id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-333186-gxs74wit	Ashhurst, Thomas Myles	The plasticity of inflammatory monocyte responses to the inflamed central nervous system	2014-10-31		.txt	text/plain	8527	388	37	Viral encephalitis and multiple sclerosis are examples of important human diseases in which the pathogenic contribution of monocytes recruited from the bone marrow plays a critical role in the clinical expression of disease, as they differentiate into macrophage or dendritic cells in the CNS to carry out effector functions. Here we review the current understanding of factors facilitating inflammatory monocyte generation, migration and entry into the brain, as well as their differentiation towards macrophages or dendritic cells in viral and autoimmune disease in relation to their respective disease outcomes. It is also possible that whilst type I IFN (IFN-a/b) and type II IFN (IFN-c) are involved in both CNS diseases, the innate differential production of IFN-a/b, crucial for virus control in the early response against CNS viruses [25] , by a variety of cell types during infection [26] may induce monocyte mobilisation differently from that seen in MS/EAE.	./cache/cord-333186-gxs74wit.txt	./txt/cord-333186-gxs74wit.txt