer	cancer	NN
cord-258787-n49zrfsp	326	8	and	and	CC
cord-258787-n49zrfsp	326	9	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	326	10	diseases	disease	NNS
cord-258787-n49zrfsp	327	1	CXCR2	CXCR2	NNS
cord-258787-n49zrfsp	327	2	:	:	:
cord-258787-n49zrfsp	327	3	From	from	IN
cord-258787-n49zrfsp	327	4	Bench	Bench	NNP
cord-258787-n49zrfsp	327	5	to	to	IN
cord-258787-n49zrfsp	327	6	Bedside	bedside	NN
cord-258787-n49zrfsp	328	1	The	the	DT
cord-258787-n49zrfsp	328	2	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	328	3	in	in	IN
cord-258787-n49zrfsp	328	4	vascular	vascular	JJ
cord-258787-n49zrfsp	328	5	inflammation	inflammation	NN
cord-258787-n49zrfsp	328	6	Leukocyte	Leukocyte	NNP
cord-258787-n49zrfsp	328	7	ligands	ligand	NNS
cord-258787-n49zrfsp	328	8	for	for	IN
cord-258787-n49zrfsp	328	9	endothelial	endothelial	JJ
cord-258787-n49zrfsp	328	10	selectins	selectin	NNS
cord-258787-n49zrfsp	328	11	:	:	:
cord-258787-n49zrfsp	328	12	specialized	specialized	NNP
cord-258787-n49zrfsp	328	13	glycoconjugates	glycoconjugate	NNS
cord-258787-n49zrfsp	328	14	that	that	WDT
cord-258787-n49zrfsp	328	15	mediate	mediate	VBP
cord-258787-n49zrfsp	328	16	rolling	roll	VBG
cord-258787-n49zrfsp	328	17	and	and	CC
cord-258787-n49zrfsp	328	18	signaling	signal	VBG
cord-258787-n49zrfsp	328	19	under	under	IN
cord-258787-n49zrfsp	328	20	flow	flow	NN
cord-258787-n49zrfsp	329	1	The	the	DT
cord-258787-n49zrfsp	329	2	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	329	3	's	's	POS
cord-258787-n49zrfsp	329	4	role	role	NN
cord-258787-n49zrfsp	329	5	during	during	IN
cord-258787-n49zrfsp	329	6	health	health	NN
cord-258787-n49zrfsp	329	7	and	and	CC
cord-258787-n49zrfsp	329	8	disease	disease	NN
cord-258787-n49zrfsp	329	9	Leukotriene	Leukotriene	NNP
cord-258787-n49zrfsp	329	10	B4-Neutrophil	B4-Neutrophil	NNP
cord-258787-n49zrfsp	329	11	elastase	elastase	NN
cord-258787-n49zrfsp	329	12	Axis	Axis	NNP
cord-258787-n49zrfsp	329	13	Drives	drive	VBZ
cord-258787-n49zrfsp	329	14	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	329	15	reverse	reverse	VBP
cord-258787-n49zrfsp	329	16	transendothelial	transendothelial	JJ
cord-258787-n49zrfsp	329	17	cell	cell	NN
cord-258787-n49zrfsp	329	18	migration	migration	NN
cord-258787-n49zrfsp	329	19	in	in	IN
cord-258787-n49zrfsp	329	20	vivo	vivo	NNP
cord-258787-n49zrfsp	329	21	Reverse	Reverse	NNP
cord-258787-n49zrfsp	329	22	Migration	migration	NN
cord-258787-n49zrfsp	329	23	of	of	IN
cord-258787-n49zrfsp	329	24	Neutrophils	Neutrophils	NNP
cord-258787-n49zrfsp	329	25	:	:	:
cord-258787-n49zrfsp	330	1	Where	where	WRB
cord-258787-n49zrfsp	330	2	,	,	,
cord-258787-n49zrfsp	330	3	When	when	WRB
cord-258787-n49zrfsp	330	4	,	,	,
cord-258787-n49zrfsp	330	5	How	how	WRB
cord-258787-n49zrfsp	330	6	,	,	,
cord-258787-n49zrfsp	330	7	and	and	CC
cord-258787-n49zrfsp	330	8	Why	why	WRB
cord-258787-n49zrfsp	330	9	?	?	.
cord-258787-n49zrfsp	331	1	The	the	DT
cord-258787-n49zrfsp	331	2	junctional	junctional	JJ
cord-258787-n49zrfsp	331	3	adhesion	adhesion	NN
cord-258787-n49zrfsp	331	4	molecule	molecule	NN
cord-258787-n49zrfsp	331	5	JAM	jam	NN
cord-258787-n49zrfsp	331	6	-	-	HYPH
cord-258787-n49zrfsp	331	7	C	C	NNP
cord-258787-n49zrfsp	331	8	regulates	regulate	VBZ
cord-258787-n49zrfsp	331	9	polarized	polarized	JJ
cord-258787-n49zrfsp	331	10	transendothelial	transendothelial	JJ
cord-258787-n49zrfsp	331	11	migration	migration	NN
cord-258787-n49zrfsp	331	12	of	of	IN
cord-258787-n49zrfsp	331	13	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	331	14	in	in	IN
cord-258787-n49zrfsp	331	15	vivo	vivo	NNP
cord-258787-n49zrfsp	331	16	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	331	17	migration	migration	NN
cord-258787-n49zrfsp	331	18	in	in	IN
cord-258787-n49zrfsp	331	19	infection	infection	NN
cord-258787-n49zrfsp	331	20	and	and	CC
cord-258787-n49zrfsp	331	21	wound	wound	NN
cord-258787-n49zrfsp	331	22	repair	repair	NN
cord-258787-n49zrfsp	331	23	:	:	:
cord-258787-n49zrfsp	331	24	going	go	VBG
cord-258787-n49zrfsp	331	25	forward	forward	RB
cord-258787-n49zrfsp	331	26	in	in	IN
cord-258787-n49zrfsp	331	27	reverse	reverse	NN
cord-258787-n49zrfsp	332	1	Getting	get	VBG
cord-258787-n49zrfsp	333	1	TANned	TANned	NNP
cord-258787-n49zrfsp	333	2	,	,	,
cord-258787-n49zrfsp	333	3	How	how	WRB
cord-258787-n49zrfsp	333	4	the	the	DT
cord-258787-n49zrfsp	333	5	tumor	tumor	NN
cord-258787-n49zrfsp	333	6	microenvironment	microenvironment	NN
cord-258787-n49zrfsp	333	7	drives	drive	VBZ
cord-258787-n49zrfsp	333	8	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	333	9	recruitment	recruitment	NN
cord-258787-n49zrfsp	333	10	Different	different	JJ
cord-258787-n49zrfsp	333	11	cytokine	cytokine	NN
cord-258787-n49zrfsp	333	12	profiles	profile	NNS
cord-258787-n49zrfsp	333	13	released	release	VBN
cord-258787-n49zrfsp	333	14	by	by	IN
cord-258787-n49zrfsp	333	15	CD4	CD4	NNP
cord-258787-n49zrfsp	333	16	+	+	CC
cord-258787-n49zrfsp	333	17	and	and	CC
cord-258787-n49zrfsp	333	18	CD8	CD8	NNP
cord-258787-n49zrfsp	333	19	+	+	CC
cord-258787-n49zrfsp	333	20	tumor	tumor	NN
cord-258787-n49zrfsp	333	21	-	-	HYPH
cord-258787-n49zrfsp	333	22	draining	drain	VBG
cord-258787-n49zrfsp	333	23	lymph	lymph	NN
cord-258787-n49zrfsp	333	24	node	node	NN
cord-258787-n49zrfsp	333	25	cells	cell	NNS
cord-258787-n49zrfsp	333	26	involved	involve	VBN
cord-258787-n49zrfsp	333	27	in	in	IN
cord-258787-n49zrfsp	333	28	mediating	mediate	VBG
cord-258787-n49zrfsp	333	29	tumor	tumor	NN
cord-258787-n49zrfsp	333	30	regression	regression	NN
cord-258787-n49zrfsp	334	1	The	the	DT
cord-258787-n49zrfsp	334	2	tumor	tumor	NN
cord-258787-n49zrfsp	334	3	-	-	HYPH
cord-258787-n49zrfsp	334	4	promoting	promote	VBG
cord-258787-n49zrfsp	334	5	actions	action	NNS
cord-258787-n49zrfsp	334	6	of	of	IN
cord-258787-n49zrfsp	334	7	TNF	tnf	NN
cord-258787-n49zrfsp	334	8	-	-	HYPH
cord-258787-n49zrfsp	334	9	alpha	alpha	NN
cord-258787-n49zrfsp	334	10	involve	involve	VBP
cord-258787-n49zrfsp	334	11	TNFR1	tnfr1	XX
cord-258787-n49zrfsp	334	12	and	and	CC
cord-258787-n49zrfsp	334	13	IL-17	IL-17	NNP
cord-258787-n49zrfsp	335	1	in	in	IN
cord-258787-n49zrfsp	335	2	ovarian	ovarian	JJ
cord-258787-n49zrfsp	335	3	cancer	cancer	NN
cord-258787-n49zrfsp	335	4	in	in	IN
cord-258787-n49zrfsp	335	5	mice	mouse	NNS
cord-258787-n49zrfsp	335	6	and	and	CC
cord-258787-n49zrfsp	335	7	humans	human	NNS
cord-258787-n49zrfsp	335	8	Granulocyte	Granulocyte	NNP
cord-258787-n49zrfsp	335	9	-	-	HYPH
cord-258787-n49zrfsp	335	10	colony	colony	NN
cord-258787-n49zrfsp	335	11	stimulating	stimulate	VBG
cord-258787-n49zrfsp	335	12	factor	factor	NN
cord-258787-n49zrfsp	335	13	promotes	promote	VBZ
cord-258787-n49zrfsp	335	14	lung	lung	NN
cord-258787-n49zrfsp	335	15	metastasis	metastasis	NN
cord-258787-n49zrfsp	335	16	through	through	IN
cord-258787-n49zrfsp	335	17	mobilization	mobilization	NN
cord-258787-n49zrfsp	335	18	of	of	IN
cord-258787-n49zrfsp	335	19	Ly6G+Ly6C+	Ly6G+Ly6C+	NNP
cord-258787-n49zrfsp	335	20	granulocytes	granulocyte	VBZ
cord-258787-n49zrfsp	335	21	Tumor	tumor	NN
cord-258787-n49zrfsp	335	22	-	-	HYPH
cord-258787-n49zrfsp	335	23	associated	associate	VBN
cord-258787-n49zrfsp	335	24	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	335	25	:	:	:
cord-258787-n49zrfsp	335	26	friend	friend	NN
cord-258787-n49zrfsp	335	27	or	or	CC
cord-258787-n49zrfsp	335	28	foe	foe	NN
cord-258787-n49zrfsp	335	29	?	?	.
cord-258787-n49zrfsp	336	1	Inhibition	inhibition	NN
cord-258787-n49zrfsp	336	2	of	of	IN
cord-258787-n49zrfsp	336	3	CXCR2	CXCR2	NNS
cord-258787-n49zrfsp	336	4	profoundly	profoundly	RB
cord-258787-n49zrfsp	336	5	suppresses	suppress	VBZ
cord-258787-n49zrfsp	336	6	inflammation	inflammation	NN
cord-258787-n49zrfsp	336	7	-	-	HYPH
cord-258787-n49zrfsp	336	8	driven	drive	VBN
cord-258787-n49zrfsp	336	9	and	and	CC
cord-258787-n49zrfsp	336	10	spontaneous	spontaneous	JJ
cord-258787-n49zrfsp	336	11	tumorigenesis	tumorigenesis	NN
cord-258787-n49zrfsp	336	12	CXCR2-expressing	cxcr2-expressing	NN
cord-258787-n49zrfsp	336	13	myeloid	myeloid	NN
cord-258787-n49zrfsp	336	14	-	-	HYPH
cord-258787-n49zrfsp	336	15	derived	derive	VBN
cord-258787-n49zrfsp	336	16	suppressor	suppressor	NN
cord-258787-n49zrfsp	336	17	cells	cell	NNS
cord-258787-n49zrfsp	336	18	are	be	VBP
cord-258787-n49zrfsp	336	19	essential	essential	JJ
cord-258787-n49zrfsp	336	20	to	to	TO
cord-258787-n49zrfsp	336	21	promote	promote	VB
cord-258787-n49zrfsp	336	22	colitis	colitis	NN
cord-258787-n49zrfsp	336	23	-	-	HYPH
cord-258787-n49zrfsp	336	24	associated	associate	VBN
cord-258787-n49zrfsp	336	25	tumorigenesis	tumorigenesis	NN
cord-258787-n49zrfsp	337	1	The	the	DT
cord-258787-n49zrfsp	337	2	oxysterol	oxysterol	NNP
cord-258787-n49zrfsp	337	3	-	-	HYPH
cord-258787-n49zrfsp	337	4	CXCR2	CXCR2	VBN
cord-258787-n49zrfsp	337	5	axis	axis	NN
cord-258787-n49zrfsp	337	6	plays	play	VBZ
cord-258787-n49zrfsp	337	7	a	a	DT
cord-258787-n49zrfsp	337	8	key	key	JJ
cord-258787-n49zrfsp	337	9	role	role	NN
cord-258787-n49zrfsp	337	10	in	in	IN
cord-258787-n49zrfsp	337	11	the	the	DT
cord-258787-n49zrfsp	337	12	recruitment	recruitment	NN
cord-258787-n49zrfsp	337	13	of	of	IN
cord-258787-n49zrfsp	337	14	tumor	tumor	NN
cord-258787-n49zrfsp	337	15	-	-	HYPH
cord-258787-n49zrfsp	337	16	promoting	promote	VBG
cord-258787-n49zrfsp	337	17	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	338	1	Distinct	distinct	JJ
cord-258787-n49zrfsp	338	2	spatio	spatio	JJ
cord-258787-n49zrfsp	338	3	-	-	HYPH
cord-258787-n49zrfsp	338	4	temporal	temporal	JJ
cord-258787-n49zrfsp	338	5	dynamics	dynamic	NNS
cord-258787-n49zrfsp	338	6	of	of	IN
cord-258787-n49zrfsp	338	7	tumor	tumor	NN
cord-258787-n49zrfsp	338	8	-	-	HYPH
cord-258787-n49zrfsp	338	9	associated	associate	VBN
cord-258787-n49zrfsp	338	10	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	338	11	in	in	IN
cord-258787-n49zrfsp	338	12	small	small	JJ
cord-258787-n49zrfsp	338	13	tumor	tumor	NN
cord-258787-n49zrfsp	338	14	lesions	lesion	NNS
cord-258787-n49zrfsp	338	15	Neutrophils	Neutrophils	NNPS
cord-258787-n49zrfsp	338	16	in	in	IN
cord-258787-n49zrfsp	338	17	homeostasis	homeostasis	NN
cord-258787-n49zrfsp	338	18	,	,	,
cord-258787-n49zrfsp	338	19	immunity	immunity	NN
cord-258787-n49zrfsp	338	20	,	,	,
cord-258787-n49zrfsp	338	21	and	and	CC
cord-258787-n49zrfsp	338	22	Cancer	Cancer	NNP
cord-258787-n49zrfsp	338	23	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	338	24	mobilization	mobilization	NN
cord-258787-n49zrfsp	338	25	via	via	IN
cord-258787-n49zrfsp	338	26	plerixafor	plerixafor	NN
cord-258787-n49zrfsp	338	27	-	-	HYPH
cord-258787-n49zrfsp	338	28	mediated	mediate	VBN
cord-258787-n49zrfsp	338	29	CXCR4	cxcr4	NN
cord-258787-n49zrfsp	338	30	inhibition	inhibition	NN
cord-258787-n49zrfsp	338	31	arises	arise	VBZ
cord-258787-n49zrfsp	338	32	from	from	IN
cord-258787-n49zrfsp	338	33	lung	lung	NN
cord-258787-n49zrfsp	338	34	demargination	demargination	NN
cord-258787-n49zrfsp	338	35	and	and	CC
cord-258787-n49zrfsp	338	36	blockade	blockade	NN
cord-258787-n49zrfsp	338	37	of	of	IN
cord-258787-n49zrfsp	338	38	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	338	39	homing	homing	NN
cord-258787-n49zrfsp	338	40	to	to	IN
cord-258787-n49zrfsp	338	41	the	the	DT
cord-258787-n49zrfsp	338	42	bone	bone	NN
cord-258787-n49zrfsp	338	43	marrow	marrow	NN
cord-258787-n49zrfsp	338	44	Imbalance	imbalance	NN
cord-258787-n49zrfsp	338	45	between	between	IN
cord-258787-n49zrfsp	338	46	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	338	47	elastase	elastase	NN
cord-258787-n49zrfsp	338	48	and	and	CC
cord-258787-n49zrfsp	338	49	its	-PRON-	PRP$
cord-258787-n49zrfsp	338	50	inhibitor	inhibitor	NN
cord-258787-n49zrfsp	338	51	alpha1-antitrypsin	alpha1-antitrypsin	VBD
cord-258787-n49zrfsp	338	52	in	in	IN
cord-258787-n49zrfsp	338	53	obesity	obesity	NN
cord-258787-n49zrfsp	338	54	alters	alter	VBZ
cord-258787-n49zrfsp	338	55	insulin	insulin	NN
cord-258787-n49zrfsp	338	56	sensitivity	sensitivity	NN
cord-258787-n49zrfsp	338	57	,	,	,
cord-258787-n49zrfsp	338	58	inflammation	inflammation	NN
cord-258787-n49zrfsp	338	59	,	,	,
cord-258787-n49zrfsp	338	60	and	and	CC
cord-258787-n49zrfsp	338	61	energy	energy	NN
cord-258787-n49zrfsp	338	62	expenditure	expenditure	NN
cord-258787-n49zrfsp	338	63	B	B	NNP
cord-258787-n49zrfsp	338	64	cell	cell	NN
cord-258787-n49zrfsp	338	65	-	-	HYPH
cord-258787-n49zrfsp	338	66	helper	helper	NN
cord-258787-n49zrfsp	338	67	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	338	68	stimulate	stimulate	VBP
cord-258787-n49zrfsp	338	69	the	the	DT
cord-258787-n49zrfsp	338	70	diversification	diversification	NN
cord-258787-n49zrfsp	338	71	and	and	CC
cord-258787-n49zrfsp	338	72	production	production	NN
cord-258787-n49zrfsp	338	73	of	of	IN
cord-258787-n49zrfsp	338	74	immunoglobulin	immunoglobulin	NN
cord-258787-n49zrfsp	338	75	in	in	IN
cord-258787-n49zrfsp	338	76	the	the	DT
cord-258787-n49zrfsp	338	77	marginal	marginal	JJ
cord-258787-n49zrfsp	338	78	zone	zone	NN
cord-258787-n49zrfsp	338	79	of	of	IN
cord-258787-n49zrfsp	338	80	the	the	DT
cord-258787-n49zrfsp	338	81	spleen	spleen	NN
cord-258787-n49zrfsp	339	1	Phenotypically	Phenotypically	NNP
cord-258787-n49zrfsp	339	2	distinct	distinct	JJ
cord-258787-n49zrfsp	339	3	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	339	4	patrol	patrol	NN
cord-258787-n49zrfsp	339	5	uninfected	uninfected	JJ
cord-258787-n49zrfsp	339	6	human	human	JJ
cord-258787-n49zrfsp	339	7	and	and	CC
cord-258787-n49zrfsp	339	8	mouse	mouse	NN
cord-258787-n49zrfsp	339	9	lymph	lymph	NN
cord-258787-n49zrfsp	339	10	nodes	node	NNS
cord-258787-n49zrfsp	339	11	Fluid	Fluid	NNP
cord-258787-n49zrfsp	339	12	phase	phase	NN
cord-258787-n49zrfsp	339	13	recognition	recognition	NN
cord-258787-n49zrfsp	339	14	molecules	molecule	NNS
cord-258787-n49zrfsp	339	15	in	in	IN
cord-258787-n49zrfsp	339	16	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	339	17	-	-	HYPH
cord-258787-n49zrfsp	339	18	dependent	dependent	JJ
cord-258787-n49zrfsp	339	19	immune	immune	JJ
cord-258787-n49zrfsp	339	20	responses	response	NNS
cord-258787-n49zrfsp	339	21	IL-17	IL-17	NNP
cord-258787-n49zrfsp	339	22	and	and	CC
cord-258787-n49zrfsp	339	23	TNFalpha	TNFalpha	NNS
cord-258787-n49zrfsp	339	24	sustain	sustain	VBP
cord-258787-n49zrfsp	339	25	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	339	26	recruitment	recruitment	NN
cord-258787-n49zrfsp	339	27	during	during	IN
cord-258787-n49zrfsp	339	28	inflammation	inflammation	NN
cord-258787-n49zrfsp	339	29	through	through	IN
cord-258787-n49zrfsp	339	30	synergistic	synergistic	JJ
cord-258787-n49zrfsp	339	31	effects	effect	NNS
cord-258787-n49zrfsp	339	32	on	on	IN
cord-258787-n49zrfsp	339	33	endothelial	endothelial	JJ
cord-258787-n49zrfsp	339	34	activation	activation	NN
cord-258787-n49zrfsp	339	35	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	339	36	-	-	HYPH
cord-258787-n49zrfsp	339	37	derived	derive	VBN
cord-258787-n49zrfsp	339	38	cytokines	cytokine	NNS
cord-258787-n49zrfsp	339	39	:	:	:
cord-258787-n49zrfsp	339	40	facts	fact	NNS
cord-258787-n49zrfsp	339	41	beyond	beyond	IN
cord-258787-n49zrfsp	339	42	expression	expression	NN
cord-258787-n49zrfsp	340	1	Conquering	conquer	VBG
cord-258787-n49zrfsp	340	2	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	341	1	How	how	WRB
cord-258787-n49zrfsp	341	2	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	341	3	kill	kill	VBP
cord-258787-n49zrfsp	341	4	microbes	microbe	NNS
cord-258787-n49zrfsp	342	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	342	2	extracellular	extracellular	JJ
cord-258787-n49zrfsp	342	3	traps	trap	NNS
cord-258787-n49zrfsp	342	4	kill	kill	VBP
cord-258787-n49zrfsp	342	5	bacteria	bacteria	NNS
cord-258787-n49zrfsp	342	6	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	342	7	extracellular	extracellular	JJ
cord-258787-n49zrfsp	342	8	traps	trap	NNS
cord-258787-n49zrfsp	342	9	:	:	:
cord-258787-n49zrfsp	342	10	the	the	DT
cord-258787-n49zrfsp	342	11	biology	biology	NN
cord-258787-n49zrfsp	342	12	of	of	IN
cord-258787-n49zrfsp	342	13	chromatin	chromatin	NN
cord-258787-n49zrfsp	342	14	externalization	externalization	NN
cord-258787-n49zrfsp	342	15	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	342	16	activation	activation	NN
cord-258787-n49zrfsp	342	17	and	and	CC
cord-258787-n49zrfsp	342	18	NETosis	netosis	NN
cord-258787-n49zrfsp	342	19	are	be	VBP
cord-258787-n49zrfsp	342	20	the	the	DT
cord-258787-n49zrfsp	342	21	major	major	JJ
cord-258787-n49zrfsp	342	22	drivers	driver	NNS
cord-258787-n49zrfsp	342	23	of	of	IN
cord-258787-n49zrfsp	342	24	thrombosis	thrombosis	NN
cord-258787-n49zrfsp	342	25	in	in	IN
cord-258787-n49zrfsp	342	26	heparin	heparin	NN
cord-258787-n49zrfsp	342	27	-	-	HYPH
cord-258787-n49zrfsp	342	28	induced	induce	VBN
cord-258787-n49zrfsp	342	29	thrombocytopenia	thrombocytopenia	NN
cord-258787-n49zrfsp	342	30	Understanding	understand	VBG
cord-258787-n49zrfsp	342	31	the	the	DT
cord-258787-n49zrfsp	342	32	roles	role	NNS
cord-258787-n49zrfsp	342	33	of	of	IN
cord-258787-n49zrfsp	342	34	cytokines	cytokine	NNS
cord-258787-n49zrfsp	342	35	and	and	CC
cord-258787-n49zrfsp	342	36	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	342	37	activity	activity	NN
cord-258787-n49zrfsp	342	38	and	and	CC
cord-258787-n49zrfsp	342	39	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	343	1	apoptosis	apoptosis	NN
cord-258787-n49zrfsp	343	2	in	in	IN
cord-258787-n49zrfsp	343	3	the	the	DT
cord-258787-n49zrfsp	343	4	protective	protective	JJ
cord-258787-n49zrfsp	343	5	versus	versus	IN
cord-258787-n49zrfsp	343	6	deleterious	deleterious	JJ
cord-258787-n49zrfsp	343	7	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	343	8	response	response	NN
cord-258787-n49zrfsp	343	9	in	in	IN
cord-258787-n49zrfsp	343	10	pneumonia	pneumonia	NN
cord-258787-n49zrfsp	343	11	Update	update	NN
cord-258787-n49zrfsp	343	12	on	on	IN
cord-258787-n49zrfsp	343	13	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	343	14	function	function	NN
cord-258787-n49zrfsp	343	15	in	in	IN
cord-258787-n49zrfsp	343	16	severe	severe	JJ
cord-258787-n49zrfsp	343	17	inflammation	inflammation	NN
cord-258787-n49zrfsp	343	18	Resolution	resolution	NN
cord-258787-n49zrfsp	343	19	of	of	IN
cord-258787-n49zrfsp	343	20	acute	acute	JJ
cord-258787-n49zrfsp	343	21	inflammation	inflammation	NN
cord-258787-n49zrfsp	343	22	and	and	CC
cord-258787-n49zrfsp	343	23	the	the	DT
cord-258787-n49zrfsp	343	24	role	role	NN
cord-258787-n49zrfsp	343	25	of	of	IN
cord-258787-n49zrfsp	343	26	resolvins	resolvin	NNS
cord-258787-n49zrfsp	343	27	in	in	IN
cord-258787-n49zrfsp	343	28	immunity	immunity	NN
cord-258787-n49zrfsp	343	29	,	,	,
cord-258787-n49zrfsp	343	30	thrombosis	thrombosis	NN
cord-258787-n49zrfsp	343	31	,	,	,
cord-258787-n49zrfsp	343	32	and	and	CC
cord-258787-n49zrfsp	343	33	vascular	vascular	JJ
cord-258787-n49zrfsp	343	34	biology	biology	NN
cord-258787-n49zrfsp	344	1	Apoptotic	apoptotic	JJ
cord-258787-n49zrfsp	344	2	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	344	3	and	and	CC
cord-258787-n49zrfsp	344	4	T	t	NN
cord-258787-n49zrfsp	344	5	cells	cell	NNS
cord-258787-n49zrfsp	344	6	sequester	sequester	VBP
cord-258787-n49zrfsp	344	7	chemokines	chemokine	NNS
cord-258787-n49zrfsp	344	8	during	during	IN
cord-258787-n49zrfsp	344	9	immune	immune	JJ
cord-258787-n49zrfsp	344	10	response	response	NN
cord-258787-n49zrfsp	344	11	resolution	resolution	NN
cord-258787-n49zrfsp	344	12	through	through	IN
cord-258787-n49zrfsp	344	13	modulation	modulation	NN
cord-258787-n49zrfsp	344	14	of	of	IN
cord-258787-n49zrfsp	344	15	CCR5	CCR5	NNP
cord-258787-n49zrfsp	344	16	expression	expression	NN
cord-258787-n49zrfsp	344	17	Tissue	tissue	NN
cord-258787-n49zrfsp	344	18	microenvironments	microenvironment	NNS
cord-258787-n49zrfsp	344	19	define	define	VBP
cord-258787-n49zrfsp	344	20	and	and	CC
cord-258787-n49zrfsp	344	21	get	get	VB
cord-258787-n49zrfsp	344	22	reinforced	reinforce	VBN
cord-258787-n49zrfsp	344	23	by	by	IN
cord-258787-n49zrfsp	344	24	macrophage	macrophage	NN
cord-258787-n49zrfsp	344	25	phenotypes	phenotype	NNS
cord-258787-n49zrfsp	344	26	in	in	IN
cord-258787-n49zrfsp	344	27	homeostasis	homeostasis	NN
cord-258787-n49zrfsp	344	28	or	or	CC
cord-258787-n49zrfsp	344	29	during	during	IN
cord-258787-n49zrfsp	344	30	inflammation	inflammation	NN
cord-258787-n49zrfsp	344	31	,	,	,
cord-258787-n49zrfsp	344	32	repair	repair	NN
cord-258787-n49zrfsp	344	33	and	and	CC
cord-258787-n49zrfsp	344	34	fibrosis	fibrosis	NN
cord-258787-n49zrfsp	344	35	Diverse	diverse	JJ
cord-258787-n49zrfsp	344	36	novel	novel	JJ
cord-258787-n49zrfsp	344	37	functions	function	NNS
cord-258787-n49zrfsp	344	38	of	of	IN
cord-258787-n49zrfsp	344	39	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	344	40	in	in	IN
cord-258787-n49zrfsp	344	41	immunity	immunity	NN
cord-258787-n49zrfsp	344	42	,	,	,
cord-258787-n49zrfsp	344	43	inflammation	inflammation	NN
cord-258787-n49zrfsp	344	44	,	,	,
cord-258787-n49zrfsp	344	45	and	and	CC
cord-258787-n49zrfsp	344	46	beyond	beyond	IN
cord-258787-n49zrfsp	344	47	Human	human	JJ
cord-258787-n49zrfsp	344	48	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	344	49	in	in	IN
cord-258787-n49zrfsp	344	50	auto	auto	NN
cord-258787-n49zrfsp	344	51	-	-	HYPH
cord-258787-n49zrfsp	344	52	immunity	immunity	NN
cord-258787-n49zrfsp	344	53	Single	single	JJ
cord-258787-n49zrfsp	344	54	-	-	HYPH
cord-258787-n49zrfsp	344	55	cell	cell	NN
cord-258787-n49zrfsp	344	56	sequencing	sequencing	NN
cord-258787-n49zrfsp	344	57	of	of	IN
cord-258787-n49zrfsp	344	58	mouse	mouse	NN
cord-258787-n49zrfsp	344	59	heart	heart	NN
cord-258787-n49zrfsp	344	60	immune	immune	JJ
cord-258787-n49zrfsp	344	61	infiltrate	infiltrate	NN
cord-258787-n49zrfsp	344	62	in	in	IN
cord-258787-n49zrfsp	344	63	pressure	pressure	NN
cord-258787-n49zrfsp	344	64	overloaddriven	overloaddriven	JJ
cord-258787-n49zrfsp	344	65	heart	heart	NN
cord-258787-n49zrfsp	344	66	failure	failure	NN
cord-258787-n49zrfsp	344	67	reveals	reveal	VBZ
cord-258787-n49zrfsp	344	68	extent	extent	NN
cord-258787-n49zrfsp	344	69	of	of	IN
cord-258787-n49zrfsp	344	70	immune	immune	JJ
cord-258787-n49zrfsp	344	71	activation	activation	NN
cord-258787-n49zrfsp	344	72	Understanding	understand	VBG
cord-258787-n49zrfsp	344	73	the	the	DT
cord-258787-n49zrfsp	344	74	multifaceted	multifaceted	JJ
cord-258787-n49zrfsp	344	75	role	role	NN
cord-258787-n49zrfsp	344	76	of	of	IN
cord-258787-n49zrfsp	344	77	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	344	78	in	in	IN
cord-258787-n49zrfsp	344	79	Cancer	cancer	NN
cord-258787-n49zrfsp	344	80	and	and	CC
cord-258787-n49zrfsp	344	81	autoimmune	autoimmune	JJ
cord-258787-n49zrfsp	344	82	diseases	disease	NNS
cord-258787-n49zrfsp	345	1	Neutrophils	neutrophils	NN
cord-258787-n49zrfsp	345	2	in	in	IN
cord-258787-n49zrfsp	345	3	atherosclerosis	atherosclerosis	NN
cord-258787-n49zrfsp	345	4	:	:	:
cord-258787-n49zrfsp	345	5	from	from	IN
cord-258787-n49zrfsp	345	6	mice	mouse	NNS
cord-258787-n49zrfsp	346	1	to	to	TO
cord-258787-n49zrfsp	346	2	man	man	VB
cord-258787-n49zrfsp	346	3	Kettritz	Kettritz	NNP
cord-258787-n49zrfsp	347	1	,	,	,
cord-258787-n49zrfsp	347	2	beta2	beta2	NN
cord-258787-n49zrfsp	347	3	integrinmediated	integrinmediate	VBN
cord-258787-n49zrfsp	347	4	cell	cell	NN
cord-258787-n49zrfsp	347	5	-	-	HYPH
cord-258787-n49zrfsp	347	6	cell	cell	NN
cord-258787-n49zrfsp	347	7	contact	contact	NN
cord-258787-n49zrfsp	347	8	transfers	transfer	NNS
cord-258787-n49zrfsp	347	9	active	active	JJ
cord-258787-n49zrfsp	347	10	myeloperoxidase	myeloperoxidase	NN
cord-258787-n49zrfsp	347	11	from	from	IN
cord-258787-n49zrfsp	347	12	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	347	13	to	to	IN
cord-258787-n49zrfsp	347	14	endothelial	endothelial	JJ
cord-258787-n49zrfsp	347	15	cells	cell	NNS
cord-258787-n49zrfsp	347	16	Auto	auto	NN
cord-258787-n49zrfsp	347	17	-	-	HYPH
cord-258787-n49zrfsp	347	18	antigenic	antigenic	JJ
cord-258787-n49zrfsp	347	19	protein	protein	NN
cord-258787-n49zrfsp	347	20	-	-	HYPH
cord-258787-n49zrfsp	347	21	DNA	dna	NN
cord-258787-n49zrfsp	347	22	complexes	complex	NNS
cord-258787-n49zrfsp	347	23	stimulate	stimulate	VBP
cord-258787-n49zrfsp	347	24	plasmacytoid	plasmacytoid	NN
cord-258787-n49zrfsp	347	25	dendritic	dendritic	JJ
cord-258787-n49zrfsp	347	26	cells	cell	NNS
cord-258787-n49zrfsp	347	27	to	to	TO
cord-258787-n49zrfsp	347	28	promote	promote	VB
cord-258787-n49zrfsp	347	29	atherosclerosis	atherosclerosis	NN
cord-258787-n49zrfsp	348	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	348	2	extracellular	extracellular	JJ
cord-258787-n49zrfsp	348	3	traps	trap	NNS
cord-258787-n49zrfsp	348	4	and	and	CC
cord-258787-n49zrfsp	348	5	endothelial	endothelial	JJ
cord-258787-n49zrfsp	348	6	dysfunction	dysfunction	NN
cord-258787-n49zrfsp	348	7	in	in	IN
cord-258787-n49zrfsp	348	8	atherosclerosis	atherosclerosis	NN
cord-258787-n49zrfsp	348	9	and	and	CC
cord-258787-n49zrfsp	348	10	thrombosis	thrombosis	NN
cord-258787-n49zrfsp	348	11	Hyperlipidemia	Hyperlipidemia	NNP
cord-258787-n49zrfsp	348	12	-	-	HYPH
cord-258787-n49zrfsp	348	13	triggered	trigger	VBN
cord-258787-n49zrfsp	348	14	neutrophilia	neutrophilia	NNP
cord-258787-n49zrfsp	348	15	promotes	promote	VBZ
cord-258787-n49zrfsp	348	16	early	early	JJ
cord-258787-n49zrfsp	348	17	atherosclerosis	atherosclerosis	NN
cord-258787-n49zrfsp	348	18	Netting	netting	NN
cord-258787-n49zrfsp	348	19	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	348	20	induce	induce	VBP
cord-258787-n49zrfsp	348	21	endothelial	endothelial	JJ
cord-258787-n49zrfsp	348	22	damage	damage	NN
cord-258787-n49zrfsp	348	23	,	,	,
cord-258787-n49zrfsp	348	24	infiltrate	infiltrate	VB
cord-258787-n49zrfsp	348	25	tissues	tissue	NNS
cord-258787-n49zrfsp	348	26	,	,	,
cord-258787-n49zrfsp	348	27	and	and	CC
cord-258787-n49zrfsp	348	28	expose	expose	VB
cord-258787-n49zrfsp	348	29	immunostimulatory	immunostimulatory	NN
cord-258787-n49zrfsp	348	30	molecules	molecule	NNS
cord-258787-n49zrfsp	348	31	in	in	IN
cord-258787-n49zrfsp	348	32	systemic	systemic	JJ
cord-258787-n49zrfsp	348	33	lupus	lupus	NN
cord-258787-n49zrfsp	348	34	erythematosus	erythematosus	NN
cord-258787-n49zrfsp	348	35	Increased	increase	VBN
cord-258787-n49zrfsp	348	36	apoptotic	apoptotic	JJ
cord-258787-n49zrfsp	348	37	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	348	38	and	and	CC
cord-258787-n49zrfsp	348	39	macrophages	macrophage	NNS
cord-258787-n49zrfsp	348	40	and	and	CC
cord-258787-n49zrfsp	348	41	impaired	impaired	JJ
cord-258787-n49zrfsp	348	42	macrophage	macrophage	NN
cord-258787-n49zrfsp	348	43	phagocytic	phagocytic	JJ
cord-258787-n49zrfsp	348	44	clearance	clearance	NN
cord-258787-n49zrfsp	348	45	of	of	IN
cord-258787-n49zrfsp	348	46	apoptotic	apoptotic	JJ
cord-258787-n49zrfsp	348	47	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	348	48	in	in	IN
cord-258787-n49zrfsp	348	49	systemic	systemic	JJ
cord-258787-n49zrfsp	348	50	lupus	lupus	NN
cord-258787-n49zrfsp	348	51	erythematosus	erythematosus	NN
cord-258787-n49zrfsp	349	1	Plasmacytoid	Plasmacytoid	NNP
cord-258787-n49zrfsp	349	2	dendritic	dendritic	JJ
cord-258787-n49zrfsp	349	3	cells	cell	NNS
cord-258787-n49zrfsp	349	4	induce	induce	VBP
cord-258787-n49zrfsp	349	5	plasma	plasma	NN
cord-258787-n49zrfsp	349	6	cell	cell	NN
cord-258787-n49zrfsp	349	7	differentiation	differentiation	NN
cord-258787-n49zrfsp	349	8	through	through	IN
cord-258787-n49zrfsp	349	9	type	type	NN
cord-258787-n49zrfsp	350	1	I	-PRON-	PRP
cord-258787-n49zrfsp	350	2	interferon	interferon	VBD
cord-258787-n49zrfsp	350	3	and	and	CC
cord-258787-n49zrfsp	350	4	interleukin	interleukin	NN
cord-258787-n49zrfsp	350	5	6	6	CD
cord-258787-n49zrfsp	351	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	351	2	activate	activate	VBP
cord-258787-n49zrfsp	351	3	plasmacytoid	plasmacytoid	NNP
cord-258787-n49zrfsp	351	4	dendritic	dendritic	JJ
cord-258787-n49zrfsp	351	5	cells	cell	NNS
cord-258787-n49zrfsp	351	6	by	by	IN
cord-258787-n49zrfsp	351	7	releasing	release	VBG
cord-258787-n49zrfsp	351	8	self	self	NN
cord-258787-n49zrfsp	351	9	-	-	HYPH
cord-258787-n49zrfsp	351	10	DNA	dna	NN
cord-258787-n49zrfsp	351	11	-	-	HYPH
cord-258787-n49zrfsp	351	12	peptide	peptide	NN
cord-258787-n49zrfsp	351	13	complexes	complex	NNS
cord-258787-n49zrfsp	351	14	in	in	IN
cord-258787-n49zrfsp	351	15	systemic	systemic	JJ
cord-258787-n49zrfsp	351	16	lupus	lupus	NN
cord-258787-n49zrfsp	351	17	erythematosus	erythematosus	NN
cord-258787-n49zrfsp	351	18	BAFF	BAFF	NNP
cord-258787-n49zrfsp	351	19	overexpression	overexpression	NN
cord-258787-n49zrfsp	351	20	is	be	VBZ
cord-258787-n49zrfsp	351	21	associated	associate	VBN
cord-258787-n49zrfsp	351	22	with	with	IN
cord-258787-n49zrfsp	351	23	autoantibody	autoantibody	NN
cord-258787-n49zrfsp	351	24	production	production	NN
cord-258787-n49zrfsp	351	25	in	in	IN
cord-258787-n49zrfsp	351	26	autoimmune	autoimmune	JJ
cord-258787-n49zrfsp	351	27	diseases	disease	NNS
cord-258787-n49zrfsp	352	1	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	352	2	contribute	contribute	VBP
cord-258787-n49zrfsp	352	3	to	to	IN
cord-258787-n49zrfsp	352	4	excess	excess	JJ
cord-258787-n49zrfsp	352	5	serum	serum	NN
cord-258787-n49zrfsp	352	6	BAFF	BAFF	NNP
cord-258787-n49zrfsp	352	7	levels	level	NNS
cord-258787-n49zrfsp	352	8	and	and	CC
cord-258787-n49zrfsp	352	9	promote	promote	VB
cord-258787-n49zrfsp	352	10	CD4	CD4	NNP
cord-258787-n49zrfsp	352	11	+	+	CC
cord-258787-n49zrfsp	352	12	T	t	NN
cord-258787-n49zrfsp	352	13	cell	cell	NN
cord-258787-n49zrfsp	352	14	and	and	CC
cord-258787-n49zrfsp	352	15	B	b	NN
cord-258787-n49zrfsp	352	16	cell	cell	NN
cord-258787-n49zrfsp	352	17	responses	response	NNS
cord-258787-n49zrfsp	352	18	in	in	IN
cord-258787-n49zrfsp	352	19	lupus	lupus	NN
cord-258787-n49zrfsp	352	20	-	-	HYPH
cord-258787-n49zrfsp	352	21	prone	prone	JJ
cord-258787-n49zrfsp	352	22	mice	mouse	NNS
cord-258787-n49zrfsp	353	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	353	2	diversity	diversity	NN
cord-258787-n49zrfsp	353	3	in	in	IN
cord-258787-n49zrfsp	353	4	health	health	NN
cord-258787-n49zrfsp	353	5	and	and	CC
cord-258787-n49zrfsp	353	6	disease	disease	NN
cord-258787-n49zrfsp	353	7	Bone	Bone	NNP
cord-258787-n49zrfsp	353	8	marrow	marrow	NN
cord-258787-n49zrfsp	353	9	myeloid	myeloid	NN
cord-258787-n49zrfsp	353	10	cells	cell	NNS
cord-258787-n49zrfsp	353	11	regulate	regulate	VBP
cord-258787-n49zrfsp	353	12	myeloid	myeloid	NN
cord-258787-n49zrfsp	353	13	-	-	HYPH
cord-258787-n49zrfsp	353	14	biased	bias	VBN
cord-258787-n49zrfsp	353	15	hematopoietic	hematopoietic	JJ
cord-258787-n49zrfsp	353	16	stem	stem	NN
cord-258787-n49zrfsp	353	17	cells	cell	NNS
cord-258787-n49zrfsp	353	18	via	via	IN
cord-258787-n49zrfsp	353	19	a	a	DT
cord-258787-n49zrfsp	353	20	histamine	histamine	NN
cord-258787-n49zrfsp	353	21	-	-	HYPH
cord-258787-n49zrfsp	353	22	dependent	dependent	JJ
cord-258787-n49zrfsp	353	23	feedback	feedback	NN
cord-258787-n49zrfsp	353	24	loop	loop	NN
cord-258787-n49zrfsp	353	25	G	G	NNP
cord-258787-n49zrfsp	353	26	-	-	HYPH
cord-258787-n49zrfsp	353	27	CSF	CSF	NNP
cord-258787-n49zrfsp	353	28	-	-	HYPH
cord-258787-n49zrfsp	353	29	induced	induce	VBN
cord-258787-n49zrfsp	353	30	sympathetic	sympathetic	JJ
cord-258787-n49zrfsp	353	31	tone	tone	NN
cord-258787-n49zrfsp	353	32	provokes	provoke	VBZ
cord-258787-n49zrfsp	353	33	fever	fever	NN
cord-258787-n49zrfsp	353	34	and	and	CC
cord-258787-n49zrfsp	353	35	primes	prime	NNS
cord-258787-n49zrfsp	353	36	antimobilizing	antimobilizing	NN
cord-258787-n49zrfsp	353	37	functions	function	NNS
cord-258787-n49zrfsp	353	38	of	of	IN
cord-258787-n49zrfsp	353	39	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	353	40	via	via	IN
cord-258787-n49zrfsp	353	41	PGE2	PGE2	NNP
cord-258787-n49zrfsp	354	1	A	a	DT
cord-258787-n49zrfsp	354	2	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	354	3	timer	timer	NN
cord-258787-n49zrfsp	354	4	coordinates	coordinate	VBZ
cord-258787-n49zrfsp	354	5	immune	immune	JJ
cord-258787-n49zrfsp	354	6	defense	defense	NN
cord-258787-n49zrfsp	354	7	and	and	CC
cord-258787-n49zrfsp	354	8	vascular	vascular	JJ
cord-258787-n49zrfsp	354	9	protection	protection	NN
cord-258787-n49zrfsp	354	10	Circadian	circadian	JJ
cord-258787-n49zrfsp	354	11	regulation	regulation	NN
cord-258787-n49zrfsp	354	12	of	of	IN
cord-258787-n49zrfsp	354	13	human	human	JJ
cord-258787-n49zrfsp	354	14	peripheral	peripheral	JJ
cord-258787-n49zrfsp	354	15	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	354	16	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	354	17	ageing	age	VBG
cord-258787-n49zrfsp	354	18	is	be	VBZ
cord-258787-n49zrfsp	354	19	regulated	regulate	VBN
cord-258787-n49zrfsp	354	20	by	by	IN
cord-258787-n49zrfsp	354	21	the	the	DT
cord-258787-n49zrfsp	354	22	microbiome	microbiome	NN
cord-258787-n49zrfsp	354	23	Tumor	tumor	NN
cord-258787-n49zrfsp	354	24	associated	associate	VBD
cord-258787-n49zrfsp	354	25	macrophages	macrophage	NNS
cord-258787-n49zrfsp	354	26	and	and	CC
cord-258787-n49zrfsp	354	27	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	354	28	in	in	IN
cord-258787-n49zrfsp	354	29	cancer	cancer	NN
cord-258787-n49zrfsp	354	30	Defining	define	VBG
cord-258787-n49zrfsp	354	31	the	the	DT
cord-258787-n49zrfsp	354	32	emergence	emergence	NN
cord-258787-n49zrfsp	354	33	of	of	IN
cord-258787-n49zrfsp	354	34	myeloid	myeloid	NN
cord-258787-n49zrfsp	354	35	-	-	HYPH
cord-258787-n49zrfsp	354	36	derived	derive	VBN
cord-258787-n49zrfsp	354	37	suppressor	suppressor	NN
cord-258787-n49zrfsp	354	38	cells	cell	NNS
cord-258787-n49zrfsp	354	39	in	in	IN
cord-258787-n49zrfsp	354	40	breast	breast	NN
cord-258787-n49zrfsp	354	41	cancer	cancer	NN
cord-258787-n49zrfsp	354	42	using	use	VBG
cord-258787-n49zrfsp	354	43	single	single	JJ
cord-258787-n49zrfsp	354	44	-	-	HYPH
cord-258787-n49zrfsp	354	45	cell	cell	NN
cord-258787-n49zrfsp	354	46	transcriptomics	transcriptomic	NNS
cord-258787-n49zrfsp	354	47	Coordinated	coordinate	VBD
cord-258787-n49zrfsp	354	48	regulation	regulation	NN
cord-258787-n49zrfsp	354	49	of	of	IN
cord-258787-n49zrfsp	354	50	myeloid	myeloid	NN
cord-258787-n49zrfsp	354	51	cells	cell	NNS
cord-258787-n49zrfsp	354	52	by	by	IN
cord-258787-n49zrfsp	354	53	tumours	tumour	NNS
cord-258787-n49zrfsp	354	54	Myeloid	myeloid	NN
cord-258787-n49zrfsp	354	55	-	-	HYPH
cord-258787-n49zrfsp	354	56	derived	derive	VBN
cord-258787-n49zrfsp	354	57	suppressor	suppressor	NN
cord-258787-n49zrfsp	354	58	cells	cell	NNS
cord-258787-n49zrfsp	354	59	coming	come	VBG
cord-258787-n49zrfsp	354	60	of	of	IN
cord-258787-n49zrfsp	354	61	age	age	NN
cord-258787-n49zrfsp	355	1	The	the	DT
cord-258787-n49zrfsp	355	2	nature	nature	NN
cord-258787-n49zrfsp	355	3	of	of	IN
cord-258787-n49zrfsp	355	4	myeloid	myeloid	NN
cord-258787-n49zrfsp	355	5	-	-	HYPH
cord-258787-n49zrfsp	355	6	derived	derive	VBN
cord-258787-n49zrfsp	355	7	suppressor	suppressor	NN
cord-258787-n49zrfsp	355	8	cells	cell	NNS
cord-258787-n49zrfsp	355	9	in	in	IN
cord-258787-n49zrfsp	355	10	the	the	DT
cord-258787-n49zrfsp	355	11	tumor	tumor	NN
cord-258787-n49zrfsp	355	12	microenvironment	microenvironment	NN
cord-258787-n49zrfsp	355	13	Survival	survival	NN
cord-258787-n49zrfsp	355	14	of	of	IN
cord-258787-n49zrfsp	355	15	residual	residual	JJ
cord-258787-n49zrfsp	355	16	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	355	17	and	and	CC
cord-258787-n49zrfsp	355	18	accelerated	accelerate	VBN
cord-258787-n49zrfsp	355	19	myelopoiesis	myelopoiesis	NN
cord-258787-n49zrfsp	355	20	limit	limit	VBP
cord-258787-n49zrfsp	355	21	the	the	DT
cord-258787-n49zrfsp	355	22	efficacy	efficacy	NN
cord-258787-n49zrfsp	355	23	of	of	IN
cord-258787-n49zrfsp	355	24	antibodymediated	antibodymediated	JJ
cord-258787-n49zrfsp	355	25	depletion	depletion	NN
cord-258787-n49zrfsp	355	26	of	of	IN
cord-258787-n49zrfsp	355	27	Ly-6G+	ly-6g+	JJ
cord-258787-n49zrfsp	355	28	cells	cell	NNS
cord-258787-n49zrfsp	355	29	in	in	IN
cord-258787-n49zrfsp	355	30	tumor	tumor	NN
cord-258787-n49zrfsp	355	31	-	-	HYPH
cord-258787-n49zrfsp	355	32	bearing	bear	VBG
cord-258787-n49zrfsp	355	33	mice	mouse	NNS
cord-258787-n49zrfsp	355	34	Human	human	JJ
cord-258787-n49zrfsp	355	35	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	355	36	in	in	IN
cord-258787-n49zrfsp	355	37	the	the	DT
cord-258787-n49zrfsp	355	38	saga	saga	NN
cord-258787-n49zrfsp	355	39	of	of	IN
cord-258787-n49zrfsp	355	40	cellular	cellular	JJ
cord-258787-n49zrfsp	355	41	heterogeneity	heterogeneity	NN
cord-258787-n49zrfsp	355	42	:	:	:
cord-258787-n49zrfsp	355	43	insights	insight	NNS
cord-258787-n49zrfsp	355	44	and	and	CC
cord-258787-n49zrfsp	355	45	open	open	JJ
cord-258787-n49zrfsp	355	46	questions	question	NNS
cord-258787-n49zrfsp	355	47	On	on	IN
cord-258787-n49zrfsp	355	48	the	the	DT
cord-258787-n49zrfsp	355	49	origin	origin	NN
cord-258787-n49zrfsp	355	50	of	of	IN
cord-258787-n49zrfsp	355	51	low	low	JJ
cord-258787-n49zrfsp	355	52	-	-	HYPH
cord-258787-n49zrfsp	355	53	density	density	NN
cord-258787-n49zrfsp	355	54	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	356	1	ER	ER	NNP
cord-258787-n49zrfsp	356	2	stress	stress	NN
cord-258787-n49zrfsp	356	3	regulates	regulate	VBZ
cord-258787-n49zrfsp	356	4	myeloid	myeloid	NN
cord-258787-n49zrfsp	356	5	-	-	HYPH
cord-258787-n49zrfsp	356	6	derived	derive	VBN
cord-258787-n49zrfsp	356	7	suppressor	suppressor	NN
cord-258787-n49zrfsp	356	8	cell	cell	NN
cord-258787-n49zrfsp	356	9	fate	fate	NN
cord-258787-n49zrfsp	356	10	through	through	IN
cord-258787-n49zrfsp	356	11	TRAIL	TRAIL	NNP
cord-258787-n49zrfsp	356	12	-	-	HYPH
cord-258787-n49zrfsp	356	13	R	r	NN
cord-258787-n49zrfsp	356	14	-	-	HYPH
cord-258787-n49zrfsp	356	15	mediated	mediate	VBN
cord-258787-n49zrfsp	356	16	apoptosis	apoptosis	NN
cord-258787-n49zrfsp	357	1	Mature	mature	JJ
cord-258787-n49zrfsp	357	2	CD10(+	CD10(+	NNP
cord-258787-n49zrfsp	357	3	)	)	-RRB-
cord-258787-n49zrfsp	357	4	and	and	CC
cord-258787-n49zrfsp	357	5	immature	immature	JJ
cord-258787-n49zrfsp	357	6	CD10(-	CD10(-	NNP
cord-258787-n49zrfsp	357	7	)	)	-RRB-
cord-258787-n49zrfsp	358	1	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	358	2	present	present	JJ
cord-258787-n49zrfsp	358	3	in	in	IN
cord-258787-n49zrfsp	358	4	G	G	NNP
cord-258787-n49zrfsp	358	5	-	-	HYPH
cord-258787-n49zrfsp	358	6	CSF	csf	NN
cord-258787-n49zrfsp	358	7	-	-	HYPH
cord-258787-n49zrfsp	358	8	treated	treat	VBN
cord-258787-n49zrfsp	358	9	donors	donor	NNS
cord-258787-n49zrfsp	358	10	display	display	VBP
cord-258787-n49zrfsp	358	11	opposite	opposite	JJ
cord-258787-n49zrfsp	358	12	effects	effect	NNS
cord-258787-n49zrfsp	358	13	on	on	IN
cord-258787-n49zrfsp	358	14	T	t	NN
cord-258787-n49zrfsp	358	15	cells	cell	NNS
cord-258787-n49zrfsp	358	16	Mouse	mouse	NN
cord-258787-n49zrfsp	358	17	versus	versus	IN
cord-258787-n49zrfsp	358	18	human	human	JJ
cord-258787-n49zrfsp	358	19	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	358	20	in	in	IN
cord-258787-n49zrfsp	358	21	Cancer	Cancer	NNP
cord-258787-n49zrfsp	358	22	:	:	:
cord-258787-n49zrfsp	358	23	a	a	DT
cord-258787-n49zrfsp	358	24	major	major	JJ
cord-258787-n49zrfsp	358	25	knowledge	knowledge	NN
cord-258787-n49zrfsp	358	26	gap	gap	NN
cord-258787-n49zrfsp	359	1	Distinct	distinct	JJ
cord-258787-n49zrfsp	359	2	functions	function	NNS
cord-258787-n49zrfsp	359	3	of	of	IN
cord-258787-n49zrfsp	359	4	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	359	5	in	in	IN
cord-258787-n49zrfsp	359	6	Cancer	Cancer	NNP
cord-258787-n49zrfsp	359	7	and	and	CC
cord-258787-n49zrfsp	359	8	its	-PRON-	PRP$
cord-258787-n49zrfsp	359	9	regulation	regulation	NN
cord-258787-n49zrfsp	360	1	The	the	DT
cord-258787-n49zrfsp	360	2	serine	serine	JJ
cord-258787-n49zrfsp	360	3	protease	protease	NN
cord-258787-n49zrfsp	360	4	inhibitor	inhibitor	NN
cord-258787-n49zrfsp	360	5	elafin	elafin	NNP
cord-258787-n49zrfsp	360	6	maintains	maintain	VBZ
cord-258787-n49zrfsp	360	7	normal	normal	JJ
cord-258787-n49zrfsp	360	8	growth	growth	NN
cord-258787-n49zrfsp	360	9	control	control	NN
cord-258787-n49zrfsp	360	10	by	by	IN
cord-258787-n49zrfsp	360	11	opposing	oppose	VBG
cord-258787-n49zrfsp	360	12	the	the	DT
cord-258787-n49zrfsp	360	13	mitogenic	mitogenic	JJ
cord-258787-n49zrfsp	360	14	effects	effect	NNS
cord-258787-n49zrfsp	360	15	of	of	IN
cord-258787-n49zrfsp	360	16	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	360	17	elastase	elastase	NN
cord-258787-n49zrfsp	360	18	Infiltrating	infiltrate	VBG
cord-258787-n49zrfsp	360	19	myeloid	myeloid	NN
cord-258787-n49zrfsp	360	20	cells	cell	NNS
cord-258787-n49zrfsp	360	21	exert	exert	VBP
cord-258787-n49zrfsp	360	22	protumorigenic	protumorigenic	JJ
cord-258787-n49zrfsp	360	23	actions	action	NNS
cord-258787-n49zrfsp	360	24	via	via	IN
cord-258787-n49zrfsp	361	1	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	361	2	elastase	elastase	NN
cord-258787-n49zrfsp	361	3	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	361	4	elastase	elastase	NN
cord-258787-n49zrfsp	361	5	induces	induce	VBZ
cord-258787-n49zrfsp	361	6	cell	cell	NN
cord-258787-n49zrfsp	361	7	proliferation	proliferation	NN
cord-258787-n49zrfsp	361	8	and	and	CC
cord-258787-n49zrfsp	361	9	migration	migration	NN
cord-258787-n49zrfsp	361	10	by	by	IN
cord-258787-n49zrfsp	361	11	the	the	DT
cord-258787-n49zrfsp	361	12	release	release	NN
cord-258787-n49zrfsp	361	13	of	of	IN
cord-258787-n49zrfsp	361	14	TGF	TGF	NNP
cord-258787-n49zrfsp	361	15	-	-	HYPH
cord-258787-n49zrfsp	361	16	alpha	alpha	NN
cord-258787-n49zrfsp	361	17	,	,	,
cord-258787-n49zrfsp	361	18	PDGF	PDGF	NNP
cord-258787-n49zrfsp	361	19	and	and	CC
cord-258787-n49zrfsp	361	20	VEGF	VEGF	NNP
cord-258787-n49zrfsp	361	21	in	in	IN
cord-258787-n49zrfsp	361	22	esophageal	esophageal	JJ
cord-258787-n49zrfsp	361	23	cell	cell	NN
cord-258787-n49zrfsp	361	24	lines	line	NNS
cord-258787-n49zrfsp	362	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	362	2	elastase	elastase	NN
cord-258787-n49zrfsp	362	3	-	-	HYPH
cord-258787-n49zrfsp	362	4	mediated	mediate	VBN
cord-258787-n49zrfsp	362	5	degradation	degradation	NN
cord-258787-n49zrfsp	362	6	of	of	IN
cord-258787-n49zrfsp	362	7	IRS-1	IRS-1	NNP
cord-258787-n49zrfsp	362	8	accelerates	accelerate	VBZ
cord-258787-n49zrfsp	362	9	lung	lung	NN
cord-258787-n49zrfsp	362	10	tumor	tumor	NN
cord-258787-n49zrfsp	362	11	growth	growth	NN
cord-258787-n49zrfsp	363	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	363	2	extracellular	extracellular	JJ
cord-258787-n49zrfsp	363	3	traps	trap	NNS
cord-258787-n49zrfsp	363	4	produced	produce	VBN
cord-258787-n49zrfsp	363	5	during	during	IN
cord-258787-n49zrfsp	363	6	inflammation	inflammation	NN
cord-258787-n49zrfsp	363	7	awaken	awaken	VBP
cord-258787-n49zrfsp	363	8	dormant	dormant	JJ
cord-258787-n49zrfsp	363	9	cancer	cancer	NN
cord-258787-n49zrfsp	363	10	cells	cell	NNS
cord-258787-n49zrfsp	363	11	in	in	IN
cord-258787-n49zrfsp	363	12	mice	mouse	NNS
cord-258787-n49zrfsp	364	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	364	2	extracellular	extracellular	JJ
cord-258787-n49zrfsp	364	3	traps	trap	NNS
cord-258787-n49zrfsp	364	4	sequester	sequester	VBP
cord-258787-n49zrfsp	364	5	circulating	circulate	VBG
cord-258787-n49zrfsp	364	6	tumor	tumor	NN
cord-258787-n49zrfsp	364	7	cells	cell	NNS
cord-258787-n49zrfsp	364	8	and	and	CC
cord-258787-n49zrfsp	364	9	promote	promote	VB
cord-258787-n49zrfsp	364	10	metastasis	metastasis	NN
cord-258787-n49zrfsp	364	11	Coagulation	coagulation	NN
cord-258787-n49zrfsp	364	12	induced	induce	VBN
cord-258787-n49zrfsp	364	13	by	by	IN
cord-258787-n49zrfsp	364	14	C3aR	c3ar	RB
cord-258787-n49zrfsp	364	15	-	-	HYPH
cord-258787-n49zrfsp	364	16	dependent	dependent	JJ
cord-258787-n49zrfsp	364	17	NETosis	netosis	NN
cord-258787-n49zrfsp	364	18	drives	drive	VBZ
cord-258787-n49zrfsp	364	19	protumorigenic	protumorigenic	JJ
cord-258787-n49zrfsp	364	20	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	364	21	during	during	IN
cord-258787-n49zrfsp	364	22	small	small	JJ
cord-258787-n49zrfsp	364	23	intestinal	intestinal	JJ
cord-258787-n49zrfsp	364	24	tumorigenesis	tumorigenesis	NN
cord-258787-n49zrfsp	364	25	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	364	26	facilitate	facilitate	VBP
cord-258787-n49zrfsp	364	27	ovarian	ovarian	JJ
cord-258787-n49zrfsp	364	28	cancer	cancer	NN
cord-258787-n49zrfsp	364	29	premetastatic	premetastatic	JJ
cord-258787-n49zrfsp	364	30	niche	niche	NN
cord-258787-n49zrfsp	364	31	formation	formation	NN
cord-258787-n49zrfsp	364	32	in	in	IN
cord-258787-n49zrfsp	364	33	the	the	DT
cord-258787-n49zrfsp	364	34	omentum	omentum	NN
cord-258787-n49zrfsp	364	35	Cancer	cancer	NN
cord-258787-n49zrfsp	364	36	cells	cell	NNS
cord-258787-n49zrfsp	364	37	induce	induce	VBP
cord-258787-n49zrfsp	364	38	metastasis	metastasis	NN
cord-258787-n49zrfsp	364	39	-	-	HYPH
cord-258787-n49zrfsp	364	40	supporting	support	VBG
cord-258787-n49zrfsp	364	41	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	364	42	extracellular	extracellular	JJ
cord-258787-n49zrfsp	364	43	DNA	dna	NN
cord-258787-n49zrfsp	364	44	traps	trap	NNS
cord-258787-n49zrfsp	365	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	365	2	extracellular	extracellular	JJ
cord-258787-n49zrfsp	365	3	traps	trap	NNS
cord-258787-n49zrfsp	365	4	promote	promote	VBP
cord-258787-n49zrfsp	365	5	inflammation	inflammation	NN
cord-258787-n49zrfsp	365	6	and	and	CC
cord-258787-n49zrfsp	365	7	development	development	NN
cord-258787-n49zrfsp	365	8	of	of	IN
cord-258787-n49zrfsp	365	9	hepatocellular	hepatocellular	JJ
cord-258787-n49zrfsp	365	10	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	365	11	in	in	IN
cord-258787-n49zrfsp	365	12	nonalcoholic	nonalcoholic	JJ
cord-258787-n49zrfsp	365	13	steatohepatitis	steatohepatitis	NN
cord-258787-n49zrfsp	365	14	Perez	Perez	NNP
cord-258787-n49zrfsp	365	15	-	-	HYPH
cord-258787-n49zrfsp	365	16	Gracia	Gracia	NNP
cord-258787-n49zrfsp	365	17	,	,	,
cord-258787-n49zrfsp	365	18	I.	I.	NNP
cord-258787-n49zrfsp	365	19	Melero	Melero	NNP
cord-258787-n49zrfsp	365	20	,	,	,
cord-258787-n49zrfsp	365	21	CXCR1	cxcr1	NN
cord-258787-n49zrfsp	365	22	and	and	CC
cord-258787-n49zrfsp	365	23	CXCR2	cxcr2	NN
cord-258787-n49zrfsp	365	24	chemokine	chemokine	NN
cord-258787-n49zrfsp	365	25	receptor	receptor	NN
cord-258787-n49zrfsp	365	26	agonists	agonist	NNS
cord-258787-n49zrfsp	365	27	produced	produce	VBN
cord-258787-n49zrfsp	365	28	by	by	IN
cord-258787-n49zrfsp	365	29	tumors	tumor	NNS
cord-258787-n49zrfsp	365	30	induce	induce	VBP
cord-258787-n49zrfsp	365	31	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	365	32	extracellular	extracellular	JJ
cord-258787-n49zrfsp	365	33	traps	trap	NNS
cord-258787-n49zrfsp	365	34	that	that	WDT
cord-258787-n49zrfsp	365	35	interfere	interfere	VBP
cord-258787-n49zrfsp	365	36	with	with	IN
cord-258787-n49zrfsp	365	37	immune	immune	JJ
cord-258787-n49zrfsp	365	38	cytotoxicity	cytotoxicity	NN
cord-258787-n49zrfsp	365	39	Genotoxic	Genotoxic	NNP
cord-258787-n49zrfsp	365	40	effects	effect	NNS
cord-258787-n49zrfsp	365	41	of	of	IN
cord-258787-n49zrfsp	365	42	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	365	43	and	and	CC
cord-258787-n49zrfsp	365	44	hypochlorous	hypochlorous	JJ
cord-258787-n49zrfsp	365	45	acid	acid	NN
cord-258787-n49zrfsp	365	46	Early	early	JJ
cord-258787-n49zrfsp	365	47	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	365	48	responses	response	NNS
cord-258787-n49zrfsp	365	49	to	to	IN
cord-258787-n49zrfsp	365	50	chemical	chemical	JJ
cord-258787-n49zrfsp	365	51	carcinogenesis	carcinogenesis	NN
cord-258787-n49zrfsp	365	52	shape	shape	NN
cord-258787-n49zrfsp	365	53	long	long	JJ
cord-258787-n49zrfsp	365	54	-	-	HYPH
cord-258787-n49zrfsp	365	55	term	term	NN
cord-258787-n49zrfsp	365	56	lung	lung	NN
cord-258787-n49zrfsp	365	57	Cancer	cancer	NN
cord-258787-n49zrfsp	365	58	susceptibility	susceptibility	NN
cord-258787-n49zrfsp	365	59	Tumor	tumor	NN
cord-258787-n49zrfsp	365	60	entrained	entrain	VBD
cord-258787-n49zrfsp	365	61	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	365	62	inhibit	inhibit	VBP
cord-258787-n49zrfsp	365	63	seeding	seed	VBG
cord-258787-n49zrfsp	365	64	in	in	IN
cord-258787-n49zrfsp	365	65	the	the	DT
cord-258787-n49zrfsp	365	66	premetastatic	premetastatic	JJ
cord-258787-n49zrfsp	365	67	lung	lung	NN
cord-258787-n49zrfsp	366	1	TRPM2	TRPM2	NNP
cord-258787-n49zrfsp	366	2	mediates	mediate	VBZ
cord-258787-n49zrfsp	366	3	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	366	4	killing	killing	NN
cord-258787-n49zrfsp	366	5	of	of	IN
cord-258787-n49zrfsp	366	6	disseminated	disseminate	VBN
cord-258787-n49zrfsp	366	7	tumor	tumor	NN
cord-258787-n49zrfsp	366	8	cells	cell	NNS
cord-258787-n49zrfsp	367	1	TRPM2	TRPM2	NNP
cord-258787-n49zrfsp	367	2	modulates	modulate	VBZ
cord-258787-n49zrfsp	367	3	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	367	4	attraction	attraction	NN
cord-258787-n49zrfsp	367	5	to	to	IN
cord-258787-n49zrfsp	367	6	murine	murine	JJ
cord-258787-n49zrfsp	367	7	tumor	tumor	NN
cord-258787-n49zrfsp	367	8	cells	cell	NNS
cord-258787-n49zrfsp	367	9	by	by	IN
cord-258787-n49zrfsp	367	10	regulating	regulate	VBG
cord-258787-n49zrfsp	367	11	CXCL2	CXCL2	NNP
cord-258787-n49zrfsp	367	12	expression	expression	NN
cord-258787-n49zrfsp	367	13	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	367	14	-	-	HYPH
cord-258787-n49zrfsp	367	15	derived	derive	VBN
cord-258787-n49zrfsp	367	16	TNFrelated	tnfrelated	JJ
cord-258787-n49zrfsp	367	17	apoptosis	apoptosis	NN
cord-258787-n49zrfsp	367	18	-	-	HYPH
cord-258787-n49zrfsp	367	19	inducing	induce	VBG
cord-258787-n49zrfsp	367	20	ligand	ligand	NN
cord-258787-n49zrfsp	367	21	(	(	-LRB-
cord-258787-n49zrfsp	367	22	TRAIL	TRAIL	NNP
cord-258787-n49zrfsp	367	23	)	)	-RRB-
cord-258787-n49zrfsp	367	24	:	:	:
cord-258787-n49zrfsp	368	1	a	a	DT
cord-258787-n49zrfsp	368	2	novel	novel	JJ
cord-258787-n49zrfsp	368	3	mechanism	mechanism	NN
cord-258787-n49zrfsp	368	4	of	of	IN
cord-258787-n49zrfsp	368	5	antitumor	antitumor	JJ
cord-258787-n49zrfsp	368	6	effect	effect	NN
cord-258787-n49zrfsp	368	7	by	by	IN
cord-258787-n49zrfsp	368	8	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	368	9	MET	MET	NNP
cord-258787-n49zrfsp	368	10	is	be	VBZ
cord-258787-n49zrfsp	368	11	required	require	VBN
cord-258787-n49zrfsp	368	12	for	for	IN
cord-258787-n49zrfsp	368	13	the	the	DT
cord-258787-n49zrfsp	368	14	recruitment	recruitment	NN
cord-258787-n49zrfsp	368	15	of	of	IN
cord-258787-n49zrfsp	368	16	anti	anti	JJ
cord-258787-n49zrfsp	368	17	-	-	JJ
cord-258787-n49zrfsp	368	18	tumoural	tumoural	JJ
cord-258787-n49zrfsp	368	19	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	368	20	Reactive	reactive	JJ
cord-258787-n49zrfsp	368	21	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	368	22	responses	response	NNS
cord-258787-n49zrfsp	368	23	dependent	dependent	JJ
cord-258787-n49zrfsp	368	24	on	on	IN
cord-258787-n49zrfsp	368	25	the	the	DT
cord-258787-n49zrfsp	368	26	receptor	receptor	NN
cord-258787-n49zrfsp	368	27	tyrosine	tyrosine	NN
cord-258787-n49zrfsp	368	28	kinase	kinase	NN
cord-258787-n49zrfsp	368	29	c	c	NNP
cord-258787-n49zrfsp	368	30	-	-	:
cord-258787-n49zrfsp	368	31	MET	MET	NNP
cord-258787-n49zrfsp	368	32	limit	limit	VB
cord-258787-n49zrfsp	368	33	Cancer	cancer	NN
cord-258787-n49zrfsp	368	34	immunotherapy	immunotherapy	NN
cord-258787-n49zrfsp	368	35	Lung	lung	NN
cord-258787-n49zrfsp	368	36	inflammation	inflammation	NN
cord-258787-n49zrfsp	368	37	promotes	promote	VBZ
cord-258787-n49zrfsp	368	38	metastasis	metastasis	NN
cord-258787-n49zrfsp	368	39	through	through	IN
cord-258787-n49zrfsp	368	40	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	368	41	protease	protease	NN
cord-258787-n49zrfsp	368	42	-	-	HYPH
cord-258787-n49zrfsp	368	43	mediated	mediate	VBN
cord-258787-n49zrfsp	368	44	degradation	degradation	NN
cord-258787-n49zrfsp	368	45	of	of	IN
cord-258787-n49zrfsp	368	46	Tsp-1	Tsp-1	NNP
cord-258787-n49zrfsp	368	47	Contribution	Contribution	NNP
cord-258787-n49zrfsp	368	48	to	to	TO
cord-258787-n49zrfsp	368	49	tumor	tumor	VB
cord-258787-n49zrfsp	368	50	angiogenesis	angiogenesis	NN
cord-258787-n49zrfsp	368	51	from	from	IN
cord-258787-n49zrfsp	368	52	innate	innate	JJ
cord-258787-n49zrfsp	368	53	immune	immune	JJ
cord-258787-n49zrfsp	368	54	cells	cell	NNS
cord-258787-n49zrfsp	368	55	within	within	IN
cord-258787-n49zrfsp	368	56	the	the	DT
cord-258787-n49zrfsp	368	57	tumor	tumor	NN
cord-258787-n49zrfsp	368	58	microenvironment	microenvironment	NN
cord-258787-n49zrfsp	368	59	:	:	:
cord-258787-n49zrfsp	368	60	implications	implication	NNS
cord-258787-n49zrfsp	368	61	for	for	IN
cord-258787-n49zrfsp	368	62	immunotherapy	immunotherapy	NN
cord-258787-n49zrfsp	369	1	An	an	DT
cord-258787-n49zrfsp	369	2	interleukin-17-mediated	interleukin-17-mediated	NNP
cord-258787-n49zrfsp	369	3	paracrine	paracrine	JJ
cord-258787-n49zrfsp	369	4	network	network	NN
cord-258787-n49zrfsp	369	5	promotes	promote	VBZ
cord-258787-n49zrfsp	369	6	tumor	tumor	NN
cord-258787-n49zrfsp	369	7	resistance	resistance	NN
cord-258787-n49zrfsp	369	8	to	to	IN
cord-258787-n49zrfsp	369	9	anti	anti	JJ
cord-258787-n49zrfsp	369	10	-	-	JJ
cord-258787-n49zrfsp	369	11	angiogenic	angiogenic	JJ
cord-258787-n49zrfsp	369	12	therapy	therapy	NN
cord-258787-n49zrfsp	370	1	Oncogenic	oncogenic	JJ
cord-258787-n49zrfsp	370	2	RAS	RAS	NNP
cord-258787-n49zrfsp	370	3	pathway	pathway	NN
cord-258787-n49zrfsp	370	4	activation	activation	NN
cord-258787-n49zrfsp	370	5	promotes	promote	VBZ
cord-258787-n49zrfsp	370	6	resistance	resistance	NN
cord-258787-n49zrfsp	370	7	to	to	IN
cord-258787-n49zrfsp	370	8	anti	anti	JJ
cord-258787-n49zrfsp	370	9	-	-	JJ
cord-258787-n49zrfsp	370	10	VEGF	vegf	JJ
cord-258787-n49zrfsp	370	11	therapy	therapy	NN
cord-258787-n49zrfsp	370	12	through	through	IN
cord-258787-n49zrfsp	370	13	G	G	NNP
cord-258787-n49zrfsp	370	14	-	-	HYPH
cord-258787-n49zrfsp	370	15	CSF	csf	NN
cord-258787-n49zrfsp	370	16	-	-	HYPH
cord-258787-n49zrfsp	370	17	induced	induce	VBN
cord-258787-n49zrfsp	370	18	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	370	19	recruitment	recruitment	NN
cord-258787-n49zrfsp	370	20	G	G	NNP
cord-258787-n49zrfsp	370	21	-	-	HYPH
cord-258787-n49zrfsp	370	22	CSF	CSF	NNP
cord-258787-n49zrfsp	370	23	-	-	HYPH
cord-258787-n49zrfsp	370	24	initiated	initiate	VBN
cord-258787-n49zrfsp	370	25	myeloid	myeloid	JJ
cord-258787-n49zrfsp	370	26	cell	cell	NN
cord-258787-n49zrfsp	370	27	mobilization	mobilization	NN
cord-258787-n49zrfsp	370	28	and	and	CC
cord-258787-n49zrfsp	370	29	angiogenesis	angiogenesis	NN
cord-258787-n49zrfsp	370	30	mediate	mediate	VBP
cord-258787-n49zrfsp	370	31	tumor	tumor	NN
cord-258787-n49zrfsp	370	32	refractoriness	refractoriness	NN
cord-258787-n49zrfsp	370	33	to	to	IN
cord-258787-n49zrfsp	370	34	anti	anti	JJ
cord-258787-n49zrfsp	370	35	-	-	JJ
cord-258787-n49zrfsp	370	36	VEGF	vegf	JJ
cord-258787-n49zrfsp	370	37	therapy	therapy	NN
cord-258787-n49zrfsp	370	38	in	in	IN
cord-258787-n49zrfsp	370	39	mouse	mouse	NN
cord-258787-n49zrfsp	370	40	models	model	NNS
cord-258787-n49zrfsp	371	1	Epithelial	epithelial	JJ
cord-258787-n49zrfsp	371	2	NOTCH	NOTCH	NNP
cord-258787-n49zrfsp	371	3	signaling	signal	VBG
cord-258787-n49zrfsp	371	4	rewires	rewire	VBZ
cord-258787-n49zrfsp	371	5	the	the	DT
cord-258787-n49zrfsp	371	6	tumor	tumor	NN
cord-258787-n49zrfsp	371	7	microenvironment	microenvironment	NN
cord-258787-n49zrfsp	371	8	of	of	IN
cord-258787-n49zrfsp	371	9	colorectal	colorectal	JJ
cord-258787-n49zrfsp	371	10	Cancer	cancer	NN
cord-258787-n49zrfsp	371	11	to	to	TO
cord-258787-n49zrfsp	371	12	drive	drive	VB
cord-258787-n49zrfsp	371	13	poor	poor	JJ
cord-258787-n49zrfsp	371	14	-	-	HYPH
cord-258787-n49zrfsp	371	15	prognosis	prognosis	NN
cord-258787-n49zrfsp	371	16	subtypes	subtype	NNS
cord-258787-n49zrfsp	371	17	and	and	CC
cord-258787-n49zrfsp	371	18	metastasis	metastasis	NN
cord-258787-n49zrfsp	371	19	Loss	loss	NN
cord-258787-n49zrfsp	371	20	of	of	IN
cord-258787-n49zrfsp	371	21	p53	p53	NN
cord-258787-n49zrfsp	372	1	triggers	trigger	NNS
cord-258787-n49zrfsp	372	2	WNT	wnt	VB
cord-258787-n49zrfsp	372	3	-	-	HYPH
cord-258787-n49zrfsp	372	4	dependent	dependent	JJ
cord-258787-n49zrfsp	372	5	systemic	systemic	JJ
cord-258787-n49zrfsp	372	6	inflammation	inflammation	NN
cord-258787-n49zrfsp	372	7	to	to	TO
cord-258787-n49zrfsp	372	8	drive	drive	VB
cord-258787-n49zrfsp	372	9	breast	breast	NN
cord-258787-n49zrfsp	372	10	cancer	cancer	NN
cord-258787-n49zrfsp	372	11	metastasis	metastasis	NN
cord-258787-n49zrfsp	372	12	Commensal	Commensal	NNP
cord-258787-n49zrfsp	372	13	microbiota	microbiota	NNS
cord-258787-n49zrfsp	372	14	promote	promote	VB
cord-258787-n49zrfsp	372	15	lung	lung	NN
cord-258787-n49zrfsp	372	16	Cancer	cancer	NN
cord-258787-n49zrfsp	372	17	development	development	NN
cord-258787-n49zrfsp	372	18	via	via	IN
cord-258787-n49zrfsp	373	1	gammadelta	gammadelta	NNP
cord-258787-n49zrfsp	373	2	t	t	NNP
cord-258787-n49zrfsp	373	3	cells	cell	VBZ
cord-258787-n49zrfsp	373	4	DNA	DNA	NNP
cord-258787-n49zrfsp	373	5	of	of	IN
cord-258787-n49zrfsp	373	6	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	373	7	extracellular	extracellular	JJ
cord-258787-n49zrfsp	373	8	traps	trap	NNS
cord-258787-n49zrfsp	373	9	promotes	promote	VBZ
cord-258787-n49zrfsp	373	10	cancer	cancer	NN
cord-258787-n49zrfsp	373	11	metastasis	metastasis	NN
cord-258787-n49zrfsp	373	12	via	via	IN
cord-258787-n49zrfsp	373	13	CCDC25	CCDC25	NNP
cord-258787-n49zrfsp	373	14	Immune	immune	NN
cord-258787-n49zrfsp	373	15	effector	effector	NN
cord-258787-n49zrfsp	373	16	monocyte	monocyte	NN
cord-258787-n49zrfsp	373	17	-	-	HYPH
cord-258787-n49zrfsp	373	18	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	373	19	cooperation	cooperation	NN
cord-258787-n49zrfsp	373	20	induced	induce	VBN
cord-258787-n49zrfsp	373	21	by	by	IN
cord-258787-n49zrfsp	373	22	the	the	DT
cord-258787-n49zrfsp	373	23	primary	primary	JJ
cord-258787-n49zrfsp	373	24	tumor	tumor	NN
cord-258787-n49zrfsp	373	25	prevents	prevent	VBZ
cord-258787-n49zrfsp	373	26	metastatic	metastatic	JJ
cord-258787-n49zrfsp	373	27	progression	progression	NN
cord-258787-n49zrfsp	373	28	of	of	IN
cord-258787-n49zrfsp	373	29	breast	breast	NN
cord-258787-n49zrfsp	373	30	cancer	cancer	NN
cord-258787-n49zrfsp	373	31	ACKR2	ackr2	NN
cord-258787-n49zrfsp	373	32	in	in	IN
cord-258787-n49zrfsp	373	33	hematopoietic	hematopoietic	JJ
cord-258787-n49zrfsp	373	34	precursors	precursor	NNS
cord-258787-n49zrfsp	373	35	as	as	IN
cord-258787-n49zrfsp	373	36	a	a	DT
cord-258787-n49zrfsp	373	37	checkpoint	checkpoint	NN
cord-258787-n49zrfsp	373	38	of	of	IN
cord-258787-n49zrfsp	373	39	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	373	40	release	release	NN
cord-258787-n49zrfsp	373	41	and	and	CC
cord-258787-n49zrfsp	373	42	anti	anti	JJ
cord-258787-n49zrfsp	373	43	-	-	JJ
cord-258787-n49zrfsp	373	44	metastatic	metastatic	JJ
cord-258787-n49zrfsp	373	45	activity	activity	NN
cord-258787-n49zrfsp	374	1	The	the	DT
cord-258787-n49zrfsp	374	2	interplay	interplay	NN
cord-258787-n49zrfsp	374	3	between	between	IN
cord-258787-n49zrfsp	374	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	374	5	and	and	CC
cord-258787-n49zrfsp	374	6	CD8(+	cd8(+	CD
cord-258787-n49zrfsp	374	7	)	)	-RRB-
cord-258787-n49zrfsp	375	1	t	t	NNP
cord-258787-n49zrfsp	375	2	cells	cell	NNS
cord-258787-n49zrfsp	375	3	improves	improve	VBZ
cord-258787-n49zrfsp	375	4	survival	survival	NN
cord-258787-n49zrfsp	375	5	in	in	IN
cord-258787-n49zrfsp	375	6	human	human	JJ
cord-258787-n49zrfsp	375	7	colorectal	colorectal	JJ
cord-258787-n49zrfsp	375	8	Cancer	Cancer	NNP
cord-258787-n49zrfsp	375	9	Tumour	tumour	NN
cord-258787-n49zrfsp	375	10	-	-	HYPH
cord-258787-n49zrfsp	375	11	elicited	elicit	VBN
cord-258787-n49zrfsp	375	12	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	375	13	engage	engage	VBP
cord-258787-n49zrfsp	375	14	mitochondrial	mitochondrial	JJ
cord-258787-n49zrfsp	375	15	metabolism	metabolism	NN
cord-258787-n49zrfsp	375	16	to	to	TO
cord-258787-n49zrfsp	375	17	circumvent	circumvent	VB
cord-258787-n49zrfsp	375	18	nutrient	nutrient	NN
cord-258787-n49zrfsp	375	19	limitations	limitation	NNS
cord-258787-n49zrfsp	375	20	and	and	CC
cord-258787-n49zrfsp	375	21	maintain	maintain	VB
cord-258787-n49zrfsp	375	22	immune	immune	JJ
cord-258787-n49zrfsp	375	23	suppression	suppression	NN
cord-258787-n49zrfsp	375	24	Population	population	NN
cord-258787-n49zrfsp	375	25	alterations	alteration	NNS
cord-258787-n49zrfsp	375	26	of	of	IN
cord-258787-n49zrfsp	375	27	L	l	NN
cord-258787-n49zrfsp	375	28	-	-	HYPH
cord-258787-n49zrfsp	375	29	arginase	arginase	NN
cord-258787-n49zrfsp	375	30	-	-	HYPH
cord-258787-n49zrfsp	375	31	and	and	CC
cord-258787-n49zrfsp	375	32	inducible	inducible	JJ
cord-258787-n49zrfsp	376	1	nitric	nitric	JJ
cord-258787-n49zrfsp	376	2	oxide	oxide	NN
cord-258787-n49zrfsp	376	3	synthaseexpressed	synthaseexpresse	VBD
cord-258787-n49zrfsp	376	4	CD11b+/CD14(-)/CD15+/CD33	cd11b+/cd14(-)/cd15+/cd33	JJ
cord-258787-n49zrfsp	376	5	+	+	CC
cord-258787-n49zrfsp	376	6	myeloid	myeloid	NN
cord-258787-n49zrfsp	376	7	-	-	HYPH
cord-258787-n49zrfsp	376	8	derived	derive	VBN
cord-258787-n49zrfsp	376	9	suppressor	suppressor	NN
cord-258787-n49zrfsp	376	10	cells	cell	NNS
cord-258787-n49zrfsp	376	11	and	and	CC
cord-258787-n49zrfsp	376	12	CD8	CD8	NNP
cord-258787-n49zrfsp	376	13	+	+	CC
cord-258787-n49zrfsp	376	14	T	T	NNP
cord-258787-n49zrfsp	376	15	lymphocytes	lymphocyte	NNS
cord-258787-n49zrfsp	376	16	in	in	IN
cord-258787-n49zrfsp	376	17	patients	patient	NNS
cord-258787-n49zrfsp	376	18	with	with	IN
cord-258787-n49zrfsp	376	19	advanced	advanced	JJ
cord-258787-n49zrfsp	376	20	-	-	HYPH
cord-258787-n49zrfsp	376	21	stage	stage	NN
cord-258787-n49zrfsp	376	22	non	non	JJ
cord-258787-n49zrfsp	376	23	-	-	JJ
cord-258787-n49zrfsp	376	24	small	small	JJ
cord-258787-n49zrfsp	376	25	cell	cell	NN
cord-258787-n49zrfsp	376	26	lung	lung	NN
cord-258787-n49zrfsp	376	27	cancer	cancer	NN
cord-258787-n49zrfsp	377	1	Arginase	Arginase	NNP
cord-258787-n49zrfsp	377	2	I	I	NNP
cord-258787-n49zrfsp	377	3	-	-	HYPH
cord-258787-n49zrfsp	377	4	producing	produce	VBG
cord-258787-n49zrfsp	377	5	myeloid	myeloid	NN
cord-258787-n49zrfsp	377	6	-	-	HYPH
cord-258787-n49zrfsp	377	7	derived	derive	VBN
cord-258787-n49zrfsp	377	8	suppressor	suppressor	NN
cord-258787-n49zrfsp	377	9	cells	cell	NNS
cord-258787-n49zrfsp	377	10	in	in	IN
cord-258787-n49zrfsp	377	11	renal	renal	JJ
cord-258787-n49zrfsp	377	12	cell	cell	NN
cord-258787-n49zrfsp	377	13	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	377	14	are	be	VBP
cord-258787-n49zrfsp	377	15	a	a	DT
cord-258787-n49zrfsp	377	16	subpopulation	subpopulation	NN
cord-258787-n49zrfsp	377	17	of	of	IN
cord-258787-n49zrfsp	377	18	activated	activate	VBN
cord-258787-n49zrfsp	377	19	granulocytes	granulocyte	NNS
cord-258787-n49zrfsp	377	20	Gut	Gut	NNP
cord-258787-n49zrfsp	377	21	Microbiota	Microbiota	NNP
cord-258787-n49zrfsp	377	22	,	,	,
cord-258787-n49zrfsp	377	23	Inflammation	inflammation	NN
cord-258787-n49zrfsp	377	24	,	,	,
cord-258787-n49zrfsp	377	25	and	and	CC
cord-258787-n49zrfsp	377	26	colorectal	colorectal	JJ
cord-258787-n49zrfsp	377	27	Cancer	Cancer	NNP
cord-258787-n49zrfsp	377	28	Cell	cell	NN
cord-258787-n49zrfsp	377	29	-	-	HYPH
cord-258787-n49zrfsp	377	30	type	type	NN
cord-258787-n49zrfsp	377	31	-	-	HYPH
cord-258787-n49zrfsp	377	32	Specific	specific	JJ
cord-258787-n49zrfsp	377	33	responses	response	NNS
cord-258787-n49zrfsp	377	34	to	to	IN
cord-258787-n49zrfsp	377	35	Interleukin-1	Interleukin-1	NNP
cord-258787-n49zrfsp	377	36	control	control	NN
cord-258787-n49zrfsp	377	37	microbial	microbial	JJ
cord-258787-n49zrfsp	377	38	invasion	invasion	NN
cord-258787-n49zrfsp	377	39	and	and	CC
cord-258787-n49zrfsp	377	40	tumor	tumor	NN
cord-258787-n49zrfsp	377	41	-	-	HYPH
cord-258787-n49zrfsp	377	42	elicited	elicit	VBN
cord-258787-n49zrfsp	377	43	inflammation	inflammation	NN
cord-258787-n49zrfsp	377	44	in	in	IN
cord-258787-n49zrfsp	377	45	colorectal	colorectal	JJ
cord-258787-n49zrfsp	377	46	Cancer	Cancer	NNP
cord-258787-n49zrfsp	377	47	Adenoma	Adenoma	NNP
cord-258787-n49zrfsp	377	48	-	-	HYPH
cord-258787-n49zrfsp	377	49	linked	link	VBN
cord-258787-n49zrfsp	377	50	barrier	barrier	NN
cord-258787-n49zrfsp	377	51	defects	defect	NNS
cord-258787-n49zrfsp	377	52	and	and	CC
cord-258787-n49zrfsp	377	53	microbial	microbial	JJ
cord-258787-n49zrfsp	377	54	products	product	NNS
cord-258787-n49zrfsp	378	1	drive	drive	VB
cord-258787-n49zrfsp	378	2	IL-23	IL-23	NNP
cord-258787-n49zrfsp	378	3	/	/	SYM
cord-258787-n49zrfsp	378	4	IL-17-mediated	il-17-mediate	VBN
cord-258787-n49zrfsp	378	5	tumour	tumour	NN
cord-258787-n49zrfsp	378	6	growth	growth	NN
cord-258787-n49zrfsp	379	1	Cross	cross	VB
cord-258787-n49zrfsp	379	2	talk	talk	NN
cord-258787-n49zrfsp	379	3	between	between	IN
cord-258787-n49zrfsp	379	4	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	379	5	and	and	CC
cord-258787-n49zrfsp	379	6	the	the	DT
cord-258787-n49zrfsp	379	7	microbiota	microbiota	NN
cord-258787-n49zrfsp	380	1	The	the	DT
cord-258787-n49zrfsp	380	2	microbiota	microbiota	NN
cord-258787-n49zrfsp	380	3	regulates	regulate	VBZ
cord-258787-n49zrfsp	380	4	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	380	5	homeostasis	homeostasis	NN
cord-258787-n49zrfsp	380	6	and	and	CC
cord-258787-n49zrfsp	380	7	host	host	NN
cord-258787-n49zrfsp	380	8	resistance	resistance	NN
cord-258787-n49zrfsp	380	9	to	to	IN
cord-258787-n49zrfsp	380	10	Escherichia	Escherichia	NNP
cord-258787-n49zrfsp	380	11	coli	coli	VBZ
cord-258787-n49zrfsp	380	12	K1	K1	NNP
cord-258787-n49zrfsp	380	13	sepsis	sepsis	NN
cord-258787-n49zrfsp	380	14	in	in	IN
cord-258787-n49zrfsp	381	1	neonatal	neonatal	JJ
cord-258787-n49zrfsp	381	2	mice	mouse	NNS
cord-258787-n49zrfsp	381	3	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	381	4	suppress	suppress	VBP
cord-258787-n49zrfsp	381	5	intraluminal	intraluminal	JJ
cord-258787-n49zrfsp	381	6	NK	NK	NNP
cord-258787-n49zrfsp	381	7	cell	cell	NN
cord-258787-n49zrfsp	381	8	-	-	HYPH
cord-258787-n49zrfsp	381	9	mediated	mediate	VBN
cord-258787-n49zrfsp	381	10	tumor	tumor	NN
cord-258787-n49zrfsp	381	11	cell	cell	NN
cord-258787-n49zrfsp	381	12	clearance	clearance	NN
cord-258787-n49zrfsp	381	13	and	and	CC
cord-258787-n49zrfsp	381	14	enhance	enhance	VB
cord-258787-n49zrfsp	381	15	extravasation	extravasation	NN
cord-258787-n49zrfsp	381	16	of	of	IN
cord-258787-n49zrfsp	381	17	disseminated	disseminate	VBN
cord-258787-n49zrfsp	381	18	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	381	19	cells	cell	NNS
cord-258787-n49zrfsp	381	20	NK	NK	NNP
cord-258787-n49zrfsp	381	21	cells	cell	NNS
cord-258787-n49zrfsp	381	22	control	control	VBP
cord-258787-n49zrfsp	381	23	tumor	tumor	NN
cord-258787-n49zrfsp	381	24	-	-	HYPH
cord-258787-n49zrfsp	381	25	promoting	promote	VBG
cord-258787-n49zrfsp	381	26	function	function	NN
cord-258787-n49zrfsp	381	27	of	of	IN
cord-258787-n49zrfsp	381	28	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	381	29	in	in	IN
cord-258787-n49zrfsp	381	30	mice	mouse	NNS
cord-258787-n49zrfsp	381	31	Peritumoural	Peritumoural	NNP
cord-258787-n49zrfsp	381	32	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	381	33	negatively	negatively	RB
cord-258787-n49zrfsp	381	34	regulate	regulate	VBP
cord-258787-n49zrfsp	381	35	adaptive	adaptive	JJ
cord-258787-n49zrfsp	381	36	immunity	immunity	NN
cord-258787-n49zrfsp	381	37	via	via	IN
cord-258787-n49zrfsp	381	38	the	the	DT
cord-258787-n49zrfsp	381	39	PD	PD	NNP
cord-258787-n49zrfsp	381	40	-	-	HYPH
cord-258787-n49zrfsp	381	41	L1	L1	NNP
cord-258787-n49zrfsp	381	42	/	/	SYM
cord-258787-n49zrfsp	381	43	PD-1	PD-1	NNP
cord-258787-n49zrfsp	381	44	signalling	signal	VBG
cord-258787-n49zrfsp	381	45	pathway	pathway	NN
cord-258787-n49zrfsp	381	46	in	in	IN
cord-258787-n49zrfsp	381	47	hepatocellular	hepatocellular	JJ
cord-258787-n49zrfsp	381	48	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	381	49	Tumour	tumour	NN
cord-258787-n49zrfsp	381	50	-	-	HYPH
cord-258787-n49zrfsp	381	51	activated	activate	VBN
cord-258787-n49zrfsp	381	52	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	381	53	in	in	IN
cord-258787-n49zrfsp	381	54	gastric	gastric	JJ
cord-258787-n49zrfsp	381	55	cancer	cancer	NN
cord-258787-n49zrfsp	381	56	foster	foster	NN
cord-258787-n49zrfsp	381	57	immune	immune	JJ
cord-258787-n49zrfsp	381	58	suppression	suppression	NN
cord-258787-n49zrfsp	381	59	and	and	CC
cord-258787-n49zrfsp	381	60	disease	disease	NN
cord-258787-n49zrfsp	381	61	progression	progression	NN
cord-258787-n49zrfsp	381	62	through	through	IN
cord-258787-n49zrfsp	381	63	GM	GM	NNP
cord-258787-n49zrfsp	381	64	-	-	HYPH
cord-258787-n49zrfsp	381	65	CSF	CSF	NNP
cord-258787-n49zrfsp	381	66	-	-	HYPH
cord-258787-n49zrfsp	381	67	PD	PD	NNP
cord-258787-n49zrfsp	381	68	-	-	HYPH
cord-258787-n49zrfsp	381	69	L1	L1	NNP
cord-258787-n49zrfsp	381	70	pathway	pathway	NN
cord-258787-n49zrfsp	381	71	Immunecheckpoint	Immunecheckpoint	NNP
cord-258787-n49zrfsp	381	72	protein	protein	NN
cord-258787-n49zrfsp	381	73	VISTA	VISTA	NNP
cord-258787-n49zrfsp	381	74	regulates	regulate	VBZ
cord-258787-n49zrfsp	381	75	antitumor	antitumor	JJ
cord-258787-n49zrfsp	381	76	immunity	immunity	NN
cord-258787-n49zrfsp	381	77	by	by	IN
cord-258787-n49zrfsp	381	78	controlling	control	VBG
cord-258787-n49zrfsp	381	79	myeloid	myeloid	JJ
cord-258787-n49zrfsp	381	80	cell	cell	NN
cord-258787-n49zrfsp	381	81	-	-	HYPH
cord-258787-n49zrfsp	381	82	mediated	mediate	VBN
cord-258787-n49zrfsp	381	83	inflammation	inflammation	NN
cord-258787-n49zrfsp	381	84	and	and	CC
cord-258787-n49zrfsp	381	85	immunosuppression	immunosuppression	NN
cord-258787-n49zrfsp	381	86	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	381	87	-	-	HYPH
cord-258787-n49zrfsp	381	88	lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	381	89	ratio	ratio	NN
cord-258787-n49zrfsp	381	90	in	in	IN
cord-258787-n49zrfsp	381	91	metastatic	metastatic	JJ
cord-258787-n49zrfsp	381	92	breast	breast	NN
cord-258787-n49zrfsp	381	93	cancer	cancer	NN
cord-258787-n49zrfsp	381	94	is	be	VBZ
cord-258787-n49zrfsp	381	95	not	not	RB
cord-258787-n49zrfsp	381	96	an	an	DT
cord-258787-n49zrfsp	381	97	independent	independent	JJ
cord-258787-n49zrfsp	381	98	predictor	predictor	NN
cord-258787-n49zrfsp	381	99	of	of	IN
cord-258787-n49zrfsp	381	100	survival	survival	NN
cord-258787-n49zrfsp	381	101	Occurrence	occurrence	NN
cord-258787-n49zrfsp	381	102	and	and	CC
cord-258787-n49zrfsp	381	103	significance	significance	NN
cord-258787-n49zrfsp	381	104	of	of	IN
cord-258787-n49zrfsp	381	105	tumor	tumor	NN
cord-258787-n49zrfsp	381	106	-	-	HYPH
cord-258787-n49zrfsp	381	107	associated	associate	VBN
cord-258787-n49zrfsp	381	108	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	381	109	in	in	IN
cord-258787-n49zrfsp	381	110	patients	patient	NNS
cord-258787-n49zrfsp	381	111	with	with	IN
cord-258787-n49zrfsp	381	112	colorectal	colorectal	JJ
cord-258787-n49zrfsp	381	113	cancer	cancer	NN
cord-258787-n49zrfsp	381	114	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	381	115	dominate	dominate	VBP
cord-258787-n49zrfsp	381	116	the	the	DT
cord-258787-n49zrfsp	381	117	immune	immune	JJ
cord-258787-n49zrfsp	381	118	cell	cell	NN
cord-258787-n49zrfsp	381	119	composition	composition	NN
cord-258787-n49zrfsp	381	120	in	in	IN
cord-258787-n49zrfsp	381	121	non	non	JJ
cord-258787-n49zrfsp	381	122	-	-	JJ
cord-258787-n49zrfsp	381	123	small	small	JJ
cord-258787-n49zrfsp	381	124	cell	cell	NN
cord-258787-n49zrfsp	381	125	lung	lung	NN
cord-258787-n49zrfsp	381	126	cancer	cancer	NN
cord-258787-n49zrfsp	381	127	Peritumoral	Peritumoral	NNP
cord-258787-n49zrfsp	381	128	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	381	129	link	link	VBP
cord-258787-n49zrfsp	381	130	inflammatory	inflammatory	JJ
cord-258787-n49zrfsp	381	131	response	response	NN
cord-258787-n49zrfsp	381	132	to	to	IN
cord-258787-n49zrfsp	381	133	disease	disease	NN
cord-258787-n49zrfsp	381	134	progression	progression	NN
cord-258787-n49zrfsp	381	135	by	by	IN
cord-258787-n49zrfsp	381	136	fostering	foster	VBG
cord-258787-n49zrfsp	381	137	angiogenesis	angiogenesis	NN
cord-258787-n49zrfsp	381	138	in	in	IN
cord-258787-n49zrfsp	381	139	hepatocellular	hepatocellular	JJ
cord-258787-n49zrfsp	381	140	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	381	141	Neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	381	142	oppose	oppose	VBP
cord-258787-n49zrfsp	381	143	uterine	uterine	JJ
cord-258787-n49zrfsp	381	144	epithelial	epithelial	JJ
cord-258787-n49zrfsp	381	145	carcinogenesis	carcinogenesis	NN
cord-258787-n49zrfsp	381	146	via	via	IN
cord-258787-n49zrfsp	381	147	debridement	debridement	NN
cord-258787-n49zrfsp	381	148	of	of	IN
cord-258787-n49zrfsp	381	149	hypoxic	hypoxic	JJ
cord-258787-n49zrfsp	381	150	tumor	tumor	NN
cord-258787-n49zrfsp	381	151	cells	cell	NNS
cord-258787-n49zrfsp	382	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	382	2	infiltration	infiltration	NN
cord-258787-n49zrfsp	382	3	is	be	VBZ
cord-258787-n49zrfsp	382	4	a	a	DT
cord-258787-n49zrfsp	382	5	favorable	favorable	JJ
cord-258787-n49zrfsp	382	6	prognostic	prognostic	JJ
cord-258787-n49zrfsp	382	7	factor	factor	NN
cord-258787-n49zrfsp	382	8	in	in	IN
cord-258787-n49zrfsp	382	9	early	early	JJ
cord-258787-n49zrfsp	382	10	stages	stage	NNS
cord-258787-n49zrfsp	382	11	of	of	IN
cord-258787-n49zrfsp	382	12	colon	colon	NN
cord-258787-n49zrfsp	382	13	cancer	cancer	NN
cord-258787-n49zrfsp	382	14	Association	Association	NNP
cord-258787-n49zrfsp	382	15	between	between	IN
cord-258787-n49zrfsp	382	16	pretreatment	pretreatment	JJ
cord-258787-n49zrfsp	382	17	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	382	18	-	-	HYPH
cord-258787-n49zrfsp	382	19	to	to	IN
cord-258787-n49zrfsp	382	20	-	-	HYPH
cord-258787-n49zrfsp	382	21	Lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	382	22	ratio	ratio	NN
cord-258787-n49zrfsp	382	23	and	and	CC
cord-258787-n49zrfsp	382	24	outcome	outcome	NN
cord-258787-n49zrfsp	382	25	of	of	IN
cord-258787-n49zrfsp	382	26	patients	patient	NNS
cord-258787-n49zrfsp	382	27	with	with	IN
cord-258787-n49zrfsp	382	28	metastatic	metastatic	JJ
cord-258787-n49zrfsp	382	29	renalcell	renalcell	NNP
cord-258787-n49zrfsp	382	30	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	382	31	treated	treat	VBN
cord-258787-n49zrfsp	382	32	with	with	IN
cord-258787-n49zrfsp	382	33	nivolumab	nivolumab	NNP
cord-258787-n49zrfsp	382	34	Baseline	Baseline	NNP
cord-258787-n49zrfsp	382	35	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	382	36	-	-	HYPH
cord-258787-n49zrfsp	382	37	to	to	IN
cord-258787-n49zrfsp	382	38	-	-	HYPH
cord-258787-n49zrfsp	382	39	lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	382	40	ratio	ratio	NN
cord-258787-n49zrfsp	382	41	(	(	-LRB-
cord-258787-n49zrfsp	382	42	NLR	NLR	NNP
cord-258787-n49zrfsp	382	43	)	)	-RRB-
cord-258787-n49zrfsp	382	44	and	and	CC
cord-258787-n49zrfsp	382	45	derived	derive	VBD
cord-258787-n49zrfsp	382	46	NLR	NLR	NNP
cord-258787-n49zrfsp	382	47	could	could	MD
cord-258787-n49zrfsp	382	48	predict	predict	VB
cord-258787-n49zrfsp	382	49	overall	overall	JJ
cord-258787-n49zrfsp	382	50	survival	survival	NN
cord-258787-n49zrfsp	382	51	in	in	IN
cord-258787-n49zrfsp	382	52	patients	patient	NNS
cord-258787-n49zrfsp	382	53	with	with	IN
cord-258787-n49zrfsp	382	54	advanced	advanced	JJ
cord-258787-n49zrfsp	382	55	melanoma	melanoma	NN
cord-258787-n49zrfsp	382	56	treated	treat	VBN
cord-258787-n49zrfsp	382	57	with	with	IN
cord-258787-n49zrfsp	382	58	nivolumab	nivolumab	NNP
cord-258787-n49zrfsp	382	59	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	382	60	to	to	TO
cord-258787-n49zrfsp	382	61	lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	382	62	ratio	ratio	NN
cord-258787-n49zrfsp	382	63	is	be	VBZ
cord-258787-n49zrfsp	382	64	associated	associate	VBN
cord-258787-n49zrfsp	382	65	with	with	IN
cord-258787-n49zrfsp	382	66	outcome	outcome	NN
cord-258787-n49zrfsp	382	67	during	during	IN
cord-258787-n49zrfsp	382	68	ipilimumab	ipilimumab	NNS
cord-258787-n49zrfsp	382	69	treatment	treatment	NN
cord-258787-n49zrfsp	382	70	Clinical	clinical	JJ
cord-258787-n49zrfsp	382	71	significance	significance	NN
cord-258787-n49zrfsp	382	72	of	of	IN
cord-258787-n49zrfsp	382	73	tumorinfiltrating	tumorinfiltrate	VBG
cord-258787-n49zrfsp	382	74	lymphocytes	lymphocyte	NNS
cord-258787-n49zrfsp	382	75	and	and	CC
cord-258787-n49zrfsp	382	76	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	382	77	-	-	HYPH
cord-258787-n49zrfsp	382	78	to	to	IN
cord-258787-n49zrfsp	382	79	-	-	HYPH
cord-258787-n49zrfsp	382	80	lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	382	81	ratio	ratio	NN
cord-258787-n49zrfsp	382	82	in	in	IN
cord-258787-n49zrfsp	382	83	patients	patient	NNS
cord-258787-n49zrfsp	382	84	with	with	IN
cord-258787-n49zrfsp	382	85	stage	stage	NN
cord-258787-n49zrfsp	382	86	III	iii	CD
cord-258787-n49zrfsp	382	87	colon	colon	NN
cord-258787-n49zrfsp	382	88	cancer	cancer	NN
cord-258787-n49zrfsp	382	89	who	who	WP
cord-258787-n49zrfsp	382	90	underwent	undergo	VBD
cord-258787-n49zrfsp	382	91	surgery	surgery	NN
cord-258787-n49zrfsp	382	92	followed	follow	VBN
cord-258787-n49zrfsp	382	93	by	by	IN
cord-258787-n49zrfsp	382	94	FOLFOX	FOLFOX	NNP
cord-258787-n49zrfsp	382	95	chemotherapy	chemotherapy	NN
cord-258787-n49zrfsp	383	1	Neutrophil	Neutrophil	NNP
cord-258787-n49zrfsp	383	2	/	/	SYM
cord-258787-n49zrfsp	383	3	lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	383	4	ratio	ratio	NN
cord-258787-n49zrfsp	383	5	predicts	predict	VBZ
cord-258787-n49zrfsp	383	6	chemotherapy	chemotherapy	NN
cord-258787-n49zrfsp	383	7	outcomes	outcome	NNS
cord-258787-n49zrfsp	383	8	in	in	IN
cord-258787-n49zrfsp	383	9	patients	patient	NNS
cord-258787-n49zrfsp	383	10	with	with	IN
cord-258787-n49zrfsp	383	11	advanced	advanced	JJ
cord-258787-n49zrfsp	383	12	colorectal	colorectal	JJ
cord-258787-n49zrfsp	383	13	cancer	cancer	NN
cord-258787-n49zrfsp	383	14	Baseline	Baseline	NNP
cord-258787-n49zrfsp	383	15	neutrophilia	neutrophilia	NN
cord-258787-n49zrfsp	383	16	,	,	,
cord-258787-n49zrfsp	383	17	derived	derive	VBN
cord-258787-n49zrfsp	383	18	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	383	19	-	-	HYPH
cord-258787-n49zrfsp	383	20	to	to	IN
cord-258787-n49zrfsp	383	21	-	-	HYPH
cord-258787-n49zrfsp	383	22	lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	383	23	ratio	ratio	NN
cord-258787-n49zrfsp	383	24	(	(	-LRB-
cord-258787-n49zrfsp	383	25	dNLR	dNLR	NNP
cord-258787-n49zrfsp	383	26	)	)	-RRB-
cord-258787-n49zrfsp	383	27	,	,	,
cord-258787-n49zrfsp	383	28	platelet	platelet	NN
cord-258787-n49zrfsp	383	29	-	-	HYPH
cord-258787-n49zrfsp	383	30	to	to	IN
cord-258787-n49zrfsp	383	31	-	-	HYPH
cord-258787-n49zrfsp	383	32	lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	383	33	ratio	ratio	NN
cord-258787-n49zrfsp	383	34	(	(	-LRB-
cord-258787-n49zrfsp	383	35	PLR	PLR	NNP
cord-258787-n49zrfsp	383	36	)	)	-RRB-
cord-258787-n49zrfsp	383	37	,	,	,
cord-258787-n49zrfsp	383	38	and	and	CC
cord-258787-n49zrfsp	383	39	outcome	outcome	NN
cord-258787-n49zrfsp	383	40	in	in	IN
cord-258787-n49zrfsp	383	41	non	non	JJ
cord-258787-n49zrfsp	383	42	small	small	JJ
cord-258787-n49zrfsp	383	43	cell	cell	NN
cord-258787-n49zrfsp	383	44	lung	lung	NN
cord-258787-n49zrfsp	383	45	cancer	cancer	NN
cord-258787-n49zrfsp	383	46	(	(	-LRB-
cord-258787-n49zrfsp	383	47	NSCLC	NSCLC	NNP
cord-258787-n49zrfsp	383	48	)	)	-RRB-
cord-258787-n49zrfsp	383	49	treated	treat	VBN
cord-258787-n49zrfsp	383	50	with	with	IN
cord-258787-n49zrfsp	383	51	Nivolumab	Nivolumab	NNP
cord-258787-n49zrfsp	383	52	or	or	CC
cord-258787-n49zrfsp	383	53	Docetaxel	Docetaxel	NNP
cord-258787-n49zrfsp	383	54	Association	Association	NNP
cord-258787-n49zrfsp	383	55	of	of	IN
cord-258787-n49zrfsp	383	56	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	383	57	/	/	SYM
cord-258787-n49zrfsp	383	58	lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	383	59	ratio	ratio	NN
cord-258787-n49zrfsp	383	60	and	and	CC
cord-258787-n49zrfsp	383	61	platelet	platelet	NN
cord-258787-n49zrfsp	383	62	/	/	SYM
cord-258787-n49zrfsp	383	63	lymphocyte	lymphocyte	NN
cord-258787-n49zrfsp	383	64	ratio	ratio	NN
cord-258787-n49zrfsp	383	65	with	with	IN
cord-258787-n49zrfsp	383	66	ER	ER	NNP
cord-258787-n49zrfsp	383	67	and	and	CC
cord-258787-n49zrfsp	383	68	PR	PR	NNP
cord-258787-n49zrfsp	383	69	in	in	IN
cord-258787-n49zrfsp	383	70	breast	breast	NN
cord-258787-n49zrfsp	383	71	cancer	cancer	NN
cord-258787-n49zrfsp	383	72	patients	patient	NNS
cord-258787-n49zrfsp	383	73	and	and	CC
cord-258787-n49zrfsp	383	74	their	-PRON-	PRP$
cord-258787-n49zrfsp	383	75	changes	change	NNS
cord-258787-n49zrfsp	383	76	after	after	IN
cord-258787-n49zrfsp	383	77	neoadjuvant	neoadjuvant	JJ
cord-258787-n49zrfsp	383	78	chemotherapy	chemotherapy	NN
cord-258787-n49zrfsp	383	79	Tumorassociated	Tumorassociated	NNP
cord-258787-n49zrfsp	383	80	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	383	81	correlate	correlate	VBP
cord-258787-n49zrfsp	383	82	with	with	IN
cord-258787-n49zrfsp	383	83	poor	poor	JJ
cord-258787-n49zrfsp	383	84	prognosis	prognosis	NN
cord-258787-n49zrfsp	383	85	in	in	IN
cord-258787-n49zrfsp	383	86	diffuse	diffuse	JJ
cord-258787-n49zrfsp	383	87	large	large	JJ
cord-258787-n49zrfsp	383	88	B	b	NN
cord-258787-n49zrfsp	383	89	-	-	HYPH
cord-258787-n49zrfsp	383	90	cell	cell	NN
cord-258787-n49zrfsp	383	91	lymphoma	lymphoma	NN
cord-258787-n49zrfsp	383	92	patients	patient	NNS
cord-258787-n49zrfsp	384	1	The	the	DT
cord-258787-n49zrfsp	384	2	significance	significance	NN
cord-258787-n49zrfsp	384	3	of	of	IN
cord-258787-n49zrfsp	384	4	tumor	tumor	NN
cord-258787-n49zrfsp	384	5	-	-	HYPH
cord-258787-n49zrfsp	384	6	associated	associate	VBN
cord-258787-n49zrfsp	384	7	neutrophil	neutrophil	NN
cord-258787-n49zrfsp	384	8	density	density	NN
cord-258787-n49zrfsp	384	9	in	in	IN
cord-258787-n49zrfsp	384	10	uterine	uterine	JJ
cord-258787-n49zrfsp	384	11	cervical	cervical	JJ
cord-258787-n49zrfsp	384	12	cancer	cancer	NN
cord-258787-n49zrfsp	384	13	treated	treat	VBN
cord-258787-n49zrfsp	384	14	with	with	IN
cord-258787-n49zrfsp	384	15	definitive	definitive	JJ
cord-258787-n49zrfsp	384	16	radiotherapy	radiotherapy	NN
cord-258787-n49zrfsp	384	17	High	high	JJ
cord-258787-n49zrfsp	384	18	density	density	NN
cord-258787-n49zrfsp	384	19	of	of	IN
cord-258787-n49zrfsp	384	20	CD66b	cd66b	NN
cord-258787-n49zrfsp	384	21	in	in	IN
cord-258787-n49zrfsp	384	22	primary	primary	JJ
cord-258787-n49zrfsp	384	23	high	high	JJ
cord-258787-n49zrfsp	384	24	-	-	HYPH
cord-258787-n49zrfsp	384	25	grade	grade	NN
cord-258787-n49zrfsp	384	26	ovarian	ovarian	JJ
cord-258787-n49zrfsp	384	27	cancer	cancer	NN
cord-258787-n49zrfsp	384	28	independently	independently	RB
cord-258787-n49zrfsp	384	29	predicts	predict	VBZ
cord-258787-n49zrfsp	384	30	response	response	NN
cord-258787-n49zrfsp	384	31	to	to	IN
cord-258787-n49zrfsp	384	32	chemotherapy	chemotherapy	NN
cord-258787-n49zrfsp	384	33	Tumour	tumour	NN
cord-258787-n49zrfsp	384	34	-	-	HYPH
cord-258787-n49zrfsp	384	35	infiltrating	infiltrate	VBG
cord-258787-n49zrfsp	384	36	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	384	37	counteract	counteract	VBP
cord-258787-n49zrfsp	384	38	anti	anti	JJ
cord-258787-n49zrfsp	384	39	-	-	JJ
cord-258787-n49zrfsp	384	40	VEGF	vegf	JJ
cord-258787-n49zrfsp	384	41	therapy	therapy	NN
cord-258787-n49zrfsp	384	42	in	in	IN
cord-258787-n49zrfsp	384	43	metastatic	metastatic	JJ
cord-258787-n49zrfsp	384	44	colorectal	colorectal	JJ
cord-258787-n49zrfsp	384	45	cancer	cancer	NN
cord-258787-n49zrfsp	384	46	Tumorinfiltrating	Tumorinfiltrating	NNP
cord-258787-n49zrfsp	384	47	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	384	48	is	be	VBZ
cord-258787-n49zrfsp	384	49	prognostic	prognostic	JJ
cord-258787-n49zrfsp	384	50	and	and	CC
cord-258787-n49zrfsp	384	51	predictive	predictive	JJ
cord-258787-n49zrfsp	384	52	for	for	IN
cord-258787-n49zrfsp	384	53	postoperative	postoperative	JJ
cord-258787-n49zrfsp	384	54	adjuvant	adjuvant	NN
cord-258787-n49zrfsp	384	55	chemotherapy	chemotherapy	NN
cord-258787-n49zrfsp	384	56	benefit	benefit	NN
cord-258787-n49zrfsp	384	57	in	in	IN
cord-258787-n49zrfsp	384	58	patients	patient	NNS
cord-258787-n49zrfsp	384	59	with	with	IN
cord-258787-n49zrfsp	384	60	gastric	gastric	JJ
cord-258787-n49zrfsp	384	61	Cancer	cancer	NN
cord-258787-n49zrfsp	384	62	Tumor	tumor	NN
cord-258787-n49zrfsp	384	63	-	-	HYPH
cord-258787-n49zrfsp	384	64	associated	associate	VBN
cord-258787-n49zrfsp	384	65	neutrophils	neutrophil	NNS
cord-258787-n49zrfsp	384	66	recruit	recruit	VBP
cord-258787-n49zrfsp	384	67	macrophages	macrophage	NNS
cord-258787-n49zrfsp	384	68	and	and	CC
cord-258787-n49zrfsp	384	69	T	T	NNP
cord-258787-n49zrfsp	384	70	-	-	HYPH
cord-258787-n49zrfsp	384	71	Regulatory	Regulatory	NNP
cord-258787-n49zrfsp	384	72	cells	cell	NNS
cord-258787-n49zrfsp	384	73	to	to	TO
cord-258787-n49zrfsp	384	74	promote	promote	VB
cord-258787-n49zrfsp	384	75	progression	progression	NN
cord-258787-n49zrfsp	384	76	of	of	IN
cord-258787-n49zrfsp	384	77	hepatocellular	hepatocellular	JJ
cord-258787-n49zrfsp	384	78	carcinoma	carcinoma	NN
cord-258787-n49zrfsp	384	79	and	and	CC
cord-258787-n49zrfsp	384	80	resistance	resistance	NN
cord-258787-n49zrfsp	384	81	to	to	IN
cord-258787-n49zrfsp	384	82	sorafenib	sorafenib	NNP