id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328763-hcbs20a0	Ifergan, Igal	Potential for Targeting Myeloid Cells in Controlling CNS Inflammation	2020-10-06		.txt	text/plain	11053	559	39	As we will discuss in this review, multiple tools have been developed in the EAE models of MS demonstrating significant regulation of disease progression by various approaches blocking myeloid cell activation and effector function, but to date, these approaches have not been tested for therapeutic efficacy in MS patients. GM-CSF has a wide array of functions, notably the survival and activation of myeloid cells, the ability to induce differentiation of dendritic cells (DCs), the polarization of macrophages toward a pro-inflammatory M1 phenotype, enhanced antigen presentation, the induction of complement-and antibody-mediated phagocytosis, and the mobilization of monocytes and other myeloid populations from bone marrow to blood (61) (62) (63) . M-CSF stimulates progenitor cells from bone marrow and plays an important regulatory role in the survival, proliferation (in mice), differentiation, phagocytosis, and chemotaxis of myeloid cells, including monocytes, macrophages, DCs, and microglia (87) (88) (89) .	./cache/cord-328763-hcbs20a0.txt	./txt/cord-328763-hcbs20a0.txt