id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-354080-glcq4qp9	Bodro, Marta	Increased CSF levels of IL-1β, IL-6, and ACE in SARS-CoV-2–associated encephalitis	2020-07-01		.txt	text/plain	1176	79	47	For the latest articles, invited commentaries, and blogs from physicians around the world NPub.org/COVID19 Clinical features, serum, and CSF characteristics including cytokines and angiotensin-converting enzyme (ACE) profile from both cases are shown in the table. Three previous case reports of CNS involvement in COVID-19 suggest different pathogenic mechanisms: direct CNS infection demonstrated by detection of SARS-CoV-2 RNA in CSF, 2 recrudescence of symptoms related to previous lesions (e.g., brain infarction) in the context of systemic infection, 3 and inflammatory-mediated mechanisms resulting in acute hemorrhagic necrotizing encephalopathy. Hence, in a study of children with acute encephalitis-like syndrome, serum anti-human coronavirus-OC43 immunoglobulin M antibodies were present in 12% of patients and levels of IL-6, IL-8, monocyte chemotactic protein-1, and Granulocyte Macrophage Colony-Stimulating Factor were increased in their CSF. The main implication of these 2 patients is that physicians should be aware of COVID-19 infections presenting or predominantly manifesting as encephalitis, likely resulting from activation of inflammatory pathways with increased ILs and ACE in CSF.	./cache/cord-354080-glcq4qp9.txt	./txt/cord-354080-glcq4qp9.txt