id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285833-7exenodj	Alkan, Ali	Double-edged sword: Granulocyte colony stimulating factors in cancer patients during the COVID-19 era	2020-07-02		.txt	text/plain	693	43	45	A few recent studies on cancer patients have shown that they are at an increased risk for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Moreover, a 5-day course of G-CSF prophylaxis in most chemotherapy regimens has been reported to be effective (4); however, limited data are available on its efficacy in COVID-19 patients. Clinical outcomes are also unpredictable in COVID-19 patients with high levels of inflammatory cytokines undergoing G-CSF prophylaxis. However, very limited data on the outcomes of chemotherapy in cancer patients in the COVID-19 era are currently available, with no specific subgroup analysis in patients treated with G-CSFs. Although the described scenarios are theoretical and speculative, both NCCN and ESMO have concluded that the benefits of G-CSF administration outweigh its risks and have, therefore, recommended its use with caution. Until more data are available, clinicians should be more cautious with the use of G-CSFs in cancer patients in the COVID-19 era.	./cache/cord-285833-7exenodj.txt	./txt/cord-285833-7exenodj.txt